Abstract:
:When Fc receptors (FcR) on normal human peripheral blood lymphocytes were induced to modulate by overnight (18 h) incubation in the presence of soluble or particulate immune complexes, the natural killer (NK) activity of the effector lymphocyte suspension, as measured against the K562 erythroleukemia cell line, was significantly, but only partially, inhibited. The NK activity which remained was always strong, and was not significantly inhibited by inclusion of antigen-antibody complexes in the cytotoxicity assay, nor was it further depleted by adsorbing the modulated cells on plastic surfaces coated with immobilized antigen-antibody complexes. Antibody-dependent cell-mediated cytotoxicity (ADCC) against rabbit antibody-sensitized Chang liver cells was totally abrogated following the modulation process, and could not be restored by exposure of modulated effector cells to trypsin, indicating that the FcR had actually been shed and were not merely being blocked with immune complexes. Although freshly isolated peripheral blood lymphocytes active in natural (or "spontaneous") cytotoxicity have been shown to bear FcR, our data indicate that NK activity against the K562 cell line can be effectively mediated by NK cells which have lost their FcR. This supports the concept that NK activity against K562 is independent of FcR, and, therefore, of IgG.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Kay HD,Fagnani R,Bonnard GDdoi
10.1002/ijc.2910240204subject
Has Abstractpub_date
1979-08-01 00:00:00pages
141-50issue
2eissn
0020-7136issn
1097-0215journal_volume
24pub_type
杂志文章abstract::Family history (FH) of lung cancer is an established risk factor for lung cancer, but the modifying effect of smoking in relatives has been rarely examined. Also, the role of FH of nonmalignant lung diseases on lung cancer risk is not well known. We examined the role of FH of cancer and nonmalignant lung diseases in l...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.24283
更新日期:2009-07-01 00:00:00
abstract::Evidence has accumulated that, in addition to the MDR1 gene-coded P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP) also mediates the multidrug resistance (MDR) of various human tumors. In the case of gastric cancer, there is little or no involvement of P-glycoprotein, and the mechanisms of MDR remai...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19961104)68:3<372::AID-IJC
更新日期:1996-11-04 00:00:00
abstract::Our aim was to compare the occurrence and prognostic significance over 14-20 years of immunocytochemically detected S100A4 and other tumour variables in primary tumours from 349 patients with operable breast cancer. For a cut-off of 1% staining of the malignant cells, the antibody to S100A4 stains positively 56% of th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-20 00:00:00
abstract::Cetuximab in combination with an irinotecan-containing regimen is a standard treatment in patients with KRAS wild-type (KRAS WT), metastatic colorectal cancer (mCRC). We investigated the addition of the oral MET inhibitor tivantinib to cetuximab + irinotecan (CETIRI) based on preclinical evidence that activation of th...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.30049
更新日期:2016-07-01 00:00:00
abstract::Management of oral leukoplakia-a potentially malignant disorder-is currently not evidence-based. Of the few randomized trials that have been reported, most have negative data. Therefore, a multi-centre, randomized, double-blind controlled trial (RCT) was undertaken to evaluate the use of low-dose beta-carotene combine...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ijc.29156
更新日期:2015-04-01 00:00:00
abstract::Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are important enzymes of DNA de novo synthesis and the salvage pathway in cancer cells, respectively. Intratumoral TS and DPD gene expressions were evaluated to determine the correlation between the expression of the 2 genes in both normal stromal tis...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20511
更新日期:2004-12-20 00:00:00
abstract::Southern blot analyses of surgical specimens of cervical carcinoma from Japanese patients showed that 3/9 samples contained human papillomavirus (HPV) type-16 DNA sequences, and 2 contained HPV type-18 DNA sequences. By Northern blot analyses, RNA transcripts of HPV DNA sequences were demonstrated in some of the tissu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370405
更新日期:1986-04-15 00:00:00
abstract::The growth of a spontaneous adenocarcinoma (ADK-1t) of BALB/c mice (H-2d, MIsb) induces progressive hyporesponsiveness of spleen cells stimulated with PHA or irradiated leukocytes from DBA/2 strain (H-2d, MIsa) in mixed leukocyte culture. This hyporesponsiveness is due to the suppressor activity of macrophage-like cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290616
更新日期:1982-06-15 00:00:00
abstract::Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subseq...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30790
更新日期:2017-09-01 00:00:00
abstract::A new non peptidic farnesyltransferase inhibitor, RPR-115135, in combination with 5-FU was studied in 10 human colon cancer cell lines (HCT-116, RKO, DLD-1, Colo-320, LoVo, SW-620, HT-29, HCT-15, Colo-205 and KM-12) carrying several mutations but well characterized for p53 and Ras status. We found that there was a sli...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10461
更新日期:2002-07-20 00:00:00
abstract::Human papillomavirus (HPV) is now recognised as a major aetiological agent in the pathogenesis of oropharyngeal carcinoma (OPC). HPV-positive tumours are associated with better outcomes compared to HPV-negative tumours, possibly due to differences in their aetiology and/or the tumour microenvironment. Increased number...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31852
更新日期:2019-01-15 00:00:00
abstract::Evidence from epidemiologic studies suggests a possible role of exogenous and endogenous hormones in colorectal carcinogenesis in women. However, with respect to exogenous hormones, in contrast to hormone replacement therapy, few cohort studies have examined oral contraceptive use in relation to colorectal cancer risk...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23079
