Abstract:
:Recent research on classical fear-conditioning in the anxiety disorders has identified overgeneralization of conditioned fear as an important conditioning correlate of anxiety pathology. Unfortunately, only one human neuroimaging study of classically conditioned fear generalization has been conducted, and the neural substrates of this clinically germane process remain largely unknown. The current generalization study employs a clinically validated generalization gradient paradigm, modified for the fMRI environment, to identify neural substrates of classically conditioned generalization that may function aberrantly in clinical anxiety. Stimuli include five rings of gradually increasing size with extreme sizes serving as cues of conditioned danger (CS+) and safety (CS-). The three intermediately sized rings serve as generalization stimuli (GSs) and create a continuum-of-size from CS+ to CS-. Results demonstrate 'positive' generalization gradients, reflected by declines in responding as the presented stimulus differentiates from CS+, in bilateral anterior insula, dorsomedial prefrontal cortex, and bilateral inferior parietal lobule. Conversely, 'negative' gradients, reflected by inclines in responding as the presented stimulus differentiates from CS+ were instantiated in bilateral ventral hippocampus, ventromedial prefrontal cortex and precuneus cortex. These results as well as those from connectivity analyses are discussed in relation to a working neurobiology of conditioned generalization centered on the hippocampus.
journal_name
Soc Cogn Affect Neuroscijournal_title
Social cognitive and affective neuroscienceauthors
Lissek S,Bradford DE,Alvarez RP,Burton P,Espensen-Sturges T,Reynolds RC,Grillon Cdoi
10.1093/scan/nst096subject
Has Abstractpub_date
2014-08-01 00:00:00pages
1134-42issue
8eissn
1749-5016issn
1749-5024pii
nst096journal_volume
9pub_type
杂志文章abstract::When subjects are required to reason about someone's false belief, a consistent pattern of brain regions are recruited including the medial prefrontal cortex, medial precuneus and bilateral temporo-parietal junction. Previous group analyses suggest that the two medial regions, but not the lateral regions, are also rec...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsl034
更新日期:2006-12-01 00:00:00
abstract::The role of ventromedial prefrontal cortex (vmPFC) in mental time travel toward the past and the future is debated. Here, patients with focal lesions to the vmPFC and brain-damaged and healthy controls mentally projected themselves to a past, present or future moment of subjective time (self-projection) and classified...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsaa163
更新日期:2020-12-31 00:00:00
abstract::Theory of mind (ToM), the capacity to reason about others' mental states, is central to healthy social development. Neural mechanisms supporting ToM may contribute to individual differences in children's social cognitive behavior. Employing a false belief functional magnetic resonance imaging paradigm, we identified p...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsz040
更新日期:2019-08-07 00:00:00
abstract::The frequency-tagging approach has generally been confined to study low-level sensory processes and always found related activation over the occipital region. Here for the first time, we investigated with it, high-level socio-cognitive functions, i.e. the processing of what other people are looking at which is referre...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx135
更新日期:2018-01-01 00:00:00
abstract::We investigated how visual and linguistic information interact in the perception of emotion. We borrowed a phenomenon from film theory which states that presentation of an as such neutral visual scene intensifies the percept of fear or suspense induced by a different channel of information, such as language. Our main ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsq050
更新日期:2011-09-01 00:00:00
abstract::Cognitive reappraisal and placebo administration constitute two different approaches for modulating one's own emotional state. Whereas reappraisal is an explicit (effortful) type of self-regulation, placebo treatment initiates implicit processes of affective control. The brain mechanisms underlying these processes hav...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsw144
更新日期:2017-03-01 00:00:00
abstract::Social closeness is a potent moderator of vicarious affect and specifically vicarious embarrassment. The neural pathways of how social closeness to another person affects our experience of vicarious embarrassment for the other's public flaws, failures and norm violations are yet unknown. To bridge this gap, we examine...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv130
更新日期:2016-03-01 00:00:00
abstract::European Americans value excitement more and calm less than Chinese. Within cultures, European Americans value excited and calm states similarly, whereas Chinese value calm more than excited states. To examine how these cultural differences influence people's immediate responses to excited vs calm facial expressions, ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv113
更新日期:2016-02-01 00:00:00
abstract::Despite robust associations between the ventral anterior cingulate cortex (vACC) and social evaluation, the role of vACC in social evaluation remains poorly understood. Two hypotheses have emerged from existing research: detection of positive valence and detection of opportunities for subjective reward. It has been di...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx132
更新日期:2018-01-01 00:00:00
abstract::Links between individual differences in risk processing and high-risk behaviors such as binge-drinking have long been the focus of active research. However, investigations in this area almost exclusively utilize decision-making focused paradigms. This emphasis makes it difficult to assess links between risk behaviors ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy038
更新日期:2018-06-01 00:00:00
abstract::Studies on culture-related differences in cognition have shown that Westerners attend more to object-related information, whereas East Asians attend more to contextual information. Neural correlates of these different culture-related visual processing styles have been reported in the ventral-visual and fronto-parietal...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsr077
更新日期:2013-02-01 00:00:00
abstract::Empathy has been supposed to be a proximate mechanism of altruistic behavior. We investigated whether empathy for pain drives actions without altruistic effects and how such actions modulate neural responses to others' pain. In two experiments, we asked healthy adults to press a button for no reason when viewing video...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx016
更新日期:2017-06-01 00:00:00
abstract::The human brain tracks dynamic changes within the social environment, forming and updating representations of individuals in our social milieu. This mechanism of social navigation builds an increasingly complex map of persons with whom we are familiar and form attachments to guide adaptive social behaviors. We examine...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx040
更新日期:2017-07-01 00:00:00
abstract::This study explores the fMRI correlates of observers making trait inferences about other people under conflicting social cues. Participants were presented with several behavioral descriptions involving an agent that implied a particular trait. The last behavior was either consistent or inconsistent with the previously...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsr064
更新日期:2012-11-01 00:00:00
abstract::In this article, we review three areas of research within adolescent social cognitive and affective neuroscience: (i) emotion reactivity and regulation, (ii) mentalizing and (iii) peer relations, including social rejection or acceptance as well as peer influence. The review provides a context for current contributions...
