Abstract:
OBJECTIVES:Platelet-rich plasma has been used in the treatment of extraction socket; however, randomized controlled clinical trial is still lacking to evaluate its effect on extraction socket healing. MATERIALS AND METHODS:Single center, assessor-blinded, parallel group, randomized controlled clinical trial was conducted. Sixty patients with indication of a simple one molar extraction in the mandible were randomized to receive plasma rich in growth factors (PRGF) or blood clot. A cross-stitch suture was placed in both groups. Clinical, radiographical, and histological assessments were performed during 10-12 weeks of follow-up. RESULTS:Cone beam CT analysis has shown that the percentage of patients where the sockets are regenerated at ≥75 % of the baseline volume was significantly higher in PRGF group (96.7 %) than the control group (45.5 %). Pain and inflammation (day 3 and day 7) have been significantly lower in PRGF group than the control group but not at day 15. Soft tissue healing scores have been significantly higher in the test group. No serious adverse events have been occurred in both groups. Histological analysis has indicated the presence of significantly thicker keratinized epithelium and significantly higher newly formed bone in the PRGF group. CONCLUSIONS:PRGF was associated with enhanced healing of extraction socket of mandibular molars throughout the observation period. CLINICAL RELEVANCE:Plasma rich in growth factors could be a useful tool to enhance the healing of extraction sockets by minimizing postoperative complications and stimulating the hard and soft tissues regeneration.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Anitua E,Murias-Freijo A,Alkhraisat MH,Orive Gdoi
10.1007/s00784-014-1278-2subject
Has Abstractpub_date
2015-04-01 00:00:00pages
589-600issue
3eissn
1432-6981issn
1436-3771journal_volume
19pub_type
杂志文章,随机对照试验abstract:OBJECTIVES:This study evaluated the influence of different rehydration media and time periods on biomechanical and structural properties of different acellular collagen matrices (ACMs). MATERIALS AND METHODS:Specimens of three ACMs (mucoderm®, Mucograft®, Dynamatrix®) were rehydrated in saline solution (SS) or human b...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1614-1
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:The main objective of this study was to evaluate clinical and radiographic outcomes of implant-supported fixed partial prostheses, comparing platform switching and standard platform concepts. MATERIALS AND METHODS:Patients with single or multiple partial edentulism were included in this prospective multicen...
journal_title:Clinical oral investigations
pub_type: 杂志文章,多中心研究
doi:10.1007/s00784-015-1462-z
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:Aberrant growth of the maxillomandibular complex in patients with cleft lip and/or palate (CL/P) can be managed with dentofacial orthopaedics. However, no consensus has been reached regarding timing and evolution of the maturational stages. Therefore, the aim of this study is to determine if patients with CL...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-021-03790-2
更新日期:2021-01-23 00:00:00
abstract:OBJECTIVES:Adhesively luted all-ceramic restorations represent a promising way to preserve and stabilize weakened tooth substance, but little information is published about the clinical performance of extensive all-ceramic restorations. MATERIALS AND METHODS:A total of 78 large CEREC 2™ single-tooth all-ceramic restor...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-011-0642-8
更新日期:2012-10-01 00:00:00
abstract::Apical periodontitis (AP) are frequent findings in contemporary dental practice in association with dental pathology or dental care. They have also been studied from an anthropological background. The purpose of this study was to compare the prevalence of apical and dental lesions in an archeological Middle Ages sampl...
journal_title:Clinical oral investigations
pub_type: 历史文章,杂志文章
doi:10.1007/s00784-005-0318-3
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Resin-based composites may leach monomers such as triethylene-glycol dimethacrylate (TEGDMA), which could contribute to intrapulpal inflammation. The aim of this investigation was to examine whether various concentrations of TEGDMA are able to influence dentally relevant Matrix metalloproteinase (MMP)-2, MMP...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03545-5
更新日期:2020-08-26 00:00:00
abstract::Optimizing the quality of tooth-colored restorations is one of the main topics of current research. But there is only little information available about university education in this field. The aim of this study was to collect and evaluate data about the different aspects of dental education in Germany concerning tooth...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840050075
更新日期:1999-03-01 00:00:00
abstract:: ...
