Abstract:
AIMS:The aims of this double-blind, controlled, crossover study were to assess the influence of food preservatives on in situ dental biofilm growth and vitality, and to evaluate their influence on the ability of dental biofilm to demineralize underlying enamel over a period of 14 days. MATERIALS AND METHODS:Twenty volunteers wore appliances with six specimens each of bovine enamel to build up intra-oral biofilms. During four test cycles of 14 days, the subjects had to place the appliance in one of the assigned controls or active solutions twice a day for a minute: negative control 0.9 % saline, 0.1 % benzoate (BA), 0.1 % sorbate (SA) and 0.2 % chlorhexidine (CHX positive control). After 14 days, the biofilms on two of the slabs were stained to visualize vital and dead bacteria to assess biofilm thickness (BT) and bacterial vitality (BV). Further, slabs were taken to determine mineral loss (ML), by quantitative light-induced laser fluorescence (QLF) and transversal microradiography (TMR), moreover the lesion depths (LD). RESULTS:Nineteen subjects completed all test cycles. Use of SA, BA and CHX resulted in a significantly reduced BV compared to NaCl (p < 0.001). Only CHX exerted a statistically significant retardation in BT as compared to saline. Differences between SA and BA were not significant (p > 0.05) for both parameters. TMR analysis revealed the highest LD values in the NaCl group (43.6 ± 44.2 μm) and the lowest with CHX (11.7 ± 39.4 μm), while SA (22.9 ± 45.2 μm) and BA (21.4 ± 38.5 μm) lay in between. Similarly for ML, the highest mean values of 128.1 ± 207.3 vol% μm were assessed for NaCl, the lowest for CHX (-16.8 ± 284.2 vol% μm), while SA and BA led to values of 83.2 ± 150.9 and 98.4 ± 191.2 vol% μm, respectively. With QLF for both controls, NaCl (-33.8 ± 101.3 mm(2) %) and CHX (-16.9 ± 69.9 mm(2) %), negative values were recorded reflecting a diminution of fluorescence, while positive values were found with SA (33.9 ± 158.2 mm(2) %) and BA (24.8 ± 118.0 mm(2) %) depicting a fluorescence gain. These differences were non-significant (p > 0.05). CONCLUSION:The biofilm model permited the assessment of undisturbed oral biofilm formation influenced by antibacterial components under clinical conditions for a period of 14 days. An effect of BA and SA on the demineralization of enamel could be demonstrated by TMR and QLF, but these new findings have to be seen as a trend. As part of our daily diet, these preservatives exert an impact on the metabolism of the dental biofilm, and therefore may even influence demineralization processes of the underlying dental enamel in situ.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Arweiler NB,Netuschil L,Beier D,Grunert S,Heumann C,Altenburger MJ,Sculean A,Nagy K,Al-Ahmad A,Auschill TMdoi
10.1007/s00784-013-1053-9subject
Has Abstractpub_date
2014-04-01 00:00:00pages
829-38issue
3eissn
1432-6981issn
1436-3771journal_volume
18pub_type
杂志文章abstract::The objective of this study is to evaluate flexural strength, flexural modulus, compressive strength, curing temperature, curing depth, volumetric shrinkage, water sorption, and hygroscopic expansion of two self-, three dual-, and three light-curing resin-based core materials. Flexural strength and water sorption were...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0405-y
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:Bony reconstruction of jaw defects using the free fibular flap and dental rehabilitation mostly requires insertion of dental implants within the transferred fibula bone. The aim of this paper was to discuss results of the implant stability with data on the possible benefit for the patient's quality of life a...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1487-3
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Long-term culture system is used to prevent the impediment of insufficient cells and is good for low starting materials such as dental pulp or periodontal ligament. In general, although cell viability and functionality are the most common aspects taken into consideration in culturing cells for...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1497-1
