Abstract:
OBJECTIVES:Evaluate the bone remodeling during orthodontic movement with corticotomy when submitted to low-intensity electrical stimulation application (microcurrent-MC) and low-level laser therapy (LLLT). MATERIAL AND METHODS:One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/corticotomy; (Cort-L) tooth movement/corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/corticotomy and laser/microcurrent alternated. Inflammation, angiogenesis, and osteogenesis were evaluated in the periodontal ligament (PDL) and alveolar bone on the 7th, 14th, and 21st days of orthodontic movement. RESULTS:The quantification of inflammatory infiltrate, angiogenesis and expression of TGF-β1, VEGF, and collagen type I were favorably modulated by the application of therapies such as low-level laser therapy (LLLT), MC, or both combined. However, electrical stimulation increased fibroblasts, osteoclasts and RANK numbers, birefringent collagen fiber organization, and BMP-7 and IL-6 expression. CONCLUSIONS:Low-level laser therapy (LLLT) and MC application both improved the process of bone remodeling during orthodontic treatment with corticotomy. Still, electrical current therapy promoted a more effective tooth displacement but presented expected root resorption similar to all experimental treatments. CLINICAL RELEVANCE:It is important to know the effects of minimally invasive therapies on cellular and molecular elements involved in the bone remodeling of orthodontic treatment associated with corticotomy surgery, in order to reduce the adverse effects in the use of this technique and to establish a safer clinical routine.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Zaniboni E,Bagne L,Camargo T,do Amaral MEC,Felonato M,de Andrade TAM,Dos Santos GMT,Caetano GF,Esquisatto MAM,Santamaria M Jr,Mendonça FASdoi
10.1007/s00784-019-02845-9subject
Has Abstractpub_date
2019-11-01 00:00:00pages
4083-4097issue
11eissn
1432-6981issn
1436-3771pii
10.1007/s00784-019-02845-9journal_volume
23pub_type
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更新日期:2020-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-08-01 00:00:00
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更新日期:2017-07-01 00:00:00