journal_title:Clinical oral investigations
pub_type: 信件
doi:10.1007/s00784-018-2619-3
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:To evaluate the prevalence, clinical features, and risk factors of dentin hypersensitivity (DH) in a Brazilian population. MATERIALS AND METHODS:300 patients at the Dentistry Clinic of the University of São Paulo participated in this study. The subjects completed a questionnaire regarding their personal inf...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1008-1
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To assess dimensional changes following alveolar ridge preservation using bovine-derived xenograft with 10% collagen and collagen membrane compared to ridge preservation by means of bovine-derived xenograft particles and collagen membrane or spontaneous healing in posterior sites. MATERIALS AND METHODS:Fort...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-019-02979-w
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the effect of different seating forces during cementation in cement-ceramic microtensile bond strength (μTBS). MATERIALS AND METHODS:Forty-five blocks (5 × 5 × 4 mm(3)) of a glass-infiltrated alumina-based ceramic (In-Ceram Alumina) were fabricated according to the manu...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-011-0668-y
更新日期:2013-01-01 00:00:00
abstract::This study (1) investigated whether the combination of an adhesive system from one manufacturer with a resin composite from the same manufacturer provides superior bonding of the resin composite to dentin compared with the combination of an adhesive system from one manufacturer with a resin composite from another manu...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-006-0077-9
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:The aim of this prospective, randomized, clinical study was to assess the effect of photobiomodulation therapy (PBM) with low-level laser irradiation (LLLI) on postoperative pain after endodontic treatment. MATERIALS AND METHODS:Sixty patients, diagnosed with irreversible pulpitis in lower molar teeth, parti...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2435-9
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the systemic and periodontal conditions, as well as the determinants of health in pregnant women with and without obesity/overweight during the second and third trimesters of pregnancy and after delivery. MATERIALS AND METHODS:In the second trimester (T1), 93 pregnant women were divided into two ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02932-x
更新日期:2020-01-01 00:00:00
abstract::Smoking is a causative factor in oral squamous cell carcinomas (SCC). Unfortunately, only poor data exist regarding the quality of life of smokers vs non-smokers with SCC. The purpose of this study is to show a correlation between variables for comprehensive interdisciplinary rehabilitation and better patient quality ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,多中心研究
doi:10.1007/s00784-011-0631-y
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:Evaluate the bone remodeling during orthodontic movement with corticotomy when submitted to low-intensity electrical stimulation application (microcurrent-MC) and low-level laser therapy (LLLT). MATERIAL AND METHODS:One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02845-9
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:The caries preventive effect of long-term use (1 year) of low-dosage (2.5 g/die) of xylitol chewing gum in a high-caries-risk adult population was evaluated. MATERIALS AND METHODS:In this randomized clinical trial, 179 high-caries-risk adults were assigned to two experimental groups, xylitol and polyols. Ca...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-017-2075-5
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The use of the autogenous periosteal graft as biological barrier has been proposed for periodontal regeneration. The aim of this study was to evaluate the histometric findings of the subepithelial connective tissue graft as barrier in intrabony defects compared to a bioabsorbable membrane. METHODS:Three-wal...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1323-1
更新日期:2015-06-01 00:00:00
abstract::This study assessed the Knoop hardness and temperature increase provided by three light curing units when using (1) the manufacturers' recommended times of photo-activation and (2) standardizing total energy density. One halogen--XL2500 (3M/ESPE)--and two light-emitting diode (LED) curing units--Freelight (3M/ESPE) an...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-005-0028-x
更新日期:2006-03-01 00:00:00
abstract::The purpose of this study was to test the hypothesis of multidimensionality of oral and general health behaviour. To evaluate the proposed behavioural dimensions, relationships with individual beliefs and socio-economic factors were explored. A simple random sample of 1190 residents born in 1972 was drawn from the pop...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840000102
更新日期:2001-06-01 00:00:00
abstract::Squamous cell carcinoma (SCC) of the oral cavity is an extremely invasive tumour of stratified squamous epithelium that spreads throughout degradation of the basement membrane (BM) and extra-cellular matrix. Oral verrucous carcinoma (VC) is a rare low-grade variant of oral SCC that penetrates into the subepithelial co...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-009-0296-y
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to determine the quality of life of periodontally compromised patients after implant treatment (primary aim) and their satisfaction with the restoration and treatment approach (secondary aim). MATERIAL AND METHODS:In this study, 61 adult subjects were evaluated following non-surg...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1561-x
更新日期:2016-05-01 00:00:00
abstract:INTRODUCTION:Decay of teeth, erosion and disintegration of hard dental tissue are a clinically often seen side effect after radiotherapy for tumours in the head and neck region. To investigate if these side effects are due to structural changes in dental hard tissues, the current literature was searched. It can influen...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-013-1034-z
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was the qualitative and quantitative evaluation of osseous graft consolidation using allogeneic bone blocks for vertical bone augmentation in an animal model. MATERIAL AND METHODS:Standardised allogeneic and autologous bone blocks were fixed on the frontal skull of 20 adult fema...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03151-0
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:The current study aimed to evaluate different CBCT exposure protocols and influencing factors affecting the subjective image quality of scans taken for endodontic indications. MATERIALS AND METHODS:Twelve extracted teeth, comprising of two sets of maxillary molars, premolars, canines and incisors, mandibula...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03524-w
更新日期:2020-08-25 00:00:00
abstract:OBJECTIVES:The study evaluates the influence of two spacer settings and three resin luting materials on the marginal and internal fit of polymer-infiltrated ceramic network (PICN) material crowns manufactured using a complete digital workflow. METHODS:Optical impressions of fifty identical dies were performed using th...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03053-1
更新日期:2020-06-01 00:00:00
abstract::The purpose of this 4-day plaque regrowth study was to assess the effect of N-chlorotaurine (NCT) mouth rinses on plaque inhibition and plaque vitality. Eighty volunteers participated in this investigator-blind, randomized, clinical controlled study in parallel groups. No oral hygiene was permitted except rinsing with...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-008-0207-7
更新日期:2009-03-01 00:00:00
abstract::Acidogenicity and the levels of mutans streptococci (MS) in dental plaque after the use of Lactobacillus rhamnosus GG (LGG) and Lactobacillus reuteri were determined. The study had a randomised, double-blind, crossover design. Thirteen volunteers used tablets containing LGG or a combination of L. reuteri SD2112 and PT...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-011-0584-1
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate long-term (≥5 years) tooth survival after resective therapy of multi-rooted, periodontally treated teeth and investigate the influence of patient-, tooth-, and dentist-related risk factors on tooth loss. MATERIALS AND METHODS:A total of 128 patients with root-resected m...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03091-9
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Stud attachments are often too adhesive and too susceptible to damage for use in geriatric patients, especially when implants are angulated. This study aimed to evaluate alternative anchoring systems comprising individual and prefabricated polyvinylsiloxane (PVS) attachments. MATERIALS AND METHODS:A total o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2568-x
更新日期:2019-03-01 00:00:00