Reduced dorsal striatal gray matter volume predicts implicit suicidal ideation in adolescents.

Abstract:

:Suicidal ideation (SI), a potent risk factor for suicide attempts, increases in adolescence. While alterations in dopaminergic functioning have been implicated in suicidal acts-particularly in adults-we do not know whether morphological alterations in dopamine-rich regions of the brain, such as the striatum, are vulnerability factors for the emergence of SI in adolescents. At baseline, a community sample of 152 adolescents (89 female; mean age: 11.41 ± 1.01 years) completed a magnetic resonance imaging (MRI) scan that was used to estimate gray matter volumes (GMVs) of three striatal structures: caudate, nucleus accumbens and putamen. At a 24 month follow-up session, participants completed a self-report measure of SI frequency [Suicidal Ideation Questionnaire (SIQ)] and the death version of the Implicit Association Test (IAT). Robust linear regression models were conducted to predict SIQ and IAT scores from striatal GMV. Bilateral putamen and left caudate GMV significantly predicted IAT scores (all Ps < 0.03). No other associations were significant (all Ps > 0.05). Our finding of reduced dorsal striatal GMV predicting implicit SI may indicate that downstream dopaminergic dysfunction is implicated in the development of overt suicidal behaviors. Self-reported SI was not associated with striatal GMV, suggesting that biological correlates of suicide risk may correlate specifically with objective measurements of SI in adolescents.

authors

Ho TC,Cichocki AC,Gifuni AJ,Catalina Camacho M,Ordaz SJ,Singh MK,Gotlib IH

doi

10.1093/scan/nsy089

subject

Has Abstract

pub_date

2018-11-08 00:00:00

pages

1215-1224

issue

11

eissn

1749-5016

issn

1749-5024

pii

5106772

journal_volume

13

pub_type

杂志文章
  • Women are better at seeing faces where there are none: an ERP study of face pareidolia.

    abstract::Event-related potentials (ERPs) were recorded in 26 right-handed students while they detected pictures of animals intermixed with those of familiar objects, faces and faces-in-things (FITs). The face-specific N170 ERP component over the right hemisphere was larger in response to faces and FITs than to objects. The ver...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsw064

    authors: Proverbio AM,Galli J

    更新日期:2016-09-01 00:00:00

  • Temporal dynamics of spontaneous default-mode network activity mediate the association between reappraisal and depression.

    abstract::Cognitive reappraisal is associated with major depressive disorder (MDD), while spontaneous activity patterns of the default mode network (DMN) is implicated in reappraisal and MDD. However, neural mechanisms subserving the close association of spontaneous reappraisal and depression are unclear. Spontaneous reappraisa...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsy092

    authors: Gao W,Chen S,Biswal B,Lei X,Yuan J

    更新日期:2018-12-04 00:00:00

  • Confidence of emotion expression recognition recruits brain regions outside the face perception network.

    abstract::Metacognitive beliefs about emotions expressed by others are crucial to social life, yet very little studied. To what extent does our confidence in emotion expression recognition depend on perceptual or other non-perceptual information? We obtained behavioral and magnetic resonance imaging measures while participants ...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsy102

    authors: Bègue I,Vaessen M,Hofmeister J,Pereira M,Schwartz S,Vuilleumier P

    更新日期:2019-01-04 00:00:00

  • Inhibition of left anterior intraparietal sulcus shows that mutual adjustment marks dyadic joint-actions in humans.

    abstract::Creating real-life dynamic contexts to study interactive behaviors is a fundamental challenge for the social neuroscience of interpersonal relations. Real synchronic interpersonal motor interactions involve online, inter-individual mutual adaptation (the ability to adapt one's movements to those of another in order to...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsy022

    authors: Era V,Candidi M,Gandolfo M,Sacheli LM,Aglioti SM

    更新日期:2018-05-01 00:00:00

  • Amygdala response to negative images in postpartum vs nulliparous women and intranasal oxytocin.

    abstract::The neuroendocrine state of new mothers may alter their neural processing of stressors in the environment through modulatory actions of oxytocin on the limbic system. We predicted that amygdala sensitivity to negatively arousing stimuli would be suppressed in postpartum compared to nulliparous women and that this supp...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/scan/nss100

    authors: Rupp HA,James TW,Ketterson ED,Sengelaub DR,Ditzen B,Heiman JR

    更新日期:2014-01-01 00:00:00

  • Neural correlates of aberrant emotional salience predict psychotic symptoms and global functioning in high-risk and first-episode psychosis.

