Abstract:
:Aberrant rule- and reward-based processes underpin abnormalities of socio-emotional behaviour in major dementias. However, these processes remain poorly characterized. Here we used music to probe rule decoding and reward valuation in patients with frontotemporal dementia (FTD) syndromes and Alzheimer's disease (AD) relative to healthy age-matched individuals. We created short melodies that were either harmonically resolved ('finished') or unresolved ('unfinished'); the task was to classify each melody as finished or unfinished (rule processing) and rate its subjective pleasantness (reward valuation). Results were adjusted for elementary pitch and executive processing; neuroanatomical correlates were assessed using voxel-based morphometry. Relative to healthy older controls, patients with behavioural variant FTD showed impairments of both musical rule decoding and reward valuation, while patients with semantic dementia showed impaired reward valuation but intact rule decoding, patients with AD showed impaired rule decoding but intact reward valuation and patients with progressive non-fluent aphasia performed comparably to healthy controls. Grey matter associations with task performance were identified in anterior temporal, medial and lateral orbitofrontal cortices, previously implicated in computing diverse biological and non-biological rules and rewards. The processing of musical rules and reward distils cognitive and neuroanatomical mechanisms relevant to complex socio-emotional dysfunction in major dementias.
journal_name
Soc Cogn Affect Neuroscijournal_title
Social cognitive and affective neuroscienceauthors
Clark CN,Golden HL,McCallion O,Nicholas JM,Cohen MH,Slattery CF,Paterson RW,Fletcher PD,Mummery CJ,Rohrer JD,Crutch SJ,Warren JDdoi
10.1093/scan/nsx140subject
Has Abstractpub_date
2018-02-01 00:00:00pages
192-202issue
2eissn
1749-5016issn
1749-5024pii
4657128journal_volume
13pub_type
杂志文章abstract::Self-affirmation reduces defensive responding to self-threats. The present study extended beyond self-threats to assess affirmation's influence on responses to negative emotional pictures as measured by the late positive potential (LPP), an event-related potential in the encephalogram that reflects motivational signif...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy036
更新日期:2018-06-01 00:00:00
abstract::This study aimed to identify vulnerability patterns in psychological, physiological and neural responses to mild psychosocial challenge in a population that is at a direct risk of developing depression, but who has not as yet succumbed to the full clinical syndrome. A group of healthy and a group of subclinically depr...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst151
更新日期:2014-10-01 00:00:00
abstract::Experimental studies using fictional moral dilemmas indicate that both automatic emotional processes and controlled cognitive processes contribute to moral judgments. However, not much is known about how people process socio-normative violations that are more common to their everyday life nor the time-course of these ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu151
更新日期:2015-08-01 00:00:00
abstract::Recent research on classical fear-conditioning in the anxiety disorders has identified overgeneralization of conditioned fear as an important conditioning correlate of anxiety pathology. Unfortunately, only one human neuroimaging study of classically conditioned fear generalization has been conducted, and the neural s...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst096
更新日期:2014-08-01 00:00:00
abstract::Recent symptom provocation studies that compared patients suffering from dental phobia with healthy controls identified hyperactivation of basal ganglia structures, but none have assessed striatal functional connectivity. We reanalyzed data from a previous functional magnetic resonance imaging study on dental phobia. ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst150
更新日期:2014-10-01 00:00:00
abstract::Approach, avoidance and the supervisory control system are fundamental to human behavior. Much past research has examined the neurophysiological models relating trait approach and avoidance. Using measures of electroencephalographic (EEG) frontal asymmetry, trait approach has been associated with greater left-frontal ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv017
更新日期:2015-10-01 00:00:00
abstract::The ability to cognitively regulate emotional responses to aversive events is essential for mental and physical health. One prerequisite of successful emotion regulation is the awareness of emotional states, which in turn is associated with the awareness of bodily signals [interoceptive awareness (IA)]. This study inv...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss089
更新日期:2013-12-01 00:00:00
abstract::Research suggests psychopathy is associated with structural brain alterations that may contribute to the affective and interpersonal deficits frequently observed in individuals with high psychopathic traits. However, the regional alterations related to different components of psychopathy are still unclear. We used vox...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv062
更新日期:2015-12-01 00:00:00
abstract::A heightened sense of self-esteem is associated with a reduced risk for several types of affective and psychiatric disorders, including depression, anxiety and eating disorders. However, little is known about how brain systems integrate self-referential processing and positive evaluation to give rise to these feelings...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu063
更新日期:2015-03-01 00:00:00
abstract::Neuroimaging studies show a correlation between activity of the ventromedial prefrontal cortex (vmPFC) and skin conductance measurements. However, little is known whether this brain region plays a causal role in regulating physiological arousal. To address this question, we employed Granger causality analysis (GCA) to...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst064
更新日期:2014-07-01 00:00:00
abstract::Individuals with autism spectrum disorders (ASD) have documented deficits in face processing, face memory and abnormal activation of the neural circuitry that supports these functions. To examine speed of processing of faces in ASD, high density event-related brain potentials were recorded to images of faces, inverted...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsp002
更新日期:2012-06-01 00:00:00
abstract::'Social brain' circuitry has recently been implicated in processing slow, gentle touch targeting a class of slow-conducting, unmyelinated nerves, CT afferents, which are present only in the hairy skin of mammals. Given the importance of such 'affective touch' in social relationships, the current functional magnetic re...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss009
更新日期:2013-04-01 00:00:00
abstract::Ostracism arouses negative affect. However, little is known about variables that influence the intensity of these negative affective responses. Two studies fill this void by incorporating work on approach- and withdrawal-related emotional states and their associated cortical activations. Study 1 found that following o...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsq027
