Maternal imprinting on cognition markers of wild type and transgenic Alzheimer's disease model mice.

abstract：:Maoto, a traditional Japanese Kampo medicine, has been used to treat various respiratory diseases, including respiratory infections and influenza. Ephedrine (EPD), the main ingredient in maoto, is also clinically used to treat respiratory diseases. However, the pharmacokinetics and distribution of EPD in the lungs aft...

journal_title：Scientific reports

authors： Matsumoto T,Kushida H,Matsushita S,Oyama Y,Suda T,Watanabe J,Kase Y,Setou M

更新日期：2017-03-08 00:00:00

abstract：:Mountain glaciers form landscapes with U-shaped valleys, roche moutonées and overdeepenings through bedrock erosion. However, little evidence for active glacial carving has been provided particularly for areas above the Equilibrium Line Altitude (ELA) where glaciers originate. This is mainly due to our lack of informa...

journal_title：Scientific reports

authors： Nishiyama R,Ariga A,Ariga T,Lechmann A,Mair D,Pistillo C,Scampoli P,Valla PG,Vladymyrov M,Ereditato A,Schlunegger F

更新日期：2019-05-06 00:00:00

abstract：:The exposure of aqueous solutions to atmospheric plasmas results in the generation of relatively long-lived secondary products such as hydrogen peroxide which are biologically active and have demonstrated anti-microbial and cytotoxic activity. The use of plasma-activated solutions in applications such as microbial dec...

journal_title：Scientific reports

authors： Boehm D,Heslin C,Cullen PJ,Bourke P

更新日期：2016-02-24 00:00:00

abstract：:Stem cell research has yielded promising advances in regenerative medicine, but standard assays generally lack the ability to combine different cell stimulations with rapid sample processing and precise fluid control. In this work, we describe the design and fabrication of a micro-scale cell stimulator capable of simu...

journal_title：Scientific reports

authors： Pavesi A,Adriani G,Rasponi M,Zervantonakis IK,Fiore GB,Kamm RD

更新日期：2015-07-02 00:00:00

abstract：:Radiation exposure during muscle development induces long-term decrements to skeletal muscle health, which contribute to reduced quality of life in childhood cancer survivors. Whether the effects of radiation on skeletal muscle are influenced by relevant physiological factors, such as obesity and exercise training rem...

journal_title：Scientific reports

authors： D'Souza D,Roubos S,Larkin J,Lloyd J,Emmons R,Chen H,De Lisio M

更新日期：2019-04-30 00:00:00

abstract：:We present combined in situ X-ray diffraction and high-speed imaging to monitor the phase evolution upon cyclic rapid laser heating and cooling mimicking the direct energy deposition of Ti-6Al-4V in real time. Additive manufacturing of the industrially relevant alloy Ti-6Al-4V is known to create a multitude of phases ...

journal_title：Scientific reports

authors： Kenel C,Grolimund D,Li X,Panepucci E,Samson VA,Sanchez DF,Marone F,Leinenbach C

更新日期：2017-11-27 00:00:00

abstract：:Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been geographical, although cultural and linguistic differences still exist between some of the districts/prefectures, especially between Okinawa and th...

journal_title：Scientific reports

authors： Saw WY,Liu X,Khor CC,Takeuchi F,Katsuya T,Kimura R,Nabika T,Ohkubo T,Tabara Y,Yamamoto K,Yokota M,Japanese Genome Variation Consortium.,Teo YY,Kato N

更新日期：2015-12-09 00:00:00

abstract：:Leiomyomas, adenomyosis, and endometriosis are reported to be risk factors for endometrial carcinoma (EC), and adenomyosis and endometriosis also for ovarian carcinoma (OC). We aimed to describe the prevalence of these conditions in EC patients with or without an OC diagnosis, and to investigate their relationship wit...

journal_title：Scientific reports

authors： Johnatty SE,Stewart CJR,Smith D,Nguyen A,O' Dwyer J,O'Mara TA,Webb PM,Spurdle AB

更新日期：2020-02-27 00:00:00

abstract：:Adolescent idiopathic scoliosis (AIS) patients have been reported to be taller and more slender than normal controls, suggesting less mechanical stiffness of their trunk and spine. For assessment of mechanical stiffness, to our best knowledge this is the first to study height-width-depth relations at the level of the ...

journal_title：Scientific reports

authors： Chen H,Schlösser TPC,Brink RC,Colo D,van Stralen M,Shi L,Chu WCW,Heng PA,Castelein RM,Cheng JCY

