Abstract:
BACKGROUND:Subclinical hypothyroidism may adversely affect the development of cardiovascular disease (CVD). Less is known about the role of low-normal thyroid function, that is higher thyroid-stimulating hormone and/or lower free thyroxine levels within the euthyroid reference range, in the development of cardio-metabolic disorders. This review is focused on the relationship of low-normal thyroid function with CVD, plasma lipids and lipoprotein function, as well as with metabolic syndrome (MetS), chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS:This narrative review, which includes results from previously published systematic reviews and meta-analyses, is based on clinical and basic research papers, obtained via MEDLINE and PubMed up to November 2014. RESULTS:Low-normal thyroid function could adversely affect the development of (subclinical) atherosclerotic manifestations. It is likely that low-normal thyroid function relates to modest increases in plasma total cholesterol, LDL cholesterol and triglycerides, and may convey pro-atherogenic changes in lipoprotein metabolism and in HDL function. Most available data support the concept that low-normal thyroid function is associated with MetS, insulin resistance and CKD, but not with high blood pressure. Inconsistent effects of low-normal thyroid function on NAFLD have been reported so far. CONCLUSIONS:Observational studies suggest that low-normal thyroid function may be implicated in the pathogenesis of CVD. Low-normal thyroid function could also play a role in the development of MetS, insulin resistance and CKD, but the relationship with NAFLD is uncertain. The extent to which low-normal thyroid function prospectively predicts cardio-metabolic disorders has been insufficiently established so far.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
van Tienhoven-Wind LJ,Dullaart RPdoi
10.1111/eci.12423subject
Has Abstractpub_date
2015-05-01 00:00:00pages
494-503issue
5eissn
0014-2972issn
1365-2362journal_volume
45pub_type
杂志文章,评审abstract:OBJECTIVES:To compare clinical outcomes among patients with acute coronary syndrome treated with zotarolimus-eluting and sirolimus-eluting stents in the SORT OUT III trial. BACKGROUND:Currently, only limited data allow direct comparison of clinical outcomes among patients with acute coronary syndrome treated with a se...
journal_title:European journal of clinical investigation
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:The mechanisms responsible for the progressive failure of hypoglycaemia counterregulation in long-standing type 1 diabetes are poorly understood. Increased brain glucose uptake during hypoglycaemia or alterations of brain energy metabolism could effect glucose sensing by the brain and thus contribute to hypo...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章
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更新日期:1998-07-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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更新日期:2013-05-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1111/j.1365-2362.1981.tb01847.x
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pub_type: 杂志文章,多中心研究
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更新日期:2015-07-01 00:00:00
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更新日期:2018-10-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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