Amygdala-medial prefrontal cortex connectivity relates to stress and mental health in early childhood.

Abstract:

:Early life stress has been associated with disrupted functional connectivity between the amygdala and medial prefrontal cortex (mPFC), but it is unknown how early in development stress-related differences in amygdala-mPFC connectivity emerge. In a resting-state functional connectivity (rs-FC) analysis with 79 four- to seven-year-old children, we found a significant correlation between more adverse experiences and weaker amygdala-mPFC rs-FC. We also found that weaker amygdala-mPFC rs-FC was associated with higher levels of aggressive behavior and attention problems. These findings suggest that the impact of stress on emotional circuitry is detectable in early childhood and that this impact is associated with mental health difficulties. Connectivity in this circuit may be useful as a marker for mental health risk and for tracking the efficacy of early interventions.

authors

Park AT,Leonard JA,Saxler PK,Cyr AB,Gabrieli JDE,Mackey AP

doi

10.1093/scan/nsy017

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

430-439

issue

4

eissn

1749-5016

issn

1749-5024

pii

4924528

journal_volume

13

pub_type

杂志文章
  • Neural correlates of mental effort evaluation--involvement of structures related to self-awareness.

    abstract::Mental effort is a limited resource which must be invested to perform mental tasks. The amount of mental effort investment that an individual experiences during task performance can be measured afterwards with the help of self-rating scales. Earlier research suggests that integration of information about somatic state...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nss136

    authors: Otto T,Zijlstra FR,Goebel R

    更新日期:2014-03-01 00:00:00

  • The association between the 5-HTTLPR and neural correlates of fear conditioning and connectivity.

    abstract::Strong evidence links the 5-HTTLPR genotype to the modulation of amygdala reactivity during fear conditioning, which is considered to convey the increased vulnerability for anxiety disorders in s-allele carriers. In addition to amygdala reactivity, the 5-HTTLPR has been shown to be related to alterations in structural...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsu108

    authors: Klucken T,Schweckendiek J,Blecker C,Walter B,Kuepper Y,Hennig J,Stark R

    更新日期:2015-05-01 00:00:00

  • Asymmetric frontal cortical activity and negative affective responses to ostracism.

    abstract::Ostracism arouses negative affect. However, little is known about variables that influence the intensity of these negative affective responses. Two studies fill this void by incorporating work on approach- and withdrawal-related emotional states and their associated cortical activations. Study 1 found that following o...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsq027

    authors: Peterson CK,Gravens LC,Harmon-Jones E

    更新日期:2011-06-01 00:00:00

  • The effect of acute tryptophan depletion on emotional distraction and subsequent memory.

    abstract::Serotonin is a key neurotransmitter involved in emotional regulation and memory. A number of studies using acute tryptophan depletion (ATD) in healthy subjects have shown that a temporary serotonin reduction both induces a negative emotional bias and impairs long-term memory. However, little is known about the specifi...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1093/scan/nsp025

    authors: Wang L,Mullette-Gillman OA,Gadde KM,Kuhn CM,McCarthy G,Huettel SA

    更新日期:2009-12-01 00:00:00

  • Neurocognitive Processing of Infant Stimuli in Mothers and Non-Mothers: Psychophysiological, Cognitive and Neuroimaging Evidence.

    abstract::Emerging evidence indicates that mothers and non-mothers show different neurocognitive responses to infant stimuli. This study investigated mothers' psychophysiological, cognitive and neuronal responses to emotional infant stimuli. A total of 35 mothers with four months old infants and 18 control women without young c...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsab002

    authors: Bjertrup A,Friis N,Væver M,Miskowiak K

    更新日期:2021-01-09 00:00:00

  • Cognitive benefit and cost of acute stress is differentially modulated by individual brain state.

    abstract::Acute stress is associated with beneficial as well as detrimental effects on cognition in different individuals. However, it is not yet known how stress can have such opposing effects. Stroop-like tasks typically show this dissociation: stress diminishes speed, but improves accuracy. We investigated accuracy and speed...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/scan/nsx043

    authors: Kohn N,Hermans EJ,Fernández G

    更新日期:2017-07-01 00:00:00

  • Short-term meditation modulates brain activity of insight evoked with solution cue.

