Abstract:
OBJECTIVES:Τhis study aims at determining the ability of cone beam computed tomography (CBCT) to visualize critical-size defects (CSD) created at rat calvaria and filled with 75/25 w/w nano-hydroxyapatite/chitosan (nHAp/CS) scaffolds, prior to their histological investigation. MATERIALS AND METHODS:Thirty adult Sprague Dawley rats, 15 males and 15 females, were used. Two CSD, 5 mm in diameter, were bilaterally trephined in the parietal bone. The right CSD was filled with nHAp/CS scaffold, while the left CSD remained empty, as the control group. Two female rats died post-operatively. Rats were euthanized at 2, 4, and 8 weeks post-surgery. Twenty-eight specimens (15 × 2 × 10 mm) were resected-containing both CSDs-and then scanned using a NewTom VGi CBCT imaging unit (Verona, Italy). The manufacturer's software trace region profile tool (NNT v6.2, Verona, Italy) was used in selected axial slices. The greyscale value (in VGiHU) and the traced/selected region of interest (ROI, in mm2) of those areas were automatically calculated. Subsequently, all specimens were histologically examined. RESULTS:An increased VGiHU (P = 0.000), was observed in the experimental group relative to the control group. The ROI of CSD (in mm2) was significantly reduced (P = 0.001) from the fourth to the eighth week in both groups. No statistically significant difference between male and female rats (P = 0.188) was observed with respect to VGiHU. CONCLUSIONS:The nHAp/CS scaffolds are easily visualized using a particular high-resolution CBCT device. CLINICAL RELEVANCE:Both the CBCT measurements and also the histological results suggest that the nHAp/CS scaffold presence contributes to new bone formation in rat calvarial CSD.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Chatzipetros E,Yfanti Z,Christopoulos P,Donta C,Damaskos S,Tsiambas E,Tsiourvas D,Kalogirou EM,Tosios KI,Tsiklakis Kdoi
10.1007/s00784-019-02939-4subject
Has Abstractpub_date
2020-01-01 00:00:00pages
437-446issue
1eissn
1432-6981issn
1436-3771pii
10.1007/s00784-019-02939-4journal_volume
24pub_type
杂志文章abstract:OBJECTIVES:The purpose of this study was to assess the efficacy of different cleansing agents in killing mixed species biofilms on silicone facial prostheses. MATERIALS AND METHODS:Two bacterial and three yeast strains, isolated from silicone facial prostheses, were selected for the mixed species biofilms. A variety o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1453-0
更新日期:2015-12-01 00:00:00
abstract::Bcl-2 is a family of proteins involved in protecting the cell against death stimuli or in promoting cell death. The aim of the present study was to determine the effect of nifedipine treatment on the expression of bcl-2 protein in rat gingival tissues. Rats were given gastric intubation with various concentrations and...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-003-0194-7
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the palatal total support tissues (TSTs) and bone support tissues (BSTs) at 5-mm paramedian section to the midsagittal suture between mouth breathers with high-narrow palates and nose breathers with normal palates and confirm the practicability and limitation on superimpo...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03004-w
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:Aggregatibacter actinomycetemcomitans, specially its highly leucotoxic strain (JP2 clone), represents an etiological factor for the onset and progression of aggressive types of periodontitis. The aims of this investigation were to investigate the most relevant periodontal pathogens in the subgingival microbio...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1653-7
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:To assess the quality of clinical practice guidelines (CPGs) on screening and diagnosis of oral cancer and to describe the characteristics of their recommendations. MATERIALS AND METHODS:We systematically searched EMBASE, MEDLINE, CPG' websites, and dentistry and oncology scientific societies to identify CP...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2668-7
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Genome-wide association studies (GWAS) and literature have identified polymorphisms in the KCNJ11, HNF1A, IRS1, TCF7L2, CDKAL1, CDKN2B, RPSAP52, GPR45 HHEX, IL18, and RUNX2 genes associated with type 2 diabetes mellitus (T2DM) and/or periodontitis (P) in diverse populations, and we sought to evaluate them as ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03717-3
更新日期:2021-01-03 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the inhibition of demineralization around enamel-dentin/restoration interface after dentin pretreatment with 2.5% titanium tetrafluoride (TiF4). MATERIALS AND METHODS:Forty dental class V cavities at the cementoenamel junction were distributed into four groups (n ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1573-6
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the effect of different endodontic solvents on the microtensile bond strength (μTBS) of various adhesives to pulp chamber dentin. MATERIAL AND METHODS:A total of 120 human third molars were selected. Canals were prepared with the ProTaper Universal system and obturated....
