Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system.

Abstract:

:In healthy individuals, direct eye contact initially leads to activation of a fast subcortical pathway, which then modulates a cortical route eliciting social cognitive processes. The aim of this study was to gain insight into the neurobiological effects of direct eye-to-eye contact using a virtual reality paradigm in individuals with posttraumatic stress disorder (PTSD) related to prolonged childhood abuse. We examined 16 healthy comparison subjects and 16 patients with a primary diagnosis of PTSD using a virtual reality functional magnetic resonance imaging paradigm involving direct vs averted gaze (happy, sad, neutral) as developed by Schrammel et al. in 2009. Irrespective of the displayed emotion, controls exhibited an increased blood oxygenation level-dependent response during direct vs averted gaze within the dorsomedial prefrontal cortex, left temporoparietal junction and right temporal pole. Under the same conditions, individuals with PTSD showed increased activation within the superior colliculus (SC)/periaqueductal gray (PAG) and locus coeruleus. Our findings suggest that healthy controls react to the exposure of direct gaze with an activation of a cortical route that enhances evaluative 'top-down' processes underlying social interactions. In individuals with PTSD, however, direct gaze leads to sustained activation of a subcortical route of eye-contact processing, an innate alarm system involving the SC and the underlying circuits of the PAG.

authors

Steuwe C,Daniels JK,Frewen PA,Densmore M,Pannasch S,Beblo T,Reiss J,Lanius RA

doi

10.1093/scan/nss105

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

88-97

issue

1

eissn

1749-5016

issn

1749-5024

pii

nss105

journal_volume

9

pub_type

杂志文章
  • A cry in the dark: depressed mothers show reduced neural activation to their own infant's cry.

    abstract::This study investigated depression-related differences in primiparous mothers' neural response to their own infant's distress cues. Mothers diagnosed with major depressive disorder (n = 11) and comparison mothers with no diagnosable psychopathology (n = 11) were exposed to their own 18-months-old infant's cry sound, a...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsq091

    authors: Laurent HK,Ablow JC

    更新日期:2012-02-01 00:00:00

  • Ventromedial prefrontal damage reduces mind-wandering and biases its temporal focus.

    abstract::Mind-wandering, an ubiquitous expression of humans' mental life, reflects a drift of attention away from the current task towards self-generated thoughts, and has been associated with activity in the brain default network. To date, however, little is understood about the contribution of individual nodes of this networ...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsw099

    authors: Bertossi E,Ciaramelli E

    更新日期:2016-11-01 00:00:00

  • From random to regular: neural constraints on the emergence of isochronous rhythm during cultural transmission.

    abstract::A core design feature of human communication systems and expressive behaviours is their temporal organization. The cultural evolutionary origins of this feature remain unclear. Here, we test the hypothesis that regularities in the temporal organization of signalling sequences arise in the course of cultural transmissi...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsy054

    authors: Lumaca M,Haumann NT,Vuust P,Brattico E,Baggio G

    更新日期:2018-09-05 00:00:00

  • Pictures of disgusting foods and disgusted facial expressions suppress the tongue motor cortex.

    abstract::The tongue holds a unique role in gustatory disgust. However, it is unclear whether the tongue representation in the motor cortex (tM1) is affected by the sight of distaste-related stimuli. Using transcranial magnetic stimulation (TMS) in healthy humans, we recorded tongue motor-evoked potentials (MEPs) as an index of...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsw129

    authors: Vicario CM,Rafal RD,Borgomaneri S,Paracampo R,Kritikos A,Avenanti A

    更新日期:2017-02-01 00:00:00

  • Putting race in context: social class modulates processing of race in the ventromedial prefrontal cortex and amygdala.

    abstract::A growing body of literature demonstrates that racial group membership can influence neural responses, e.g. when individuals perceive or interact with persons of another race. However, little attention has been paid to social class, a factor that interacts with racial inequalities in American society. We extend previo...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsx052

    authors: Firat RB,Hitlin S,Magnotta V,Tranel D

    更新日期:2017-08-01 00:00:00

  • Dissociable patterns of brain activity for mentalizing about known others: a role for attachment.