    abstract::Meditation has been shown to improve creativity in some situation. However, little is known about the brain systems underling insight into a problem when the person fails to solve the problem. Here, we examined the neural correlation using Chinese Remote Association Test, as a measure of creativity. We provide a solut...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsu032

    authors: Ding X,Tang YY,Cao C,Deng Y,Wang Y,Xin X,Posner MI

    更新日期:2015-01-01 00:00:00

  • Dual brain stimulation enhances interpersonal learning through spontaneous movement synchrony.

    abstract::Social interactive learning denotes the ability to acquire new information from a conspecific-a prerequisite for cultural evolution and survival. As inspired by recent neurophysiological research, here we tested whether social interactive learning can be augmented by exogenously synchronizing oscillatory brain activit...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsaa080

    authors: Pan Y,Novembre G,Song B,Zhu Y,Hu Y

    更新日期:2021-01-18 00:00:00

  • The anterior insular and anterior cingulate cortices in emotional processing for self-face recognition.

    abstract::Individuals can experience embarrassment when exposed to self-feedback images, depending on the extent of the divergence from the internal representation of the standard self. Our previous work implicated the anterior insular cortex (AI) and the anterior cingulate cortex (ACC) in the processing of embarrassment; howev...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nst011

    authors: Morita T,Tanabe HC,Sasaki AT,Shimada K,Kakigi R,Sadato N

    更新日期:2014-05-01 00:00:00

  • Behavioral and neuronal determinants of negative reciprocity in the ultimatum game.

    abstract::The rejection of unfair offers in the ultimatum game (UG) indicates negative reciprocity. The model of strong reciprocity claims that negative reciprocity reflects prosociality because the rejecting individual is sacrificing resources in order to punish unfair behavior. However, a recent study found that the rejection...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsw069

    authors: Kaltwasser L,Hildebrandt A,Wilhelm O,Sommer W

    更新日期:2016-10-01 00:00:00

  • Global brain dynamics during social exclusion predict subsequent behavioral conformity.

    abstract::Individuals react differently to social experiences; for example, people who are more sensitive to negative social experiences, such as being excluded, may be more likely to adapt their behavior to fit in with others. We examined whether functional brain connectivity during social exclusion in the fMRI scanner can be ...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsy007

    authors: Wasylyshyn N,Hemenway Falk B,Garcia JO,Cascio CN,O'Donnell MB,Bingham CR,Simons-Morton B,Vettel JM,Falk EB

    更新日期:2018-02-01 00:00:00

  • Age-related differences in neural activities during risk taking as revealed by functional MRI.

    abstract::Previous research has clearly documented that risky decision making is different in young and older adults. Yet, there has been a relative dearth of research that seeks to understand such age-related changes in the neural activities associated with risk taking. To address this research issue, 21 men (12 young men, mea...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsm033

    authors: Lee TM,Leung AW,Fox PT,Gao JH,Chan CC

    更新日期:2008-03-01 00:00:00

  • Mismatch or allostatic load? Timing of life adversity differentially shapes gray matter volume and anxious temperament.

    abstract::Traditionally, adversity was defined as the accumulation of environmental events (allostatic load). Recently however, a mismatch between the early and the later (adult) environment (mismatch) has been hypothesized to be critical for disease development, a hypothesis that has not yet been tested explicitly in humans. W...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv137

    authors: Kuhn M,Scharfenort R,Schümann D,Schiele MA,Münsterkötter AL,Deckert J,Domschke K,Haaker J,Kalisch R,Pauli P,Reif A,Romanos M,Zwanzger P,Lonsdorf TB

    更新日期:2016-04-01 00:00:00

  • Morning brain: Real-world neural evidence that high school class times matter.

    abstract::Researchers, parents, and educators consistently observe a stark mismatch between biologically preferred and socially imposed sleep-wake hours in adolescents, fueling debate about high school start times. We contribute neural evidence to this debate with electroencephalogram (EEG) data collected from high school stude...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsaa142

    authors: Dikker S,Haegens S,Bevilacqua D,Davidesco I,Wan L,Kaggen L,McClintock J,Chaloner K,Ding M,West T,Poeppel D

