Abstract:
OBJECTIVES:This in situ study aims to evaluate the effects of chlorhexidine (CHX) mouth rinsing on biofilm formation and moreover on the disruption of existing mature dental biofilms. METHODS:Biofilms were formed in situ by five volunteers on bovine enamel specimens fixed to individual acrylic splints. For biofilm formation analysis, the volunteers intraorally exposed the splint for 48 h. Mouth rinsing using 10 ml of 0.2% CHX or water as control was performed for 30 s every 12 h. For analysis of biofilm disruption, the biofilm was formed on enamel specimens for 48 h. Then, the first CHX rinse was carried out. A second rinse followed after an additional 12 h, again for 30 s using 10 ml of 0.2% CHX. Biofilm vitality was imaged by fluorescence microscopy after vital fluorescence staining. Additionally, the ultrastructure of the biofilm was examined by transmission electron microscopy. RESULTS:Rinses with 0.2% CHX significantly reduced biofilm formation on enamel. Both biofilm colonization and vitality were dramatically impaired. Moreover, a considerable biofilm disruption induced by the CHX rinses was observed. Remarkably, a single application of CHX to a 48-h mature biofilm causes biofilm ultrastructure alterations and induces a substantial reduction in biofilm thickness and bacterial vitality. CONCLUSIONS:CHX mouth rinses induced a significant inhibition of biofilm formation on native enamel. Furthermore, an important biofilm disrupting effect under in situ conditions was detected. CLINICAL RELEVANCE:CHX rinses could be used as a short-term treatment protocol for biofilm management focused on patients unable to reach adequate oral hygiene.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Martínez-Hernández M,Reda B,Hannig Mdoi
10.1007/s00784-020-03250-3subject
Has Abstractpub_date
2020-11-01 00:00:00pages
3843-3853issue
11eissn
1432-6981issn
1436-3771pii
10.1007/s00784-020-03250-3journal_volume
24pub_type
杂志文章abstract:OBJECTIVES:We evaluated the effects of low-level laser therapy (LLLT) using an infrared laser (IRL) and a red laser (RL) on the pulp of molar teeth in rats after dental bleaching to assess inflammation, collagen fiber maturation, and tertiary dentin formation. MATERIALS AND METHODS:Eighty Wistar rats (Rattus norvegicu...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03258-9
更新日期:2020-11-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1901-5
更新日期:2017-05-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
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更新日期:2013-03-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03053-1
更新日期:2020-06-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0391-0
更新日期:2011-06-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1784-5
更新日期:2017-01-01 00:00:00
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更新日期:2015-09-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
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更新日期:2016-11-01 00:00:00
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更新日期:2019-06-01 00:00:00
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更新日期:2020-08-01 00:00:00
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更新日期:2019-04-01 00:00:00
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更新日期:2021-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00
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更新日期:2019-09-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-007-0124-1
更新日期:2007-12-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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更新日期:2012-10-01 00:00:00
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更新日期:2019-02-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-018-2727-0
更新日期:2019-07-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03071-z
更新日期:2020-06-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章
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更新日期:1997-06-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1674-2
更新日期:2016-09-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-015-1597-y
更新日期:2016-06-01 00:00:00