Abstract:
:The present study focuses on the correlation between the expression pattern of β-catenin (component of Wnt signaling), ΔNp63 (proliferation marker), and Notch 1 (transmembrane receptor) in oral squamous cell carcinoma. The study also aims to investigate the interaction between β-catenin and ΔNp63 in oral cancer. Furthermore, we also analyzed the prognostic significance of β-catenin, ΔNp63, and Notch 1 in oral squamous cell carcinoma. Immunohistochemical analysis of β-catenin, ΔNp63, and Notch 1 were done in 62 cases of oral squamous cell carcinoma. Co-immunoprecipitation analysis was done to study the possible interaction between β-catenin and ΔNp63 in oral cancer. Kaplan-Meier method was used to estimate overall and disease-free survival, and the Log-rank test was used to compare the resulting curves. Statistically significant positive correlation was found between the localization of β-catenin and the expression of ΔNp63 (p = 0.001**, r (s) = 0.427), whereas, no significant association was found between the expression pattern of β-catenin and Notch 1. Interestingly, interaction between β-catenin and ΔNp63 was observed in oral carcinoma. Moreover, β-catenin and ΔNp63 may be related to worst survival in oral carcinoma. Statistically significant positive association between localization of β-catenin and expression of ΔNp63 suggests that they might have dependent roles in maintaining the proliferation of oral carcinoma cells. In addition, the downregulated expression of Notch 1 was related to invasion and differentiation status of oral carcinoma cells. Furthermore, β-catenin and ΔNp63 may be used as independent prognostic markers of oral carcinoma. On the other hand, interaction of β-catenin with ΔNp63 may be a key event in maintaining the proliferation of oral carcinoma cells. The present study indicates that β-catenin and ΔNp63 may be used as independent prognostic markers of oral carcinoma and the interaction of β-catenin with ΔNp63 may be a crucial event in regulating proliferation and differentiation of oral carcinoma cells, which may be used as a target for therapeutic implications.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Ravindran G,Devaraj Hdoi
10.1007/s00784-011-0605-0subject
Has Abstractpub_date
2012-08-01 00:00:00pages
1275-88issue
4eissn
1432-6981issn
1436-3771journal_volume
16pub_type
杂志文章abstract:OBJECTIVES:The aim of this study was to compare mechanical sensitivity on the tongue using quantitative sensory testing (QST) and psychological factors using the General Health Questionnaire (GHQ) between burning mouth syndrome (BMS) patients and healthy participants. MATERIALS AND METHODS:Participants comprised 20 fe...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2488-9
更新日期:2019-02-01 00:00:00
abstract::The aims of this paper were to critically review the role of radiographic imaging before lower third molar removal and to suggest a strategy for preoperative imaging based on available scientific evidence and clinical experience. Original articles and reviews including the MESH terms "third molar" and "radiography" we...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-008-0200-1
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:Bisphosphonate-associated osteonecrosis of the jaw is a severe side effect in patients receiving nitrogen-containing bisphosphonates (N-BPs). One characteristic is its high recurrence rate; therefore, basic research for new therapeutic options is necessary. N-BPs inhibit the farnesylpyrophosphate synthase in...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1320-4
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:An optimized oral health-related section and a video training were developed and validated for the interRAI suite of instruments. The latter is completed by professional non-dental caregivers and used in more than 40 countries to assess care needs of older adults. METHODS:The optimized oral health-related s...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03669-8
更新日期:2020-11-16 00:00:00
abstract:OBJECTIVE:Biomechanical orthodontics loading of the periodontium initiates a cascade of inflammatory signaling events that induce periodontal remodeling and finally facilitate orthodontic tooth movement. Pattern recognition receptors such as toll-like receptors (TLRs) have been well characterized for their ability to i...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03111-8
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to compare wound healing and patient pain perception of single-incision (single-incision, modified single-incision) and trap-door surgical techniques to harvest subepithelial connective tissue grafts from the palate. MATERIAL AND METHODS:Thirty-six patients were selected for root co...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1204-7
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the influence of [2-(methacryloyloxy)ethyl] trimethylammonium chloride (METAC) in the physico-chemical properties, antibacterial activity and cytotoxicity of an experimental resin-based sealant. MATERIALS AND METHODS:An experimental resin-based sealant was formulated wi...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02971-4
更新日期:2020-02-01 00:00:00
abstract::Optimizing the quality of tooth-colored restorations is one of the main topics of current research. But there is only little information available about university education in this field. The aim of this study was to collect and evaluate data about the different aspects of dental education in Germany concerning tooth...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840050075
更新日期:1999-03-01 00:00:00
abstract::Bcl-2 is a family of proteins involved in protecting the cell against death stimuli or in promoting cell death. The aim of the present study was to determine the effect of nifedipine treatment on the expression of bcl-2 protein in rat gingival tissues. Rats were given gastric intubation with various concentrations and...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-003-0194-7
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:Root canal treatment failures often correlate with persistent biomaterial-associated endodontic infections. The aim of the present study was to assess the impact of endodontic obturation material sampling from root canals with posttreatment apical periodontitis on improving standard study protocols. MATERIA...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1231-4
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:The aim was to study self-image and the level of psychological symptoms in patients with symptoms attributed to their dental restorative materials. MATERIALS AND METHODS:A questionnaire containing questions regarding dental and medical history was answered by 257 participants, one group with local oral symp...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2707-4
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the root canal morphology of mandibular first premolar teeth in a population from southwestern China by micro-computed tomography (micro-CT). MATERIALS AND METHODS:Human mandibular first premolars (115) were selected and prepared for micro-CT analysis with a slice thickness o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0778-1
