Abstract:
PURPOSE:Staphylococcus aureus bloodstream infections (SA BSI) are associated with substantial mortality. The rapid emergence of methicillin-resistant S. aureus (MRSA), known to be associated with worse outcome, may blur advances made regarding mortality attributed to SA BSI caused by methicillin-sensitive S. aureus (MSSA) strains. In the unusual setting of a very low MRSA prevalence institution, we investigated incidence, mortality and trends of BSI caused by MSSA over the last 20 years. OBJECTIVE:To evaluate and demonstrate trends in incidence and mortality of MSSA BSI as well as risk factors for mortality. METHODS:Retrospective, observational analysis of the prospective bloodstream infection cohort at the University Hospital Basel between January 1993 and December 2013. All patients with blood cultures positive for MSSA were included. All patients were analysed regarding pertinent demographic, clinical and antimicrobial treatment data. We calculated incidence, temporal trends and mortality of MSSA BSI. RESULTS:1328 episodes of MSSA BSI were identified, accounting for a yearly incidence ranging from 2.1 to 4.5 per 10 000 patient-days (p = 0.2 for trend). Overall mortality was 19.3% and did not improve over time. Community-acquired MSSA BSI significantly increased over time, while nosocomial cases decreased (p <0.05). CONCLUSIONS:Mortality related to MSSA BSI remains high and unchanged over the last 20 years. Despite advances in treatment and supportive care in medicine during the last 20 years survival did not improve and, therefore, new approaches are required to lower mortality in MSSA BSI.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Wiggli BJ,Frei R,Laffer R,Tschudin Sutter S,Widmer AFdoi
10.4414/smw.2017.14508subject
Has Abstractpub_date
2017-09-30 00:00:00pages
w14508eissn
1424-7860issn
1424-3997pii
smw-14508journal_volume
147pub_type
杂志文章abstract::Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. While current therapeutic options for hepatitis C are limited, recent progress in the understanding of the biology of HCV led to the identification of novel targets for antiviral interven...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2001/21/smw-06097
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abstract::Over the last few years atypical antipsychotics have been used increasingly in the pharmacological treatment of schizophrenia. This review provides an overview of the pharmacological and clinical characteristics of atypical antipsychotics. In particular we discuss their efficacy in treating psychotic and negative symp...
journal_title:Swiss medical weekly
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doi:2003/05/smw-10003
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abstract::This paper focuses on the relationships between schizophrenia and religion, on the basis of a review of literature and the data of an ongoing study about religiousness and spiritual coping conducted among outpatients with chronic schizophrenia. Religion (including both spirituality and religiousness) is salient in the...
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doi:2004/25/smw-10322
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pub_type: 杂志文章,评审
doi:10.4414/smw.2015.14103
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journal_title:Swiss medical weekly
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doi:2002/09/smw-09800
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/21/smw-12013
更新日期:2008-05-31 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12494
更新日期:2009-03-21 00:00:00
abstract::Increased survival rates after orthotopic liver transplantation (OLT) in patients with end-stage liver disease have become possible due to an advanced understanding of the pathophysiology of liver disease, the establishment of multiorgan procurement and preservation techniques, and the development of safer and more po...
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doi:2007/13/smw-11681
更新日期:2007-04-07 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2001/41/smw-09751
更新日期:2001-10-20 00:00:00
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doi:smw-12495
更新日期:2009-02-07 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2014.14053
更新日期:2014-12-04 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:2003/21/smw-10230
更新日期:2003-05-31 00:00:00
abstract::Cartilage hair hypoplasia (CHH) is a rare autosomal recessive ribosomopathy characterised by skeletal and integumentary system manifestations. It may also present with varied forms and intensities of haematopoietic and/or immune disorders. We report a 27-year-old female who presented a picture of combined immunodefici...
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doi:10.4414/smw.2015.14098
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更新日期:2019-05-19 00:00:00
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doi:10.4414/smw.2012.13534
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doi:10.4414/smw.2018.14615
更新日期:2018-04-26 00:00:00
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pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13698
更新日期:2012-11-05 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2007/45/smw-11697
更新日期:2007-11-17 00:00:00
abstract::Of the two million people estimated to be newly infected with human immunodeficiency virus (HIV) every year, 95% live in poorer regions of the world where effective HIV treatment is not universally available. Strategies to reduce the spread of HIV infection, which predominantly occurs via sexual contact, are urgently ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2018.14580
更新日期:2018-01-26 00:00:00
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pub_type: 杂志文章
doi:smw-12604
更新日期:2009-09-05 00:00:00
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pub_type: 杂志文章,评审
doi:10.4414/smw.2018.14706
更新日期:2018-12-30 00:00:00