更新日期：2017-04-18 00:00:00

abstract：:The accurate prediction of the impact of an amino acid substitution on the thermal stability of a protein is a central issue in protein science, and is of key relevance for the rational optimization of various bioprocesses that use enzymes in unusual conditions. Here we present one of the first computational tools to ...

journal_title：Scientific reports

authors： Pucci F,Bourgeas R,Rooman M

更新日期：2016-03-18 00:00:00

abstract：:El Niño-Southern Oscillation (ENSO), which is one of the main drivers of Earth's inter-annual climate variability, often causes a wide range of climate anomalies, and the advance prediction of ENSO is always an important and challenging scientific issue. Since a unified and complete ENSO theory has yet to be establish...

journal_title：Scientific reports

authors： Yan J,Mu L,Wang L,Ranjan R,Zomaya AY

更新日期：2020-05-15 00:00:00

abstract：:Convenient drug-resistance testing of viral mutants is indispensable to effective treatment of viral infection. We developed a novel fluorometric assay for phenotypic differentiation of drug-resistant mutants of human immunodeficiency virus-I protease (HIV-PR) which uses enzymatic and peptide-specific fluorescence (FL...

journal_title：Scientific reports

authors： Zhu Q,Yu Z,Kabashima T,Yin S,Dragusha S,El-Mahdy AF,Ejupi V,Shibata T,Kai M

更新日期：2015-05-19 00:00:00

abstract：:Enteric redmouth disease caused by the bacterial pathogen Yersinia ruckeri is the main reason for antimicrobial prescription, and a cause of substantial economic losses and decreased animal welfare in aquaculture. Given the importance of the intestinal microbiota in digestion and disease, our aim was to investigate wh...

journal_title：Scientific reports

authors： Villumsen KR,Ohtani M,Forberg T,Aasum E,Tinsley J,Bojesen AM

更新日期：2020-10-12 00:00:00

abstract：:The growing amount of longitudinal data for a large population of patients has necessitated the application of algorithms that can discover patterns to inform patient management. This study demonstrates how temporal patterns generated from a combination of clinical and imaging measurements improve residual survival pr...

journal_title：Scientific reports

authors： Smedley NF,Ellingson BM,Cloughesy TF,Hsu W

更新日期：2018-09-26 00:00:00

abstract：:Twisting light in both phase and intensity has recently drawn great interests in various fields related to light-matter interactions such as optical manipulation of particles and quantum entanglement of photons. Conventionally, bulky optical components are required to produce such twisted optical beams, which signific...

journal_title：Scientific reports

authors： Zhang Y,Yang X,Gao J

更新日期：2018-03-20 00:00:00

abstract：:Inhibition of return (IOR), typically explored in cueing paradigms, is a performance cost associated with previously attended locations and has been suggested as a crucial attentional mechanism that biases orientation towards novelty. In their seminal IOR paper, Posner and Cohen (1984) showed that IOR is coded in spat...

journal_title：Scientific reports

authors： He T,Ding Y,Wang Z

更新日期：2015-11-13 00:00:00

abstract：:Interleukin-10 (IL-10) plays a central role in regulation of intestinal mucosal homeostasis and prevention of inflammatory bowel disease (IBD). We previously reported that CD11b(hi) regulatory dendritic cells (DCs) can produce more IL-10, and CD11b can negatively regulate Toll-like receptors (TLRs)-induced inflammator...

journal_title：Scientific reports

authors： Hu X,Han C,Jin J,Qin K,Zhang H,Li T,Li N,Cao X

更新日期：2016-05-18 00:00:00

abstract：:Sixty norovirus outbreaks that occurred in Pudong District, Shanghai in 2017 and affected 959 people were summarised. Of the outbreaks, 29 (48.3%), 27 (45.0%), and 4 (6.7%) occurred in kindergartens, primary schools, and middle schools, respectively. Although the total number of outbreaks peaked in March (13/60, 21.7%...

journal_title：Scientific reports

authors： Wang Y,Hao L,Pan L,Xue C,Liu Q,Zhao X,Zhu W

更新日期：2018-10-15 00:00:00

abstract：:In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this case antibiotics do not provide an effective cure as the bacteria ar...

journal_title：Scientific reports

authors： Rox K,Jansen R,Loof TG,Gillen CM,Bernecker S,Walker MJ,Chhatwal GS,Müller R

