Abstract:
:Autism spectrum disorders (ASD) are often associated with impairments in judgment of facial expressions. This impairment is often accompanied by diminished eye contact and atypical amygdala responses to face stimuli. The current study used a within-subjects design to examine the effects of natural viewing and an experimental eye-gaze manipulation on amygdala responses to faces. Individuals with ASD showed less gaze toward the eye region of faces relative to a control group. Among individuals with ASD, reduced eye gaze was associated with higher threat ratings of neutral faces. Amygdala signal was elevated in the ASD group relative to controls. This elevated response was further potentiated by experimentally manipulating gaze to the eye region. Potentiation by the gaze manipulation was largest for those individuals who exhibited the least amount of naturally occurring gaze toward the eye region and was associated with their subjective threat ratings. Effects were largest for neutral faces, highlighting the importance of examining neutral faces in the pathophysiology of autism and questioning their use as control stimuli with this population. Overall, our findings provide support for the notion that gaze direction modulates affective response to faces in ASD.
journal_name
Soc Cogn Affect Neuroscijournal_title
Social cognitive and affective neuroscienceauthors
Tottenham N,Hertzig ME,Gillespie-Lynch K,Gilhooly T,Millner AJ,Casey BJdoi
10.1093/scan/nst050subject
Has Abstractpub_date
2014-01-01 00:00:00pages
106-17issue
1eissn
1749-5016issn
1749-5024pii
nst050journal_volume
9pub_type
杂志文章abstract::The rapid extraction of facial identity and emotional expressions is critical for adapted social interactions. These biologically relevant abilities have been associated with early neural responses on the face sensitive N170 component. However, whether all facial expressions uniformly modulate the N170, and whether th...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx110
更新日期:2017-12-01 00:00:00
abstract::Aberrant rule- and reward-based processes underpin abnormalities of socio-emotional behaviour in major dementias. However, these processes remain poorly characterized. Here we used music to probe rule decoding and reward valuation in patients with frontotemporal dementia (FTD) syndromes and Alzheimer's disease (AD) re...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx140
更新日期:2018-02-01 00:00:00
abstract::Strong evidence links the 5-HTTLPR genotype to the modulation of amygdala reactivity during fear conditioning, which is considered to convey the increased vulnerability for anxiety disorders in s-allele carriers. In addition to amygdala reactivity, the 5-HTTLPR has been shown to be related to alterations in structural...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu108
更新日期:2015-05-01 00:00:00
abstract::Behavioral research has demonstrated an advantage for females compared with males in social information processing. However, little is known about sex-related differences in brain activation during understanding of self and others. In the current functional magnetic resonance imaging study, this was assessed in late a...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst015
更新日期:2014-04-01 00:00:00
abstract::Humans produce hand movements to manipulate objects, but also make hand movements to convey socially relevant information to one another. The mirror neuron system (MNS) is activated during the observation and execution of actions. Previous neuroimaging experiments have identified the inferior parietal lobule (IPL) and...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsm004
更新日期:2007-06-01 00:00:00
abstract::Recent research on classical fear-conditioning in the anxiety disorders has identified overgeneralization of conditioned fear as an important conditioning correlate of anxiety pathology. Unfortunately, only one human neuroimaging study of classically conditioned fear generalization has been conducted, and the neural s...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst096
更新日期:2014-08-01 00:00:00
abstract::The 'own-age bias' in face processing suggests that the age of a face constitutes one important factor that influences attention to and memory for faces. The present experiment investigated electrophysiological correlates of processing faces of younger and older individuals. Younger participants were presented with pi...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsq074
更新日期:2011-09-01 00:00:00
abstract::Experimental studies using fictional moral dilemmas indicate that both automatic emotional processes and controlled cognitive processes contribute to moral judgments. However, not much is known about how people process socio-normative violations that are more common to their everyday life nor the time-course of these ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu151
更新日期:2015-08-01 00:00:00
abstract::Exaggerated anticipatory anxiety during expectation of performance-related situations is an important feature of the psychopathology of social anxiety disorder (SAD). The neural basis of anticipatory anxiety in SAD has not been investigated in controlled studies. The current study used functional magnetic resonance im...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst129
更新日期:2014-09-01 00:00:00
abstract::Social information influences decision-making through an integration of information derived from individual experience with that derived from observing the actions of others. This raises the question as to which extent one should utilize social information. One strategy is to make use of uncertainty estimates, leading...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1093/scan/nst173
更新日期:2014-11-01 00:00:00
abstract::A heightened sense of self-esteem is associated with a reduced risk for several types of affective and psychiatric disorders, including depression, anxiety and eating disorders. However, little is known about how brain systems integrate self-referential processing and positive evaluation to give rise to these feelings...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu063
更新日期:2015-03-01 00:00:00
abstract::Empathy has been supposed to be a proximate mechanism of altruistic behavior. We investigated whether empathy for pain drives actions without altruistic effects and how such actions modulate neural responses to others' pain. In two experiments, we asked healthy adults to press a button for no reason when viewing video...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx016
更新日期:2017-06-01 00:00:00
abstract::The subjective and behavioral effects of intracranial electrical stimulation (iES) have been studied for decades, but there is a knowledge gap regarding the relationship between the magnitude of electric current and the type, intensity and valence of evoked subjective experiences. We report on rare iES data from 18 ne...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsz015
更新日期:2019-05-17 00:00:00
