Abstract:
:Suicidal ideation (SI), a potent risk factor for suicide attempts, increases in adolescence. While alterations in dopaminergic functioning have been implicated in suicidal acts-particularly in adults-we do not know whether morphological alterations in dopamine-rich regions of the brain, such as the striatum, are vulnerability factors for the emergence of SI in adolescents. At baseline, a community sample of 152 adolescents (89 female; mean age: 11.41 ± 1.01 years) completed a magnetic resonance imaging (MRI) scan that was used to estimate gray matter volumes (GMVs) of three striatal structures: caudate, nucleus accumbens and putamen. At a 24 month follow-up session, participants completed a self-report measure of SI frequency [Suicidal Ideation Questionnaire (SIQ)] and the death version of the Implicit Association Test (IAT). Robust linear regression models were conducted to predict SIQ and IAT scores from striatal GMV. Bilateral putamen and left caudate GMV significantly predicted IAT scores (all Ps < 0.03). No other associations were significant (all Ps > 0.05). Our finding of reduced dorsal striatal GMV predicting implicit SI may indicate that downstream dopaminergic dysfunction is implicated in the development of overt suicidal behaviors. Self-reported SI was not associated with striatal GMV, suggesting that biological correlates of suicide risk may correlate specifically with objective measurements of SI in adolescents.
journal_name
Soc Cogn Affect Neuroscijournal_title
Social cognitive and affective neuroscienceauthors
Ho TC,Cichocki AC,Gifuni AJ,Catalina Camacho M,Ordaz SJ,Singh MK,Gotlib IHdoi
10.1093/scan/nsy089subject
Has Abstractpub_date
2018-11-08 00:00:00pages
1215-1224issue
11eissn
1749-5016issn
1749-5024pii
5106772journal_volume
13pub_type
杂志文章abstract::Research has shown that thoughts of one's; own death (i.e. mortality salience; MS) increase aspects of intergroup bias. However, the extent to which MS influences neural activity underlying basic person perception processes has not been examined. In the current study, event-related brain potentials were used as measur...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsp041
更新日期:2010-03-01 00:00:00
abstract::Synchronous movement is a key component of social behaviour in several species including humans. Recent theories have suggested a link between interpersonal synchrony of brain oscillations and interpersonal movement synchrony. The present study investigated this link. Using transcranial alternating current stimulation...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsw172
更新日期:2017-01-24 00:00:00
abstract::Approach, avoidance and the supervisory control system are fundamental to human behavior. Much past research has examined the neurophysiological models relating trait approach and avoidance. Using measures of electroencephalographic (EEG) frontal asymmetry, trait approach has been associated with greater left-frontal ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv017
更新日期:2015-10-01 00:00:00
abstract::Intranasal oxytocin (OT) has previously been found to increase spirituality, an effect moderated by OT-related genotypes. This pre-registered study sought to conceptually replicate and extend those findings. Using a single dose of intranasal OT vs placebo (PL), we investigated experimental treatment effects, and moder...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy068
更新日期:2018-09-11 00:00:00
abstract::Early life stress has been associated with disrupted functional connectivity between the amygdala and medial prefrontal cortex (mPFC), but it is unknown how early in development stress-related differences in amygdala-mPFC connectivity emerge. In a resting-state functional connectivity (rs-FC) analysis with 79 four- to...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsy017
更新日期:2018-04-01 00:00:00
abstract::Humans have a fundamental need for strong interpersonal bonds, yet individuals differ appreciably in their degree of social integration. That these differences are also substantially heritable has spurred interest in biological mechanisms underlying the quality and quantity of individuals' social relationships. We pro...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsu132
更新日期:2015-06-01 00:00:00
abstract::This functional magnetic resonance imaging (fMRI) research explores how observers make causal beliefs about an event in terms of the person or situation. Thirty-four participants read various short descriptions of social events that implied either the person or the situation as the cause. Half of them were explicitly ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss022
更新日期:2013-06-01 00:00:00
abstract::Aversive social learning experiences might play a significant role in the aetiology of social anxiety disorder. Therefore, we investigated emotional learning and unlearning processes in healthy humans using a social conditioning paradigm. Forty-nine healthy subjects participated in a 2-day fMRI differential conditioni...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsr095
更新日期:2013-03-01 00:00:00
abstract::The accurate estimation of the proximity of threat is important for biological survival and to assess relevant events of everyday life. We addressed the question of whether proximal as compared with distal vocal threat would lead to a perceptual advantage for the perceiver. Accordingly, we sought to highlight the neur...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsw004
更新日期:2016-05-01 00:00:00
abstract::A growing body of literature demonstrates that racial group membership can influence neural responses, e.g. when individuals perceive or interact with persons of another race. However, little attention has been paid to social class, a factor that interacts with racial inequalities in American society. We extend previo...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx052
更新日期:2017-08-01 00:00:00
abstract::This study investigated depression-related differences in primiparous mothers' neural response to their own infant's distress cues. Mothers diagnosed with major depressive disorder (n = 11) and comparison mothers with no diagnosable psychopathology (n = 11) were exposed to their own 18-months-old infant's cry sound, a...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsq091
更新日期:2012-02-01 00:00:00
abstract::Besides food restriction, hyperactivity is considered a key behavioral trait of anorexia nervosa (AN), playing a major role in the pathogenesis and progression of the disorder. However, the underlying neurophysiology remains poorly understood. We used functional magnetic resonance imaging during two affective go/no-go...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst070
更新日期:2014-07-01 00:00:00
abstract::East Asians have been found to allocate relatively greater attention to background objects, whereas European Americans have been found to allocate relatively greater attention to foreground objects. This is well documented across a variety of cognitive measures. We used a modification of the Ganis and Kutas (2003) N40...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsp038
