Abstract:
:Serotonin is a key neurotransmitter involved in emotional regulation and memory. A number of studies using acute tryptophan depletion (ATD) in healthy subjects have shown that a temporary serotonin reduction both induces a negative emotional bias and impairs long-term memory. However, little is known about the specific effects of ATD on emotional memory. Using functional magnetic resonance imaging (fMRI), we investigated the effect of ATD on negative memory and executive function in healthy volunteers. Our emotional oddball task required participants to distinguish infrequently presented targets from distracting negative and neutral pictures. Memory for the distracting pictures was tested 1 h following the fMRI session. ATD selectively enhanced memory for negative distractors relative to neutral distractors and increased activation in response to the negative distractors in the left orbital-inferior frontal, dorsomedial prefrontal and bilateral angular gyri. ATD also induced greater activation in the left inferior frontal gyrus and anterior cingulate across all stimuli. Stronger frontal activation to distractors was positively correlated with memory performance on ATD but not control days, indicating a possible compensatory mechanism for coping with increased task demand under the ATD challenge. These findings highlight the importance of serotonin in negative memory with implications for mood disorders.
journal_name
Soc Cogn Affect Neuroscijournal_title
Social cognitive and affective neuroscienceauthors
Wang L,Mullette-Gillman OA,Gadde KM,Kuhn CM,McCarthy G,Huettel SAdoi
10.1093/scan/nsp025subject
Has Abstractpub_date
2009-12-01 00:00:00pages
357-68issue
4eissn
1749-5016issn
1749-5024pii
nsp025journal_volume
4pub_type
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