Abstract：
OBJECTIVES:To explore the pathophysiology of proliferative verrucous leukoplakia, a rare oral disorder that exhibits high rates of recurrence and malignant transformation, through a RNAseq case-control study. MATERIAL AND METHODS:We obtained oral biopsies from 10 patients with verrucous leukoplakia lesions and from the mucosa of 5 healthy individuals for sequencing using RNAseq technology. Using bioinformatic methods, we investigated gene expression and enrichment differences between patients both with and without the disorder. We applied network biology methods to investigate functional relations among those genes that were differentially deregulated. RESULTS:We detected 140 differentially expressed genes with distinct roles in immune surveillance, tissue and organ morphogenesis, development, and organization. Of these 140 genes, 111 have been previously described as cancer expression biomarkers, being oral squamous cell carcinoma the most represented type of cancer among them. Of these 140 genes, 26 were prioritized for further investigation as biomarkers using larger sample sizes. CONCLUSIONS:The gene expression patterns of healthy and unhealthy patients differed in 140 genes whose deregulation has a functional impact on normal functioning of the immune system. This immune expression profile provides a plausible hypothesis to explain the transformation to oral squamous cell carcinoma observed in 6 of the 10 assayed cases. CLINICAL RELEVANCE:By determining the molecular bases of the proliferative verrucous leukoplakia disorder and identifying early biomarkers of malignancy, this can allow us to develop new treatment strategies.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Llorens C,Soriano B,Trilla-Fuertes L,Bagan L,Ramos-Ruiz R,Gamez-Pozo A,Peña C,Bagan JVdoi
10.1007/s00784-020-03575-zsubject
Has Abstractpub_date
2020-09-11 00:00:00eissn
1432-6981issn
1436-3771pii
10.1007/s00784-020-03575-zpub_type
杂志文章abstract：OBJECTIVE:To establish the association between adipokine levels and markers of periodontal involvement as risk indicators of early stages of RA (eRA) and the interaction between the presence of markers of periodontal disease with adipokine in eRA individuals. MATERIALS AND METHODS:Fifty-one patients with a diagnosis o...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03469-0
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to assess postoperative pain in a prospective randomized clinical trial comparing two groups, using the Reciproc® system in one group and the ProTaper® rotary system in the other. MATERIAL AND METHODS:The study included 78 male patients, aged 18-64 years (mean age of 26 years), wit...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-015-1692-0
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVES:The objective of the study was to compare the retreatability of three calcium silicate-containing sealers (BioRoot RCS, MTA Fillapex, Endo C.P.M.) and an epoxy resin-based sealer (AH Plus) with different root canal instruments (Hedström files, Reciproc R40, Mtwo retreatment file R 25/.05 + Mtwo 40/.06, and F...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-017-2156-5
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to evaluate impact of periodontal surgery on periodontal health and on glycaemia control of type 1 and type 2 (T1DM; T2DM) diabetics with severe periodontitis, during 12 months follow-up, in comparison with non-diabetic controls. MATERIALS AND METHODS:A total of 23 T1DM and 10...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-016-1819-y
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Few studies regarding the distribution of pediatric oral diseases are available. Thus, the aim of this study was to investigate the incidence and demographic profile of neoplasms and non-neoplastic lesions among children and adolescents (0-19 years old). METHODS:A retrospective descriptive cross-sectional s...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2581-0
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to validate the reproducibility and observer variability of the Functional Implant Prosthodontic Score (FIPS), while considering the level of dental experience for intra- and inter-examiner analysis. MATERIALS AND METHODS:A total of 44 examiners (n = 31 undergraduate dental student...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-017-2332-7
更新日期：2018-07-01 00:00:00
abstract：:In the original version of this article, the following were noted for correction. ...
journal_title：Clinical oral investigations
pub_type： 已发布勘误
doi：10.1007/s00784-020-03657-y
更新日期：2020-10-26 00:00:00
abstract：OBJECTIVE:Our aim was to assess the anti-biofilm ability of previously unverified individual D-amino acids (DAAs), to produce plasma polymer encapsulated DAAs (PPEDAAs), to measure the shell thickness and subsequent release of DAAs, and to assess the effects of PPEDAAs on Enterococcus faecalis biofilms. MATERIALS AND ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03663-0
更新日期：2020-11-02 00:00:00
abstract：OBJECTIVE:Biomechanical orthodontics loading of the periodontium initiates a cascade of inflammatory signaling events that induce periodontal remodeling and finally facilitate orthodontic tooth movement. Pattern recognition receptors such as toll-like receptors (TLRs) have been well characterized for their ability to i...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-03111-8
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:This study aims to compare the clinical outcomes of a combination of enamel matrix derivatives (EMD) and a synthetic bone graft (biphasic calcium phosphate) with EMD alone in wide and deep one- and two-wall intrabony defects 36 months after treatment. MATERIAL AND METHODS:Thirty patients with chronic period...
