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The use of NaOCl in combination with CHX produces cytotoxic product.

Abstract：

OBJECTIVES:The combination of sodium hypochlorite (NaOCl) and chlorhexidine (CHX) yields a "precipitate potentially toxic" (PPT). The aim of this study was to evaluate the tissue response to implanted polyethylene tubes filled with PPT-soaked fibrin sponge. METHODS:Forty rats received four polyethylene tubes each; each tube was filled with fibrin sponge soaked by 2.5 % NaOCl, 2.0 % CHX, PPT (2.5 % NaOCl plus 2.0 % CHX), or not soaked (control). The observation time points were 7, 15, 30, 60, and 90 days. At each time point, eight animals were killed, and the tubes and surrounding tissues were removed, fixed, and prepared for light microscopic analysis by performing glycol methacrylate embedding, serial cutting into 3-μm sections, and hematoxylin-eosin staining. Qualitative and quantitative evaluations of the reactions were performed. Results were statistically analyzed by Kruskal-Wallis test (p < 0.05). RESULTS:All chemical solutions caused moderate reactions at 7 days. On day 30, PPT group was more cytotoxic than the control group and the CHX group (p < 0.05). On days 15 and 60, PPT group was more cytotoxic than the control group (p < 0.05). On day 90, there was no statistically significant difference between the different groups. CONCLUSION:PPT is more cytotoxic than NaOCl and CHX alone, particularly in the short term. CLINICAL SIGNIFICANCE:Protocols which suggest the use of CHX and NaOCl must be revised because this mixture produces cytotoxic product.

journal_name

Clin Oral Investig

journal_title

Clinical oral investigations

authors

Cintra LT,Watanabe S,Samuel RO,da Silva Facundo AC,de Azevedo Queiroz IO,Dezan-Júnior E,Gomes-Filho JE

doi

10.1007/s00784-013-1049-5

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

935-40

issue

3

eissn

1432-6981

issn

1436-3771

journal_volume

18

pub_type

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