Abstract:
OBJECTIVE:SLC22A4/5 single nucleotide polymorphisms (SNPs) have been reported to affect inflammatory diseases. We report the relationship of these polymorphisms with adiposity and tooth loss as elucidated in a 10-year follow-up study. METHODS:Participants of the Study of Health in Pomerania (SHIP, N = 4105) were genotyped for the polymorphisms c.1507C > T in SLC22A4 (rs1050152) and -207C > G in SLC22A5 (rs2631367) using allele-specific real-time PCR assays. A total of 1817 subjects, 934 female and 883 male aged 30-80 years, underwent follow-up 10 years later (SHIP-2) and were assessed for adiposity and tooth loss. RESULTS:The frequencies of the rarer SLC22A4 TT and SLC22A5 CC alleles were 16.7% and 20.3%, respectively. In women, tooth loss was associated with genotype TT vs. CC with incidence rate ratio IRR = 0.74 (95%C.I. 0.60-0.92) and CC vs. GG IRR = 0.79 (0.65-0.96) for SLC22A4 and SLC22A5 SNPs, respectively. In men, no such associations were observed. In the follow-up examination, the relationship between tooth loss and these SNPs was in parallel with measures of body shape such as BMI, body weight, waist circumference, or body fat accumulation. The association between muscle strength and body fat mass was modified by the genotypes studied. CONCLUSIONS:SLC22A4 c.150C > T and SLC22A5 -207C > G polymorphisms are associated with tooth loss and markers of body shape in women but not in men. CLINICAL RELEVANCE:Tooth loss may be related to obesity beyond inflammatory mechanisms, conceivably with a genetic background.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Meisel P,Pagels S,Grube M,Jedlitschky G,Völzke H,Kocher Tdoi
10.1007/s00784-020-03594-wsubject
Has Abstractpub_date
2021-02-01 00:00:00pages
701-709issue
2eissn
1432-6981issn
1436-3771pii
10.1007/s00784-020-03594-wjournal_volume
25pub_type
杂志文章abstract::The aim of this study was to compare different methods of detection of Helicobacter pylori (H. pylori) in the dental plaque of dyspeptic patients. After recording the clinical indices, culture and polymerase chain reaction (PCR) methods were performed on plaque samples, while rapid urease test in addition to these tes...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-007-0104-5
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the palatal total support tissues (TSTs) and bone support tissues (BSTs) at 5-mm paramedian section to the midsagittal suture between mouth breathers with high-narrow palates and nose breathers with normal palates and confirm the practicability and limitation on superimpo...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03004-w
更新日期:2020-03-01 00:00:00
abstract::Denture-related stomatitis (DRS) is still a dilemma in removable prosthodontics. The aim of this study was to investigate the relationship of DRS with the presence of Candida albicans hyphae and Lactobacillus. A total of 91 patients wearing maxillary and mandibular complete dentures were included in the present study ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-008-0240-6
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to introduce a novel three-dimensional (3D) method to quantify the relative amount of different tissue components in bone substitute-treated defects by means of integration of confocal laser imaging into micro-computed tomography (μCT) analysis. MATERIALS AND METHODS:One standardize...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1081-5
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:The main purpose of this prospective, double-blind, randomized study was to evaluate anaesthetic parameters, postoperative analgesia and vasoactive properties of levobupivacaine and bupivacaine for lower third molar surgery. MATERIAL AND METHODS:Sixty patients (ASA I) were scheduled for lower third molar su...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1114-0
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To evaluate denosumab, a human monoclonal antibody that mimics the effects of osteoprotegerin in bone metabolism, as a topical treatment of root surface to be used prior to delayed tooth replantation. MATERIALS AND METHODS:Thirty-six rats' right incisors were used. Teeth were extracted and divided into: del...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03430-1
更新日期:2020-07-29 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate impact of periodontal surgery on periodontal health and on glycaemia control of type 1 and type 2 (T1DM; T2DM) diabetics with severe periodontitis, during 12 months follow-up, in comparison with non-diabetic controls. MATERIALS AND METHODS:A total of 23 T1DM and 10...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1819-y
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to investigate the antimicrobial efficacy of antiseptics in saliva-derived microcosm biofilms, and to examine phenotypic adaption of bacteria upon repeated exposure to sub-inhibitory antiseptic concentrations. METHODS:Saliva-derived biofilms were formed mimicking caries- or gingi...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03613-w
更新日期:2020-10-08 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1487-3
更新日期:2016-01-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2500-4
更新日期:2019-02-01 00:00:00
abstract::The alveolar cleft in patients with clefts of lip, alveolus and palate (CLAP) is usually reconstructed with an autologous bone graft. Harvesting of autologous bone grafts is associated with more or less donor site morbidity. Donor site morbidity could be eliminated if bone is fabricated by growth factor-aided tissue e...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-011-0547-6
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Information about the spectrum of microorganisms in the intraimplant cavities of two-piece dental implants is scarce. The purpose of this study was to assess the intraimplant microflora of two-piece dental implants by conventional biochemical testing, matrix-assisted laser desorption/ionization time-of-flight...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0805-2
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:This study investigated the antibacterial properties and micro-hardness of polyacrylic acid (PAA)-coated copper iodide (CuI) nanoparticles incorporated into glass ionomer-based materials, and the effect of PAA-CuI on collagen degradation. MATERIALS AND METHODS:PAA-CuI nanoparticles were incorporated into gl...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1799-y
更新日期:2017-01-01 00:00:00
abstract::In the original version of this article, the following were noted for correction. ...