    abstract::Neurobiological and behavioral findings suggest that psychosis is associated with corticolimbic hyperactivity during the processing of emotional salience. This has not been widely studied in the early stages of psychosis, and the impact of these abnormalities on psychotic symptoms and global functioning is unknown. We...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv035

    authors: Modinos G,Tseng HH,Falkenberg I,Samson C,McGuire P,Allen P

    更新日期:2015-10-01 00:00:00

  • Autism is characterized by dorsal anterior cingulate hyperactivation during social target detection.

    abstract::Though the functional neural correlates of impaired cognitive control and social dysfunction in autism spectrum disorders (ASD) have been delineated, brain regions implicated in poor cognitive control of social information is a novel area of autism research. We recently reported in a non-clinical sample that detection...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsp017

    authors: Dichter GS,Felder JN,Bodfish JW

    更新日期:2009-09-01 00:00:00

  • Impaired inhibitory control in anorexia nervosa elicited by physical activity stimuli.

    abstract::Besides food restriction, hyperactivity is considered a key behavioral trait of anorexia nervosa (AN), playing a major role in the pathogenesis and progression of the disorder. However, the underlying neurophysiology remains poorly understood. We used functional magnetic resonance imaging during two affective go/no-go...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nst070

    authors: Kullmann S,Giel KE,Hu X,Bischoff SC,Teufel M,Thiel A,Zipfel S,Preissl H

    更新日期:2014-07-01 00:00:00

  • Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system.

    abstract::In healthy individuals, direct eye contact initially leads to activation of a fast subcortical pathway, which then modulates a cortical route eliciting social cognitive processes. The aim of this study was to gain insight into the neurobiological effects of direct eye-to-eye contact using a virtual reality paradigm in...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nss105

    authors: Steuwe C,Daniels JK,Frewen PA,Densmore M,Pannasch S,Beblo T,Reiss J,Lanius RA

    更新日期:2014-01-01 00:00:00

  • Multivariate neural biomarkers of emotional states are categorically distinct.

    abstract::Understanding how emotions are represented neurally is a central aim of affective neuroscience. Despite decades of neuroimaging efforts addressing this question, it remains unclear whether emotions are represented as distinct entities, as predicted by categorical theories, or are constructed from a smaller set of unde...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv032

    authors: Kragel PA,LaBar KS

    更新日期:2015-11-01 00:00:00

  • Theta resting EEG in the right TPJ is associated with individual differences in implicit intergroup bias.

    abstract::Why are some people more biased than others in their implicit evaluations during social interaction? The dispositional determinants of individual differences in implicit intergroup bias are poorly understood. Here, we explored whether such variability might be explained by stable neural traits. For that purpose, we us...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsz007

    authors: Schiller B,Gianotti LRR,Baumgartner T,Knoch D

    更新日期:2019-03-05 00:00:00

  • DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety.

    abstract::Behavioral inhibition (BI), a temperament characterized by vigilance to novelty, sensitivity to approach-withdrawal cues and social reticence in childhood, is associated with risk for anxiety in adolescence. Independent studies link reward hyper-responsivity to BI, adolescent anxiety and dopamine gene variants. This e...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nst001

    authors: Pérez-Edgar K,Hardee JE,Guyer AE,Benson BE,Nelson EE,Gorodetsky E,Goldman D,Fox NA,Pine DS,Ernst M

    更新日期:2014-04-01 00:00:00

  • The human mirror neuron system: a link between action observation and social skills.

    abstract::The discovery of the mirror neuron system (MNS) has led researchers to speculate that this system evolved from an embodied visual recognition apparatus in monkey to a system critical for social skills in humans. It is accepted that the MNS is specialized for processing animate stimuli, although the degree to which soc...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsl022

    authors: Oberman LM,Pineda JA,Ramachandran VS

    更新日期:2007-03-01 00:00:00

  • Cognitive influences on the affective representation of touch and the sight of touch in the human brain.

