Abstract：
:Smoking is a causative factor in oral squamous cell carcinomas (SCC). Unfortunately, only poor data exist regarding the quality of life of smokers vs non-smokers with SCC. The purpose of this study is to show a correlation between variables for comprehensive interdisciplinary rehabilitation and better patient quality of life (LQ). A total collective of 1,761 patients from 38 hospitals within the German-language area of Germany, Austria and Switzerland (DÖSAK-REHAB-STUDIE) yielding 1,652 patients' questionnaires containing 147 items were evaluated. They refer to the periods before (t1) and immediately after surgery (t2), as well as at least 6 months later (t3). LQ was determined by the patient and ranges from 0% to 100%. Significant differences were found between smokers (80%) and non-smokers (20%) with respect to diagnosis, therapy and rehabilitation. Disabilities and impairments in speech, appearance, chewing/swallowing, pain and LQ were examined. Smokers were more often and more severely affected. Differences were found in the size of the tumour, scar tissue, ingestion, functionality of the facial muscles and a numb feeling in the head and shoulder area. Smoking has a severe effect on the oral cavity. Non-smokers suffer far less from the effects of SCC and the ensuing therapy. During therapy and rehabilitation, the LQ is much higher in non-smokers. This supports the importance of enhanced efforts to inform people about the consequences of smoking so as to prevent them from smoking. Moreover, psychological support might be helpful to give up smoking.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Krüskemper G,Handschel Jdoi
10.1007/s00784-011-0631-ysubject
Has Abstractpub_date
2012-10-01 00:00:00pages
1353-61issue
5eissn
1432-6981issn
1436-3771journal_volume
16pub_type
杂志文章,多中心研究abstract：INTRODUCTION:To compare, by Micro-CT and confocal laser scanning microscopy (CLSM), the ability of the Wave One Gold and Wave One systems to remove filling material from mesial canals of mandibular molars, effective time spent; quantity of extruded material, and percentage of sealer in the dentinal tubules after retrea...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2441-y
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVES:Pain and trismus are the most common postoperative complications following a surgical removal of the lower third molar. This randomized, double-blind, placebo-controlled clinical trial evaluated the effect of orally administrated magnesium on postoperative pain and trismus after surgical removal of the lower...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-020-03335-z
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVES:Adhesively luted all-ceramic restorations represent a promising way to preserve and stabilize weakened tooth substance, but little information is published about the clinical performance of extensive all-ceramic restorations. MATERIALS AND METHODS:A total of 78 large CEREC 2™ single-tooth all-ceramic restor...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-011-0642-8
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:Root migration occurs after most third molar coronectomy and a portion may be exposed in the oral cavity. This study compared the root migration rate, surgical morbidities after third molar coronectomy with or without adjunctive guided bone regeneration (GBR). METHODS:A split-mouth randomized clinical trial wa...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-018-2594-8
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVES:To evaluate the marginal and internal fit of CAD/CAM-generated frameworks for 4-unit, fixed dental prostheses (FDPs) from zirconia (Z) and cobalt-chromium alloy (C) made with conventional (CI) and digital impressions (DI). MATERIALS AND METHODS:A titanium model was digitized with an intraoral scanner (DI, L...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1513-5
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate through a systematic review the extraction of third molars as a risk factor for temporomandibular disorders (TMDs). TYPES OF STUDIES REVIEWED:Randomized and nonrandomized controlled clinical trials where patients underwent third molar extraction and with qualitative eva...
journal_title：Clinical oral investigations
pub_type： 杂志文章,评审
doi：10.1007/s00784-020-03277-6
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVES:Most patients with bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) report a previous tooth extraction at the necrosis site before the diagnosis was made. At older ages, most teeth are extracted due to periodontal disease, which is per se another BP-ONJ trigger factor. The aim of this study was t...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-013-0974-7
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:This study aimed to investigate the root canal morphology of mandibular first premolar teeth in a population from southwestern China by micro-computed tomography (micro-CT). MATERIALS AND METHODS:Human mandibular first premolars (115) were selected and prepared for micro-CT analysis with a slice thickness o...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-012-0778-1
更新日期：2013-04-01 00:00:00
abstract：AIM:The aim of this study was to compare the effectiveness of 2% articaine and 2% lignocaine in achieving adequate anesthesia in children between the age group of 6-13 years using inferior alveolar nerve block. METHODS:A triple blinded randomized controlled trial was conducted in 180 participants (90 patients- 2% arti...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-018-2775-5
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVES:Several theories have been proposed regarding the genesis of sialoliths, including the organic core theory, which suggests epithelial or bacterial etiology originating in the central core. Our aim was to use novel methodologies to analyze central areas (the core) of calculi from sialolithiasis patients. MAT...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-012-0870-6
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVES:Recently, novel biphasic calcium phosphate (BCP) scaffolds have emerged as a new class of bone grafts with osteoinductive potential demonstrating the ability to form ectopic bone in extra-skeletal sites. The aim of the present study was to perform an osteogenic gene array to target possible genes responsible...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-016-1825-0
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:This study aims to test the influence of different surface treatments and conditioning on the shear bond strength between polyetherketone (PEEK) and composite. MATERIALS AND METHODS:Surfaces (570 plates) were used untreated, etched, air-particle abraded or activated with silica-modified alumina oxide. Surfa...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-014-1294-2
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVES:This study aims to investigate the additional influence of multiple applications of antimicrobial photodynamic therapy (aPDT) in smokers with chronic periodontitis. MATERIALS AND METHODS:Twenty smokers with chronic periodontitis were treated in a split-mouth design study with aPDT adjunct to Scaling and Roo...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-018-2740-3
