Abstract：
OBJECTIVES:To explore whether a computed tomography (CT) examination of the head and neck region induces biological damage and whether the damage was correlated with the radiation dose. MATERIALS AND METHODS:Peripheral blood was taken from 33 individuals who received head and neck CT examinations. Blood samples were divided into three groups: the control group and the in vivo and in vitro irradiation groups. The number of DNA double-strand breaks was estimated by comparing the changes in the rates of γ-H2AX foci formation in the peripheral blood before and after CT examination. The absorbed dose and effective dose were calculated with the software VirtualDose based on the Monte Carlo method, and the absorbed doses in blood were estimated accordingly. RESULTS:The γ-H2AX foci rates were increased in the in vivo (p < 0.001) and in vitro irradiation groups (p < 0.001) after CT examination when compared with those in the control group. The rate of γ-H2AX foci formation showed linear dose-responses for the CT dose index volume (CTDIvol), dose-length product (DLP), and blood dose after CT examination. CONCLUSIONS:A CT examination of the head and neck region provides a high enough radiation dose to induce DNA double-strand breaks in cells in the peripheral blood. There was a linear correlation between the formation of DNA double-strand breaks and radiation doses after CT examination. CLINICAL RELEVANCE:In addition to ensuring image quality, in a real clinical situation, the scanning area should be strictly administered, and repeated operations should be avoided to minimise the patient's radiation dose.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Yang P,Wang S,Liu D,Zhao H,Li Gdoi
10.1007/s00784-020-03331-3subject
Has Abstractpub_date
2020-12-01 00:00:00pages
4617-4624issue
12eissn
1432-6981issn
1436-3771pii
10.1007/s00784-020-03331-3journal_volume
24pub_type
杂志文章abstract：:Regular screening through white light inspection of the entire oral mucosa is the most important examination method to identify precancerous lesions and early oral carcinoma. Additionally, the physiologic autofluorescence of the oral mucosa has been described as a novel screening method for the detection of mucosal le...
journal_title：Clinical oral investigations
pub_type： 临床试验,杂志文章
doi：10.1007/s00784-010-0455-1
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVES:A group of adolescents with oral piercings was studied to determine the presence of metallic particles in cells exfoliated from the mucosa surrounding their metal oral piercings and the association between such particles and the metal jewelry, and to evaluate subsequent tissue implications. MATERIALS AND ME...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2626-4
更新日期：2019-04-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-014-1294-2
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVES:To explore the pathophysiology of proliferative verrucous leukoplakia, a rare oral disorder that exhibits high rates of recurrence and malignant transformation, through a RNAseq case-control study. MATERIAL AND METHODS:We obtained oral biopsies from 10 patients with verrucous leukoplakia lesions and from th...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03575-z
更新日期：2020-09-11 00:00:00
abstract：OBJECTIVES:The aim of this comprehensive literature review is to provide recommendations and guidelines for dental implant therapy in patients with a history of radiation in the head and neck region. For the first time, a meta-analysis comparing the implant survival in irradiated and non-irradiated patients was perform...
journal_title：Clinical oral investigations
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00784-013-1134-9
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:To establish the association between adipokine levels and markers of periodontal involvement as risk indicators of early stages of RA (eRA) and the interaction between the presence of markers of periodontal disease with adipokine in eRA individuals. MATERIALS AND METHODS:Fifty-one patients with a diagnosis o...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03469-0
更新日期：2020-08-01 00:00:00
abstract：:The aim of this study was to compare detection of non-cavitated approximal caries lesions in images from seven solid-state intraoral digital receptors, with particular focus on two task-specific enhancement filters. One hundred and sixty approximal non-cavitated surfaces were radiographed under standardized conditions...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-007-0173-5
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:Biomechanical orthodontics loading of the periodontium initiates a cascade of inflammatory signaling events that induce periodontal remodeling and finally facilitate orthodontic tooth movement. Pattern recognition receptors such as toll-like receptors (TLRs) have been well characterized for their ability to i...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-03111-8
更新日期：2020-04-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1669-z
更新日期：2016-09-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-12-01 00:00:00
abstract：OBJECTIVES:The aim of the present study was the qualitative and quantitative evaluation of osseous graft consolidation using allogeneic bone blocks for vertical bone augmentation in an animal model. MATERIAL AND METHODS:Standardised allogeneic and autologous bone blocks were fixed on the frontal skull of 20 adult fema...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-03151-0
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:Geranylgeraniol (GGOH) has been reported as a potential treatment option for bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ). The aim of this study was to analyze the effects of GGOH on endothelial progenitor cells (EPC) after bisphosphonate treatment in vitro. MATERIALS AND METHODS:EPC were in...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-014-1394-z
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVES:To develop and evaluate predictive nomogram for extended duration of surgery in patients following mandibular third molars (M3M) removal. MATERIALS AND METHODS:A retrospectively observational study was performed and designed. A credible random split-sample method was used to divide data into training and va...