    abstract::The human brain tracks dynamic changes within the social environment, forming and updating representations of individuals in our social milieu. This mechanism of social navigation builds an increasingly complex map of persons with whom we are familiar and form attachments to guide adaptive social behaviors. We examine...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsx040

    authors: Laurita AC,Hazan C,Spreng RN

    更新日期:2017-07-01 00:00:00

  • Psychopathic traits are associated with cortical and subcortical volume alterations in healthy individuals.

    abstract::Research suggests psychopathy is associated with structural brain alterations that may contribute to the affective and interpersonal deficits frequently observed in individuals with high psychopathic traits. However, the regional alterations related to different components of psychopathy are still unclear. We used vox...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv062

    authors: Vieira JB,Ferreira-Santos F,Almeida PR,Barbosa F,Marques-Teixeira J,Marsh AA

    更新日期:2015-12-01 00:00:00

  • Elevated amygdala response to faces and gaze aversion in autism spectrum disorder.

    abstract::Autism spectrum disorders (ASD) are often associated with impairments in judgment of facial expressions. This impairment is often accompanied by diminished eye contact and atypical amygdala responses to face stimuli. The current study used a within-subjects design to examine the effects of natural viewing and an exper...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nst050

    authors: Tottenham N,Hertzig ME,Gillespie-Lynch K,Gilhooly T,Millner AJ,Casey BJ

    更新日期:2014-01-01 00:00:00

  • Add a picture for suspense: neural correlates of the interaction between language and visual information in the perception of fear.

    abstract::We investigated how visual and linguistic information interact in the perception of emotion. We borrowed a phenomenon from film theory which states that presentation of an as such neutral visual scene intensifies the percept of fear or suspense induced by a different channel of information, such as language. Our main ...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsq050

    authors: Willems RM,Clevis K,Hagoort P

    更新日期:2011-09-01 00:00:00

  • Amygdala response to negative images in postpartum vs nulliparous women and intranasal oxytocin.

    abstract::The neuroendocrine state of new mothers may alter their neural processing of stressors in the environment through modulatory actions of oxytocin on the limbic system. We predicted that amygdala sensitivity to negatively arousing stimuli would be suppressed in postpartum compared to nulliparous women and that this supp...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/scan/nss100

    authors: Rupp HA,James TW,Ketterson ED,Sengelaub DR,Ditzen B,Heiman JR

    更新日期:2014-01-01 00:00:00

  • Short-term meditation modulates brain activity of insight evoked with solution cue.

    abstract::Meditation has been shown to improve creativity in some situation. However, little is known about the brain systems underling insight into a problem when the person fails to solve the problem. Here, we examined the neural correlation using Chinese Remote Association Test, as a measure of creativity. We provide a solut...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsu032

    authors: Ding X,Tang YY,Cao C,Deng Y,Wang Y,Xin X,Posner MI

    更新日期:2015-01-01 00:00:00

  • Gender-specific expression of the DRD4 gene on adolescent delinquency, anger and thrill seeking.

    abstract::The present study investigated gender differences in the associations between the DRD4 variable number tandem repeat (VNTR) polymorphism and adolescent delinquency, short temper and thrill seeking. We also explored whether the gender-specific expression of the DRD4 can be explained by gender differences in the exposur...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsq020

    authors: Dmitrieva J,Chen C,Greenberger E,Ogunseitan O,Ding YC

    更新日期:2011-01-01 00:00:00

  • Neural correlates of effective and ineffective mood induction.

    abstract::Emotional reactivity and the ability to modulate an emotional state, which are important factors for psychological well-being, are often dysregulated in psychiatric disorders. Neural correlates of emotional states have mostly been studied at the group level, thereby neglecting individual differences in the intensity o...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nst055

    authors: Kohn N,Falkenberg I,Kellermann T,Eickhoff SB,Gur RC,Habel U

    更新日期:2014-06-01 00:00:00

  • Neural mechanisms underlying the integration of situational information into attribution outcomes.

