Abstract:
OBJECTIVE:Azithromycin is a macrolide antibiotic that appears to have both antibacterial and anti-inflammatory properties. This study aimed to investigate the effect of azithromycin on the production of pro-inflammatory cytokines and chemokines by human gingival fibroblasts (HGF) in vitro. MATERIALS AND METHODS:The effects of azithromycin (0.1 to 10 μg/mL) on the production of interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein 1 (MCP-1), and growth-regulated oncogene (GRO) by human gingival fibroblasts cultured in the presence or absence of Porphyromonas gingivalis lipopolysaccharide (LPS) was studied. Cytokine and chemokine protein levels in the culture supernatant were assessed using a Luminex® multiplex immunoassay. RESULTS:P. gingivalis LPS induced cytokine/chemokine (IL-6, IL-8, MCP-1, and GRO) protein production in HGFs, and this effect was suppressed by azithromycin at all concentrations tested. CONCLUSIONS:This study demonstrates that azithromycin suppresses P. gingivalis LPS-induced cytokine/chemokine protein production in HGF, which may explain some of the clinical benefits observed with the adjunctive use of azithromycin in the treatment of periodontitis. CLINICAL RELEVANCE:The current study examines the anti-inflammatory properties of azithromycin which may make it useful as an adjunct treatment to periodontitis. Specifically, we used azithromycin to modulate the production of pro-inflammatory cytokines by gingival fibroblasts known to be important in periodontal inflammation.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Doyle CJ,Fitzsimmons TR,Marchant C,Dharmapatni AA,Hirsch R,Bartold PMdoi
10.1007/s00784-014-1249-7subject
Has Abstractpub_date
2015-03-01 00:00:00pages
221-7issue
2eissn
1432-6981issn
1436-3771journal_volume
19pub_type
杂志文章abstract:OBJECTIVES:Bisphosphonate-associated osteonecrosis of the jaw is a severe side effect in patients receiving nitrogen-containing bisphosphonates (N-BPs). One characteristic is its high recurrence rate; therefore, basic research for new therapeutic options is necessary. N-BPs inhibit the farnesylpyrophosphate synthase in...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1320-4
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:This case series compared the clinical survival of tooth-implant-supported (TI-S) and tooth-supported (T-S) three-unit fixed dental prostheses (FDPs) with zirconia frameworks and described the incidence of biological and technical complications. MATERIALS AND METHODS:Forty-four patients received 27 TI-S FDP...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1594-1
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:To determine the detectability of the intra-oral photographic method in comparison to the baseline, comprehensive dental examination (CDE), in children when performed by different levels of dental practitioners. MATERIALS AND METHODS:As part of a quality assurance program, intra-oral photographs were obtain...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2700-y
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Dental materials and oral hygiene products may be responsible for oral contact allergic reactions. We aimed to determine the occurrence of allergies in patients with symptomatic oral lichen planus (OLP), oral lichenoid lesions (OLLs) and stomatitis and investigate if patch testing could identify contact aller...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2053-y
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate repair after endodontic surgery using two- and tridimensional imaging methods. MATERIALS AND METHODS:Periapical radiographs and cone beam computed tomography (CBCT) were performed before the surgeries and after 48 h (baseline), 4 months, and 8 months. The area (square mi...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1225-2
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To assess the association between periodontal disease and Helicobacter pylori (H. pylori) infection in oral cavity. MATERIALS AND METHODS:We searched PubMed, Embase, Web of Science, Cochrane library, Gray literature, and clinicaltrials.gov for eligible studies up to September 25, 2019. Odds ratios (ORs) and...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析
doi:10.1007/s00784-020-03330-4
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the effects of three different fluoride-releasing agents on preventing white spot lesions that occur during treatment with full coverage rapid maxillary expanders. MATERIALS AND METHODS:A total of 48 patients with transverse maxillary deficiency were randomly assigned to f...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2749-7
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:The main purpose of this study was to investigate the detailed healing process of the roots and surrounding periodontium [cementum, periodontal ligament (PDL), and bone] at different time points after intentional root damage with miniscrew implants (MSIs). MATERIALS AND METHODS:After cone-beam computed tomo...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2194-z
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:We evaluated the effects of low-level laser therapy (LLLT) using an infrared laser (IRL) and a red laser (RL) on the pulp of molar teeth in rats after dental bleaching to assess inflammation, collagen fiber maturation, and tertiary dentin formation. MATERIALS AND METHODS:Eighty Wistar rats (Rattus norvegicu...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03258-9
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:Symptoms of temporomandibular joint (TMJ) dysfunction can seriously compromise patients' quality of life. The aim of our study was to use magnetic resonance imaging (MRI) T2 mapping of the articular disc to determine whether T2 mapping of the TMJ disc is feasible in routine clinical imaging and to assess the...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1154-5
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The use of the autogenous periosteal graft as biological barrier has been proposed for periodontal regeneration. The aim of this study was to evaluate the histometric findings of the subepithelial connective tissue graft as barrier in intrabony defects compared to a bioabsorbable membrane. METHODS:Three-wal...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1323-1
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate differences between the virtually planned and clinically achieved implant positions in completely template-guided implantations as a function of the type of edentulous space, the residual natural dentition, and the surgical implementation. MATERIALS AND METHODS:Fifty-...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2339-8
更新日期:2018-07-01 00:00:00
abstract::The aim of this study was to compare the short-term performance of a session of single photodynamic therapy (PDT) and of a conventional ultrasonic debridement (UST) in persistent pockets of maintenance patients. In a prospective, randomized, controlled, single-blind clinical study, patients with chronic periodontitis ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-009-0347-4
