Abstract:
:The gut microbiome has tremendous potential to impact health and disease. Various environmental toxicants, including insecticides, have been shown to alter gut microbiome community structures. However, the mechanism that compositionally and functionally regulates gut microbiota remains unclear. Quorum sensing is known to modulate intra- and interspecies gene expression and coordinate population responses. It is unknown whether quorum sensing is disrupted when environmental toxicants cause perturbations in the gut microbiome community structure. To reveal the response of the quorum-sensing system to environmental exposure, we use a combination of Illumina-based 16S rRNA gene amplicon and shotgun metagenome sequencing to examine the impacts of a widely used organophosphate insecticide, malathion, on the gut microbiome trajectory, quorum sensing system and behaviors related to quorum sensing, such as motility and pathogenicity. Our results demonstrated that malathion perturbed the gut microbiome development, quorum sensing and quorum sensing related behaviors. These findings may provide a novel mechanistic understanding of the role of quorum-sensing in the gut microbiome toxicity of malathion.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Gao B,Chi L,Tu P,Bian X,Thomas J,Ru H,Lu Kdoi
10.1016/j.toxlet.2017.10.023subject
Has Abstractpub_date
2018-02-01 00:00:00pages
52-57eissn
0378-4274issn
1879-3169pii
S0378-4274(17)31446-7journal_volume
283pub_type
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