abstract::Individuals can experience embarrassment when exposed to self-feedback images, depending on the extent of the divergence from the internal representation of the standard self. Our previous work implicated the anterior insular cortex (AI) and the anterior cingulate cortex (ACC) in the processing of embarrassment; howev...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst011
更新日期:2014-05-01 00:00:00
abstract::Neurobiological and behavioral findings suggest that psychosis is associated with corticolimbic hyperactivity during the processing of emotional salience. This has not been widely studied in the early stages of psychosis, and the impact of these abnormalities on psychotic symptoms and global functioning is unknown. We...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv035
更新日期:2015-10-01 00:00:00
abstract::The role of ventromedial prefrontal cortex (vmPFC) in mental time travel toward the past and the future is debated. Here, patients with focal lesions to the vmPFC and brain-damaged and healthy controls mentally projected themselves to a past, present or future moment of subjective time (self-projection) and classified...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsaa163
更新日期:2020-12-31 00:00:00
abstract::The recognition of threatening faces is important for making social judgments. For example, threatening facial features of defendants could affect the decisions of jurors during a trial. Previous neuroimaging studies using faces of members of the general public have identified a pivotal role of the amygdala in perceiv...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsr085
更新日期:2013-02-01 00:00:00
abstract::While abnormal processing of performance feedback has been associated with obsessive-compulsive disorder (OCD), neural responses to different kinds of feedback information, especially to ambiguous feedback are widely unknown. Using fMRI and a performance adaptive time-estimation task, we acquired blood oxygenation lev...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst095
更新日期:2014-08-01 00:00:00
abstract::Cognitive reappraisal is associated with major depressive disorder (MDD), while spontaneous activity patterns of the default mode network (DMN) is implicated in reappraisal and MDD. However, neural mechanisms subserving the close association of spontaneous reappraisal and depression are unclear. Spontaneous reappraisa...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy092
更新日期:2018-12-04 00:00:00
abstract::Research has illustrated that the brain regions implicated in moral cognition comprise a robust and broadly distributed network. However, understanding how these brain regions interact and give rise to the complex interplay of cognitive processes underpinning human moral cognition is still in its infancy. We used func...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss139
更新日期:2014-03-01 00:00:00
abstract::Stress has a critical impact on affective and cognitive processing. Based on rodent data suggesting that endocannabinoid signaling via CB1 receptors serves as an emotional buffer, we hypothesized that a common variant of the gene coding for the CB1 receptor modulates affective processing under stress (CNR1; rs1049353 ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy083
更新日期:2018-11-08 00:00:00
abstract::Recent electrophysiological research indicates that perceivers differentiate others on the basis of race extremely quickly. However, most categorization studies have been limited to White participants, neglecting potential differences in processing between racial groups. Moreover, the extent to which race interferes w...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsm012
更新日期:2007-09-01 00:00:00
abstract::This study explores the fMRI correlates of observers making trait inferences about other people under conflicting social cues. Participants were presented with several behavioral descriptions involving an agent that implied a particular trait. The last behavior was either consistent or inconsistent with the previously...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsr064
更新日期:2012-11-01 00:00:00
abstract::Mood disorders are characterized by impaired emotion regulation abilities, reflected in alterations in frontolimbic brain functioning during regulation. However, little is known about differences in brain function when comparing regulatory strategies. Reappraisal and emotional acceptance are effective in downregulatin...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv003
更新日期:2015-09-01 00:00:00
abstract::Serotonin is a key neurotransmitter involved in emotional regulation and memory. A number of studies using acute tryptophan depletion (ATD) in healthy subjects have shown that a temporary serotonin reduction both induces a negative emotional bias and impairs long-term memory. However, little is known about the specifi...
journal_title:Social cognitive and affective neuroscience
pub_type: 临床试验,杂志文章
doi:10.1093/scan/nsp025
更新日期:2009-12-01 00:00:00
abstract::The orbitofrontal cortex extends into the laterally adjacent inferior frontal gyrus. We analyzed how voxel-level functional connectivity of the inferior frontal gyrus and orbitofrontal cortex is related to depression in 282 people with major depressive disorder (125 were unmedicated) and 254 controls, using FDR correc...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsaa014
更新日期:2020-01-30 00:00:00
abstract::Emotional experiences are frequently shaped by the emotional responses of co-present others. Research has shown that people constantly monitor and adapt to the incoming social-emotional signals, even without face-to-face interaction. And yet, the neural processes underlying such emotional transmissions have not been d...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx049
更新日期:2017-08-01 00:00:00
abstract::Recent approaches for understanding the neural basis of pain empathy emphasize the dynamic construction of networks underlying this multifaceted social cognitive process. Inter-subject phase synchronization (ISPS) is an approach for exploratory analysis of task-fMRI data that reveals brain networks dynamically synchro...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsaa025
更新日期:2020-05-11 00:00:00
abstract::In this article, we review three areas of research within adolescent social cognitive and affective neuroscience: (i) emotion reactivity and regulation, (ii) mentalizing and (iii) peer relations, including social rejection or acceptance as well as peer influence. The review provides a context for current contributions...
journal_title:Social cognitive and affective neuroscience
pub_type: 社论,评审
doi:10.1093/scan/nsr099
更新日期:2012-01-01 00:00:00
abstract::Major depressive disorder (MDD) has been associated with abnormalities in cortical thickness and autonomic function. Adolescence is a time notable for brain development and MDD onset. In healthy adolescents, greater resting state vagal activity (RVA) is associated with lower cortical thickness. The relationship betwee...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy046
更新日期:2018-09-04 00:00:00