Abstract:
OBJECTIVES:The aim of the present study was the qualitative and quantitative evaluation of osseous graft consolidation using allogeneic bone blocks for vertical bone augmentation in an animal model. MATERIAL AND METHODS:Standardised allogeneic and autologous bone blocks were fixed on the frontal skull of 20 adult female pigs and covered with a resorbable collagen membrane. Animals were sacrificed after 2 and 6 months. Specimens were histologically and histomorphometrically analysed focusing on the amount of vital bone, residual bone substitute material and connective tissue. Furthermore, the amount of expression of bone matrix proteins (collagen type I and osteocalcin) and de novo vessel formation (von Willebrand factor) were quantified by immunohistochemistry. RESULTS:Significantly more allogeneic bone blocks failed for both evaluation time points (p < 0.05). Allogeneic blocks showed significantly less vital bone with more connective tissue formation compared to autologous bone blocks. Increased vessel formation could be detected for both evaluation time points in the contact area of autologous bone with local bone. The expression of collagen type I and osteocalcin was significantly lower in the allogeneic bone graft. CONCLUSIONS:Allogeneic cancellous bone blocks showed a significantly higher failure rate compared to autologous bone blocks. Allogeneic bone blocks seemed to negatively affect bone formation or negatively influence the host in the long term, and increased connective tissue formation and block loss should be anticipated. CLINICAL RELEVANCE:In order to maintain patient safety and treatment success clinicians should be persuaded to make a conscious choice of the applied biomaterials with regard to their components and structure.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Moest T,Frabschka J,Kesting MR,Schmitt CM,Frohwitter G,Lutz R,Schlegel KAdoi
10.1007/s00784-019-03151-0subject
Has Abstractpub_date
2020-08-01 00:00:00pages
2867-2879issue
8eissn
1432-6981issn
1436-3771pii
10.1007/s00784-019-03151-0journal_volume
24pub_type
杂志文章abstract::The translucency of teeth allows the non-destructive subsurface visualisation of their microstructure by confocal laser scanning microscopy (CLSM) at a level of about 150 microns below the surface. The dentine-enamel junction (DEJ) is accessible only directly adjacent to the cervix of the tooth. Therefore teeth have t...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840050038
更新日期:1998-03-01 00:00:00
abstract::This study (1) investigated whether the combination of an adhesive system from one manufacturer with a resin composite from the same manufacturer provides superior bonding of the resin composite to dentin compared with the combination of an adhesive system from one manufacturer with a resin composite from another manu...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-006-0077-9
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination. MATERIALS AND MET...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-0939-x
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:The objective of the study is to compare skeletal and dental changes in class II patients treated with fixed functional appliances (FFA) that pursue different biomechanical concepts: (1) FMA (Functional Mandibular Advancer) from first maxillary molar to first mandibular molar through inclined planes and (2) H...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2111-5
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:Facial asymmetry is one of the main concerns in patients with a dentofacial deformity. The aims of the study were to (1) evaluate the changes in facial asymmetry after bimaxillary surgery for asymmetric skeletal class II deformity and (2) compare preoperative and postoperative facial asymmetry of class II pa...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2462-6
更新日期:2019-02-01 00:00:00
abstract::The objective of this prospective clinical follow-up was to evaluate the 2-year clinical performance of a nanofilled resin composite in class II restorations. The restorations were made with and without intermediary layer of a nanofilled flowable resin composite studied in an intraindividual comparison. Each participa...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-010-0485-8
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Ex-vivo evaluation of the detectability of vertical root fractures (VRFs) using digital subtraction radiography (DSR) and conventional digital periapical radiography (CDPR); investigation of the effect of root canal filling, x-ray angulation, and thickness of the VRF in the diagnostic accuracy. MATERIALS AND...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03245-0
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:This study aimed to compare (18)F-fluorodesoxyglucose positron emission tomography/MRI ((18)F-FDG-PET-MRI) fusion images, including diffusion-weighted imaging (DWI), (18)F-FDG-PET/CT, and ultrasound (US) regarding their performance in nodal staging of patients with head and neck squamous cell carcinoma (HNSCC...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1050-z
更新日期:2014-04-01 00:00:00
abstract::The alveolar cleft in patients with clefts of lip, alveolus and palate (CLAP) is usually reconstructed with an autologous bone graft. Harvesting of autologous bone grafts is associated with more or less donor site morbidity. Donor site morbidity could be eliminated if bone is fabricated by growth factor-aided tissue e...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-011-0547-6
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:To describe changes in growth factor mediators in the gingival crevicular fluid (GCF) of patients with aggressive periodontitis (AgP) undergoing regenerative (GTR) and access flap (AF) surgery. MATERIALS AND METHODS:This was a 12-month, single-blind, split-mouth RCT involving 18 AgP patients with a bilatera...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2752-z
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:The present longitudinal study aimed to compare changes in the lower third molar position and nerve involvement in orthodontically treated patients with and without premolar extractions. MATERIALS AND METHODS:The sample consisted of pretreatment and posttreatment panoramic radiographs of 349 orthodontically...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1148-3
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:Τhis study aims at determining the ability of cone beam computed tomography (CBCT) to visualize critical-size defects (CSD) created at rat calvaria and filled with 75/25 w/w nano-hydroxyapatite/chitosan (nHAp/CS) scaffolds, prior to their histological investigation. MATERIALS AND METHODS:Thirty adult Spragu...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02939-4
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. MATERIALS AND METHODS:This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-2010-1