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:Ventilator-associated pneumonia (VAP) is the most frequent hospital-acquired infections in intensive care units (ICU). In the bundle of care to prevent the VAP, the oral care is very important strategies, to decrease the oropharyngeal bacterial colonization and presence of causative bacteria of VAP. In view ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2289-6
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:To compare, by Micro-CT and confocal laser scanning microscopy (CLSM), the ability of the Wave One Gold and Wave One systems to remove filling material from mesial canals of mandibular molars, effective time spent; quantity of extruded material, and percentage of sealer in the dentinal tubules after retrea...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2441-y
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The present study evaluated the effect of an enamel matrix derivative (EMD) and platelet-rich fibrin (PRF)-modified porcine-derived collagen matrix (PDCM) on human umbilical vein endothelial cells (HUVEC) in vitro. MATERIALS AND METHODS:PDCM (mucoderm®) was prepared to 6 mm (±0.1 mm) diameter discs. PDCM sa...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2170-7
更新日期:2018-03-01 00:00:00
abstract::The aim of the study was the morphological analysis of coronal dentin caries and the modifications induced by different pretreatments with phosphoric acid or sodium hypochlorite. Carious dentin specimens were obtained from human molars affected by carious lesions. Specimens were divided in four groups and submitted to...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00784-003-0221-8
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:To investigate the relationship between sleep disorders, morning hyposalivation, and subjective feeling of dry mouth. MATERIALS AND METHODS:A cross-sectional, observational, clinical study was carried out in a homogenous population sample which consists of Greek male soldiers without any medical history. Af...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03029-1
更新日期:2020-05-01 00:00:00
abstract::Aim of this investigation was to evaluate the validity and reproducibility of the universal visual scoring systems (UniViSS) on occlusal surfaces in vitro. The validity study included 65 third molars. Following to reach a UniViSS consensus diagnosis for each surface, all teeth were histologically prepared and evaluate...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0390-1
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:Information about the spectrum of microorganisms in the intraimplant cavities of two-piece dental implants is scarce. The purpose of this study was to assess the intraimplant microflora of two-piece dental implants by conventional biochemical testing, matrix-assisted laser desorption/ionization time-of-flight...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0805-2
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:Bioactive proteins are sequestered in human dentine and play a decisive role in dental pulp regeneration and repair. They can be released and exposed on the dentine surface by acids, but also chelators, such as ethylenediaminetetraacetic acid (EDTA). The objectives of this study were (i) to evaluate whether ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1824-1
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the effect of fracture orientation on the detection accuracy of vertical root fractures (VRFs) in non-endodontically treated teeth using four different cone beam computed tomography (CBCT) units. MATERIALS AND METHODS:Thirty eight out of 148 extracted human permanent teeth we...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02905-0
更新日期:2019-12-01 00:00:00
abstract::The aim of this retrospective study was to determine the outcome of orthodontic treatment carried out on patients by postgraduate students at the Katholieke Universiteit Leuven, Belgium. The treatment outcome of 292 'final examination' patients and of 287 'control' patients was compared by means of the Peer Assessment...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840000094
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the systemic and periodontal conditions, as well as the determinants of health in pregnant women with and without obesity/overweight during the second and third trimesters of pregnancy and after delivery. MATERIALS AND METHODS:In the second trimester (T1), 93 pregnant women were divided into two ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02932-x
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Candida albicans is a common fungal infection and is commensal in 40-65 % of healthy adults. The development and pharmacokinetics of a novel sustained release clotrimazole varnish (Clot-SRV) for topical oral use have been reported. The aim of this study was to compare the efficacy of this varnish with clotri...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1259-5
更新日期:2015-03-01 00:00:00
abstract::To present the safety profile, the early healing phase and the clinical outcomes at 24 weeks following treatment of human intrabony defects with open flap debridement (OFD) alone or with OFD and rhGDF-5 adsorbed onto a particulate β-tricalcium phosphate (β-TCP) carrier. Twenty chronic periodontitis patients, each with...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-011-0610-3
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:The corona disease (COVID-19) is developing into one of the greatest challenges for healthcare professionals around the world. In this article, we report the detailed actions taken in the Department of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians-University (LMU), Munich...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03440-z
更新日期:2020-08-01 00:00:00
abstract::The aim of this randomized double-blinded preliminary study was to evaluate the clinical and microbiological long-term effects of an essential-oil-containing mouth rinse as the active agent utilized in the "one-stage full-mouth disinfection protocol." Probing pocket depth and plaque and gingival indices were evaluated...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-008-0219-3
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:To assess and compare the pharmacological effect of different drugs on pain relief after periodontal surgery. MATERIALS AND METHODS:Five databases were searched up to September 2019. The eligible studies comprised randomized clinical trials, involving only adult individuals that received any periodontal sur...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析
doi:10.1007/s00784-020-03401-6
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:The study aimed at assessing, as primary objective, the periapical status and quality of root fillings, and, as secondary objective, the endodontic treatment need of a German urban population in a cross-sectional study 20 years after the first one. MATERIALS AND METHODS:Clinical and radiographic data of 353...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2566-z
更新日期:2019-03-01 00:00:00