Abstract:
:Regular screening through white light inspection of the entire oral mucosa is the most important examination method to identify precancerous lesions and early oral carcinoma. Additionally, the physiologic autofluorescence of the oral mucosa has been described as a novel screening method for the detection of mucosal lesions that are not visible by white light. This study aimed to evaluate the sensitivity and specificity of the autofluorescence examination. Seventy-eight patients were examined in this study. All of them suffered from suspicious oral mucosal lesions. Two different investigation methods were applied: the standard examination by white light and an examination by a novel light source of 400 nm that evoked a green light emission (>500 nm) in normal mucosa. It was proposed that malignant oral mucosal lesions show different autofluorescence characteristics than the green autofluorescence of healthy mucosa. Red autofluorescence indicated SCC with a sensitivity of 20% and a specificity of 98%. The results showed that dysplasia and carcinoma could be identified with a sensitivity of 96% and a specificity of 18% by using the autofluorescence method. The sensitivity decreased according to the grade of mucosal keratosis and was influenced by the localisation of the lesion. In conclusion, benign as well as malignant oral lesions could not be distinguished by a diminished autofluorescence signal. A red autofluorescence signal, however, could indicate cancerous processes of the oral mucosa.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Koch FP,Kaemmerer PW,Biesterfeld S,Kunkel M,Wagner Wdoi
10.1007/s00784-010-0455-1subject
Has Abstractpub_date
2011-12-01 00:00:00pages
975-82issue
6eissn
1432-6981issn
1436-3771journal_volume
15pub_type
临床试验,杂志文章abstract:OBJECTIVE:Intrapapillary injection (IPI) has been suggested to improve pulpal anesthesia of mandibular teeth and to avoid complications from inferior alveolar nerve block (IANB). This study aimed to determine and compare clinical efficacies and prostaglandin E2 (PGE2) levels between IPI and IANB. MATERIALS AND METHODS...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
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更新日期:2020-02-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-011-0584-1
更新日期:2012-06-01 00:00:00
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journal_title:Clinical oral investigations
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-06 00:00:00
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更新日期:2016-03-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0875-1
更新日期:2013-11-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
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更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1958-1
更新日期:2017-06-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2630-8
更新日期:2019-06-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03524-w
更新日期:2020-08-25 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
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更新日期:1998-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2021-01-23 00:00:00
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pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 已发布勘误
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更新日期:2020-10-26 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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