Abstract:
OBJECTIVE:To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with persistent suspicious oral mucosal lesions (PSOML). SUBJECTS AND METHODS:Whole unstimulated saliva samples were collected from age-, sex-, and race-matched patients who had a lesion in the oral cavity and for whom open biopsies were performed. The patients included OSCC (n = 6), OED (n = 10), and PSOML (n = 32). Hydrophilic metabolites in saliva samples were comprehensively analyzed using capillary electrophoresis mass spectrometry. To evaluate the discrimination ability of a combination of multiple markers, a multiple logistic regression (MLR) model was developed to differentiate OSCC/OED from PSOML. RESULTS:Six metabolites were significantly different in OSCC/OED compared with PSOML. From these six metabolites, ornithine, o-hydroxybenzoate, and ribose 5-phosphate (R5P) were used to develop the MLR model, which resulted in a high value for the area under receiver operating characteristic curve (AUC 0.871, 95% confidential interval (CI) 0.760-0.982; p < 0.001) to discriminate OSCC/OED from PSOML. CONCLUSIONS:This is the first study to identify salivary metabolites that discriminate OSCC/OED from PSOML rather than from healthy controls. The profiles of salivary metabolites were significantly different between OSCC/OED and PSOML. The ability to discriminate OSCC/OED from PSOML is important for dentists who are not oral surgery specialists. These salivary metabolites showed potential for non-invasive screening to discriminate OSCC/OED from PSOML. CLINICAL RELEVANCE:Salivary metabolites in this study showed potential for non-invasive screening to discriminate OSCC/OED from PSOML.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Ishikawa S,Wong DTW,Sugimoto M,Gleber-Netto FO,Li F,Tu M,Zhang Y,Akin D,Iino Mdoi
10.1007/s00784-018-2777-3subject
Has Abstractpub_date
2019-09-01 00:00:00pages
3557-3563issue
9eissn
1432-6981issn
1436-3771pii
10.1007/s00784-018-2777-3journal_volume
23pub_type
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更新日期:2017-01-01 00:00:00
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更新日期:2019-01-01 00:00:00
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更新日期:2021-01-01 00:00:00