Abstract：
OBJECTIVES:Several theories have been proposed regarding the genesis of sialoliths, including the organic core theory, which suggests epithelial or bacterial etiology originating in the central core. Our aim was to use novel methodologies to analyze central areas (the core) of calculi from sialolithiasis patients. MATERIALS AND METHODS:The structures of the halves of six submandibular salivary stones were analyzed by scanning electron microscopy (SEM). After structural analysis, from the other six halves, samples from the central parts of the core and peripheral parts of the core were digested with trypsin and analyzed by matrix-assisted laser desorption ionization-time of flight mass spectrometry. The peptide mass fingerprints were compared with the results of in silico digestion. RESULTS:SEM analysis of the sialoliths showed that organic structures (collagen/fibrous-like structures, bacterial fragments) were visible only outside of the core in the concentric layers of external areas, but not in the core area. The mass spectrometry (MS)/MS post-source decay experiments were completed from the four, most intense signals observed in the MS spectrum and human defensin was proven to be present in three of the examined samples, originated from the peripheral region of three cores. CONCLUSIONS:Although proteomic analysis demonstrated defensin protein in the peripheral region of the core in three sialoliths, SEM failed to prove organic structures in the core. CLINICAL RELEVANCE:New investigation modalities still cannot prove organic structures in the core, henceforward challenging the organic core theory.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Szalma J,Böddi K,Lempel E,Sieroslawska AF,Szabó Z,Harfouche R,Olasz L,Takátsy A,Guttman Adoi
10.1007/s00784-012-0870-6subject
Has Abstractpub_date
2013-09-01 00:00:00pages
1709-17issue
7eissn
1432-6981issn
1436-3771journal_volume
17pub_type
杂志文章abstract：:Fluoride is used in dentistry as a prophylactic agent to reduce caries rates due to the demineralization/remineralization effect and its influence on the metabolism of cariogenic bacteria. The purpose of this study was to evaluate the cytotoxic effects of sodium fluoride (NaF) on three different cell lines and the ant...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-002-0157-4
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVES:We aimed to determine the immunolocalization patterns of the interleukin (IL)-6 signaling complex in epithelialized and non-epithelialized apical lesions of endodontic origin (ALEOs). MATERIALS AND METHODS:Epithelialized (n = 8) and non-epithelialized (n = 7) ALEOs were obtained from teeth with indication o...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03738-y
更新日期：2021-01-07 00:00:00
abstract：OBJECTIVE:The objective of the study is to compare skeletal and dental changes in class II patients treated with fixed functional appliances (FFA) that pursue different biomechanical concepts: (1) FMA (Functional Mandibular Advancer) from first maxillary molar to first mandibular molar through inclined planes and (2) H...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-017-2111-5
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to evaluate the efficacy of four different side-to-side toothbrushes and the impact of various brushing parameters on noncontact biofilm removal in an adjustable interdental space model. MATERIALS AND METHODS:A three-species biofilm, consisting of Porphyromonas gingivalis, Fu...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-016-1969-y
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVES:Transglutaminase-2 (TGM-2) protein is involved in the cross-linking of matrix proteins resulting in several fibrotic disorders and can be induced by reactive oxygen species (ROS). Little is known about its role in the development of oral submucocal fibrosis (OSF). Hence, we hypothesize that TGM-2 may have a ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1579-0
更新日期：2016-06-01 00:00:00
abstract：:This study aims to evaluate the inclinations of right and left sides the mandibular fossa in Asian population using computed tomography (CT) images and determine its effects according to the parameters of gender, age, and asymmetry. CT images of the heads of 198 Asian subjects [95 females aged 44.2 ± 20.7 years, range...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-011-0518-y
更新日期：2012-04-01 00:00:00
abstract：:This paper attempts to identify characteristics of a longitudinal clinical study's "dropout" population (1974-1996) of patients using overdentures. This study included 395 subjects. Dropouts were identified as persons who did not respond to letters or telephone calls after participating in the study for up to 2 years,...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-003-0238-z
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:The aim of this systematic review and meta-analysis (SRM) was to assess the postoperative pain (PP) after non-surgical endodontic retreatment (NSER) in a one visit compared to multiple visits. The PICO question used was "Does NSER in patients with unsatisfactory endodontic treatment in a one-visit visit have...
journal_title：Clinical oral investigations
pub_type： 杂志文章,meta分析
doi：10.1007/s00784-020-03767-7
更新日期：2021-02-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine the influence of experience and gender on the radiographic detection of proximal caries lesions and on therapeutic decisions. MATERIALS AND METHODS:A survey of 220 examiners (students and employees at three universities and dentists in the field) was taken using a standa...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-017-2078-2
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate differences between the virtually planned and clinically achieved implant positions in completely template-guided implantations as a function of the type of edentulous space, the residual natural dentition, and the surgical implementation. MATERIALS AND METHODS:Fifty-...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2339-8
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to investigate the caries-preventive effect of newly developed fluoride and fluoride-free toothpastes specially designed for erosion prevention. The hypothesis was that these products might also show superior caries-inhibiting effect than regular fluoride toothpastes, since they were...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-016-1789-0
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:To explore the pathophysiology of proliferative verrucous leukoplakia, a rare oral disorder that exhibits high rates of recurrence and malignant transformation, through a RNAseq case-control study. MATERIAL AND METHODS:We obtained oral biopsies from 10 patients with verrucous leukoplakia lesions and from th...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03575-z
更新日期：2020-09-11 00:00:00
abstract：OBJECTIVE:To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with persistent suspicious oral mucosal lesions (PSOML). SUBJECTS AND METHODS:Whole unstimulated saliva samples were collected from age-, sex-, and race-m...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2777-3
更新日期：2019-09-01 00:00:00
abstract：:This study investigated the ability and efficacy of an Er:YAG laser with a fluorescence feedback system for caries removal in deciduous teeth. Seventy-nine carious lesions were excavated using a fluorescence-controlled Er:YAG laser. Endpoint of treatment was defined by emission of fluorescence from the dentine surface...