journal_title:Social cognitive and affective neuroscience
pub_type: 社论,评审
doi:10.1093/scan/nsr099
更新日期:2012-01-01 00:00:00
abstract::Humans have a fundamental need for strong interpersonal bonds, yet individuals differ appreciably in their degree of social integration. That these differences are also substantially heritable has spurred interest in biological mechanisms underlying the quality and quantity of individuals' social relationships. We pro...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu132
更新日期:2015-06-01 00:00:00
abstract::Recent approaches for understanding the neural basis of pain empathy emphasize the dynamic construction of networks underlying this multifaceted social cognitive process. Inter-subject phase synchronization (ISPS) is an approach for exploratory analysis of task-fMRI data that reveals brain networks dynamically synchro...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsaa025
更新日期:2020-05-11 00:00:00
abstract::The subjective and behavioral effects of intracranial electrical stimulation (iES) have been studied for decades, but there is a knowledge gap regarding the relationship between the magnitude of electric current and the type, intensity and valence of evoked subjective experiences. We report on rare iES data from 18 ne...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsz015
更新日期:2019-05-17 00:00:00
abstract::The present study used functional magnetic resonance imaging to investigate brain processes associated with the inhibition of socially undesirable speech. It is tested whether the inhibition of undesirable speech is solely related to brain areas associated with classical stop signal tasks or rather also involves brain...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsr030
更新日期:2012-04-01 00:00:00
abstract::This study investigated depression-related differences in primiparous mothers' neural response to their own infant's distress cues. Mothers diagnosed with major depressive disorder (n = 11) and comparison mothers with no diagnosable psychopathology (n = 11) were exposed to their own 18-months-old infant's cry sound, a...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsq091
更新日期:2012-02-01 00:00:00
abstract::Autism spectrum disorders (ASD) are often associated with impairments in judgment of facial expressions. This impairment is often accompanied by diminished eye contact and atypical amygdala responses to face stimuli. The current study used a within-subjects design to examine the effects of natural viewing and an exper...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst050
更新日期:2014-01-01 00:00:00
abstract::Individuals react differently to social experiences; for example, people who are more sensitive to negative social experiences, such as being excluded, may be more likely to adapt their behavior to fit in with others. We examined whether functional brain connectivity during social exclusion in the fMRI scanner can be ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy007
更新日期:2018-02-01 00:00:00
abstract::We tested two competing models for the brain basis of emotion, the basic emotion theory and the conceptual act theory of emotion, using resting-state functional connectivity magnetic resonance imaging (rs-fcMRI). The basic emotion view hypothesizes that anger, sadness, fear, disgust and happiness each arise from a bra...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv013
更新日期:2015-09-01 00:00:00
abstract::Though the functional neural correlates of impaired cognitive control and social dysfunction in autism spectrum disorders (ASD) have been delineated, brain regions implicated in poor cognitive control of social information is a novel area of autism research. We recently reported in a non-clinical sample that detection...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsp017
更新日期:2009-09-01 00:00:00
abstract::Emerging evidence indicates that mothers and non-mothers show different neurocognitive responses to infant stimuli. This study investigated mothers' psychophysiological, cognitive and neuronal responses to emotional infant stimuli. A total of 35 mothers with four months old infants and 18 control women without young c...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsab002
更新日期:2021-01-09 00:00:00
abstract::While abnormal processing of performance feedback has been associated with obsessive-compulsive disorder (OCD), neural responses to different kinds of feedback information, especially to ambiguous feedback are widely unknown. Using fMRI and a performance adaptive time-estimation task, we acquired blood oxygenation lev...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst095
更新日期:2014-08-01 00:00:00
abstract::Research has shown that thoughts of one's; own death (i.e. mortality salience; MS) increase aspects of intergroup bias. However, the extent to which MS influences neural activity underlying basic person perception processes has not been examined. In the current study, event-related brain potentials were used as measur...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsp041
更新日期:2010-03-01 00:00:00
abstract::Social information influences decision-making through an integration of information derived from individual experience with that derived from observing the actions of others. This raises the question as to which extent one should utilize social information. One strategy is to make use of uncertainty estimates, leading...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1093/scan/nst173
更新日期:2014-11-01 00:00:00
abstract::Research on the effects of media violence exposure has shown robust associations among violent media exposure, increased aggressive behavior, and decreased empathy. Preliminary research indicates that frequent players of violent video games may have differences in emotional and cognitive processes compared to infreque...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx115
更新日期:2017-12-01 00:00:00
abstract::Visual working memory (VWM) capacity is affected by motivational influences; however, little is known about how reward-related brain activities facilitate the VWM systems. To investigate the dynamic relationship between VWM- and reward-related brain activities, we conducted time-frequency analyses using electroencepha...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss027
更新日期:2013-06-01 00:00:00