journal_title：Clinical oral investigations
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doi：10.1007/s00784-020-03499-8
更新日期：2020-08-10 00:00:00
abstract：OBJECTIVE:The purpose of this study was to compare temperature variation during osteotomies with trephine drills under different irrigation conditions: without irrigation, external irrigation, and double irrigation. MATERIALS AND METHODS:Synthetic blocks of bone (type I density) were used for drilling procedures with ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-013-1163-4
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVES:The purpose of this study is to compare pressures at the apical foramen created by conventional syringe irrigation and the GentleWave™ System, which releases high-velocity degassed irrigants to the pulp chamber and uses broad-spectrum sound energy for cleaning. MATERIALS AND METHODS:The apical pressure gene...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1632-z
更新日期：2016-09-01 00:00:00
abstract：:The aim of this randomized double-blinded preliminary study was to evaluate the clinical and microbiological long-term effects of an essential-oil-containing mouth rinse as the active agent utilized in the "one-stage full-mouth disinfection protocol." Probing pocket depth and plaque and gingival indices were evaluated...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-008-0219-3
更新日期：2009-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00784-020-03245-0
更新日期：2020-10-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-016-1849-5
更新日期：2017-05-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2013-01-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03570-4
更新日期：2020-09-10 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-008-0207-7
更新日期：2009-03-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-010-0405-y
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:The aim of this systematic review and meta-analysis (SRM) was to assess the postoperative pain (PP) after non-surgical endodontic retreatment (NSER) in a one visit compared to multiple visits. The PICO question used was "Does NSER in patients with unsatisfactory endodontic treatment in a one-visit visit have...
journal_title：Clinical oral investigations
pub_type： 杂志文章,meta分析
doi：10.1007/s00784-020-03767-7
更新日期：2021-02-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03545-5
更新日期：2020-08-26 00:00:00
abstract：OBJECTIVES:The purpose of this prospective clinical trial was to examine the clinical and patient outcomes following esthetic reconstruction of interdental papilla loss in anterior teeth, using an injectable, non-animal-based, hyaluronic acid gel. MATERIALS AND METHODS:Ten systemically healthy adults, with at least on...
journal_title：Clinical oral investigations
pub_type： 临床试验,杂志文章
doi：10.1007/s00784-015-1677-z
更新日期：2016-09-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1514-4
更新日期：2016-03-01 00:00:00
abstract：:The main objective of this study was to identify the risk factors for the incidence of visible caries experience in a cohort of preschool children living in Flanders. Data were collected from 1,057 children; validated questionnaires on oral health-related behaviour were completed by parents at birth (2003-2004), at ag...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-011-0579-y
更新日期：2012-06-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-012-0875-1
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:Aggregatibacter actinomycetemcomitans, specially its highly leucotoxic strain (JP2 clone), represents an etiological factor for the onset and progression of aggressive types of periodontitis. The aims of this investigation were to investigate the most relevant periodontal pathogens in the subgingival microbio...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1653-7
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:Several theories have been proposed regarding the genesis of sialoliths, including the organic core theory, which suggests epithelial or bacterial etiology originating in the central core. Our aim was to use novel methodologies to analyze central areas (the core) of calculi from sialolithiasis patients. MAT...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-012-0870-6
更新日期：2013-09-01 00:00:00
