当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Longitudinal Patterns in Clinical and Imaging Measurements Predict Residual Survival in Glioblastoma Patients.

Longitudinal Patterns in Clinical and Imaging Measurements Predict Residual Survival in Glioblastoma Patients.

Abstract：

:The growing amount of longitudinal data for a large population of patients has necessitated the application of algorithms that can discover patterns to inform patient management. This study demonstrates how temporal patterns generated from a combination of clinical and imaging measurements improve residual survival prediction in glioblastoma patients. Temporal patterns were identified with sequential pattern mining using data from 304 patients. Along with patient covariates, the patterns were incorporated as features in logistic regression models to predict 2-, 6-, or 9-month residual survival at each visit. The modeling approach that included temporal patterns achieved test performances of 0.820, 0.785, and 0.783 area under the receiver operating characteristic curve for predicting 2-, 6-, and 9-month residual survival, respectively. This approach significantly outperformed models that used tumor volume alone (p < 0.001) or tumor volume combined with patient covariates (p < 0.001) in training. Temporal patterns involving an increase in tumor volume above 122 mm3/day, a decrease in KPS across multiple visits, moderate neurologic symptoms, and worsening overall neurologic function suggested lower residual survival. These patterns are readily interpretable and found to be consistent with known prognostic indicators, suggesting they can provide early indicators to clinicians of changes in patient state and inform management decisions.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Smedley NF,Ellingson BM,Cloughesy TF,Hsu W

doi

10.1038/s41598-018-32397-z

subject

Has Abstract

pub_date

2018-09-26 00:00:00

pages

14429

issue

1

issn

2045-2322

pii

10.1038/s41598-018-32397-z

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Moonlight controls lunar-phase-dependency and regular oscillation of clock gene expressions in a lunar-synchronized spawner fish, Goldlined spinefoot.

    abstract：:Goldlined spinefoot, Siganus guttatus, inhabits tropical and subtropical waters and synchronizes its spawning around the first quarter moon likely using an hourglass-like lunar timer. In previous studies, we have found that clock genes (Cryptochrome3 and Period1) could play the role of state variable in the diencephal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24538-1

    authors： Takeuchi Y,Kabutomori R,Yamauchi C,Miyagi H,Takemura A,Okano K,Okano T

    更新日期：2018-04-18 00:00:00

  • Topologic connection between 2-D layered structures and 3-D diamond structures for conventional semiconductors.

    abstract：:When coming to identify new 2D materials, our intuition would suggest us to look from layered instead of 3D materials. However, since graphite can be hypothetically derived from diamond by stretching it along its [111] axis, many 3D materials can also potentially be explored as new candidates for 2D materials. Using a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24660

    authors： Wang J,Zhang Y

    更新日期：2016-04-19 00:00:00

  • Bispectrum Features and Multilayer Perceptron Classifier to Enhance Seizure Prediction.

    abstract：:The ability to accurately forecast seizures could significantly improve the quality of life of patients with drug-refractory epilepsy. Prediction capabilities rely on the adequate identification of seizure activity precursors from electroencephalography recordings. Although a long list of features has been proposed, n...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33969-9

    authors： Bou Assi E,Gagliano L,Rihana S,Nguyen DK,Sawan M

    更新日期：2018-10-19 00:00:00

  • Melatonin modulates red-ox state and decreases viability of rat pancreatic stellate cells.

    abstract：:In this work we have studied the effects of pharmacological concentrations of melatonin (1 µM-1 mM) on pancreatic stellate cells (PSC). Cell viability was analyzed by AlamarBlue test. Production of reactive oxygen species (ROS) was monitored following CM-H2DCFDA and MitoSOX Red-derived fluorescence. Total protein carb...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63433-6

    authors： Gonzalez A,Estaras M,Martinez-Morcillo S,Martinez R,García A,Estévez M,Santofimia-Castaño P,Tapia JA,Moreno N,Pérez-López M,Míguez MP,Blanco-Fernández G,Lopez-Guerra D,Fernandez-Bermejo M,Mateos JM,Vara D,Roncero V,Sali

    更新日期：2020-04-14 00:00:00

  • New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.

    abstract：:The development and maturation of cortical circuits relies on the coordinated actions of long and short range axonal guidance cues. In this regard, the class 3 semaphorins and their receptors have been seen to be involved in the development and maturation of the hippocampal connections. However, although the role of m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19794-0

    authors： Mata A,Gil V,Pérez-Clausell J,Dasilva M,González-Calixto MC,Soriano E,García-Verdugo JM,Sanchez-Vives MV,Del Río JA