更新日期：2017-09-18 00:00:00

abstract：:In many human cancers, including hepatocellular carcinoma (HCC), high density of infiltrating tumor-associated macrophages (TAM) is associated with poor prognosis. Most TAMs express a M2 phenotype subsequently supporting tumor growth. How tumor cells polarize these TAMs to a pro-tumor M2 phenotype is still poorly unde...

journal_title：Scientific reports

authors： Shiau DJ,Kuo WT,Davuluri GVN,Shieh CC,Tsai PJ,Chen CC,Lin YS,Wu YZ,Hsiao YP,Chang CP

更新日期：2020-08-12 00:00:00

abstract：:Soils - constituting the largest terrestrial carbon pool - are vulnerable to climatic warming. Currently existing uncertainties regarding carbon fluxes within terrestrial systems can be addressed by studies of past carbon cycle dynamics and related climate change recorded in sedimentary successions. Here we show an ex...

journal_title：Scientific reports

authors： Pieńkowski G,Hodbod M,Ullmann CV

更新日期：2016-08-24 00:00:00

abstract：:Pancreatic cancer (PC), as the leading cause of cancer death worldwide, is one of the deadliest tumors with a very low 5-year survival rate. Therefore, it is urgent to seek new biomarkers of PC for more accurate and reliable treatments. To identify the differentially expressed miRNAs (DEM) in PC tissues, we performed ...

journal_title：Scientific reports

authors： Wang HL,Zhou R,Liu J,Chang Y,Liu S,Wang XB,Huang MF,Zhao Q

更新日期：2017-09-13 00:00:00

abstract：:This study utilized a Förster resonance energy transfer (FRET)-based molecular tension sensor and live cell imaging to evaluate the effect of osteocytes, a mechanosensitive bone cell, on the migratory behavior of tumor cells. Two cell lines derived from MDA-MB-231 breast cancer cells were transfected with the vinculin...

journal_title：Scientific reports

authors： Li F,Chen A,Reeser A,Wang Y,Fan Y,Liu S,Zhao X,Prakash R,Kota D,Li BY,Yokota H,Liu J

更新日期：2019-04-04 00:00:00

abstract：:The aberrant expression of human sodium iodide symporter (NIS) in breast cancer (BC) has raised the possibility of using targeted radioiodide therapy. Here we investigate modulation of endogenous, functional NIS expression by histone deacetylase inhibitors (HDACi) in vitro and in vivo. Luciferase reporter based initia...

journal_title：Scientific reports

authors： Kelkar MG,Senthilkumar K,Jadhav S,Gupta S,Ahn BC,De A

更新日期：2016-01-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ashokkumar M,Sonawane A,Sperk M,Tripathy SP,Neogi U,Hanna LE

更新日期：2020-08-10 00:00:00

abstract：:Oligomers populated during the early amyloid aggregation process are more toxic than mature fibrils, but pinpointing the exact toxic species among highly dynamic and heterogeneous aggregation intermediates remains a major challenge. β-barrel oligomers, structurally-determined recently for a slow-aggregating peptide de...

journal_title：Scientific reports

authors： Sun Y,Ge X,Xing Y,Wang B,Ding F

更新日期：2018-07-09 00:00:00

abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...

journal_title：Scientific reports

authors： Lopes-Marques M,Serrano C,Cardoso AR,Salazar R,Seixas S,Amorim A,Azevedo L,Prata MJ

更新日期：2020-07-14 00:00:00

abstract：:For the first time, a design of a "deflecting elastic prism" is proposed and implemented for waves in a chiral medium. A novel model of an elastic lattice connected to a non-uniform system of gyroscopic spinners is designed to create a unidirectional wave pattern, which can be diverted by modifying the arrangement of ...

journal_title：Scientific reports

authors： Carta G,Jones IS,Movchan NV,Movchan AB,Nieves MJ

更新日期：2017-01-31 00:00:00

abstract：:Scrophularia striata, commonly known as figwort, is one of the most important medicinal plants that mainly grows in cold regions of the Zagros Mountains (West of Iran). Although the chemical composition of this plant species has not yet been explored, people living in Ilam province (W Iran) have used it for many years...

journal_title：Scientific reports

authors： Zargoosh Z,Ghavam M,Bacchetta G,Tavili A

更新日期：2019-11-05 00:00:00

abstract：:The potential energy profile of an ideal binary switch is a symmetric double well. Switching between the wells without energy dissipation requires time-modulating the height of the potential barrier separating the wells and tilting the profile towards the desired well at the precise juncture when the barrier disappear...

journal_title：Scientific reports

authors： Fashami MS,Atulasimha J,Bandyopadhyay S

更新日期：2013-11-13 00:00:00