Abstract：
OBJECTIVES:The purpose of this prospective clinical trial was to examine the clinical and patient outcomes following esthetic reconstruction of interdental papilla loss in anterior teeth, using an injectable, non-animal-based, hyaluronic acid gel. MATERIALS AND METHODS:Ten systemically healthy adults, with at least one anterior site with class I or II interdental papilla loss, were recruited. Following local anesthesia, ∼0.2 ml of hyaluronic acid gel was injected directly into the base of the papilla. The injection was repeated twice 21 days later. Patients were seen monthly for follow-up. Lost papilla surface area was calculated from digital clinical photographs taken at baseline and at 4 and 6 months postoperatively. Differences in lost papilla surface area between baseline and postoperative time points were statistically analyzed. Participants completed questionnaires (satisfaction surveys). RESULTS:Seventeen sites (13 maxillary, 4 mandibular) were treated in 9 females who completed the study. The lost inderdental papilla area at baseline and at the 4- and 6-month postoperative visits was 1.2 ± 1.8 mm(2) (mean ± SD), 0.6 ± 0.9 mm(2), and 0.7 ± 0.7 mm(2), respectively. Differences between baseline and postoperative visits were statistically significant (p < 0.0001). Two thirds of the patients would choose to undergo the procedure again. CONCLUSIONS:Use of hyaluronic acid gel to treat interdental papilla loss resulted in significant improvement at 6 months. Patients expressed satisfaction with the obtained improvement and dissatisfaction with the associated procedure discomfort. CLINICAL RELEVANCE:Treatment of interdental papilla loss (black triangle) by hyaluronic acid gel injection appears a promising modality to address this esthetic patient concern.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Awartani FA,Tatakis DNdoi
10.1007/s00784-015-1677-zsubject
Has Abstractpub_date
2016-09-01 00:00:00pages
1775-80issue
7eissn
1432-6981issn
1436-3771pii
10.1007/s00784-015-1677-zjournal_volume
20pub_type
临床试验,杂志文章abstract：OBJECTIVE:A study is made of the main oral manifestations of patients with rheumatoid arthritis (RA), particularly salivary flow, and of its possible association to periodontal disease. MATERIAL AND METHODS:A prospective comparative study was made of 146 patients (73 with RA and 73 controls), recording pocket depth, c...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-016-1745-z
更新日期：2016-12-01 00:00:00
abstract：INTRODUCTION:Decay of teeth, erosion and disintegration of hard dental tissue are a clinically often seen side effect after radiotherapy for tumours in the head and neck region. To investigate if these side effects are due to structural changes in dental hard tissues, the current literature was searched. It can influen...
journal_title：Clinical oral investigations
pub_type： 杂志文章,评审
doi：10.1007/s00784-013-1034-z
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the effect of fluoride dentifrices combined with sodium hexametaphosphate (HMP) on enamel demineralization in vitro. MATERIAL AND METHODS:Enamel bovine blocks were selected by initial surface hardness (SHi) and then divided into five experimental groups (n = 12): placebo...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1707-x
更新日期：2016-11-01 00:00:00
abstract：:The aims of this study were threefold: (1) to describe iatrogenic lesions to oral branches of the trigeminal nerve, signs and symptoms, and functional status, (2) to report on a simple neurosensory examination method, and (3) to discuss means of prevention of iatrogenic injury. The etiology and functional status of 44...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-006-0089-5
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVES:To develop and evaluate predictive nomogram for extended duration of surgery in patients following mandibular third molars (M3M) removal. MATERIALS AND METHODS:A retrospectively observational study was performed and designed. A credible random split-sample method was used to divide data into training and va...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03499-8
更新日期：2020-08-10 00:00:00
abstract：OBJECTIVES:This work aimed to comparatively evaluate the three modalities of vestibuloplasty around implants in the posterior mandible. MATERIALS AND METHODS:Forty patients who presented with a shallow vestibule and insufficient keratinized gingiva were divided into three groups: apically positioned flap only (APF gro...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-017-2320-y
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVES:Stud attachments are often too adhesive and too susceptible to damage for use in geriatric patients, especially when implants are angulated. This study aimed to evaluate alternative anchoring systems comprising individual and prefabricated polyvinylsiloxane (PVS) attachments. MATERIALS AND METHODS:A total o...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2568-x
更新日期：2019-03-01 00:00:00
abstract：:This study evaluated by standardised digitised periapical radiography the crestal bone maintenance around modified diameter internal hex implants with variable thread design and narrow neck loaded with different procedures. Forty implants were placed in 25 patients. Twenty implants were conventionally loaded, 20 ones ...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-009-0314-0
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVES:Facial asymmetry is one of the main concerns in patients with a dentofacial deformity. The aims of the study were to (1) evaluate the changes in facial asymmetry after bimaxillary surgery for asymmetric skeletal class II deformity and (2) compare preoperative and postoperative facial asymmetry of class II pa...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2462-6
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVES:The aim of the present study was the qualitative and quantitative evaluation of osseous graft consolidation using allogeneic bone blocks for vertical bone augmentation in an animal model. MATERIAL AND METHODS:Standardised allogeneic and autologous bone blocks were fixed on the frontal skull of 20 adult fema...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-03151-0
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:Investigate the biochemistry of in vivo healthy oral tissues through Raman spectroscopy. We aimed to characterize the biochemical features of healthy condition in oral subsites (buccal mucosa, lip, tongue, and gingiva) of healthy subjects. More specifically, we investigated Raman spectral characteristics and...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2714-5
更新日期：2019-07-01 00:00:00
abstract：:Airway management in infants with Pierre Robin sequence (PRS) is often challenging. Advancement of the tongue base using mandibular distraction in neonates can avoid tracheotomy and is increasingly propagated. The osteotomies can be performed via intra- and extraoral approaches. Nowadays, for precise bone cutting, pie...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-006-0091-y
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVES:Most patients with bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) report a previous tooth extraction at the necrosis site before the diagnosis was made. At older ages, most teeth are extracted due to periodontal disease, which is per se another BP-ONJ trigger factor. The aim of this study was t...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-013-0974-7
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:To describe the number of second primary malignancies in a series of 33 patients with proliferative verrucous leukoplakia (PVL), detailing the mean time between primary malignancies and their clinical characteristics. MATERIALS AND METHODS:Two groups of patients were included in this study: group 1 comprise...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-03059-9
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:Azithromycin is a macrolide antibiotic that appears to have both antibacterial and anti-inflammatory properties. This study aimed to investigate the effect of azithromycin on the production of pro-inflammatory cytokines and chemokines by human gingival fibroblasts (HGF) in vitro. MATERIALS AND METHODS:The ef...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-014-1249-7
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVES:This study aims to compare the clinical outcomes of a combination of enamel matrix derivatives (EMD) and a synthetic bone graft (biphasic calcium phosphate) with EMD alone in wide and deep one- and two-wall intrabony defects 36 months after treatment. MATERIAL AND METHODS:Thirty patients with chronic period...