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the palatal total support tissues (TSTs) and bone support tissues (BSTs) at 5-mm paramedian section to the midsagittal suture between mouth breathers with high-narrow palates and nose breathers with normal palates and confirm the practicability and limitation on superimpo...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03004-w
更新日期:2020-03-01 00:00:00
abstract::This study investigated the ability and efficacy of an Er:YAG laser with a fluorescence feedback system for caries removal in deciduous teeth. Seventy-nine carious lesions were excavated using a fluorescence-controlled Er:YAG laser. Endpoint of treatment was defined by emission of fluorescence from the dentine surface...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章
doi:10.1007/s00784-007-0169-1
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:Transglutaminase-2 (TGM-2) protein is involved in the cross-linking of matrix proteins resulting in several fibrotic disorders and can be induced by reactive oxygen species (ROS). Little is known about its role in the development of oral submucocal fibrosis (OSF). Hence, we hypothesize that TGM-2 may have a ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1579-0
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:Mandibular reconstruction after segmental mandibulectomy can be challenging without virtual surgical planning and osteotomy guides. The purpose of this study was to analyze anatomic parameters to facilitate the evaluation of ideal fibula wedge osteotomies to reconstruct the neomandibula in a simple and cost-...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03177-4
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:The present study evaluated the effect of an enamel matrix derivative (EMD) and platelet-rich fibrin (PRF)-modified porcine-derived collagen matrix (PDCM) on human umbilical vein endothelial cells (HUVEC) in vitro. MATERIALS AND METHODS:PDCM (mucoderm®) was prepared to 6 mm (±0.1 mm) diameter discs. PDCM sa...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2170-7
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:To identify predictors in patient profiles, and to develop, internally validate, and calibrate prediction models for the persistence of self-reported orofacial pain at the 6-month and 12-month follow-up in patients with myofascial pain. MATERIALS AND METHODS:A cohort of 63 adult patients with moderate to se...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03570-4
更新日期:2020-09-10 00:00:00
abstract:OBJECTIVES:Τhis study aims at determining the ability of cone beam computed tomography (CBCT) to visualize critical-size defects (CSD) created at rat calvaria and filled with 75/25 w/w nano-hydroxyapatite/chitosan (nHAp/CS) scaffolds, prior to their histological investigation. MATERIALS AND METHODS:Thirty adult Spragu...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02939-4
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:This aimed to assess the potential role of chronic stress in saliva secretion, xerostomia, and oral health in a population attending a saliva clinic. MATERIALS AND METHODS:Data of 114 patients who met the inclusion criteria and completed all questionnaires were analyzed in this study. Participants completed ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2393-2
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:Pain and trismus are the most common postoperative complications following a surgical removal of the lower third molar. This randomized, double-blind, placebo-controlled clinical trial evaluated the effect of orally administrated magnesium on postoperative pain and trismus after surgical removal of the lower...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-020-03335-z
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:To evaluate the prevalence, clinical features, and risk factors of dentin hypersensitivity (DH) in a Brazilian population. MATERIALS AND METHODS:300 patients at the Dentistry Clinic of the University of São Paulo participated in this study. The subjects completed a questionnaire regarding their personal inf...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1008-1
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:It is well accepted that stage-specific embryonic antigen (SSEA)-4 is an antigen that is useful to isolate adult stem cells analogous to embryonic stem cells. Therefore, in the present study, we investigated whether SSEA-4 can also be used as a marker to identify human deciduous dental pulp (D-DP) stem cells...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1260-z
更新日期:2015-03-01 00:00:00
abstract::The present study examines the three-dimensional (3D) morphology of early approximal subsurface enamel caries lesions and subjacent dentin reactions in deciduous molars. Twenty-three extracted primary molars were embedded in Technovit 9100 and serial sections were cut using a saw microtome. Forty approximal lesions we...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840050066
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:Recent scientific evidences suggest a relevant role of the oral cavity in the transmission and pathogenicity of SARS-CoV-2. METHODS:A literature search was performed in PubMed, up to April 30, 2020, focusing on SARS-CoV-2, COVID-19, oral cavity, and antimicrobial agents. RESULTS:Oral viral load of SARS-CoV...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03413-2
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate through a systematic review the extraction of third molars as a risk factor for temporomandibular disorders (TMDs). TYPES OF STUDIES REVIEWED:Randomized and nonrandomized controlled clinical trials where patients underwent third molar extraction and with qualitative eva...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-020-03277-6
更新日期:2020-10-01 00:00:00
abstract::The aim of this retrospective study was to determine the outcome of orthodontic treatment carried out on patients by postgraduate students at the Katholieke Universiteit Leuven, Belgium. The treatment outcome of 292 'final examination' patients and of 287 'control' patients was compared by means of the Peer Assessment...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840000094
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVES:Advanced oral cancer is a major public health concern because of a lack of effective prevention and treatment. Triptolide (TPL), a diterpenoid triepoxide derived from the Chinese herb Tripterygium wilfordii, has been demonstrated to possess strong anticancer properties. In this study, we investigated whether...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1808-1
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate the caries-preventive effect of newly developed fluoride and fluoride-free toothpastes specially designed for erosion prevention. The hypothesis was that these products might also show superior caries-inhibiting effect than regular fluoride toothpastes, since they were...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1789-0
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:In this in vitro study, we assessed filling characteristics (adaptation, homogeneity, sealer percentage, position of the carrier) of warm and cold obturation methods in curved root canals. MATERIALS AND METHODS:A reciprocating method was used to prepare 90 curved roots (25 ° average curvature) to an apical ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1674-2
更新日期:2016-09-01 00:00:00