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Interleukin 8 (IL-8) is a pro-angiogenic, pro-inflammatory mediator that belongs to the family of chemokines. Due to its pro-angiogenic characteristic, it may play a vital role in tumour angiogenesis and progression. OBJECTIVES:This study was designed to estimate the levels of salivary IL-8 in oral precance...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-012-0723-3
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVES:Detecting bacterial activity is considered a promising approach to monitor shifts from symbiosis to dysbiosis in oral microbiome. The present study aimed at investigating both the relative bacterial activity and the lactate dehydrogenase (ldh) gene expression of caries-associated bacteria in a site-specific ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03691-w
更新日期：2020-11-23 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the immunohistochemical expressions of PD1, CD4+, and CD8+ in premalignant lesions (OPML) that were transformed into oral squamous cell carcinoma OSCC (OPML-OSCC), in OSCC and also in premalignant lesions that were not transformed into OSCC (OPML-NOSSC). MATERIALS AND ME...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2622-8
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVES:The purpose of this experimental in vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multi-phosphonate molecules on the development of experimental peri-implantitis. MATERIAL AND METHODS:Eight beagle dogs received 5 tests and 5 control implants each ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03708-4
更新日期：2021-01-06 00:00:00
abstract：OBJECTIVES:This animal study was conducted to evaluate the osteocyte index in the peri-implant bone around immediately restored implants under static lateral overload. MATERIAL AND METHODS:Seven mongrel dogs received three implants on each side of the mandible. Forty-two implants were distributed into three groups (14...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03662-1
更新日期：2020-11-05 00:00:00
abstract：OBJECTIVES:This study aimed to investigate the effect of fracture orientation on the detection accuracy of vertical root fractures (VRFs) in non-endodontically treated teeth using four different cone beam computed tomography (CBCT) units. MATERIALS AND METHODS:Thirty eight out of 148 extracted human permanent teeth we...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-02905-0
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to compare the effect of one-stage full-mouth disinfection (FMD) and conventional quadrant scaling in four weekly sessions (QS) on periodontal clinical parameters and halitosis among individuals with advanced chronic periodontitis. MATERIALS AND METHODS:In this randomized cont...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-016-1959-0
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Long-term culture system is used to prevent the impediment of insufficient cells and is good for low starting materials such as dental pulp or periodontal ligament. In general, although cell viability and functionality are the most common aspects taken into consideration in culturing cells for...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1497-1
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:To explore whether a computed tomography (CT) examination of the head and neck region induces biological damage and whether the damage was correlated with the radiation dose. MATERIALS AND METHODS:Peripheral blood was taken from 33 individuals who received head and neck CT examinations. Blood samples were d...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03331-3
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVES:To analyze the potential of human dental pulp stem cells (hDPSCs) for maintaining their undifferentiated status and osteogenic differentiation capacity when arranged in cell sheets (CSs) for future application in bone replacement. MATERIALS AND METHODS:CSs were formed after being induced for 10-15 days by c...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2630-8
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVES:Intermittent parathyroid hormone (PTH) exerts anabolic effects on bone and has been approved for osteoporosis therapy. The dual actions of PTH are mediated primarily through the parathyroid hormone 1 receptor (PTH1R). Upon ligand binding, PTH1R activates diverse signaling pathways, including cAMP/protein kin...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-013-0985-4
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:It is well accepted that stage-specific embryonic antigen (SSEA)-4 is an antigen that is useful to isolate adult stem cells analogous to embryonic stem cells. Therefore, in the present study, we investigated whether SSEA-4 can also be used as a marker to identify human deciduous dental pulp (D-DP) stem cells...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-014-1260-z
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine reports of perceptual distortion evoked by transient deafferentation and burning pain as models of aspects of burning mouth syndrome (BMS). MATERIALS AND METHODS:Sixteen healthy women took part in three experimental sessions that included exposure to lingual nerve block,...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-016-1994-x
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVES:To assess the internal and external morphologies of the mesiobuccal (MB) root of maxillary molars presenting a third root canal (MB3), using micro-computed tomography (micro-CT). MATERIAL AND METHODS:Two-hundred and sixty-five extracted maxillary first and second molars with different root configurations we...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03284-7
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to compare the effects of a hemostatic collagen sponge and a collagen sponge sealed with a bio-adhesive material on the palatal donor sites with the purpose of minimizing postoperative pain after epithelialized gingival graft (EGG) harvesting. MATERIAL AND METHODS:The present study...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-018-2455-5
更新日期：2019-01-01 00:00:00
abstract：:The aim of this study was to determine the prevalence of dental erosion in young Icelandic adults (19-22 years old) and patients with gastroesophageal reflux disease (GERD), in relation to their soft drink consumption and gastroesophageal reflux. Eighty subjects (40 males and 40 females), comprising 57 young adults (m...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-003-0252-1
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVES:Bisphosphonates and denosumab are antiresorptive drugs used for the treatment of osteoporosis and oncological tumors. A severe side effect is osteonecrosis of the jaw. Monocyte/macrophage dysfunction is considered to play a distinct role in osteonecrosis. THP-1 monocytic cells were used in this study to eluc...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-014-1358-3
更新日期：2015-07-01 00:00:00
