Identification and characterization of estrogen-like components in commercial resin-based dental restorative materials.

Abstract:

:Recently, resin-based dental restorative materials have been targeted as potential sources of xenoestrogens, specifically bisphenol A (BPA) and bisphenol A dimethacrylate (BAD), which could contribute to overall estrogen load and result in deleterious side effects. The present study used high-pressure liquid chromatography (HPLC) to analyze twenty-eight different commercially available dental resins for the presence of BPA and/or BAD. In addition, sublines of the MCF-7 human breast tumor cell line were cultured in the presence of eluates from eleven of the dental resins and assessed for proliferative responses using the sulforhodamine B assay. Only one resin, Delton II, had detectable levels of BPA or BAD that could be verified by Fourier transform infrared spectrometry. Likewise, eluates from Delton II were the only samples that elicited a significant proliferative response in two of the MCF-7 sublines tested. Therefore, we conclude that dental resins in general do not represent a significant source of BPA or BAD exposure.

journal_name

Clin Oral Investig

authors

Lewis JB,Rueggeberg FA,Lapp CA,Ergle JW,Schuster GS

doi

10.1007/s007840050087

keywords:

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

107-13

issue

3

eissn

1432-6981

issn

1436-3771

journal_volume

3

pub_type

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