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1929-6
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:The clinical standard for alveolar cleft osteoplasty is augmentation with autologous bone being available in limited amounts and might be associated with donor site morbidity. The aim of the present study was the creation of tissue-engineered bone grafts and their in vivo evaluation regarding their potential...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2050-1
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Ex-vivo evaluation of the detectability of vertical root fractures (VRFs) using digital subtraction radiography (DSR) and conventional digital periapical radiography (CDPR); investigation of the effect of root canal filling, x-ray angulation, and thickness of the VRF in the diagnostic accuracy. MATERIALS AND...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03245-0
更新日期:2020-10-01 00:00:00
abstract::Dear Professor Dr. Matthias Hannig. Editor-in-Chief Clinical Oral Investigations. Following the publication of our paper by Calvo Guirado et al, 2015 [1] in Clinical Oral Investigations, it came to light that a certain part of the text at the materials and methods and results sections were similar. ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00784-018-2763-9
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:To analyze the potential of human dental pulp stem cells (hDPSCs) for maintaining their undifferentiated status and osteogenic differentiation capacity when arranged in cell sheets (CSs) for future application in bone replacement. MATERIALS AND METHODS:CSs were formed after being induced for 10-15 days by c...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2630-8
更新日期:2019-06-01 00:00:00
abstract::Resin-bonded fixed partial dentures (RBFPD) are used as a minimal invasive, tooth-preventing alternative for replacing anterior teeth. Zirconia cantilever restorations were supposed to show sufficient strength for a clinical application. The aim of this investigation was to determine the fracture characteristics of ca...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-009-0254-8
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:This randomized clinical trial evaluated the survival of direct restorations on first permanent molars (FPMs) with molar incisor hypomineralization (MIH) and its impact on self-reported dental pain and dental anxiety. MATERIAL AND METHOD:FPMs with MIH of 35 patients aged 7 to 16 years were included. The FPMs...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03459-2
更新日期:2020-07-21 00:00:00
abstract:OBJECTIVES:This work aimed to comparatively evaluate the three modalities of vestibuloplasty around implants in the posterior mandible. MATERIALS AND METHODS:Forty patients who presented with a shallow vestibule and insufficient keratinized gingiva were divided into three groups: apically positioned flap only (APF gro...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2320-y
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate whether a specific interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism had any influence on the development of changes in maxillary sinus, particularly in the presence of etiological factors of dental origin. MATERIALS AND METHODS:The study population included 1...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1424-5
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:The main purpose of this prospective, double-blind, randomized study was to evaluate anaesthetic parameters, postoperative analgesia and vasoactive properties of levobupivacaine and bupivacaine for lower third molar surgery. MATERIAL AND METHODS:Sixty patients (ASA I) were scheduled for lower third molar su...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1114-0
更新日期:2014-01-01 00:00:00
abstract::This study evaluated the colour parameters of composite and ceramic shade guides determined using a colorimeter and digital imaging method with illuminants at different colour temperatures. Two different resin composite shade guides, namely Charisma (Heraeus Kulzer) and Premise (Kerr Corporation), and two different ce...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-009-0329-6
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:This study aimed to measure modifications of mastication after immediate loading full-arch prosthesis (ILFAP) rehabilitation. MATERIALS AND METHOD:Fourteen patients were observed before and 6 months after ILFAP rehabilitation when masticating two natural, standardized foods (peanut and carrot) and three mode...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0787-0
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:The aim of the present study is to evaluate the possible correlation between sealer penetration into dentinal tubules and sealing ability both in presence and absence of smear layer. MATERIALS AND METHODS:Fourteen maxillary central incisors were treated with 5.25 % NaOCl +10 % EDTA to remove the smear layer...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1878-0
更新日期:2017-05-01 00:00:00
abstract::The purpose of the present study was to decide whether composite resin or conventional glass ionomer cement should be preferred as a base material in endodontically treated premolars. Twelve extracted human maxillary premolars were mounted in a universal testing machine at a 35 degrees angle. Cuspal stiffness was dete...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s007840050049
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:To evaluate, longitudinally, the impacts of orthognathic surgery in patients with skeletal class II malocclusion on oral health-related quality of life (OHRQoL), temporomandibular disorders (TMD) and psychological symptoms. MATERIALS AND METHODS:Forty-three patients with skeletal class II malocclusion who w...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03709-3
更新日期:2021-01-07 00:00:00
abstract:INTRODUCTION:To compare, by Micro-CT and confocal laser scanning microscopy (CLSM), the ability of the Wave One Gold and Wave One systems to remove filling material from mesial canals of mandibular molars, effective time spent; quantity of extruded material, and percentage of sealer in the dentinal tubules after retrea...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2441-y
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the diagnostic efficacy of CBCT-MRI fused images for articular disc calcification of temporomandibular joint (TMJ). MATERIALS AND METHODS:Twenty patients (24 TMJs) whose image examinations showed dense bodies in the TMJ space were included in the study. The locations of dense bodies evaluated by...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03497-w
更新日期:2020-08-12 00:00:00
abstract:OBJECTIVES:Numerous different attachments are used to retain overdentures on implants. The purpose of this study was to evaluate a new chairside attachment system based on polyvinylsiloxane (PVS). MATERIAL AND METHODS:A total of 250 specimens were fabricated (n = 10) to measure the retention force (RF) in dependence o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1307-1
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:To describe changes in growth factor mediators in the gingival crevicular fluid (GCF) of patients with aggressive periodontitis (AgP) undergoing regenerative (GTR) and access flap (AF) surgery. MATERIALS AND METHODS:This was a 12-month, single-blind, split-mouth RCT involving 18 AgP patients with a bilatera...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2752-z
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the periodontal healing pattern of dehiscence-type defects following different chemical root conditioning modalities. MATERIALS AND METHODS:Buccal osseous dehiscence defects were created on six teeth of seven dogs. After dental plaque accumulation, defects were tr...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0848-4
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the effects of a hemostatic collagen sponge and a collagen sponge sealed with a bio-adhesive material on the palatal donor sites with the purpose of minimizing postoperative pain after epithelialized gingival graft (EGG) harvesting. MATERIAL AND METHODS:The present study...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2455-5
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to determine the quality of life of periodontally compromised patients after implant treatment (primary aim) and their satisfaction with the restoration and treatment approach (secondary aim). MATERIAL AND METHODS:In this study, 61 adult subjects were evaluated following non-surg...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1561-x
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination. MATERIALS AND MET...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-0939-x
更新日期:2014-01-01 00:00:00