Abstract:
OBJECTIVES:This study was established to investigate whether the chemokines CXCL1, CCL2, and CCL5 are produced in periodontal cells and tissues and, if so, whether their levels are regulated by microbial and/or mechanical signals. MATERIALS AND METHODS:The chemokine expression and protein levels in gingival biopsies from patients with and without periodontitis were analyzed by RT-PCR and immunohistochemistry. The chemokines were also analyzed in gingival biopsies from rats subjected to experimental periodontitis and/or orthodontic tooth movement. Additionally, chemokine levels were determined in periodontal fibroblasts exposed to the periodontopathogen Fusobacterium nucleatum and mechanical forces by RT-PCR and ELISA. RESULTS:Higher CXCL1, CCL2, and CCL5 levels were found in human and rat gingiva from sites of periodontitis as compared with periodontally healthy sites. In the rat experimental periodontitis model, the bacteria-induced upregulation of these chemokines was significantly counteracted by orthodontic forces. In vitro, F. nucleatum caused a significant upregulation of all chemokines at 1 day. When the cells were subjected simultaneously to F. nucleatum and mechanical forces, the upregulation of chemokines was significantly inhibited. The transcriptional findings were paralleled at protein level. CONCLUSIONS:This study provides original evidence in vitro and in vivo that the chemokines CXCL1, CCL2, and CCL5 are regulated by both microbial and mechanical signals in periodontal cells and tissues. Furthermore, our study revealed that biomechanical forces can counteract the stimulatory actions of F. nucleatum on these chemokines. CLINICAL RELEVANCE:Mechanical loading might aggravate periodontal infection by compromising the recruitment of immunoinflammatory cells.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Rath-Deschner B,Memmert S,Damanaki A,Nokhbehsaim M,Eick S,Cirelli JA,Götz W,Deschner J,Jäger A,Nogueira AVBdoi
10.1007/s00784-020-03244-1subject
Has Abstractpub_date
2020-10-01 00:00:00pages
3661-3670issue
10eissn
1432-6981issn
1436-3771pii
10.1007/s00784-020-03244-1journal_volume
24pub_type
杂志文章abstract:OBJECTIVES:The aim of this comprehensive literature review is to provide recommendations and guidelines for dental implant therapy in patients with a history of radiation in the head and neck region. For the first time, a meta-analysis comparing the implant survival in irradiated and non-irradiated patients was perform...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00784-013-1134-9
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to evaluate the effect of early functional loading to plateaued implants on bone formation and implant stability in a dog model. MATERIALS AND METHODS:Early loading (EL), nonloading control, and delayed loading (DL) groups were compared using six beagle dogs under functional lo...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-0929-z
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:The caries preventive effect of long-term use (1 year) of low-dosage (2.5 g/die) of xylitol chewing gum in a high-caries-risk adult population was evaluated. MATERIALS AND METHODS:In this randomized clinical trial, 179 high-caries-risk adults were assigned to two experimental groups, xylitol and polyols. Ca...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-017-2075-5
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:This aimed to assess the potential role of chronic stress in saliva secretion, xerostomia, and oral health in a population attending a saliva clinic. MATERIALS AND METHODS:Data of 114 patients who met the inclusion criteria and completed all questionnaires were analyzed in this study. Participants completed ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2393-2
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:The aim of this research was to analyse the dental discolouration caused by mineral trioxide aggregate (MTA) induced by bismuth oxide and also assess the colour stability of other dental cements. MATERIALS AND METHODS:Bismuth oxide, calcium tungstate and zirconium oxide were placed in contact with sodium hy...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1466-8
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:This systematic review (SR) aimed to summarise and critically appraise available evidence about the association between the synergistic consumption of alcohol and tobacco and the occurrence of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS:Observational studies investigating the association betw...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析
doi:10.1007/s00784-019-02958-1
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Reconstruction of large and complex bone segments is a challenging problem facing maxillofacial surgery. The majority of current regenerative approaches rely on extrinsic vascularization, which is deficient after cancer ablation and irradiation. The aim of the study was to investigate the efficacy of intrinsi...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1143-8
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVES:The purpose of this study is to compare pressures at the apical foramen created by conventional syringe irrigation and the GentleWave™ System, which releases high-velocity degassed irrigants to the pulp chamber and uses broad-spectrum sound energy for cleaning. MATERIALS AND METHODS:The apical pressure gene...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1632-z
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:To evaluate the diagnostic efficacy of CBCT-MRI fused images for articular disc calcification of temporomandibular joint (TMJ). MATERIALS AND METHODS:Twenty patients (24 TMJs) whose image examinations showed dense bodies in the TMJ space were included in the study. The locations of dense bodies evaluated by...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03497-w
更新日期:2020-08-12 00:00:00
abstract::Within the context of preventing non-communicable diseases, the World Health Report (2002) and the WHO Global Oral Health Program (2003) put forward a new strategy of disease prevention and health promotion. Greater emphasis is placed on developing global policies in oral health promotion and oral disease prevention. ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-007-0178-0
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to examine reports of perceptual distortion evoked by transient deafferentation and burning pain as models of aspects of burning mouth syndrome (BMS). MATERIALS AND METHODS:Sixteen healthy women took part in three experimental sessions that included exposure to lingual nerve block,...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1994-x
更新日期:2017-07-01 00:00:00
abstract::Fluoride is used in dentistry as a prophylactic agent to reduce caries rates due to the demineralization/remineralization effect and its influence on the metabolism of cariogenic bacteria. The purpose of this study was to evaluate the cytotoxic effects of sodium fluoride (NaF) on three different cell lines and the ant...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-002-0157-4