journal_title：Clinical oral investigations
pub_type： 临床试验,杂志文章
doi：10.1007/s00784-007-0169-1
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVES:In this in vitro study, we assessed filling characteristics (adaptation, homogeneity, sealer percentage, position of the carrier) of warm and cold obturation methods in curved root canals. MATERIALS AND METHODS:A reciprocating method was used to prepare 90 curved roots (25 ° average curvature) to an apical ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1674-2
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:There is an increasing number of oral squamous cell carcinoma (OSCC) associated with HPV-16. However, p16 expression by immunohistochemistry as the current gold standard for a surrogate marker for virus infection reveals unsatisfying diagnostic accuracy. The aim of this study was to investigate a new rapid t...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03601-0
更新日期：2020-10-23 00:00:00
abstract：OBJECTIVES:This study aims to investigate the additional influence of multiple applications of antimicrobial photodynamic therapy (aPDT) in smokers with chronic periodontitis. MATERIALS AND METHODS:Twenty smokers with chronic periodontitis were treated in a split-mouth design study with aPDT adjunct to Scaling and Roo...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-018-2740-3
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVES:The present case-control study aims to assess the occurrence of alexithymic traits in burning mouth syndrome (BMS) subjects and to correlate alexithymic traits to anxious and depressive traits in BMS subjects. MATERIALS AND METHODS:Prospectively enrolled BMS and control subjects were administered the 20-ite...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1416-5
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate long-term (≥5 years) tooth survival after resective therapy of multi-rooted, periodontally treated teeth and investigate the influence of patient-, tooth-, and dentist-related risk factors on tooth loss. MATERIALS AND METHODS:A total of 128 patients with root-resected m...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-03091-9
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVES:The clinical standard for alveolar cleft osteoplasty is augmentation with autologous bone being available in limited amounts and might be associated with donor site morbidity. The aim of the present study was the creation of tissue-engineered bone grafts and their in vivo evaluation regarding their potential...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-017-2050-1
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVES:Recent scientific evidences suggest a relevant role of the oral cavity in the transmission and pathogenicity of SARS-CoV-2. METHODS:A literature search was performed in PubMed, up to April 30, 2020, focusing on SARS-CoV-2, COVID-19, oral cavity, and antimicrobial agents. RESULTS:Oral viral load of SARS-CoV...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03413-2
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:This prospective randomized clinical trial aimed to evaluate the long-term behavior of metal-free double crown retained dentures with secondary crowns and dental frameworks made of the fiber-reinforced composite Vectris(©) on all-ceramic primary crowns (IPS Empress 2(©)) over a period of up to 14 years and t...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-015-1597-y
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:This study compared the effects of mold material and diameter on the thickness of cured composite remnants and depth of cure (DOC) of resin-based composites (RBC). MATERIAL AND METHODS:One Polywave® curing light was used to photo-cure two shades of the same "bulk-fill" RBC in 4, 6, or 10-mm internal diameter...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1672-4
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:Τhis study aims at determining the ability of cone beam computed tomography (CBCT) to visualize critical-size defects (CSD) created at rat calvaria and filled with 75/25 w/w nano-hydroxyapatite/chitosan (nHAp/CS) scaffolds, prior to their histological investigation. MATERIALS AND METHODS:Thirty adult Spragu...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-02939-4
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:We aimed at investigating whether the interaction between the local inflammation, periodontitis, and obesity is independently associated with systemic inflammation. METHODS:From the population-based Study of Health in Pomerania, 3366 participants, without (2366) and with (1000) obesity, were studied for the...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03514-y
更新日期：2020-08-22 00:00:00
abstract：OBJECTIVES:Ventilator-associated pneumonia (VAP) is the most frequent hospital-acquired infections in intensive care units (ICU). In the bundle of care to prevent the VAP, the oral care is very important strategies, to decrease the oropharyngeal bacterial colonization and presence of causative bacteria of VAP. In view ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-017-2289-6
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVES:This study aimed to investigate the root canal morphology of mandibular first premolar teeth in a population from southwestern China by micro-computed tomography (micro-CT). MATERIALS AND METHODS:Human mandibular first premolars (115) were selected and prepared for micro-CT analysis with a slice thickness o...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-012-0778-1
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVES:The study aimed at assessing, as primary objective, the periapical status and quality of root fillings, and, as secondary objective, the endodontic treatment need of a German urban population in a cross-sectional study 20 years after the first one. MATERIALS AND METHODS:Clinical and radiographic data of 353...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2566-z
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:This work aimed to study the role of inflammation in medication-related osteonecrosis of the jaw (MRONJ) in rats with focus on Wnt signaling. METHODS:A total of 36 female Wistar rats (12 weeks ± 200 g) were divided into 2 groups (n = 6) in 3 experiments: saline (SAL) and zoledronic acid (ZOL). For MRONJ indu...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03551-7
更新日期：2021-02-01 00:00:00
abstract：OBJECTIVES:The study evaluates the influence of two spacer settings and three resin luting materials on the marginal and internal fit of polymer-infiltrated ceramic network (PICN) material crowns manufactured using a complete digital workflow. METHODS:Optical impressions of fifty identical dies were performed using th...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-03053-1
更新日期：2020-06-01 00:00:00