journal_title：Clinical oral investigations
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00784-015-1522-4
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVES:To evaluate the marginal and internal fit of CAD/CAM-generated frameworks for 4-unit, fixed dental prostheses (FDPs) from zirconia (Z) and cobalt-chromium alloy (C) made with conventional (CI) and digital impressions (DI). MATERIALS AND METHODS:A titanium model was digitized with an intraoral scanner (DI, L...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1513-5
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:The aim of this in vitro study was to compare fluorescence-aided caries excavation with conventional excavation based on the Martens and Vickers hardness of dentin at the cavity floor after caries removal. MATERIALS AND METHODS:In total, 20 extracted human teeth with dentin caries were bisected through the l...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-013-0999-y
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:This animal study was conducted to evaluate the osteocyte index in the peri-implant bone around immediately restored implants under static lateral overload. MATERIAL AND METHODS:Seven mongrel dogs received three implants on each side of the mandible. Forty-two implants were distributed into three groups (14...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03662-1
更新日期：2020-11-05 00:00:00
abstract：OBJECTIVES:Adhesively luted all-ceramic restorations represent a promising way to preserve and stabilize weakened tooth substance, but little information is published about the clinical performance of extensive all-ceramic restorations. MATERIALS AND METHODS:A total of 78 large CEREC 2™ single-tooth all-ceramic restor...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-011-0642-8
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVES:Transglutaminase-2 (TGM-2) protein is involved in the cross-linking of matrix proteins resulting in several fibrotic disorders and can be induced by reactive oxygen species (ROS). Little is known about its role in the development of oral submucocal fibrosis (OSF). Hence, we hypothesize that TGM-2 may have a ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1579-0
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to assess whether alveolar ridge preservation (ARP) can reduce the need of ridge augmentation at posterior tooth sites. MATERIAL AND METHODS:This study enrolled patients who received dental implants at posterior tooth sites during 2013-2019. Demographic data and dental treatment hi...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-021-03778-y
更新日期：2021-01-11 00:00:00
abstract：OBJECTIVES:To evaluate the prevalence, clinical features, and risk factors of dentin hypersensitivity (DH) in a Brazilian population. MATERIALS AND METHODS:300 patients at the Dentistry Clinic of the University of São Paulo participated in this study. The subjects completed a questionnaire regarding their personal inf...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-013-1008-1
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:The aims of this study were to determine the quality of life of periodontally compromised patients after implant treatment (primary aim) and their satisfaction with the restoration and treatment approach (secondary aim). MATERIAL AND METHODS:In this study, 61 adult subjects were evaluated following non-surg...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1561-x
更新日期：2016-05-01 00:00:00
abstract：: ...
journal_title：Clinical oral investigations
pub_type： 评论,信件
doi：10.1007/s00784-018-2788-0
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVES:The aim of the present study was to investigate different fluorescence-based, two-color viability assays for visualization and quantification of initial bacterial adherence and to establish reliable alternatives to the ethidium bromide staining procedure. MATERIALS AND METHODS:Bacterial colonization was att...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-012-0792-3
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:Root migration occurs after most third molar coronectomy and a portion may be exposed in the oral cavity. This study compared the root migration rate, surgical morbidities after third molar coronectomy with or without adjunctive guided bone regeneration (GBR). METHODS:A split-mouth randomized clinical trial wa...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-018-2594-8
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate factors associated with the incidence of erosive tooth wear (ETW) among adults at different ages in Tokyo using multifactorial logistic regression analysis. MATERIALS AND METHODS:The study sample consisted of a total of 1108 subjects aged 15 to 89 years in Tokyo, Japan....
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-017-2065-7
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVES:This prospective randomized clinical trial aimed to evaluate the long-term behavior of metal-free double crown retained dentures with secondary crowns and dental frameworks made of the fiber-reinforced composite Vectris(©) on all-ceramic primary crowns (IPS Empress 2(©)) over a period of up to 14 years and t...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-015-1597-y
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess the effects of three different fluoride-releasing agents on preventing white spot lesions that occur during treatment with full coverage rapid maxillary expanders. MATERIALS AND METHODS:A total of 48 patients with transverse maxillary deficiency were randomly assigned to f...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2749-7
更新日期：2019-08-01 00:00:00
abstract：:This study evaluated the surface roughness change and wear provided by different dentifrices on root dentine previously exposed to erosive challenges. According to a randomized complete block design, 150 slabs of bovine root dentine (6 x 3 x 2 mm) were ground flat and polished. In an area of 4 x 3 mm on the dentine su...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-004-0262-7
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVES:The aims of this study were to investigate the antimicrobial efficacy of antiseptics in saliva-derived microcosm biofilms, and to examine phenotypic adaption of bacteria upon repeated exposure to sub-inhibitory antiseptic concentrations. METHODS:Saliva-derived biofilms were formed mimicking caries- or gingi...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03613-w
更新日期：2020-10-08 00:00:00
abstract：OBJECTIVES:The aim of this study was to compare mechanical sensitivity on the tongue using quantitative sensory testing (QST) and psychological factors using the General Health Questionnaire (GHQ) between burning mouth syndrome (BMS) patients and healthy participants. MATERIALS AND METHODS:Participants comprised 20 fe...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2488-9
更新日期：2019-02-01 00:00:00
abstract：:The aim of this study was to investigate the possible association of a distinct combination of polymorphisms in the interleukin (IL)-1 gene cluster on gingival bleeding tendency in young adult Arabs with plaque-induced gingivitis. Fifty otherwise healthy, nonsmoking volunteers, 19-28 years of age, participated. Clinic...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-007-0120-5
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the effect of daily exposure to a denture cleanser on a multispecies biofilm. MATERIALS AND METHODS:Multispecies biofilms (five bacteria and Candida albicans) were developed for 64.5 h on acrylic resin specimens and randomized into control and experimental groups. In the...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-014-1210-9
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to evaluate and compare the osteoblastic differentiation ability of dedifferentiated fat (DFAT) cells and adipose stem cells (ASCs) from the buccal fat pad (BFP). MATERIALS AND METHODS:We isolated human DFAT cells and ASCs from the BFP of a patient who underwent oral and maxill...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-013-1166-1
更新日期：2014-11-01 00:00:00
