Abstract:
OBJECTIVES:Ventilator-associated pneumonia (VAP) is the most frequent hospital-acquired infections in intensive care units (ICU). In the bundle of care to prevent the VAP, the oral care is very important strategies, to decrease the oropharyngeal bacterial colonization and presence of causative bacteria of VAP. In view of the paucity of medical economics studies, our objective was to determine the cost of implementing this oral care program for preventing VAP. MATERIALS AND METHODS:In five ICUs, during period 1, caregivers used a foam stick for oral care and, during period 2, a stick and tooth brushing with aspiration. Budgetary effect of the new program from the hospital's point of view was analyzed for both periods. The costs avoided were calculated from the incidence density of VAP (cases per 1000 days of intubation). The cost study included device cost, benefit lost, and ICU cost (medication, employer and employee contributions, blood sample analysis…). RESULTS:A total of 2030 intubated patients admitted to the ICUs benefited from oral care. The cost of implementing the study protocol was estimated to be €11,500 per year. VAP rates decreased significantly between the two periods (p1 = 12.8% and p2 = 8.5%, p = 0.002). The VAP revenue was ranged from €28,000 to €45,000 and the average cost from €39,906 to €42,332. The total cost assessment calculated was thus around €1.9 million in favor of the new oral care program. CONCLUSION AND CLINICAL RELEVANCE:Our study showed that the implementation of a simple strategy improved the quality of patient care is economically viable. TRIAL REGISTRATION:NCT02400294.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Ory J,Mourgues C,Raybaud E,Chabanne R,Jourdy JC,Belard F,Guérin R,Cosserant B,Faure JS,Calvet L,Pereira B,Guelon D,Traore O,Gerbaud Ldoi
10.1007/s00784-017-2289-6subject
Has Abstractpub_date
2018-06-01 00:00:00pages
1945-1951issue
5eissn
1432-6981issn
1436-3771pii
10.1007/s00784-017-2289-6journal_volume
22pub_type
杂志文章abstract:OBJECTIVES:Different studies suggest that inflammation as well as hypoxia leads to an increase of p53 protein levels. However, the implication of p53 during oral inflammatory processes is still unknown. The aim of this study was therefore to investigate the effect of hypoxia and inflammation on p53 regulation in human ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1679-x
更新日期:2016-09-01 00:00:00
abstract::Within the context of preventing non-communicable diseases, the World Health Report (2002) and the WHO Global Oral Health Program (2003) put forward a new strategy of disease prevention and health promotion. Greater emphasis is placed on developing global policies in oral health promotion and oral disease prevention. ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-007-0178-0
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:The combination of sodium hypochlorite (NaOCl) and chlorhexidine (CHX) yields a "precipitate potentially toxic" (PPT). The aim of this study was to evaluate the tissue response to implanted polyethylene tubes filled with PPT-soaked fibrin sponge. METHODS:Forty rats received four polyethylene tubes each; eac...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1049-5
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:Resin polymerisation shrinkage reduces the congruence of the denture base with denture-bearing tissues and thereby decreases the retention of conventionally fabricated dentures. CAD/CAM denture manufacturing is a subtractive process, and polymerisation shrinkage is not an issue anymore. Therefore, CAD/CAM de...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2369-2
更新日期:2018-11-01 00:00:00
abstract::The aim of this study was to evaluate the elemental release from a Ni-Cr dental casting alloy subjected to 10% hydrogen peroxide (HP) or 10% carbamide peroxide (CP) solutions and to determine the composition of surface oxide layer formed on alloy samples. Cylinder-shaped 15 specimens were cast from a Ni-Cr alloy and d...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0391-0
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to investigate the role of hyperbaric oxygen (HBO) in the healing of teeth extraction sockets and in alveolar ridge preservation. This may provide an experimental basis for the widespread application of HBO in oral implantation. METHODS:A total of 32 beagle dogs were included i...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03117-2
更新日期:2020-08-01 00:00:00
abstract::The aim of the study was the morphological analysis of coronal dentin caries and the modifications induced by different pretreatments with phosphoric acid or sodium hypochlorite. Carious dentin specimens were obtained from human molars affected by carious lesions. Specimens were divided in four groups and submitted to...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00784-003-0221-8
更新日期:2003-09-01 00:00:00
abstract::The aim of the current study was to evaluate the prevalence of psychopathological symptoms in patients who self-reported different forms of bruxism by means of clinical and anamnestic diagnostic criteria. Eighty-five participants were divided into four groups as sleep bruxers (12), awake bruxers (24), sleep-awake brux...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0492-9
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:Several theories have been proposed regarding the genesis of sialoliths, including the organic core theory, which suggests epithelial or bacterial etiology originating in the central core. Our aim was to use novel methodologies to analyze central areas (the core) of calculi from sialolithiasis patients. MAT...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0870-6
更新日期:2013-09-01 00:00:00
abstract::This study investigated the ability and efficacy of an Er:YAG laser with a fluorescence feedback system for caries removal in deciduous teeth. Seventy-nine carious lesions were excavated using a fluorescence-controlled Er:YAG laser. Endpoint of treatment was defined by emission of fluorescence from the dentine surface...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章
doi:10.1007/s00784-007-0169-1
更新日期:2008-09-01 00:00:00
abstract::The aim was to determine the relationship between mercury content of resting and stimulated saliva, and blood and urine. Eighty subjects participated; 40 of them attributed their self-reported complaints to dental amalgam (patients), the others were matched with respect to age, sex and amalgam restorations (controls)....