    更新日期:2020-10-17 00:00:00

  • Autistic traits are associated with diminished neural response to affective touch.

    abstract::'Social brain' circuitry has recently been implicated in processing slow, gentle touch targeting a class of slow-conducting, unmyelinated nerves, CT afferents, which are present only in the hairy skin of mammals. Given the importance of such 'affective touch' in social relationships, the current functional magnetic re...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nss009

    authors: Voos AC,Pelphrey KA,Kaiser MD

    更新日期:2013-04-01 00:00:00

  • Functional connectivity of the right inferior frontal gyrus and orbitofrontal cortex in depression.

    abstract::The orbitofrontal cortex extends into the laterally adjacent inferior frontal gyrus. We analyzed how voxel-level functional connectivity of the inferior frontal gyrus and orbitofrontal cortex is related to depression in 282 people with major depressive disorder (125 were unmedicated) and 254 controls, using FDR correc...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsaa014

    authors: Rolls ET,Cheng W,Du J,Wei D,Qiu J,Dai D,Zhou Q,Xie P,Feng J

    更新日期:2020-01-30 00:00:00

  • Overlapping and non-overlapping brain regions for theory of mind and self reflection in individual subjects.

    abstract::When subjects are required to reason about someone's false belief, a consistent pattern of brain regions are recruited including the medial prefrontal cortex, medial precuneus and bilateral temporo-parietal junction. Previous group analyses suggest that the two medial regions, but not the lateral regions, are also rec...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsl034

    authors: Saxe R,Moran JM,Scholz J,Gabrieli J

    更新日期:2006-12-01 00:00:00

  • Fear boosts the early neural coding of faces.

    abstract::The rapid extraction of facial identity and emotional expressions is critical for adapted social interactions. These biologically relevant abilities have been associated with early neural responses on the face sensitive N170 component. However, whether all facial expressions uniformly modulate the N170, and whether th...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsx110

    authors: Turano MT,Lao J,Richoz AR,Lissa P,Degosciu SBA,Viggiano MP,Caldara R

    更新日期:2017-12-01 00:00:00

  • Wait, what? Assessing stereotype incongruities using the N400 ERP component.

    abstract::Numerous discoveries regarding stereotypes have been uncovered by utilizing techniques and methods developed by cognitive psychologists. The present study continues this tradition by borrowing psychophysiological techniques used for the study of memory and language, and applying them to the study of stereotypes. In th...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsp004

    authors: White KR,Crites SL Jr,Taylor JH,Corral G

    更新日期:2009-06-01 00:00:00

  • Neural activity during affect labeling predicts expressive writing effects on well-being: GLM and SVM approaches.

    abstract::Affect labeling (putting feelings into words) is a form of incidental emotion regulation that could underpin some benefits of expressive writing (i.e. writing about negative experiences). Here, we show that neural responses during affect labeling predicted changes in psychological and physical well-being outcome measu...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsx084

    authors: Memarian N,Torre JB,Haltom KE,Stanton AL,Lieberman MD

    更新日期:2017-09-01 00:00:00

  • Functional mechanisms involved in the internal inhibition of taboo words.

    abstract::The present study used functional magnetic resonance imaging to investigate brain processes associated with the inhibition of socially undesirable speech. It is tested whether the inhibition of undesirable speech is solely related to brain areas associated with classical stop signal tasks or rather also involves brain...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsr030

    authors: Severens E,Kühn S,Hartsuiker RJ,Brass M

    更新日期:2012-04-01 00:00:00

  • Theta resting EEG in the right TPJ is associated with individual differences in implicit intergroup bias.

    abstract::Why are some people more biased than others in their implicit evaluations during social interaction? The dispositional determinants of individual differences in implicit intergroup bias are poorly understood. Here, we explored whether such variability might be explained by stable neural traits. For that purpose, we us...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsz007

    authors: Schiller B,Gianotti LRR,Baumgartner T,Knoch D

    更新日期:2019-03-05 00:00:00

  • Family socioeconomic status modulates the coping-related neural response of offspring.