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:This paper aims to observe peri-implant time-related vertical bone level and soft tissue changes with immediate, non-detached glass-ceramic (lithium-disilicate) individualized abutments and dis-/reconnections. MATERIALS AND METHODS:Sixteen split-mouth patients received provisionalized immediate definitive i...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-017-2136-9
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Root migration occurs after most third molar coronectomy and a portion may be exposed in the oral cavity. This study compared the root migration rate, surgical morbidities after third molar coronectomy with or without adjunctive guided bone regeneration (GBR). METHODS:A split-mouth randomized clinical trial wa...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2594-8
更新日期:2019-04-01 00:00:00
abstract::Aim of this investigation was to evaluate the validity and reproducibility of the universal visual scoring systems (UniViSS) on occlusal surfaces in vitro. The validity study included 65 third molars. Following to reach a UniViSS consensus diagnosis for each surface, all teeth were histologically prepared and evaluate...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0390-1
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:The aim of the present study is to provide a detailed macroscopic mapping of the palatal and tuberal blood supply applying anatomical methods and studying specific anastomoses to bridge the gap between basic structural and empirical clinical knowledge. MATERIALS AND METHODS:Ten cadavers (three dentate, seve...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2538-3
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. MATERIALS AND METHODS:This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-2010-1
更新日期:2017-09-01 00:00:00
abstract::Dear Professor Dr. Matthias Hannig. Editor-in-Chief Clinical Oral Investigations. Following the publication of our paper by Calvo Guirado et al, 2015 [1] in Clinical Oral Investigations, it came to light that a certain part of the text at the materials and methods and results sections were similar. ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00784-018-2763-9
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate whether the osteoinductive properties of bone-conditioned medium (BCM) harvested from cortical bone chips within a clinically relevant short-term period can enhance the biologic characteristics of deproteinized bovine bone mineral (DBBM) in vitro. MATERIALS AND METHOD...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03528-6
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:The purpose of this prospective clinical trial was to examine the clinical and patient outcomes following esthetic reconstruction of interdental papilla loss in anterior teeth, using an injectable, non-animal-based, hyaluronic acid gel. MATERIALS AND METHODS:Ten systemically healthy adults, with at least on...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章
doi:10.1007/s00784-015-1677-z
更新日期:2016-09-01 00:00:00
abstract::The aim of this study was to evaluate the elemental release from a Ni-Cr dental casting alloy subjected to 10% hydrogen peroxide (HP) or 10% carbamide peroxide (CP) solutions and to determine the composition of surface oxide layer formed on alloy samples. Cylinder-shaped 15 specimens were cast from a Ni-Cr alloy and d...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0391-0
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:Targeted modifications of the bulk implant surfaces using bioactive agents provide a promising tool for improvement of the long-term bony and soft tissue integration of dental implants. In this study, we assessed the cellular responses of primary human gingival fibroblasts (HGF) to different surface modifica...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1784-5
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this case series was to evaluate the new bone formation following guided bone regeneration (GBR) with a calcium phosphosilicate (CPS), alloplastic bone putty at peri-implant dehiscence defects and to assess survival rate of implants placed in the augmented sites after 12 months of function. M...