更新日期:2008-02-01 00:00:00
abstract::The survival experience of 284 patients with cancer of the cervix uteri registered by the population-based Zimbabwe National Cancer Registry in 1995-1997 is described. The vital status of these subjects was established by linkage with death registration and by retrieval of patient files from medical records department...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11670
更新日期:2004-03-20 00:00:00
abstract::Hamster embryos were exposed in utero to the action of sodium nitrite (NaNO2) and morpholine (Mo) administered simultaneously by stomach tube to the mothers on the 11th or 12th day of pregnancy. Embryo cells were examined for chromosomal aberrations, micronuclear formation, morphological or malignant transformation an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910240316
更新日期:1979-09-15 00:00:00
abstract::The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and BRAF mutation. Genome-wide hypomethylation may also play an important role in genomic instability. However, the relation between global DN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23470
更新日期:2008-06-15 00:00:00
abstract::Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.31338
更新日期:2018-10-01 00:00:00
abstract::Normal transcription displays a high degree of flexibility over the choice, timing and magnitude of mRNA expression levels that tend to oscillate and cycle. These processes allow for combinatorial actions, feedback control and fine-tuning. A central role has emerged for the transcriptional co-repressor proteins such a...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.25181
更新日期:2010-06-01 00:00:00
abstract::Screening for cancer has to be carefully organized for maximum effectiveness, and introduced in full understanding of the natural history of the disease. There are major potential harms as well as benefits from screening. The current state of art for breast, cervix and prostate cancer screening is reviewed, only for b...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.25081
更新日期:2010-03-01 00:00:00
abstract::Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960703)67:1<24::AID-IJC6
更新日期:1996-07-03 00:00:00
abstract::The association between Lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n = 13,100) were identified from the Finnish Hospital Discharge Registry from 1969-2012. These patients were linked with sub...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31025
更新日期:2018-01-01 00:00:00
abstract::China was one of the countries with the highest esophagus cancer risk in the world during the 1970s. This report provides data on time trends of esophagus cancer incidence and mortality during the 1970s-90s in selected geographic areas of China. Information on newly diagnosed cancer cases and cancer deaths is based on...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10706
更新日期:2002-11-20 00:00:00
abstract::A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350107
更新日期:1985-01-15 00:00:00
abstract::Corpus uteri cancer is the most common gynecological malignancy in most developed countries. The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy-corrected mortality rates of corpus uteri cancer, overall and stratif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33219
更新日期:2021-02-01 00:00:00
abstract::This large population-based study compared breast-conserving surgery with radiation therapy (BCT) with mastectomy on (long-term) breast cancer-specific (BCSS) and overall survival (OS), and investigated the influence of several prognostic factors. Patients with primary T1-2N0-2M0 breast cancer, diagnosed between 1999 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31034
更新日期:2018-01-01 00:00:00
abstract::Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen-detected cancer (SDC). In this case-case study, we investigated whether the size of longitudinal fluctuations in mammographic percent density (PD fluctuation) was associated with the ratio of IC versus SDC among screened women...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30427
更新日期:2017-01-01 00:00:00
abstract::Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12ql3-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathol...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960904)67:5<632::AID-IJC
更新日期:1996-09-04 00:00:00
abstract::A 30-kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian compared to European descent. This polymorphism creates a chimera with the APOBEC3A (A3A) coding region and A3B 3'UTR, and is associated with an increased risk for breast cancer in Asian women. Here, we explo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33463
更新日期:2021-01-07 00:00:00
abstract::The epidemiologic association between physical activity and breast cancer has been corroborated in many studies. Some inconsistencies remain, possibly due to variation in life periods for exposure assessment, confounding and undetected effect modification. In our cohort study, we address some of these questions by tak...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10447
更新日期:2002-07-01 00:00:00
abstract::A human ovarian adenocarcinoma cell line (PE04) has been established as a xenograft in nude mice. In vitro, this cell line is estrogen receptor (ER)-positive and its growth is stimulated by 17 beta-estradiol at concentrations between 10(-12) and 10(-6) M. When xenografted, PE04 cells remain ER-positive and also posses...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550323
更新日期:1993-09-30 00:00:00
abstract::In this report, we quantified HTLV-I provirus load using the AmpliSensor system, which utilizes fluorescence to measure PCR products. With this method, provirus loads could be measured within 6 hr, and the results obtained correlated well with those obtained by other methods. Samples from 256 blood donors, who were po...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990611)81:6<859::aid-ijc
更新日期:1999-06-11 00:00:00