    更新日期：2018-01-22 00:00:00

  • Parasite infection accelerates age polyethism in young honey bees.

    abstract：:Honey bees (Apis mellifera) are important pollinators and their health is threatened worldwide by persistent exposure to a wide range of factors including pesticides, poor nutrition, and pathogens. Nosema ceranae is a ubiquitous microsporidian associated with high colony mortality. We used lab micro-colonies of honey ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22042

    authors： Lecocq A,Jensen AB,Kryger P,Nieh JC

    更新日期：2016-02-25 00:00:00

  • Computational design and characterization of nanobody-derived peptides that stabilize the active conformation of the β2-adrenergic receptor (β2-AR).

    abstract：:This study aimed to design and functionally characterize peptide mimetics of the nanobody (Nb) related to the β2-adrenergic receptor (β2-AR) (nanobody-derived peptide, NDP). We postulated that the computationally derived and optimized complementarity-determining region 3 (CDR3) of Nb is sufficient for its interaction ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52934-8

    authors： Sencanski M,Glisic S,Šnajder M,Veljkovic N,Poklar Ulrih N,Mavri J,Vrecl M

    更新日期：2019-11-12 00:00:00

  • Digital barcodes of suspension array using laser induced breakdown spectroscopy.

    abstract：:We show a coding method of suspension array based on the laser induced breakdown spectroscopy (LIBS), which promotes the barcodes from analog to digital. As the foundation of digital optical barcodes, nanocrystals encoded microspheres are prepared with self-assembly encapsulation method. We confirm that digital multip...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36511

    authors： He Q,Liu Y,He Y,Zhu L,Zhang Y,Shen Z

    更新日期：2016-11-03 00:00:00

  • Protective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model.

    abstract：:Staphylococcus aureus can cause different types of diseases from mild skin infections to life-threatening sepsis worldwide. Owing to the emergence and transmission of multidrug-resistant strains, developing an impactful immunotherapy especially vaccine control approach against S. aureus infections is increasingly enco...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22044-y

    authors： Yu W,Yao D,Yu S,Wang X,Li X,Wang M,Liu S,Feng Z,Chen X,Li W,Wang L,Liu W,Ma J,Yu L,Tong C,Song B,Cui Y

    更新日期：2018-02-26 00:00:00

  • Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells.

    abstract：:Despite advances in stem cell research, cell transplantation therapy for liver failure is impeded by a shortage of human primary hepatocytes (HPH), along with current differentiation protocol limitations. Several studies have examined the concept of co-culture of human induced pluripotent cells (hiPSCs) with various t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45514-3

    authors： Pettinato G,Lehoux S,Ramanathan R,Salem MM,He LX,Muse O,Flaumenhaft R,Thompson MT,Rouse EA,Cummings RD,Wen X,Fisher RA

    更新日期：2019-06-20 00:00:00

  • Fungal Elevational Rapoport pattern from a High Mountain in Japan.

    abstract：:Little is known of how fungal distribution ranges vary with elevation. We studied fungal diversity and community composition from 740 to 2940 m above sea level on Mt. Norikura, Japan, sequencing the ITS2 region. There was a clear trend, repeated across each of the fungal phyla (Basidiomycota, Ascomycota, Zygomycota, C...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43025-9

    authors： Ogwu MC,Takahashi K,Dong K,Song HK,Moroenyane I,Waldman B,Adams JM

    更新日期：2019-04-25 00:00:00

  • Dramatic pressure-driven enhancement of bulk skyrmion stability.

    abstract：:The recent discovery of magnetic skyrmion lattices initiated a surge of interest in the scientific community. Several novel phenomena have been shown to emerge from the interaction of conducting electrons with the skyrmion lattice, such as a topological Hall-effect and a spin-transfer torque at ultra-low current densi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21347

    authors： Levatić I,Popčević P,Šurija V,Kruchkov A,Berger H,Magrez A,White JS,Rønnow HM,Živković I

    更新日期：2016-02-19 00:00:00

  • The application of homemade Neosinocalamus affinis AC in electrokinetic removal technology on heavy metal removal from the MSWI fly ash.

    abstract：:This present paper was focused on the manufacture of activated carbon (AC) and its application in the electrokinetic remediation (EKR) technology on removal of the heavy metals (HMs) from the municipal solid waste incineration fly ash. AC was produced from Neosinocalamus affinis (NF) by chemical activation with H3PO4 ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39312

    authors： Liu K,Huang T,Huang X,Yu L,Muhammad F,Jiao B,Li D

    更新日期：2016-12-21 00:00:00

  • Creating the Functional Single-Ring GroEL-GroES Chaperonin Systems via Modulating GroEL-GroES Interaction.

