Abstract:
:Bcl-2 is a family of proteins involved in protecting the cell against death stimuli or in promoting cell death. The aim of the present study was to determine the effect of nifedipine treatment on the expression of bcl-2 protein in rat gingival tissues. Rats were given gastric intubation with various concentrations and durations of nifedipine. Nifedipine-untreated and dimethylsulfoxide (DMSO)-treated animals served as control groups. The gingival tissues were dissected and the expression of bcl-2 protein was determined immunohistochemically. The results showed that the numbers of bcl-2-positive cells in the gingiva of nifedipine-treated animals were significantly higher than in the control groups. These numbers increased parallel to increased concentration and duration of nifedipine treatment. The results suggest that nifedipine treatment may induce the expression of bcl-2 protein in rat gingival tissue in a dose- and duration-dependent fashion and that this proto-oncogenic protein may play a role in nifedipine-induced gingival hyperplasia.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Handajani J,Santoso AL,Haniastuti T,Utoro T,Sosroseno Wdoi
10.1007/s00784-003-0194-7keywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
56-8issue
1eissn
1432-6981issn
1436-3771journal_volume
7pub_type
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pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-018-2707-4
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更新日期:2014-09-01 00:00:00
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-12-01 00:00:00
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更新日期:2007-09-01 00:00:00
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-009-0329-6
更新日期:2010-12-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-009-0314-0
更新日期:2010-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-05-01 00:00:00
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更新日期:2001-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
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更新日期:2009-12-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析
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更新日期:2020-01-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-09-01 00:00:00