How much do we know about hemolytic capability of pathogenic Candida species?

Abstract:

:Hemolytic factor production by pathogenic Candida species is considered an important attribute in promoting survival within the mammal host through the ability to assimilate iron from the hemoglobin-heme group. Hemolytic capability has been evaluated for Candida species based on hemolysis zones on plate assay, analysis of hemolytic activity in liquid culture medium, and hemolysis from cell-free culture broth. The production of hemolytic factor is variable among Candida species, where C. parapsilosis is the less hemolytic species. In general, no intraspecies differences in beta-hemolytic activities are found among isolates belonging to C. albicans, C. glabrata, C. krusei, C. tropicalis, and C. parapsilosis. The production of hemolytic factor by Candida species is affected by several factors such as glucose supplementation in the culture medium, blood source, presence of erythrocytes and hemoglobin, and presence of electrolytes. On the basis of existing achievements, more researches are still needed in order to extend our knowledge about the biochemical nature of hemolytic molecules produced by distinct Candida species, the mechanism of hemolysis, and the molecular basis of the hemolytic factor expression.

journal_title

Folia microbiologica

authors

Furlaneto MC,Góes HP,Perini HF,Dos Santos RC,Furlaneto-Maia L

doi

10.1007/s12223-018-0584-5

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

405-412

issue

4

eissn

0015-5632

issn

1874-9356

pii

10.1007/s12223-018-0584-5

journal_volume

63

pub_type

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