    abstract：:Chaperonin and cochaperonin, represented by E. coli GroEL and GroES, are essential molecular chaperones for protein folding. The double-ring assembly of GroEL is required to function with GroES, and a single-ring GroEL variant GroELSR forms a stable complex with GroES, arresting the chaperoning reaction cycle. GroES I...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10499-4

    authors： Illingworth M,Ellis H,Chen L

    更新日期：2017-08-29 00:00:00

  • The structure of SeviL, a GM1b/asialo-GM1 binding R-type lectin from the mussel Mytilisepta virgata.

    abstract：:SeviL is a recently isolated lectin found to bind to the linear saccharides of the ganglioside GM1b (Neu5Ac[Formula: see text](2-3)Gal[Formula: see text](1-3)GalNAc[Formula: see text](1-4)Gal[Formula: see text](1-4)Glc) and its precursor, asialo-GM1 (Gal[Formula: see text](1-3)GalNAc[Formula: see text](1-4)Gal[Formula...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78926-7

    authors： Kamata K,Mizutani K,Takahashi K,Marchetti R,Silipo A,Addy C,Park SY,Fujii Y,Fujita H,Konuma T,Ikegami T,Ozeki Y,Tame JRH

    更新日期：2020-12-16 00:00:00

  • PPARα activation protects against cholestatic liver injury.

    abstract：:Intrahepatic cholestasis induced by drug toxicity, bile salt export pump (BSEP) deficiency, or pregnancy frequently causes cholestatic liver damage, which ultimately may lead to liver fibrosis and cirrhosis. Here, the preventive and therapeutic effects of peroxisome proliferator-activated receptor α (PPARα) signaling ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10524-6

    authors： Zhao Q,Yang R,Wang J,Hu DD,Li F

    更新日期：2017-08-30 00:00:00

  • Tactile perception of randomly rough surfaces.

    abstract：:Most everyday surfaces are randomly rough and self-similar on sufficiently small scales. We investigated the tactile perception of randomly rough surfaces using 3D-printed samples, where the topographic structure and the statistical properties of scale-dependent roughness were varied independently. We found that the t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72890-y

    authors： Sahli R,Prot A,Wang A,Müser MH,Piovarči M,Didyk P,Bennewitz R

    更新日期：2020-09-25 00:00:00

  • UbC-StarTrack, a clonal method to target the entire progeny of individual progenitors.

    abstract：:Clonal cell analysis defines the potential of single cells and the diversity they can produce. To achieve this, we have developed a novel adaptation of the genetic tracing strategy, UbC-StarTrack, which attributes a specific and unique color-code to single neural precursors, allowing all their progeny to be tracked. W...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33896

    authors： Figueres-Oñate M,García-Marqués J,López-Mascaraque L

    更新日期：2016-09-22 00:00:00

  • Modality-specific improvements in sensory processing among baseball players.

    abstract：:Long-term skills training is known to induce neuroplastic alterations, but it is still debated whether these changes are always modality-specific or can be supramodal components. To address this issue, we compared finger-targeted somatosensory-evoked and auditory-evoked potentials under both Go (response) and Nogo (re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81852-x

    authors： Yamashiro K,Yamazaki Y,Siiya K,Ikarashi K,Baba Y,Otsuru N,Onishi H,Sato D

    更新日期：2021-01-26 00:00:00

  • A pilot-scale forward osmosis membrane system for concentrating low-strength municipal wastewater: performance and implications.

    abstract：:Recovery of nutrients and energy from municipal wastewater has attracted much attention in recent years; however, its efficiency is significantly limited by the low-strength properties of municipal wastewater. Herein, we report a pilot-scale forward osmosis (FO) system using a spiral-wound membrane module to concentra...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21653

    authors： Wang Z,Zheng J,Tang J,Wang X,Wu Z

    更新日期：2016-02-22 00:00:00

  • Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy.

    abstract：:Known susceptibility loci together can only explain about 6-8% of the disease heritability of IgA nephropathy (IgAN), suggesting that there are still a large number of genetic variants remained to be discovered. We previously identified IgAN and systemic lupus erythematosus (SLE)/lupus nephritis (LN) shared many loci ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35781

    authors： Zhou XJ,Nath SK,Qi YY,Sun C,Hou P,Zhang YM,Lv JC,Shi SF,Liu LJ,Chen R,Yang W,He KZ,Li Y,Zhang H

    更新日期：2016-11-02 00:00:00

  • Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche.