    abstract::When forming impressions and trying to figure out why other people behave the way they do, we should take into account not only dispositional factors (i.e., personality traits) but also situational constraints as potential causes for a behavior. However, in their attributions, people often ignore the importance of sit...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nst019

    authors: Brosch T,Schiller D,Mojdehbakhsh R,Uleman JS,Phelps EA

    更新日期:2013-08-01 00:00:00

  • Developmental effects of aggressive behavior in male adolescents assessed with structural and functional brain imaging.

    abstract::Aggressive behavior is common during adolescence. Although aggression-related functional changes in the ventromedial prefrontal cortex (vmPFC) and frontopolar cortex (FPC) have been reported in adults, the neural correlates of aggressive behavior in adolescents, particularly in the context of structural neurodevelopme...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsp036

    authors: Strenziok M,Krueger F,Heinecke A,Lenroot RK,Knutson KM,van der Meer E,Grafman J

    更新日期:2011-01-01 00:00:00

  • Dual brain stimulation enhances interpersonal learning through spontaneous movement synchrony.

    abstract::Social interactive learning denotes the ability to acquire new information from a conspecific-a prerequisite for cultural evolution and survival. As inspired by recent neurophysiological research, here we tested whether social interactive learning can be augmented by exogenously synchronizing oscillatory brain activit...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsaa080

    authors: Pan Y,Novembre G,Song B,Zhu Y,Hu Y

    更新日期:2021-01-18 00:00:00

  • Mismatch or allostatic load? Timing of life adversity differentially shapes gray matter volume and anxious temperament.

    abstract::Traditionally, adversity was defined as the accumulation of environmental events (allostatic load). Recently however, a mismatch between the early and the later (adult) environment (mismatch) has been hypothesized to be critical for disease development, a hypothesis that has not yet been tested explicitly in humans. W...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv137

    authors: Kuhn M,Scharfenort R,Schümann D,Schiele MA,Münsterkötter AL,Deckert J,Domschke K,Haaker J,Kalisch R,Pauli P,Reif A,Romanos M,Zwanzger P,Lonsdorf TB

    更新日期:2016-04-01 00:00:00

  • When is giving an impulse? An ERP investigation of intuitive prosocial behavior.

    abstract::Human prosociality is often assumed to emerge from exerting reflective control over initial, selfish impulses. However, recent findings suggest that prosocial actions can also stem from processes that are fast, automatic and intuitive. Here, we attempt to clarify when prosocial behavior may be intuitive by examining p...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv077

    authors: Carlson RW,Aknin LB,Liotti M

    更新日期:2016-07-01 00:00:00

  • Inconsistencies in spontaneous and intentional trait inferences.

    abstract::This study explores the fMRI correlates of observers making trait inferences about other people under conflicting social cues. Participants were presented with several behavioral descriptions involving an agent that implied a particular trait. The last behavior was either consistent or inconsistent with the previously...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsr064

    authors: Ma N,Vandekerckhove M,Baetens K,Van Overwalle F,Seurinck R,Fias W

    更新日期:2012-11-01 00:00:00

  • Dynamic functional integration of distinct neural empathy systems.

    abstract::Recent evidence points to two separate systems for empathy: a vicarious sharing emotional system that supports our ability to share emotions and mental states and a cognitive system that involves cognitive understanding of the perspective of others. Several recent models offer new evidence regarding the brain regions ...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 社论

    doi:10.1093/scan/nst107

    authors: Shamay-Tsoory SG

    更新日期:2014-01-01 00:00:00

  • Neural evidence for an association between social proficiency and sensitivity to social reward.

    abstract::Data from developmental psychology suggests a link between the growth of socio-emotional competences and the infant's sensitivity to the salience of social stimuli. The aim of the present study was to find evidence for this relationship in healthy adults. Thirty-five participants were recruited based on their score ab...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nst033

    authors: Gossen A,Groppe SE,Winkler L,Kohls G,Herrington J,Schultz RT,Gründer G,Spreckelmeyer KN

    更新日期:2014-05-01 00:00:00

  • Situation and person attributions under spontaneous and intentional instructions: an fMRI study.