    abstract::Substantial research links economic adversity to poor coping in stressful or threatening environments. Neuroimaging studies suggest that activation of the right ventrolateral prefrontal cortex (rVLPFC) plays a key role in self-control, and it seems that individual differences in neurocognitive systems underlying self-...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nss039

    authors: Yanagisawa K,Masui K,Furutani K,Nomura M,Yoshida H,Ura M

    更新日期:2013-08-01 00:00:00

  • Situating Language in a Minimal Social Context: How Seeing a Picture of the Speaker's Face Affects Language Comprehension.

    abstract::Natural use of language involves at least two individuals. Some studies have focused on the interaction between senders in communicative situations and how the knowledge about the speaker can bias language comprehension. However, the mere effect of a face as social context on language processing remains unknown. In th...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsab009

    authors: Hernández-Gutiérrez D,Muñoz F,Sánchez-García J,Sommer W,Abdel Rahman R,Casado P,Jiménez-Ortega L,Espuny J,Fondevila S,Martín-Loeches M

    更新日期:2021-01-20 00:00:00

  • Mapping the impairment in decoding static facial expressions of emotion in prosopagnosia.

    abstract::Acquired prosopagnosia is characterized by a deficit in face recognition due to diverse brain lesions, but interestingly most prosopagnosic patients suffering from posterior lesions use the mouth instead of the eyes for face identification. Whether this bias is present for the recognition of facial expressions of emot...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsx068

    authors: Fiset D,Blais C,Royer J,Richoz AR,Dugas G,Caldara R

    更新日期:2017-08-01 00:00:00

  • Reduced dorsal striatal gray matter volume predicts implicit suicidal ideation in adolescents.

    abstract::Suicidal ideation (SI), a potent risk factor for suicide attempts, increases in adolescence. While alterations in dopaminergic functioning have been implicated in suicidal acts-particularly in adults-we do not know whether morphological alterations in dopamine-rich regions of the brain, such as the striatum, are vulne...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsy089

    authors: Ho TC,Cichocki AC,Gifuni AJ,Catalina Camacho M,Ordaz SJ,Singh MK,Gotlib IH

    更新日期:2018-11-08 00:00:00

  • Cognitive influences on the affective representation of touch and the sight of touch in the human brain.

    abstract::We show that the affective experience of touch and the sight of touch can be modulated by cognition, and investigate in an fMRI study where top-down cognitive modulations of bottom-up somatosensory and visual processing of touch and its affective value occur in the human brain. The cognitive modulation was produced by...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsn005

    authors: McCabe C,Rolls ET,Bilderbeck A,McGlone F

    更新日期:2008-06-01 00:00:00

  • Sex differences in the human reward system: convergent behavioral, autonomic and neural evidence.

    abstract::Several studies have suggested that females and males differ in reward behaviors and their underlying neural circuitry. Whether human sex differences extend across neural and behavioral levels for both rewards and punishments remains unclear. We studied a community sample of 221 young women and men who performed a mon...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsaa104

    authors: Warthen KG,Boyse-Peacor A,Jones KG,Sanford B,Love TM,Mickey BJ

    更新日期:2020-09-24 00:00:00

  • Individual differences in neural correlates of fear conditioning as a function of 5-HTTLPR and stressful life events.

    abstract::Fear learning is a crucial process in the pathogeneses of psychiatric disorders, which highlights the need to identify specific factors contributing to interindividual variation. We hypothesized variation in the serotonin transporter gene (5-HTTLPR) and stressful life events (SLEs) to be associated with neural correla...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nss005

    authors: Klucken T,Alexander N,Schweckendiek J,Merz CJ,Kagerer S,Osinsky R,Walter B,Vaitl D,Hennig J,Stark R

    更新日期:2013-03-01 00:00:00

  • Repetitive transcranial magnetic stimulation modulates the impact of a negative mood induction.

    abstract::High frequency repetitive Transcranial Magnetic Stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been found to alleviate depressive symptoms. However, the mechanisms driving these effects are still poorly understood. In the current study, we tested the idea that this intervention protects ag...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/scan/nsw180

    authors: Möbius M,Lacomblé L,Meyer T,Schutter DJLG,Gielkens T,Becker ES,Tendolkar I,van Eijndhoven P

    更新日期:2017-04-01 00:00:00