Abstract:
OBJECTIVES:Recent scientific evidences suggest a relevant role of the oral cavity in the transmission and pathogenicity of SARS-CoV-2. METHODS:A literature search was performed in PubMed, up to April 30, 2020, focusing on SARS-CoV-2, COVID-19, oral cavity, and antimicrobial agents. RESULTS:Oral viral load of SARS-CoV-2 has been associated with the severity of COVID-19, and thus, a reduction in the oral viral load could be associated with a decrease in the severity of the condition. Similarly, a decrease in the oral viral load would diminish the amount of virus expelled and reduce the risk of transmission, since (i) during the first 10 days, the virus mainly accumulates at the nasal, oral, and pharyngeal area; (ii) the number of angiotensin-converting enzyme (ACE2) receptor is greater in the salivary glands as compared with the lungs; and (iii) salivary droplets represent the most relevant transmission route. To reduce the oral viral load, antiseptic agents may be used, although the evidence on its efficacy is indirect and weak. CONCLUSIONS:Antiseptic mouth rinses, such as those containing cetylpyridinium chloride or povidone-iodine, may be able to decrease the severity of COVID-19 by reducing oral viral load in infected subjects and decreasing the risk of transmission by limiting viral load in droplets, generated in normal life, or in aerosols, produced during dental procedures. Well-designed clinical and preclinical research must be conducted to support these hypotheses. CLINICAL RELEVANCE:Antiseptic mouth rinses may help in decreasing the severity of COVID-19 and in reducing the risk of transmission.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Herrera D,Serrano J,Roldán S,Sanz Mdoi
10.1007/s00784-020-03413-2subject
Has Abstractpub_date
2020-08-01 00:00:00pages
2925-2930issue
8eissn
1432-6981issn
1436-3771pii
10.1007/s00784-020-03413-2journal_volume
24pub_type
杂志文章abstract::The aim of this randomized double-blinded preliminary study was to evaluate the clinical and microbiological long-term effects of an essential-oil-containing mouth rinse as the active agent utilized in the "one-stage full-mouth disinfection protocol." Probing pocket depth and plaque and gingival indices were evaluated...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-008-0219-3
更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-015-1505-5
更新日期:2016-03-01 00:00:00
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doi:10.1007/s00784-015-1708-9
更新日期:2016-11-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1579-0
更新日期:2016-06-01 00:00:00
abstract::The aim of this study was to investigate the possible association of a distinct combination of polymorphisms in the interleukin (IL)-1 gene cluster on gingival bleeding tendency in young adult Arabs with plaque-induced gingivitis. Fifty otherwise healthy, nonsmoking volunteers, 19-28 years of age, participated. Clinic...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-007-0120-5
更新日期:2007-09-01 00:00:00
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doi:10.1007/s00784-019-02932-x
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:A group of adolescents with oral piercings was studied to determine the presence of metallic particles in cells exfoliated from the mucosa surrounding their metal oral piercings and the association between such particles and the metal jewelry, and to evaluate subsequent tissue implications. MATERIALS AND ME...
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pub_type: 杂志文章
doi:10.1007/s00784-018-2626-4
更新日期:2019-04-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,多中心研究
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更新日期:2015-03-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-0939-x
更新日期:2014-01-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2071-9
更新日期:2017-12-01 00:00:00
abstract::Dear Professor Dr. Matthias Hannig. Editor-in-Chief Clinical Oral Investigations. Following the publication of our paper by Calvo Guirado et al, 2015 [1] in Clinical Oral Investigations, it came to light that a certain part of the text at the materials and methods and results sections were similar. ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00784-018-2763-9
更新日期:2019-01-01 00:00:00
abstract::This study assessed the Knoop hardness and temperature increase provided by three light curing units when using (1) the manufacturers' recommended times of photo-activation and (2) standardizing total energy density. One halogen--XL2500 (3M/ESPE)--and two light-emitting diode (LED) curing units--Freelight (3M/ESPE) an...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-005-0028-x
更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-019-02939-4
更新日期:2020-01-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03151-0
更新日期:2020-08-01 00:00:00
abstract::Previous work showed that a single application of 40% chlorhexidine varnish, EC40, reduced plaque acidogenicity upon sucrose challenge during less than 3 weeks. It was questioned whether lactic acid production could be reduced significantly longer when the treatment was intensified. Therefore, the effects of three con...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-006-0079-7
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate through a systematic review the extraction of third molars as a risk factor for temporomandibular disorders (TMDs). TYPES OF STUDIES REVIEWED:Randomized and nonrandomized controlled clinical trials where patients underwent third molar extraction and with qualitative eva...
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pub_type: 杂志文章,评审
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更新日期:2020-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-015-1466-8
更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-015-1561-x
更新日期:2016-05-01 00:00:00
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journal_title:Clinical oral investigations
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doi:10.1007/s00784-013-1163-4
更新日期:2014-09-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2723-4
更新日期:2019-07-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1082-4
更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-020-03691-w
更新日期:2020-11-23 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-017-2229-5
更新日期:2018-04-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-2010-1
更新日期:2017-09-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-016-1849-5
更新日期:2017-05-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03594-w
更新日期:2021-02-01 00:00:00
abstract::The goal of this investigation was to evaluate the effect of postoperative exposure of two different bioresorbable membranes on the guided tissue regeneration (GTR) healing results compared to nonexposed sites. In each of 25 patients one pair of contralateral intrabony lesions was treated either with polylactic acid (...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840050021
更新日期:1997-09-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1674-2
更新日期:2016-09-01 00:00:00