更新日期:2011-06-01 00:00:00
abstract::Neuroimaging studies on moral decision-making have thus far largely focused on differences between moral judgments with opposing utilitarian (well-being maximizing) and deontological (duty-based) content. However, these studies have investigated moral dilemmas involving extreme situations, and did not control for two ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsr005
更新日期:2012-04-01 00:00:00
abstract::Studies of human fear learning suggest that a reliable discrimination between safe and threatening stimuli is important for survival and mental health. In the current study, we applied the subsequent memory paradigm in order to identify neurophysiological correlates of successful threat and safety learning. We recorde...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsab015
更新日期:2021-02-01 00:00:00
abstract::Is moral beauty different from facial beauty? Two functional magnetic resonance imaging experiments were performed to answer this question. Experiment 1 investigated the network of moral aesthetic judgments and facial aesthetic judgments. Participants performed aesthetic judgments and gender judgments on both faces an...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu123
更新日期:2015-06-01 00:00:00
abstract::In healthy individuals, direct eye contact initially leads to activation of a fast subcortical pathway, which then modulates a cortical route eliciting social cognitive processes. The aim of this study was to gain insight into the neurobiological effects of direct eye-to-eye contact using a virtual reality paradigm in...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss105
更新日期:2014-01-01 00:00:00
abstract::Using functional magnetic resonance imaging, we investigated neural activity associated with self-reflection in depressed [current major depressive episode (MDE)] and healthy control participants, focusing on medial cortex areas previously shown to be associated with self-reflection. Both the MDE and healthy control g...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsp022
更新日期:2009-12-01 00:00:00
abstract::Early life stress has been associated with disrupted functional connectivity between the amygdala and medial prefrontal cortex (mPFC), but it is unknown how early in development stress-related differences in amygdala-mPFC connectivity emerge. In a resting-state functional connectivity (rs-FC) analysis with 79 four- to...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy017
更新日期:2018-04-01 00:00:00
abstract::Social information influences decision-making through an integration of information derived from individual experience with that derived from observing the actions of others. This raises the question as to which extent one should utilize social information. One strategy is to make use of uncertainty estimates, leading...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1093/scan/nst173
更新日期:2014-11-01 00:00:00
abstract::The disposition for prosocial conduct, which contributes to cooperation as arising during social interaction, requires cortical network dynamics responsive to the development of social ties, or care about the interests of specific interaction partners. Here, we formulate a dynamic computational model that accurately p...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu138
更新日期:2015-06-01 00:00:00
abstract::Parenting styles are robust predictors of offspring outcomes, yet little is known about their neural underpinnings. In this study, 44 parent-adolescent dyads (Mage of adolescent = 12.9) completed a laboratory guessing task while EEG was continuously recorded. In the task, each pair member received feedback about their...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsw130
更新日期:2017-03-01 00:00:00
abstract::Autism spectrum disorders (ASD) are often associated with impairments in judgment of facial expressions. This impairment is often accompanied by diminished eye contact and atypical amygdala responses to face stimuli. The current study used a within-subjects design to examine the effects of natural viewing and an exper...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst050
更新日期:2014-01-01 00:00:00
abstract::Theory of mind (ToM), the capacity to reason about others' mental states, is central to healthy social development. Neural mechanisms supporting ToM may contribute to individual differences in children's social cognitive behavior. Employing a false belief functional magnetic resonance imaging paradigm, we identified p...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsz040
更新日期:2019-08-07 00:00:00
abstract::Human prosociality is often assumed to emerge from exerting reflective control over initial, selfish impulses. However, recent findings suggest that prosocial actions can also stem from processes that are fast, automatic and intuitive. Here, we attempt to clarify when prosocial behavior may be intuitive by examining p...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv077
更新日期:2016-07-01 00:00:00
abstract::Several prominent theories spanning clinical, social and developmental psychology suggest that people are motivated to see the world as a sensible orderly place. These theories presuppose that randomness is aversive because it is associated with unpredictability. If this is the case, thinking that the world is random ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu097
更新日期:2015-05-01 00:00:00
abstract::Despite being one of the healthiest developmental periods, morbidity and mortality rates increase dramatically during adolescence, largely due to preventable, risky behaviors. Heightened reward sensitivity, coupled with ineffective cognitive control, has been proposed to underlie adolescents' risk taking. In this stud...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv026
更新日期:2015-10-01 00:00:00
abstract::Serotonin is a key neurotransmitter involved in emotional regulation and memory. A number of studies using acute tryptophan depletion (ATD) in healthy subjects have shown that a temporary serotonin reduction both induces a negative emotional bias and impairs long-term memory. However, little is known about the specifi...
journal_title:Social cognitive and affective neuroscience
pub_type: 临床试验,杂志文章
doi:10.1093/scan/nsp025
更新日期:2009-12-01 00:00:00
abstract::The subjective and behavioral effects of intracranial electrical stimulation (iES) have been studied for decades, but there is a knowledge gap regarding the relationship between the magnitude of electric current and the type, intensity and valence of evoked subjective experiences. We report on rare iES data from 18 ne...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsz015
更新日期:2019-05-17 00:00:00
abstract::Mindfulness--an attentive non-judgmental focus on present experiences--is increasingly incorporated in psychotherapeutic treatments as a skill fostering emotion regulation. Neurobiological mechanisms of actively induced emotion regulation are associated with prefrontally mediated down-regulation of, for instance, the ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst043
更新日期:2014-06-01 00:00:00