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840000089
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVES:Τhis study aims at determining the ability of cone beam computed tomography (CBCT) to visualize critical-size defects (CSD) created at rat calvaria and filled with 75/25 w/w nano-hydroxyapatite/chitosan (nHAp/CS) scaffolds, prior to their histological investigation. MATERIALS AND METHODS:Thirty adult Spragu...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02939-4
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:This in situ study aims to evaluate the effects of chlorhexidine (CHX) mouth rinsing on biofilm formation and moreover on the disruption of existing mature dental biofilms. METHODS:Biofilms were formed in situ by five volunteers on bovine enamel specimens fixed to individual acrylic splints. For biofilm for...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03250-3
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate whether a specific interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism had any influence on the development of changes in maxillary sinus, particularly in the presence of etiological factors of dental origin. MATERIALS AND METHODS:The study population included 1...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1424-5
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:There is a long history of studies into cystic lesions of the jaws. However, there is little data on postoperative bone regeneration. The aim of the study was to calculate the size of the residual bone lesions after cystostomies and cystectomies to predict the postoperative bone healing. MATERIAL AND METHOD...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02826-y
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:Transglutaminase-2 (TGM-2) protein is involved in the cross-linking of matrix proteins resulting in several fibrotic disorders and can be induced by reactive oxygen species (ROS). Little is known about its role in the development of oral submucocal fibrosis (OSF). Hence, we hypothesize that TGM-2 may have a ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1579-0
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:The aim was to study self-image and the level of psychological symptoms in patients with symptoms attributed to their dental restorative materials. MATERIALS AND METHODS:A questionnaire containing questions regarding dental and medical history was answered by 257 participants, one group with local oral symp...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2707-4
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the biological effects of MTA Repair HP and ProRoot MTA on human periodontal ligament stem cells (hPDLSCs) after exposure to acidic and neutral environments. MATERIALS AND METHODS:Discs of each material (n = 30) were exposed to phosphate buffered saline (pH = 7.4) or buty...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02822-2
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:The aim of this retrospective cephalometric study was to compare treatment outcomes with "bite jumping appliance" (BJA) or Andresen-Häupl type activator. It especially focused on skeletal and dental structures in patients with class II malocclusion. The study hypothesis was that differences in treatment-rela...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03115-4
更新日期:2020-07-01 00:00:00
abstract::This paper presents a short review of three groups of tools which can be or are used for the tissue engineering of mineralized oral structures: growth factor delivery systems (GFDS) and surface bioactivation with covalent bound peptides or with nanomechanically linked proteins. According to the reported personal exper...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s007840050128
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:This study investigated the effect of passive ultrasonic irrigation (PUI) on diffusion of hydroxyl ions through radicular dentine. MATERIALS AND METHODS:After chemomechanical preparation of root canals in 60 human teeth, the cementoenamel junction and the apical 3 mm of each root were covered with fast-setti...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1500-x
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:To determine the frequency of oral infection with potential for spread (OIPS) and behavioural risk factors in patients referred to a regional tertiary care-centre for OIPS assessment and clearance. MATERIALS AND METHODS:A database search of all referrals to the Oral and Maxillofacial Diseases unit of HUH in...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2518-7
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:Albumin has a known capability to modulate free serum concentrations of proteins produced by tumour cells. The technique of spin probe labelling of albumin followed by electron paramagnetic resonance (EPR) spectroscopy may allow identification of these structural and functional changes, which regularly occur...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-011-0655-3
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:This study was established to investigate whether the chemokines CXCL1, CCL2, and CCL5 are produced in periodontal cells and tissues and, if so, whether their levels are regulated by microbial and/or mechanical signals. MATERIALS AND METHODS:The chemokine expression and protein levels in gingival biopsies f...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03244-1
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare mechanical sensitivity on the tongue using quantitative sensory testing (QST) and psychological factors using the General Health Questionnaire (GHQ) between burning mouth syndrome (BMS) patients and healthy participants. MATERIALS AND METHODS:Participants comprised 20 fe...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2488-9
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the effect of different endodontic solvents on the microtensile bond strength (μTBS) of various adhesives to pulp chamber dentin. MATERIAL AND METHODS:A total of 120 human third molars were selected. Canals were prepared with the ProTaper Universal system and obturated....
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1929-6
更新日期:2017-03-01 00:00:00
abstract::The aim of the study was to investigate the temperature rise of a nanocomposite and a conventional hybrid dental composite during photopolymerization when cured with halogen curing lamp (QHT) and light-emitting diode (LED). Temperature rise during photopolymerization of two commercially available composites (Filtek Su...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-008-0236-2
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:This study aimed to assess self- and proxy-rated changes in the oral health-related quality of life (OHRQoL) in adult patients with intellectual disabilities after dental treatment in general anesthesia. METHODS:The OHRQoL in 52 adult patients with intellectual and developmental disabilities was assessed pr...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02820-4
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:This study aimed to examine the electromyographic activity of superficial masseter and anterior temporal muscles during chewing gum and gummy jelly mastication in healthy subjects to reveal the difference of neuromuscular control of jaw-closing muscles, according to the food texture. MATERIALS AND METHODS:E...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2754-x
更新日期:2019-09-01 00:00:00
abstract:AIMS:The aims of this double-blind, controlled, crossover study were to assess the influence of food preservatives on in situ dental biofilm growth and vitality, and to evaluate their influence on the ability of dental biofilm to demineralize underlying enamel over a period of 14 days. MATERIALS AND METHODS:Twenty vol...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1053-9
更新日期:2014-04-01 00:00:00