    abstract::This functional magnetic resonance imaging (fMRI) research explores how observers make causal beliefs about an event in terms of the person or situation. Thirty-four participants read various short descriptions of social events that implied either the person or the situation as the cause. Half of them were explicitly ...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nss022

    authors: Kestemont J,Vandekerckhove M,Ma N,Van Hoeck N,Van Overwalle F

    更新日期:2013-06-01 00:00:00

  • Novel response patterns during repeated presentation of affective and neutral stimuli.

    abstract::Repeated stimulus presentations are commonly used in social and affective neuroimaging tasks, but much remains to be known about how the brain processes such repetitions. Using functional magnetic resonance imaging, we found three groups of brain regions with distinct response patterns during repeated presentations of...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsw104

    authors: Satpute AB,Hanington L,Barrett LF

    更新日期:2016-12-01 00:00:00

  • Sustained happiness? Lack of repetition suppression in right-ventral visual cortex for happy faces.

    abstract::Emotional stimuli have been shown to preferentially engage initial attention but their sustained effects on neural processing remain largely unknown. The present study evaluated whether emotional faces engage sustained neural processing by examining the attenuation of neural repetition suppression to repeated emotiona...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsq058

    authors: Suzuki A,Goh JO,Hebrank A,Sutton BP,Jenkins L,Flicker BA,Park DC

    更新日期:2011-09-01 00:00:00

  • The neural components of empathy: predicting daily prosocial behavior.

    abstract::Previous neuroimaging studies on empathy have not clearly identified neural systems that support the three components of empathy: affective congruence, perspective-taking, and prosocial motivation. These limitations stem from a focus on a single emotion per study, minimal variation in amount of social context provided...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nss088

    authors: Morelli SA,Rameson LT,Lieberman MD

    更新日期:2014-01-01 00:00:00

  • A voxel-based lesion study on facial emotion recognition after penetrating brain injury.

    abstract::The ability to read emotions in the face of another person is an important social skill that can be impaired in subjects with traumatic brain injury (TBI). To determine the brain regions that modulate facial emotion recognition, we conducted a whole-brain analysis using a well-validated facial emotion recognition task...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nss041

    authors: Dal Monte O,Krueger F,Solomon JM,Schintu S,Knutson KM,Strenziok M,Pardini M,Leopold A,Raymont V,Grafman J

    更新日期:2013-08-01 00:00:00

  • Post-traumatic stress and age variation in amygdala volumes among youth exposed to trauma.

    abstract::Theoretically, normal developmental variation in amygdala volumes may be altered under conditions of severe stress. The purpose of this article was to examine whether posttraumatic stress moderates the association between age and amygdala volumes in youth exposed to traumatic events who are experiencing symptoms of po...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv053

    authors: Weems CF,Klabunde M,Russell JD,Reiss AL,Carrión VG

    更新日期:2015-12-01 00:00:00

  • Electrophysiological correlates of processing faces of younger and older individuals.

    abstract::The 'own-age bias' in face processing suggests that the age of a face constitutes one important factor that influences attention to and memory for faces. The present experiment investigated electrophysiological correlates of processing faces of younger and older individuals. Younger participants were presented with pi...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsq074

    authors: Ebner NC,He Y,Fichtenholtz HM,McCarthy G,Johnson MK

    更新日期:2011-09-01 00:00:00

  • An asymmetry in past and future mental time travel following vmPFC damage.

    abstract::The role of ventromedial prefrontal cortex (vmPFC) in mental time travel toward the past and the future is debated. Here, patients with focal lesions to the vmPFC and brain-damaged and healthy controls mentally projected themselves to a past, present or future moment of subjective time (self-projection) and classified...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsaa163

    authors: Ciaramelli E,Anelli F,Frassinetti F

    更新日期:2020-12-31 00:00:00

  • Reduced dorsal striatal gray matter volume predicts implicit suicidal ideation in adolescents.

    abstract::Suicidal ideation (SI), a potent risk factor for suicide attempts, increases in adolescence. While alterations in dopaminergic functioning have been implicated in suicidal acts-particularly in adults-we do not know whether morphological alterations in dopamine-rich regions of the brain, such as the striatum, are vulne...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsy089

    authors: Ho TC,Cichocki AC,Gifuni AJ,Catalina Camacho M,Ordaz SJ,Singh MK,Gotlib IH

    更新日期:2018-11-08 00:00:00