journal_title:Clinical oral investigations
pub_type: 已发布勘误
doi:10.1007/s00784-020-03657-y
更新日期:2020-10-26 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-003-0194-7
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to validate the reproducibility and observer variability of the Functional Implant Prosthodontic Score (FIPS), while considering the level of dental experience for intra- and inter-examiner analysis. MATERIALS AND METHODS:A total of 44 examiners (n = 31 undergraduate dental student...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2332-7
更新日期:2018-07-01 00:00:00
abstract::Regular screening through white light inspection of the entire oral mucosa is the most important examination method to identify precancerous lesions and early oral carcinoma. Additionally, the physiologic autofluorescence of the oral mucosa has been described as a novel screening method for the detection of mucosal le...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章
doi:10.1007/s00784-010-0455-1
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVES:Stud attachments are often too adhesive and too susceptible to damage for use in geriatric patients, especially when implants are angulated. This study aimed to evaluate alternative anchoring systems comprising individual and prefabricated polyvinylsiloxane (PVS) attachments. MATERIALS AND METHODS:A total o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2568-x
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate long-term (≥5 years) tooth survival after resective therapy of multi-rooted, periodontally treated teeth and investigate the influence of patient-, tooth-, and dentist-related risk factors on tooth loss. MATERIALS AND METHODS:A total of 128 patients with root-resected m...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03091-9
更新日期:2020-07-01 00:00:00
abstract::The present study examines the three-dimensional (3D) morphology of early approximal subsurface enamel caries lesions and subjacent dentin reactions in deciduous molars. Twenty-three extracted primary molars were embedded in Technovit 9100 and serial sections were cut using a saw microtome. Forty approximal lesions we...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840050066
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:To assess the association between periodontal disease and Helicobacter pylori (H. pylori) infection in oral cavity. MATERIALS AND METHODS:We searched PubMed, Embase, Web of Science, Cochrane library, Gray literature, and clinicaltrials.gov for eligible studies up to September 25, 2019. Odds ratios (ORs) and...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析
doi:10.1007/s00784-020-03330-4
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:The aim of the meta-analysis was to clarify the efficacy of non-surgical periodontal treatment (NSPT) in improving rheumatoid arthritis (RA) disease activity. METHODS:A systematic literature search was conducted using the PubMed, Embase, and Cochrane databases up to October 2020. A total of nine studies wer...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-021-03807-w
更新日期:2021-01-29 00:00:00
abstract:OBJECTIVES:Periodontitis is associated with systemic inflammation, elevated platelet activation and enhanced risk for cardiovascular diseases, while periodontal treatment reduces tissue inflammation and shows desirable effects on the oral biofilm and dental health. However, subgingival debridement during conservative t...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章
doi:10.1007/s00784-019-03049-x
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Dental materials and oral hygiene products may be responsible for oral contact allergic reactions. We aimed to determine the occurrence of allergies in patients with symptomatic oral lichen planus (OLP), oral lichenoid lesions (OLLs) and stomatitis and investigate if patch testing could identify contact aller...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2053-y
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of daily exposure to a denture cleanser on a multispecies biofilm. MATERIALS AND METHODS:Multispecies biofilms (five bacteria and Candida albicans) were developed for 64.5 h on acrylic resin specimens and randomized into control and experimental groups. In the...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-014-1210-9
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:To assess the accuracy of intraoral digital impressions for gingival contour captured in the esthetic zone in vivo. MATERIAL AND METHODS:Five participants with full upper dentition were recruited. For each participant, three scans were taken using two intraoral scanning (IOS) systems (3Shape TRIOS Color, TR...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03105-6
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:This study examines accuracy of dental impressions and following plaster models taken during treatment with fixed appliances. MATERIALS AND METHODS:A maxillary typodont was provided with brackets. Three examiners took impressions three times each of the variants: brackets only, archwire fixed by alastics, l...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1514-4
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:To assess dimensional changes following alveolar ridge preservation using bovine-derived xenograft with 10% collagen and collagen membrane compared to ridge preservation by means of bovine-derived xenograft particles and collagen membrane or spontaneous healing in posterior sites. MATERIALS AND METHODS:Fort...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-019-02979-w
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to evaluate whether the current guidelines of the International Association of Dental Traumatology (IADT) for emergency care of traumatised teeth result in lower complication rates. MATERIALS AND METHODS:Therapeutic strategies of 361 dental injuries in 291 patients treated at a...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0817-y
更新日期:2013-06-01 00:00:00
abstract::The goal of this in vitro study was to identify the most suitable dye for endodontic dye leakage studies, which could be a further step towards standardisation. The root canals of 70 extracted, single-rooted human adult teeth were enlarged to apical size 50 using hand instruments. The teeth were divided into seven gro...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-009-0299-8
更新日期:2010-06-01 00:00:00