Abstract:
OBJECTIVES:We aimed to determine the immunolocalization patterns of the interleukin (IL)-6 signaling complex in epithelialized and non-epithelialized apical lesions of endodontic origin (ALEOs). MATERIALS AND METHODS:Epithelialized (n = 8) and non-epithelialized (n = 7) ALEOs were obtained from teeth with indication of extraction in patients with clinical diagnosis of apical periodontitis. All tissues were subjected to routine processing for histopathologic examination and primary antibodies for IL-6, IL-6 receptor (R), and glycoprotein (gp)-130 were used for immunohistochemistry and double immunofluorescence co-localization. RESULTS:IL-6, IL-6R, and gp-130 were immunolocalized in endothelial cells and mononuclear leukocytes in a diffuse pattern within the connective tissue of epithelialized and non-epithelialized ALEOs. In the epithelialized lesions, two different patterns were identified: IL-6 signaling complex was localized within the proliferating epithelium in a diffuse intracellular pattern and in a cell membrane localization pattern within the mature epithelial lining, showing a decreased intensity towards the surface layers. CONCLUSIONS:IL-6, IL-6R, and gp-130 localized to mononuclear inflammatory cells, vascular endothelial cells, and immature proliferating epithelia in a diffuse pattern and in mature lining epithelia in a localized cell membrane pattern, supporting a role for epithelial proliferation during cyst formation. Additional cell membrane co-localization of IL-6 receptor complex suggests classic signaling involvement in addition to trans-signaling.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Schweitzer C,Garrido M,Paredes R,Stoore C,Reyes M,Bologna-Molina R,Fernández A,Hernández Rios Mdoi
10.1007/s00784-020-03738-ysubject
Has Abstractpub_date
2021-01-07 00:00:00eissn
1432-6981issn
1436-3771pii
10.1007/s00784-020-03738-ypub_type
杂志文章abstract:OBJECTIVES:The aim of the present study was the qualitative and quantitative evaluation of osseous graft consolidation using allogeneic bone blocks for vertical bone augmentation in an animal model. MATERIAL AND METHODS:Standardised allogeneic and autologous bone blocks were fixed on the frontal skull of 20 adult fema...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03151-0
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:To assess the internal and external morphologies of the mesiobuccal (MB) root of maxillary molars presenting a third root canal (MB3), using micro-computed tomography (micro-CT). MATERIAL AND METHODS:Two-hundred and sixty-five extracted maxillary first and second molars with different root configurations we...
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doi:10.1007/s00784-020-03284-7
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abstract::The aim of this retrospective study was to determine the outcome of orthodontic treatment carried out on patients by postgraduate students at the Katholieke Universiteit Leuven, Belgium. The treatment outcome of 292 'final examination' patients and of 287 'control' patients was compared by means of the Peer Assessment...
journal_title:Clinical oral investigations
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doi:10.1007/s007840000094
更新日期:2001-03-01 00:00:00
abstract::This retrospective study investigated the frequency and time history of chipping or facings failure of three-unit and four-unit tooth-supported metal ceramic (MC) fixed partial prostheses (FPDs). Six hundred fifty-four MC FPDs were inserted according to a standardized treatment protocol at the Department of Prosthodon...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-011-0511-5
更新日期:2012-04-01 00:00:00
abstract::From a preventive point of view collection of data concerning carious and non-carious cervical tooth defects is definitely important. Consequently, the prevalence and distribution of different root lesions were studied and correlated with behavioral and biological factors in 50- to 60-year-old German individuals (n = ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840050097
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:This randomized clinical trial evaluated the survival of direct restorations on first permanent molars (FPMs) with molar incisor hypomineralization (MIH) and its impact on self-reported dental pain and dental anxiety. MATERIAL AND METHOD:FPMs with MIH of 35 patients aged 7 to 16 years were included. The FPMs...
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doi:10.1007/s00784-020-03459-2
更新日期:2020-07-21 00:00:00
abstract:OBJECTIVES:The aim of this paper is to evaluate the influence of the internal anatomy on the leakage of root canals filled with the thermoplastic technique. MATERIALS AND METHODS:The upper central incisors (UCI) and mesial roots of the lower molars (MRLM) (n = 12 each) were tested regarding leakage using the gas-enhan...
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更新日期:2018-04-01 00:00:00
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doi:10.1007/s00784-019-02974-1
更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-002-0157-4
更新日期:2002-06-01 00:00:00
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更新日期:2016-09-01 00:00:00
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doi:10.1007/s00784-015-1416-5
更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-014-1292-4
更新日期:2015-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1998-09-01 00:00:00
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更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-020-03709-3
更新日期:2021-01-07 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1115-z
更新日期:2014-01-01 00:00:00
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更新日期:2020-06-01 00:00:00
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doi:10.1007/s00784-018-2752-z
更新日期:2019-08-01 00:00:00
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更新日期:2019-09-01 00:00:00
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更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-013-1105-1
更新日期:2014-05-01 00:00:00
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doi:10.1007/s00784-007-0166-4
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To establish the association between adipokine levels and markers of periodontal involvement as risk indicators of early stages of RA (eRA) and the interaction between the presence of markers of periodontal disease with adipokine in eRA individuals. MATERIALS AND METHODS:Fifty-one patients with a diagnosis o...
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doi:10.1007/s00784-020-03469-0
更新日期:2020-08-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-009-0333-x
更新日期:2010-10-01 00:00:00
abstract::The effect of fluoride released by bioadhesive tablets was evaluated in an in situ model in human volunteers. Eight volunteers carried four to six polished human enamel samples in a lower lingual device for a period of 5 days without fluoride supplements (control) and 5 days using one bioadhesive tablet (0.5 mg F) per...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s007840000076
更新日期:2000-09-01 00:00:00
abstract::This study evaluated the 10-year clinical performance of high-viscosity glass-ionomer cement placed in posterior permanent teeth by means of the Atraumatic Restorative Treatment (ART) approach. One operator placed 167 single- and 107 multiple-surface restorations in 43 high-risk caries pregnant women (mean decayed tee...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-009-0378-x
更新日期:2011-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00784-018-2544-5
更新日期:2019-03-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1993-y
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:Our aim was to assess the anti-biofilm ability of previously unverified individual D-amino acids (DAAs), to produce plasma polymer encapsulated DAAs (PPEDAAs), to measure the shell thickness and subsequent release of DAAs, and to assess the effects of PPEDAAs on Enterococcus faecalis biofilms. MATERIALS AND ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03663-0
更新日期:2020-11-02 00:00:00