    abstract::We show that the affective experience of touch and the sight of touch can be modulated by cognition, and investigate in an fMRI study where top-down cognitive modulations of bottom-up somatosensory and visual processing of touch and its affective value occur in the human brain. The cognitive modulation was produced by...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsn005

    authors: McCabe C,Rolls ET,Bilderbeck A,McGlone F

    更新日期:2008-06-01 00:00:00

  • Cultural differences in the visual processing of meaning: detecting incongruities between background and foreground objects using the N400.

    abstract::East Asians have been found to allocate relatively greater attention to background objects, whereas European Americans have been found to allocate relatively greater attention to foreground objects. This is well documented across a variety of cognitive measures. We used a modification of the Ganis and Kutas (2003) N40...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsp038

    authors: Goto SG,Ando Y,Huang C,Yee A,Lewis RS

    更新日期:2010-06-01 00:00:00

  • Brain structural thickness and resting state autonomic function in adolescents with major depression.

    abstract::Major depressive disorder (MDD) has been associated with abnormalities in cortical thickness and autonomic function. Adolescence is a time notable for brain development and MDD onset. In healthy adolescents, greater resting state vagal activity (RVA) is associated with lower cortical thickness. The relationship betwee...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsy046

    authors: Koenig J,Westlund Schreiner M,Klimes-Dougan B,Ubani B,Mueller B,Kaess M,Cullen KR

    更新日期:2018-09-04 00:00:00

  • Psychopathic traits are associated with cortical and subcortical volume alterations in healthy individuals.

    abstract::Research suggests psychopathy is associated with structural brain alterations that may contribute to the affective and interpersonal deficits frequently observed in individuals with high psychopathic traits. However, the regional alterations related to different components of psychopathy are still unclear. We used vox...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv062

    authors: Vieira JB,Ferreira-Santos F,Almeida PR,Barbosa F,Marques-Teixeira J,Marsh AA

    更新日期:2015-12-01 00:00:00

  • Altered emotional and BOLD responses to negative, positive and ambiguous performance feedback in OCD.

    abstract::While abnormal processing of performance feedback has been associated with obsessive-compulsive disorder (OCD), neural responses to different kinds of feedback information, especially to ambiguous feedback are widely unknown. Using fMRI and a performance adaptive time-estimation task, we acquired blood oxygenation lev...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nst095

    authors: Becker MP,Nitsch AM,Schlösser R,Koch K,Schachtzabel C,Wagner G,Miltner WH,Straube T

    更新日期:2014-08-01 00:00:00

  • Neural dynamics of social tie formation in economic decision-making.

    abstract::The disposition for prosocial conduct, which contributes to cooperation as arising during social interaction, requires cortical network dynamics responsive to the development of social ties, or care about the interests of specific interaction partners. Here, we formulate a dynamic computational model that accurately p...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsu138

    authors: Bault N,Pelloux B,Fahrenfort JJ,Ridderinkhof KR,van Winden F

    更新日期:2015-06-01 00:00:00

  • Amygdala activation during reading of emotional adjectives--an advantage for pleasant content.

    abstract::This event-related functional magnetic resonance imaging (fMRI) study investigated brain activity elicited by emotional adjectives during silent reading without specific processing instructions. Fifteen healthy volunteers were asked to read a set of randomly presented high-arousing emotional (pleasant and unpleasant) ...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsn027

    authors: Herbert C,Ethofer T,Anders S,Junghofer M,Wildgruber D,Grodd W,Kissler J

    更新日期:2009-03-01 00:00:00

  • Mindfulness disposition and default-mode network connectivity in older adults.

    abstract::An extensive body of research defines the default-mode network (DMN) to be one of the critical networks of the human brain, playing a pivotal functional role in processes of internal mentation. Alterations in the connectivity of this network as a function of aging have been found, with reductions associated with funct...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nss115

    authors: Shaurya Prakash R,De Leon AA,Klatt M,Malarkey W,Patterson B

    更新日期:2013-01-01 00:00:00

  • Sending mixed signals: worry is associated with enhanced initial error processing but reduced call for subsequent cognitive control.

    abstract::Worry is reliably associated with overactive action-monitoring processes as measured by the error-related negativity (ERN). However, worry is not associated with error-related behavioral adjustments which are typically used to infer increased cognitive control following errors. We hypothesized that this disconnect bet...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv046

    authors: Moran TP,Bernat EM,Aviyente S,Schroder HS,Moser JS

    更新日期:2015-11-01 00:00:00

  • The functional role of ventral anterior cingulate cortex in social evaluation: disentangling valence from subjectively rewarding opportunities.