journal_title:Clinical oral investigations
pub_type: 杂志文章,多中心研究
doi:10.1007/s00784-014-1268-4
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the contamination level of toothbrushes by mutans streptococci (MS) and the efficacy of antimicrobial solutions: cetylpyridinium chloride 0.05 % (CPC; Cepacol™) and chlorhexidine 0.12 % (CHX; Periogard™), to disinfect toothbrushes of preschool-aged children in day-care centers. MATERIAL AND METHO...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-013-1169-y
更新日期:2014-11-01 00:00:00
abstract::This study evaluated the colour parameters of composite and ceramic shade guides determined using a colorimeter and digital imaging method with illuminants at different colour temperatures. Two different resin composite shade guides, namely Charisma (Heraeus Kulzer) and Premise (Kerr Corporation), and two different ce...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-009-0329-6
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to examine the effects of surface pre-treatment on CAD/CAM materials including ceramics, zirconia, resin-infiltrated ceramic, and resin-based composite. MATERIALS AND METHODS:Specimens were made of ten CAD/CAM materials (Celtra Duo, Degudent, D; Vita Suprinity, Vita, D; E.max CAD, ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2365-6
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:To evaluate the diagnostic efficacy of CBCT-MRI fused images for articular disc calcification of temporomandibular joint (TMJ). MATERIALS AND METHODS:Twenty patients (24 TMJs) whose image examinations showed dense bodies in the TMJ space were included in the study. The locations of dense bodies evaluated by...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03497-w
更新日期:2020-08-12 00:00:00
abstract::This study evaluated the surface roughness change and wear provided by different dentifrices on root dentine previously exposed to erosive challenges. According to a randomized complete block design, 150 slabs of bovine root dentine (6 x 3 x 2 mm) were ground flat and polished. In an area of 4 x 3 mm on the dentine su...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-004-0262-7
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVES:This study aimed to survey dentists in Germany to identify their favored materials for the fabrication of tooth-supported single crowns (SCs) depending on the location of the abutment teeth and the preparation margin. MATERIALS AND METHODS:The survey included questions regarding demographic characteristics ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03363-9
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the acidogenicity of dual-species biofilms of bifidobacteria and Streptococcus mutans. MATERIALS AND METHODS:The following strains were tested: Bifidobacterium dentium DSM20436, Parascardovia denticolens DSM10105, and Scardovia inopinata DSM10107. Streptococcus mutans UA...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1958-1
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the root canal morphology of mandibular first premolar teeth in a population from southwestern China by micro-computed tomography (micro-CT). MATERIALS AND METHODS:Human mandibular first premolars (115) were selected and prepared for micro-CT analysis with a slice thickness o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0778-1
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:The main purpose of this study was to investigate the detailed healing process of the roots and surrounding periodontium [cementum, periodontal ligament (PDL), and bone] at different time points after intentional root damage with miniscrew implants (MSIs). MATERIALS AND METHODS:After cone-beam computed tomo...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2194-z
更新日期:2018-03-01 00:00:00
abstract:: ...
journal_title:Clinical oral investigations
pub_type: 信件
doi:10.1007/s00784-018-2619-3
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:The aim of this retrospective cephalometric study was to compare treatment outcomes with "bite jumping appliance" (BJA) or Andresen-Häupl type activator. It especially focused on skeletal and dental structures in patients with class II malocclusion. The study hypothesis was that differences in treatment-rela...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03115-4
更新日期:2020-07-01 00:00:00
abstract::Airway management in infants with Pierre Robin sequence (PRS) is often challenging. Advancement of the tongue base using mandibular distraction in neonates can avoid tracheotomy and is increasingly propagated. The osteotomies can be performed via intra- and extraoral approaches. Nowadays, for precise bone cutting, pie...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-006-0091-y
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:For well-defined deep (> 2/3 dentin extension) carious lesions, selective (SE) or stepwise (SW) carious tissue removals have been recommended, while there is limited comparative evidence for both. We compared SE and SW over 24 months in a randomized controlled trial. METHODS:A two-arm superiority trial was ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-020-03536-6
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to evaluate whether the current guidelines of the International Association of Dental Traumatology (IADT) for emergency care of traumatised teeth result in lower complication rates. MATERIALS AND METHODS:Therapeutic strategies of 361 dental injuries in 291 patients treated at a...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0817-y
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:To compare selective COX-2 inhibitors with ibuprofen in terms of analgesia, rescue medication consumption, and adverse effects after impacted third molar removal. MATERIALS AND METHODS:Electronic databases were searched. Single dose, double-blind, randomized, and controlled clinical trials comparing the ana...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析
doi:10.1007/s00784-019-02910-3
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Lithium disilicate can easily be machined by CAM techniques in its metasilicate status. Due to slightly inferior material properties, the material is not yet recommended for three-unit fixed dental prosthesis (FDP) as it is the case for the press material up to the second bicuspid. Therefore, the aim of this...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1191-8
更新日期:2014-12-01 00:00:00