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVES:Cell-free DNA (cfDNA) harboring mutations has been found in patients with diseases. Experimental studies have shown that cfDNA can be transmitted, leading to transformations in the host. In the present study, we evaluated whether bone allograft material contains cfDNA and whether this foreign cfDNA can be re...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02867-3
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate impact of periodontal surgery on periodontal health and on glycaemia control of type 1 and type 2 (T1DM; T2DM) diabetics with severe periodontitis, during 12 months follow-up, in comparison with non-diabetic controls. MATERIALS AND METHODS:A total of 23 T1DM and 10...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1819-y
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:Emdogain, containing an extract of fetal porcine enamel matrix proteins, is a potent stimulator of in vitro osteoclastogenesis. The underlying molecular mechanisms are, however, unclear. MATERIAL AND METHODS:Here, we have addressed the role of transforming growth factor-beta receptor type 1 (TGF-βRI) kinase...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1129-6
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVES:Bony reconstruction of jaw defects using the free fibular flap and dental rehabilitation mostly requires insertion of dental implants within the transferred fibula bone. The aim of this paper was to discuss results of the implant stability with data on the possible benefit for the patient's quality of life a...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1487-3
更新日期:2016-01-01 00:00:00
abstract::Oral verrucous carcinoma (OVC) is a rare variant of squamous cell carcinoma with a characteristic morphology and specific behavior. To date, few studies are available focusing the prevalence and clinicopathologic features of the oral verrucous carcinoma in Brazilian population. A total of 3,500 primary oral well-diffe...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-006-0050-7
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:This study investigated the antibacterial properties and micro-hardness of polyacrylic acid (PAA)-coated copper iodide (CuI) nanoparticles incorporated into glass ionomer-based materials, and the effect of PAA-CuI on collagen degradation. MATERIALS AND METHODS:PAA-CuI nanoparticles were incorporated into gl...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1799-y
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:To explore the pathophysiology of proliferative verrucous leukoplakia, a rare oral disorder that exhibits high rates of recurrence and malignant transformation, through a RNAseq case-control study. MATERIAL AND METHODS:We obtained oral biopsies from 10 patients with verrucous leukoplakia lesions and from th...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03575-z
更新日期:2020-09-11 00:00:00
abstract::The purpose of the present study was to examine the effects of a newly developed water-soluble reduced chitosan on Streptococcus mutans, plaque regrowth, and biofilm vitality. A 1.0%, water-soluble reduced chitosan, with pH ranging from 6.0 to 6.5, molecular weights between 3,000 and 5,000 Da, and 70% degree of deacet...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-006-0038-3
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVES:Root resorptions due to a reduced repair function of cementoblasts are common side effects during orthodontic tooth movement (OTM). The mechanisms, which lead to an impaired cementoblast function, are not fully understood. Therefore, we aimed to investigate changes in the gene expression of cementoblasts dur...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1167-0
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:Geranylgeraniol (GGOH) has been reported as a potential treatment option for bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ). The aim of this study was to analyze the effects of GGOH on endothelial progenitor cells (EPC) after bisphosphonate treatment in vitro. MATERIALS AND METHODS:EPC were in...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1394-z
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:SLC22A4/5 single nucleotide polymorphisms (SNPs) have been reported to affect inflammatory diseases. We report the relationship of these polymorphisms with adiposity and tooth loss as elucidated in a 10-year follow-up study. METHODS:Participants of the Study of Health in Pomerania (SHIP, N = 4105) were genot...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03594-w
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to validate the reproducibility and observer variability of the Functional Implant Prosthodontic Score (FIPS), while considering the level of dental experience for intra- and inter-examiner analysis. MATERIALS AND METHODS:A total of 44 examiners (n = 31 undergraduate dental student...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2332-7
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the push-out bond strength of three calcium silicate cements to dentine after two different irrigation regimes. MATERIALS AND METHODS:One hundred eighty 2-mm-thick root sections were prepared. The sections were divided into three main groups (n = 60). In group A, the sec...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1082-4
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:The aim of the meta-analysis was to clarify the efficacy of non-surgical periodontal treatment (NSPT) in improving rheumatoid arthritis (RA) disease activity. METHODS:A systematic literature search was conducted using the PubMed, Embase, and Cochrane databases up to October 2020. A total of nine studies wer...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-021-03807-w
更新日期:2021-01-29 00:00:00
abstract:OBJECTIVE:To describe and explore the association between proxy-reported sleep bruxism (SB) and quality of life (QoL) in a population of Colombian children belonging to different social layers. METHODS:The parents of 1556, 6-13-year-old school children, were administered the Pediatric Inventory of Quality of Life (Ped...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1901-5
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:Genome-wide association studies (GWAS) and literature have identified polymorphisms in the KCNJ11, HNF1A, IRS1, TCF7L2, CDKAL1, CDKN2B, RPSAP52, GPR45 HHEX, IL18, and RUNX2 genes associated with type 2 diabetes mellitus (T2DM) and/or periodontitis (P) in diverse populations, and we sought to evaluate them as ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03717-3
更新日期:2021-01-03 00:00:00
abstract::Dear Professor Dr. Matthias Hannig. Editor-in-Chief Clinical Oral Investigations. Following the publication of our paper by Calvo Guirado et al, 2015 [1] in Clinical Oral Investigations, it came to light that a certain part of the text at the materials and methods and results sections were similar. ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00784-018-2763-9
更新日期:2019-01-01 00:00:00
abstract::Regular screening through white light inspection of the entire oral mucosa is the most important examination method to identify precancerous lesions and early oral carcinoma. Additionally, the physiologic autofluorescence of the oral mucosa has been described as a novel screening method for the detection of mucosal le...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章
doi:10.1007/s00784-010-0455-1
更新日期:2011-12-01 00:00:00