更新日期:2010-06-01 00:00:00
abstract::Traditionally, adversity was defined as the accumulation of environmental events (allostatic load). Recently however, a mismatch between the early and the later (adult) environment (mismatch) has been hypothesized to be critical for disease development, a hypothesis that has not yet been tested explicitly in humans. W...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv137
更新日期:2016-04-01 00:00:00
abstract::Behavioral research has demonstrated an advantage for females compared with males in social information processing. However, little is known about sex-related differences in brain activation during understanding of self and others. In the current functional magnetic resonance imaging study, this was assessed in late a...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst015
更新日期:2014-04-01 00:00:00
abstract::Autism spectrum disorders (ASD) are often associated with impairments in judgment of facial expressions. This impairment is often accompanied by diminished eye contact and atypical amygdala responses to face stimuli. The current study used a within-subjects design to examine the effects of natural viewing and an exper...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nst050
更新日期:2014-01-01 00:00:00
abstract::The eyes provide important information for decoding the mental states of others. In this fMRI study we examined how reading the mind in the eyes develops across adolescence and we tested the developmental trajectories of brain regions involved in this basic perceptual mind-reading ability. Participants from three age ...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsr020
更新日期:2012-01-01 00:00:00
abstract::Using functional magnetic resonance imaging, we investigated neural activity associated with self-reflection in depressed [current major depressive episode (MDE)] and healthy control participants, focusing on medial cortex areas previously shown to be associated with self-reflection. Both the MDE and healthy control g...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsp022
更新日期:2009-12-01 00:00:00
abstract::In healthy individuals, direct eye contact initially leads to activation of a fast subcortical pathway, which then modulates a cortical route eliciting social cognitive processes. The aim of this study was to gain insight into the neurobiological effects of direct eye-to-eye contact using a virtual reality paradigm in...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss105
更新日期:2014-01-01 00:00:00
abstract::Individuals with autism spectrum disorders (ASD) have documented deficits in face processing, face memory and abnormal activation of the neural circuitry that supports these functions. To examine speed of processing of faces in ASD, high density event-related brain potentials were recorded to images of faces, inverted...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsp002
更新日期:2012-06-01 00:00:00
abstract::Research has illustrated that the brain regions implicated in moral cognition comprise a robust and broadly distributed network. However, understanding how these brain regions interact and give rise to the complex interplay of cognitive processes underpinning human moral cognition is still in its infancy. We used func...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss139
更新日期:2014-03-01 00:00:00
abstract::Worry is reliably associated with overactive action-monitoring processes as measured by the error-related negativity (ERN). However, worry is not associated with error-related behavioral adjustments which are typically used to infer increased cognitive control following errors. We hypothesized that this disconnect bet...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv046
更新日期:2015-11-01 00:00:00
abstract::'Social brain' circuitry has recently been implicated in processing slow, gentle touch targeting a class of slow-conducting, unmyelinated nerves, CT afferents, which are present only in the hairy skin of mammals. Given the importance of such 'affective touch' in social relationships, the current functional magnetic re...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss009
更新日期:2013-04-01 00:00:00
abstract::Emotional stimuli have been shown to preferentially engage initial attention but their sustained effects on neural processing remain largely unknown. The present study evaluated whether emotional faces engage sustained neural processing by examining the attenuation of neural repetition suppression to repeated emotiona...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsq058
更新日期:2011-09-01 00:00:00
abstract::Despite the risks, people enjoy giving advice. One explanation is that giving beneficial advice can result in reflected glory, ego boosts or reputation enhancement. However, giving poor advice can be socially harmful (being perceived as incompetent or untrustworthy). In both circumstances, we have a vested interest in...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv020
更新日期:2015-10-01 00:00:00
abstract::While a persuasion network has been proposed, little is known about how network connections between brain regions contribute to attitude change. Two possible mechanisms have been advanced. One hypothesis predicts that attitude change results from increased connectivity between structures implicated in affective and ex...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsx126
更新日期:2017-12-01 00:00:00
abstract::Substantial research links economic adversity to poor coping in stressful or threatening environments. Neuroimaging studies suggest that activation of the right ventrolateral prefrontal cortex (rVLPFC) plays a key role in self-control, and it seems that individual differences in neurocognitive systems underlying self-...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nss039
更新日期:2013-08-01 00:00:00
abstract::Studies of human fear learning suggest that a reliable discrimination between safe and threatening stimuli is important for survival and mental health. In the current study, we applied the subsequent memory paradigm in order to identify neurophysiological correlates of successful threat and safety learning. We recorde...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsab015
更新日期:2021-02-01 00:00:00
abstract::Understanding how emotions are represented neurally is a central aim of affective neuroscience. Despite decades of neuroimaging efforts addressing this question, it remains unclear whether emotions are represented as distinct entities, as predicted by categorical theories, or are constructed from a smaller set of unde...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv032
更新日期:2015-11-01 00:00:00
abstract::Theoretically, normal developmental variation in amygdala volumes may be altered under conditions of severe stress. The purpose of this article was to examine whether posttraumatic stress moderates the association between age and amygdala volumes in youth exposed to traumatic events who are experiencing symptoms of po...
journal_title:Social cognitive and affective neuroscience
pub_type: 杂志文章
doi:10.1093/scan/nsv053
更新日期:2015-12-01 00:00:00