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:The present dental bleaching case report describes a new method that precisely quantifies the daily wearing-times of the bleaching product by inserting a microsensor in the acetate custom tray. The bleaching efficacy was also discussed since the patient was previously submitted to enamel microabrasion. METH...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2439-5
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The aim of this investigation was to assess the currently available evidence concerning the complications and risk factors influencing the outcome of autotransplantation of teeth in humans. MATERIALS AND METHODS:Electronic searches were conducted to identify randomized controlled and prospective clinical tr...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00784-015-1473-9
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to quantify the blue light that passes through different incremental thicknesses of bulk fill in comparison to conventional resin-based composites (RBCs) and to relate it to the induced mechanical properties. MATERIALS AND METHODS:Seven bulk fill, five nanohybrid and two flowable R...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1177-y
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:The development of white spot lesions around orthodontic brackets and gingivitis is a common problem during orthodontic treatment with fixed appliances. This prospective randomized double-blind controlled clinical trial investigated the preventive efficacy of a one-time application of two commonly used fluor...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-016-1730-6
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVES:Several studies have shown the possible involvement of Helicobacter pylori infection in individuals with recurrent aphthous stomatitis (RAS), but the relationship remains controversial. This meta-analysis was performed to validate the association between RAS and H. pylori infection. MATERIALS AND METHODS:Th...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00784-014-1230-5
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Few studies regarding the distribution of pediatric oral diseases are available. Thus, the aim of this study was to investigate the incidence and demographic profile of neoplasms and non-neoplastic lesions among children and adolescents (0-19 years old). METHODS:A retrospective descriptive cross-sectional s...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2581-0
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate factors associated with the incidence of erosive tooth wear (ETW) among adults at different ages in Tokyo using multifactorial logistic regression analysis. MATERIALS AND METHODS:The study sample consisted of a total of 1108 subjects aged 15 to 89 years in Tokyo, Japan....
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2065-7
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Biomechanical orthodontics loading of the periodontium initiates a cascade of inflammatory signaling events that induce periodontal remodeling and finally facilitate orthodontic tooth movement. Pattern recognition receptors such as toll-like receptors (TLRs) have been well characterized for their ability to i...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03111-8
更新日期:2020-04-01 00:00:00
abstract::This study investigated the ability and efficacy of an Er:YAG laser with a fluorescence feedback system for caries removal in deciduous teeth. Seventy-nine carious lesions were excavated using a fluorescence-controlled Er:YAG laser. Endpoint of treatment was defined by emission of fluorescence from the dentine surface...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章
doi:10.1007/s00784-007-0169-1
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:This study aimed to examine the electromyographic activity of superficial masseter and anterior temporal muscles during chewing gum and gummy jelly mastication in healthy subjects to reveal the difference of neuromuscular control of jaw-closing muscles, according to the food texture. MATERIALS AND METHODS:E...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2754-x
更新日期:2019-09-01 00:00:00
abstract::Recently, resin-based dental restorative materials have been targeted as potential sources of xenoestrogens, specifically bisphenol A (BPA) and bisphenol A dimethacrylate (BAD), which could contribute to overall estrogen load and result in deleterious side effects. The present study used high-pressure liquid chromatog...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840050087
更新日期:1999-09-01 00:00:00
abstract::In the original version of this article, the following were noted for correction. ...
journal_title:Clinical oral investigations
pub_type: 已发布勘误
doi:10.1007/s00784-020-03657-y
更新日期:2020-10-26 00:00:00
abstract::The goal of the study was to develop a validated manual preparation process that conforms to the requirements of validation guidelines. Twelve dental transmission devices from various manufacturers (turbines, handpieces, and contra-angle handpieces) were artificially contaminated with bovine hemoglobin for the test. T...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0425-7
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:Information about the spectrum of microorganisms in the intraimplant cavities of two-piece dental implants is scarce. The purpose of this study was to assess the intraimplant microflora of two-piece dental implants by conventional biochemical testing, matrix-assisted laser desorption/ionization time-of-flight...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0805-2
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:The purpose of this double-blind, randomised trial was to compare the clinical performance of a hybrid composite (Clearfil AP-X, Kuraray, Tokyo) and a nanocomposite (Filtek Z350, 3M ESPE, St. Paul, MN) over a period of 2 years in non-carious class V lesions using a modified US Public Health Service (USPHS) sy...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-012-0780-7
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:Analgesics are one of the most frequently used medicines. Self-medication and misuse have been described in the literature. The purpose of this study was to document analgesic (mis)use in a population seeking emergency dental treatment. MATERIAL AND METHODS:Patients consulting a dental emergency service wer...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2228-6
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:This work aimed to comparatively evaluate the three modalities of vestibuloplasty around implants in the posterior mandible. MATERIALS AND METHODS:Forty patients who presented with a shallow vestibule and insufficient keratinized gingiva were divided into three groups: apically positioned flap only (APF gro...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2320-y
更新日期:2018-06-01 00:00:00