    abstract::Despite robust associations between the ventral anterior cingulate cortex (vACC) and social evaluation, the role of vACC in social evaluation remains poorly understood. Two hypotheses have emerged from existing research: detection of positive valence and detection of opportunities for subjective reward. It has been di...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsx132

    authors: Rigney AE,Koski JE,Beer JS

    更新日期:2018-01-01 00:00:00

  • Electrophysiological correlates of processing faces of younger and older individuals.

    abstract::The 'own-age bias' in face processing suggests that the age of a face constitutes one important factor that influences attention to and memory for faces. The present experiment investigated electrophysiological correlates of processing faces of younger and older individuals. Younger participants were presented with pi...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsq074

    authors: Ebner NC,He Y,Fichtenholtz HM,McCarthy G,Johnson MK

    更新日期:2011-09-01 00:00:00

  • Add a picture for suspense: neural correlates of the interaction between language and visual information in the perception of fear.

    abstract::We investigated how visual and linguistic information interact in the perception of emotion. We borrowed a phenomenon from film theory which states that presentation of an as such neutral visual scene intensifies the percept of fear or suspense induced by a different channel of information, such as language. Our main ...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsq050

    authors: Willems RM,Clevis K,Hagoort P

    更新日期:2011-09-01 00:00:00

  • Mismatch or allostatic load? Timing of life adversity differentially shapes gray matter volume and anxious temperament.

    abstract::Traditionally, adversity was defined as the accumulation of environmental events (allostatic load). Recently however, a mismatch between the early and the later (adult) environment (mismatch) has been hypothesized to be critical for disease development, a hypothesis that has not yet been tested explicitly in humans. W...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv137

    authors: Kuhn M,Scharfenort R,Schümann D,Schiele MA,Münsterkötter AL,Deckert J,Domschke K,Haaker J,Kalisch R,Pauli P,Reif A,Romanos M,Zwanzger P,Lonsdorf TB

    更新日期:2016-04-01 00:00:00

  • The integration of facial and vocal cues during emotional change perception: EEG markers.

    abstract::The ability to detect emotional changes is of primary importance for social living. Though emotional signals are often conveyed by multiple modalities, how emotional changes in vocal and facial modalities integrate into a unified percept has yet to be directly investigated. To address this issue, we asked participants...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsv083

    authors: Chen X,Pan Z,Wang P,Yang X,Liu P,You X,Yuan J

    更新日期:2016-07-01 00:00:00

  • Perceiving actions before they happen:Psychological dimensions scaffold neural action prediction.

    abstract::The social world buzzes with action. People constantly walk, talk, eat, work, play, snooze, and so on. To interact with others successfully, we need to both understand their current actions and predict their future actions. Here we used functional neuroimaging to test the hypothesis that people do both at the same tim...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsaa126

    authors: Thornton MA,Tamir DI

    更新日期:2020-09-28 00:00:00

  • Behavioral and neuronal determinants of negative reciprocity in the ultimatum game.

    abstract::The rejection of unfair offers in the ultimatum game (UG) indicates negative reciprocity. The model of strong reciprocity claims that negative reciprocity reflects prosociality because the rejecting individual is sacrificing resources in order to punish unfair behavior. However, a recent study found that the rejection...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsw069

    authors: Kaltwasser L,Hildebrandt A,Wilhelm O,Sommer W

    更新日期:2016-10-01 00:00:00

  • Hippocampal Subfields Alterations in Paediatric Patients with Post-Traumatic Stress Disorder.

    abstract::The hippocampus, a key structure with distinct subfield functions, is strongly implicated in the pathophysiology of post-traumatic stress disorder (PTSD); however, few studies of hippocampus subfields in PTSD have focused on paediatric patients. We therefore investigated hippocampal subfield volume using an automated ...

    journal_title:Social cognitive and affective neuroscience

    pub_type: 杂志文章

    doi:10.1093/scan/nsaa162

    authors: Li L,Pan N,Zhang L,Lui S,Huang X,Xu X,Wang S,Lei D,Li L,Kemp GJ,Gong Q

    更新日期:2020-12-14 00:00:00