Abstract:
OBJECTIVES:Albumin has a known capability to modulate free serum concentrations of proteins produced by tumour cells. The technique of spin probe labelling of albumin followed by electron paramagnetic resonance (EPR) spectroscopy may allow identification of these structural and functional changes, which regularly occur as consequence of binding tumour metabolites as ligands. The aim of the present study was a proof of principle evaluation of EPR-analysis of peripheral blood samples as possible predictor for oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS:The present study is designed as gender-matched cohort. EPR was tested after retrieval of peripheral blood samples. The study group is represented by 32 patients with OSCC, and the control group consisted of 30 healthy patients. RESULTS:Overall analysis exhibited a diagnostic sensitivity of 72% (23/32 OSCC group) and a specificity of 80% (24/30 control group). Subgroup analysis revealed ten patients with elevated leukocytes (>10,000/μl; n = 9 [OSCC group] and n = 1 [control group]). After exclusion of patients with elevated white blood cell count, sensitivity considerably increased to 87% and specificity to 83%. CONCLUSION:EPR analysis of peripheral blood samples might be appropriate to support the clinician in primary and follow-up diagnosis of potential tumours such as OSCC. Unfortunately, subgroup analysis characterises the method vulnerable to inflammation. CLINICAL RELEVANCE:Nevertheless, our preliminary results are intriguing, as diagnosis of OSCC appears possible by simple peripheral blood examination. Thus, further appraisal of this novel method with inclusion of different tumour entities, systemic conditions and inflammation in a larger study population appears highly valuable.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Moergel M,Kämmerer PW,Schnurr K,Klein MO,Al-Nawas Bdoi
10.1007/s00784-011-0655-3subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1529-33issue
6eissn
1432-6981issn
1436-3771journal_volume
16pub_type
杂志文章abstract:OBJECTIVES:This study aimed to investigate the root canal morphology of mandibular first premolar teeth in a population from southwestern China by micro-computed tomography (micro-CT). MATERIALS AND METHODS:Human mandibular first premolars (115) were selected and prepared for micro-CT analysis with a slice thickness o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0778-1
更新日期:2013-04-01 00:00:00
abstract::Dear Professor Dr. Matthias Hannig. Editor-in-Chief Clinical Oral Investigations. Following the publication of our paper by Calvo Guirado et al, 2015 [1] in Clinical Oral Investigations, it came to light that a certain part of the text at the materials and methods and results sections were similar. ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00784-018-2763-9
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:To explore the pathophysiology of proliferative verrucous leukoplakia, a rare oral disorder that exhibits high rates of recurrence and malignant transformation, through a RNAseq case-control study. MATERIAL AND METHODS:We obtained oral biopsies from 10 patients with verrucous leukoplakia lesions and from th...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03575-z
更新日期:2020-09-11 00:00:00
abstract:OBJECTIVES:Nitrogen-containing bisphosphonates induce osteonecrosis mostly in the jaw and less frequently in other bones. Because of the crucial role of periosteal perfusion in bone repair, we investigated zoledronate-induced microcirculatory reactions in the mandibular periosteum in comparison with those in the tibia ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1347-6
更新日期:2015-07-01 00:00:00
abstract::The aims of this study were to evaluate clinically and microbiologically the effects of two resin-modified glass-ionomer cements (RMGICs) used as liners after incomplete dentine caries removal and to identify Streptococcus mutans and Streptococcus sobrinus strains isolated from dentine samples, before and after indire...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-009-0304-2
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the chemokine expression profiles in gingival crevicular fluid (GCF) and serum in patients with advanced chronic periodontitis and to assess the impact of smoking on local and systemic levels of chemokines. MATERIALS AND METHODS:Thirty patients with chronic periodonti...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1314-2
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:This study was designed to investigate the antimicrobial properties, compressive strength and fluoride release capacities of high-viscous glass ionomer cements (GICs) after incorporation of cinnamon and thyme essential oils. MATERIALS AND METHODS:Experimental-modified GICs were prepared by incorporation of ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03493-0
更新日期:2020-08-15 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of daily exposure to a denture cleanser on a multispecies biofilm. MATERIALS AND METHODS:Multispecies biofilms (five bacteria and Candida albicans) were developed for 64.5 h on acrylic resin specimens and randomized into control and experimental groups. In the...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-014-1210-9
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:This study evaluated the danger zone (DZ) in mesial roots of mandibular molars and the correlation between anatomical references of the DZ and some anatomical landmarks including tooth/root length, depth of mesial and distal grooves, and inter-canal orifices distance. MATERIAL AND METHODS:Twenty-eight mesia...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03686-7
更新日期:2020-11-24 00:00:00
abstract:OBJECTIVES:Milling is a crucial step in producing restorations using computer-aided design and computer-aided manufacturing (CAD/CAM) systems. In this study the trueness of currently available milling devices was evaluated. MATERIALS AND METHODS:Thirty clinical cases (ten inlays, ten crowns, ten onlays) were milled fr...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1916-y
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the effects of three different fluoride-releasing agents on preventing white spot lesions that occur during treatment with full coverage rapid maxillary expanders. MATERIALS AND METHODS:A total of 48 patients with transverse maxillary deficiency were randomly assigned to f...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2749-7
更新日期:2019-08-01 00:00:00
abstract::Previous work showed that a single application of 40% chlorhexidine varnish, EC40, reduced plaque acidogenicity upon sucrose challenge during less than 3 weeks. It was questioned whether lactic acid production could be reduced significantly longer when the treatment was intensified. Therefore, the effects of three con...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-006-0079-7