journal_title：Clinical oral investigations
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00784-015-1522-4
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVES:Candida albicans is a common fungal infection and is commensal in 40-65 % of healthy adults. The development and pharmacokinetics of a novel sustained release clotrimazole varnish (Clot-SRV) for topical oral use have been reported. The aim of this study was to compare the efficacy of this varnish with clotri...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-014-1259-5
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to assess whether alveolar ridge preservation (ARP) can reduce the need of ridge augmentation at posterior tooth sites. MATERIAL AND METHODS:This study enrolled patients who received dental implants at posterior tooth sites during 2013-2019. Demographic data and dental treatment hi...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-021-03778-y
更新日期：2021-01-11 00:00:00
abstract：OBJECTIVES:The aim of this retrospective cephalometric study was to compare treatment outcomes with "bite jumping appliance" (BJA) or Andresen-Häupl type activator. It especially focused on skeletal and dental structures in patients with class II malocclusion. The study hypothesis was that differences in treatment-rela...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-03115-4
更新日期：2020-07-01 00:00:00
abstract：AIM:The primary objective of this study was (1) to evaluate the 5-year clinical outcome of regenerative periodontal therapy (RPT) using minimally invasive surgery and a collagen-enriched bovine-derived xenograft and (2) to identify predictors for clinical attachment level (CAL) gain and vertical radiographic bone (RB) ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-017-2208-x
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:To describe and explore the association between proxy-reported sleep bruxism (SB) and quality of life (QoL) in a population of Colombian children belonging to different social layers. METHODS:The parents of 1556, 6-13-year-old school children, were administered the Pediatric Inventory of Quality of Life (Ped...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-016-1901-5
更新日期：2017-05-01 00:00:00
abstract：:In the original version of this article, the following were noted for correction. ...
journal_title：Clinical oral investigations
pub_type： 已发布勘误
doi：10.1007/s00784-020-03657-y
更新日期：2020-10-26 00:00:00
abstract：OBJECTIVES:Ankaferd BloodStopper® (ABS) is an herbal extract which has been used historically as a hemostatic agent in traditional Turkish medicine. ABS comprises of standardized mixture of herbs Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica. In addition to its hemostatic e...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2399-9
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:Emdogain, containing an extract of fetal porcine enamel matrix proteins, is a potent stimulator of in vitro osteoclastogenesis. The underlying molecular mechanisms are, however, unclear. MATERIAL AND METHODS:Here, we have addressed the role of transforming growth factor-beta receptor type 1 (TGF-βRI) kinase...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-013-1129-6
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVES:This paper aims to observe peri-implant time-related vertical bone level and soft tissue changes with immediate, non-detached glass-ceramic (lithium-disilicate) individualized abutments and dis-/reconnections. MATERIALS AND METHODS:Sixteen split-mouth patients received provisionalized immediate definitive i...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-017-2136-9
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:The aim of this study is to compare wound healing and patient pain perception of single-incision (single-incision, modified single-incision) and trap-door surgical techniques to harvest subepithelial connective tissue grafts from the palate. MATERIAL AND METHODS:Thirty-six patients were selected for root co...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-014-1204-7
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:This study aimed to measure modifications of mastication after immediate loading full-arch prosthesis (ILFAP) rehabilitation. MATERIALS AND METHOD:Fourteen patients were observed before and 6 months after ILFAP rehabilitation when masticating two natural, standardized foods (peanut and carrot) and three mode...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-012-0787-0
更新日期：2013-05-01 00:00:00
abstract：:The aim of this study was to determine the prevalence of dental erosion in young Icelandic adults (19-22 years old) and patients with gastroesophageal reflux disease (GERD), in relation to their soft drink consumption and gastroesophageal reflux. Eighty subjects (40 males and 40 females), comprising 57 young adults (m...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-003-0252-1
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVES:In this single-blinded, prospective, randomized, controlled clinical trial, the effectiveness of an ozone gas or NaOCl/CHX disinfection protocol was compared within the root canal treatment of apical periodontitis. MATERIALS AND METHODS:Sixty permanent teeth were randomly allocated to one technique. The cli...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-016-1849-5
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:Cell-free DNA (cfDNA) harboring mutations has been found in patients with diseases. Experimental studies have shown that cfDNA can be transmitted, leading to transformations in the host. In the present study, we evaluated whether bone allograft material contains cfDNA and whether this foreign cfDNA can be re...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-02867-3
更新日期：2019-12-01 00:00:00