    abstract：:While implicated in therapeutic resistance, malignant progenitor cell cycle kinetics have been difficult to quantify in real-time. We developed an efficient lentiviral bicistronic fluorescent, ubiquitination-based cell cycle indicator reporter (Fucci2BL) to image live single progenitors on a defined niche coupled with...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23885

    authors： Pineda G,Lennon KM,Delos Santos NP,Lambert-Fliszar F,Riso GL,Lazzari E,Marra MA,Morris S,Sakaue-Sawano A,Miyawaki A,Jamieson CH

    更新日期：2016-04-04 00:00:00

  • The origin of sheep settlement in Western Mediterranean.

    abstract：:The arrival of Neolithic culture in North Africa, especially domestic animals has been essentially documented from archaeological records. As the data relative to sheep are scarce, we studied the genetic relationship between Moroccan sheep breeds and Mediterranean ones using the sequencing of 628 bp of the mitochondri...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67246-5

    authors： Kandoussi A,Boujenane I,Auger C,Serranito B,Germot A,Piro M,Maftah A,Badaoui B,Petit D

    更新日期：2020-06-23 00:00:00

  • Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species.

    abstract：:The AMP-activated kinase (AMPK) is a major energy sensor metabolic enzyme that is activated early during T cell immune responses but its role in the generation of effector T cells is still controversial. Using both in vitro and in vivo models of T cell proliferation, we show herein that AMPK is dispensable for early T...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78715-2

    authors： Lepez A,Pirnay T,Denanglaire S,Perez-Morga D,Vermeersch M,Leo O,Andris F

    更新日期：2020-12-10 00:00:00

  • The Identification of a 1916 Irish Rebel: New Approach for Estimating Relatedness From Low Coverage Homozygous Genomes.

    abstract：:Thomas Kent was an Irish rebel who was executed by British forces in the aftermath of the Easter Rising armed insurrection of 1916 and buried in a shallow grave on Cork prison's grounds. In 2015, ninety-nine years after his death, a state funeral was offered to his living family to honor his role in the struggle for I...

    journal_title：Scientific reports

    pub_type： 历史文章,杂志文章

    doi：10.1038/srep41529

    authors： Fernandes D,Sirak K,Novak M,Finarelli JA,Byrne J,Connolly E,Carlsson JE,Ferretti E,Pinhasi R,Carlsson J

    更新日期：2017-01-30 00:00:00

  • Anemia and its associated factors among Adolescents in Kuwait.

    abstract：:We estimated the prevalence of anemia among school children and investigated factors associated with this problem in Kuwait. A cross-sectional study was conducted on 1415 adolescents randomly selected from middle schools in Kuwait. Hemoglobin, iron, ferritin, folate and vitamin B12, in addition to many other laborator...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60816-7

    authors： Shaban L,Al-Taiar A,Rahman A,Al-Sabah R,Mojiminiyi O

    更新日期：2020-04-03 00:00:00

  • Author Correction: Rectosigmoidal manifestations of venous malformations: MR imaging findings and interdisciplinary therapeutic modalities.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-59025-z

    authors： Brill R,Brill E,Uller W,Teusch V,Gufler H,Hammer S,Fellner C,Evert K,Goldann C,Helm M,Rosendahl J,Wohlgemuth WA

    更新日期：2020-02-07 00:00:00

  • Enhancing participation to health screening campaigns by group interactions.

    abstract：:Improving the prevention efficacy of health screening campaigns by increasing their attendance rate represents a challenge that calls for new strategies. This paper analyzes the response to a Pap test screening campaign of 155,000 women over the last decade. Using a mathematical model of statistical physics origins we...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09904

    authors： Burioni R,Contucci P,Fedele M,Vernia C,Vezzani A

    更新日期：2015-04-23 00:00:00

  • Author Correction: Parasite transmission between trophic levels stabilizes predator-prey interaction.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-49487-1

    authors： Rogawa A,Ogata S,Mougi A

    更新日期：2019-10-15 00:00:00

  • Influence of free charge carrier density on the magnetic behavior of (Zn,Co)O thin film studied by Field Effect modulation of magnetotransport.

    abstract：:The origin of (ferro)magnetic ordering in transition metal doped ZnO is a still open question. For applications it is fundamental to establish if it arises from magnetically ordered impurity clusters embedded into the semiconducting matrix or if it originates from ordering of magnetic ions dilute into the host lattice...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36336-w

    authors： Bellingeri E,Rusponi S,Lehnert A,Brune H,Nolting F,Leveratto A,Plaza A,Marré D

    更新日期：2019-01-16 00:00:00