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:To assess how to control, detect, and treat secondary caries. This review serves to inform a joint ORCA/EFCD consensus process. METHODS:Systematic and non-systematic reviews were performed or consulted and narratively synthesized. RESULTS:Secondary (or recurrent) caries is defined as a lesion associated wi...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-020-03268-7
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare temperature variation during osteotomies with trephine drills under different irrigation conditions: without irrigation, external irrigation, and double irrigation. MATERIALS AND METHODS:Synthetic blocks of bone (type I density) were used for drilling procedures with ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1163-4
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To assess and compare the pharmacological effect of different drugs on pain relief after periodontal surgery. MATERIALS AND METHODS:Five databases were searched up to September 2019. The eligible studies comprised randomized clinical trials, involving only adult individuals that received any periodontal sur...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析
doi:10.1007/s00784-020-03401-6
更新日期:2020-08-01 00:00:00
abstract::Within the context of preventing non-communicable diseases, the World Health Report (2002) and the WHO Global Oral Health Program (2003) put forward a new strategy of disease prevention and health promotion. Greater emphasis is placed on developing global policies in oral health promotion and oral disease prevention. ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-007-0178-0
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:To assess the perception of oral health and oral care needs, barriers and current practices as perceived by managers and caregivers in organizations for people with disabilities in Flanders. MATERIALS AND METHODS:Two questionnaires were developed, one for managers and one for caregivers. The questionnaires ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03071-z
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:This study aims to investigate the additional influence of multiple applications of antimicrobial photodynamic therapy (aPDT) in smokers with chronic periodontitis. MATERIALS AND METHODS:Twenty smokers with chronic periodontitis were treated in a split-mouth design study with aPDT adjunct to Scaling and Roo...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2740-3
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:Edible oils are an empiric approach for the prevention of oral diseases. The present in situ study investigated the effect of edible oils on initial bacterial colonization of enamel surfaces. METHODS AND MATERIALS:Initial biofilm formation was performed on enamel specimens mounted on maxillary splints and ca...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-012-0734-0
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to investigate the effects of fixed functional therapy on oropharyngeal airway dimensions and hyoid bone positions in Class II patients and make comparison with an untreated Class II group. MATERIALS AND METHODS:Eighteen patients (8 girls, 10 boys; mean age 13.62 ± 1.92 years)...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1659-1
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the effect of simulated gastric acid solution on surface topography and bending properties of esthetic coated nickel-titanium (NiTi) archwires. MATERIALS AND METHODS:Three brands of as-received white-coated superelastic NiTi upper archwires were used in this study: D...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03438-7
更新日期:2020-07-03 00:00:00
abstract:OBJECTIVES:The main purpose of this prospective, double-blind, randomized study was to evaluate anaesthetic parameters, postoperative analgesia and vasoactive properties of levobupivacaine and bupivacaine for lower third molar surgery. MATERIAL AND METHODS:Sixty patients (ASA I) were scheduled for lower third molar su...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1114-0
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:This study aims to test the influence of different surface treatments and conditioning on the shear bond strength between polyetherketone (PEEK) and composite. MATERIALS AND METHODS:Surfaces (570 plates) were used untreated, etched, air-particle abraded or activated with silica-modified alumina oxide. Surfa...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1294-2
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:We aimed at investigating whether the interaction between the local inflammation, periodontitis, and obesity is independently associated with systemic inflammation. METHODS:From the population-based Study of Health in Pomerania, 3366 participants, without (2366) and with (1000) obesity, were studied for the...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03514-y
更新日期:2020-08-22 00:00:00
abstract::Complex human tissues harbour stem cells and/or precursor cells, which are responsible for tissue development or repair. Recently, dental tissues such as periodontal ligament (PDL), dental papilla or dental follicle have been identified as easily accessible sources of undifferentiated cells. The dental stem cell biolo...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-007-0170-8
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:This animal study was conducted to evaluate the osteocyte index in the peri-implant bone around immediately restored implants under static lateral overload. MATERIAL AND METHODS:Seven mongrel dogs received three implants on each side of the mandible. Forty-two implants were distributed into three groups (14...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03662-1
更新日期:2020-11-05 00:00:00
abstract::In the original version of this article, the following were noted for correction. ...
journal_title:Clinical oral investigations
pub_type: 已发布勘误
doi:10.1007/s00784-020-03657-y
更新日期:2020-10-26 00:00:00
abstract:OBJECTIVES:We aimed to determine the immunolocalization patterns of the interleukin (IL)-6 signaling complex in epithelialized and non-epithelialized apical lesions of endodontic origin (ALEOs). MATERIALS AND METHODS:Epithelialized (n = 8) and non-epithelialized (n = 7) ALEOs were obtained from teeth with indication o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03738-y
更新日期:2021-01-07 00:00:00
abstract:OBJECTIVES:The aim of this study was to examine the influence of experience and gender on the radiographic detection of proximal caries lesions and on therapeutic decisions. MATERIALS AND METHODS:A survey of 220 examiners (students and employees at three universities and dentists in the field) was taken using a standa...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2078-2
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the association between salivary and plaque arginine levels/ADS activities with dental caries. MATERIALS AND METHODS:A systematic search was performed as per PRISMA statement using PubMed, Scopus, Cochrane Library, and Web of Science. Published studies that invest...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00784-017-2322-9
更新日期:2018-03-01 00:00:00