Abstract:
:The development is reported of an ultra-rapid, point-of-care diagnostic device which harnesses surface acoustic wave (SAW) biochips, to detect HIV in a finger prick of blood within 10 seconds (sample-in-result-out). The disposable quartz biochip, based on microelectronic components found in every consumer smartphone, is extremely fast because no complex labelling, amplification or wash steps are needed. A pocket-sized control box reads out the SAW signal and displays results electronically. High analytical sensitivity and specificity are found with model and real patient blood samples. The findings presented here open up the potential of consumer electronics to cut lengthy test waiting times, giving patients on the spot access to potentially life-saving treatment and supporting more timely public health interventions to prevent disease transmission.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Turbé V,Gray ER,Lawson VE,Nastouli E,Brookes JC,Weiss RA,Pillay D,Emery VC,Verrips CT,Yatsuda H,Athey D,McKendry RAdoi
10.1038/s41598-017-11887-6subject
Has Abstractpub_date
2017-09-20 00:00:00pages
11971issue
1issn
2045-2322pii
10.1038/s41598-017-11887-6journal_volume
7pub_type
杂志文章abstract::The aim of the present study was to compare the clinical, radiological and histomorphometrical outcome of simultaneous implant placement following augmentation of atrophic maxillary sinuses using allograft (block or particles). Consecutive patients with maxillary residual alveolar ridge height ≤3 mm, scheduled for sin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65874-5
更新日期:2020-06-03 00:00:00
abstract::Most dogs worldwide are free-ranging animals that form relationships mainly with conspecifics, yet research has focused mainly on the dog-human bond, leading to the hypothesis that dogs evolved specific abilities to form a unique relationship with humans. Although widespread, this hypothesis has not, as yet, been test...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40164-x
更新日期:2019-03-05 00:00:00
abstract::Kaposiform hemangioendothelioma (KHE) is a relatively rare vascular tumor with an aggressive and infiltrating nature. Previous studies have revealed an exclusive relationship between KHE and Kasabach-Merritt Phenomenon (KMP), which is associated with high morbidity and mortality. No universally accepted treatment moda...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep36261
更新日期:2016-10-31 00:00:00
abstract::Chronic stress and prolonged activation of defence pathways have deleterious consequences for the cell. Dietary restriction is believed to be beneficial as it induces the cellular stress response machinery. We report here that although the phenomenon is beneficial in a wild-type cell, dietary restriction leads to an i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33433
更新日期:2016-09-16 00:00:00
abstract::Through the use of the technique of time-of-flight mass spectroscopy, we obtain strong-field ionization yields for randomly oriented 1,2-dichloroethylene (1,2-DCE) (C2H2Cl2) and 2-butene (C4H8). We are interested in studying the effect of conformal structure in strong-field ionization and, in particular, the role of m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42149
更新日期:2017-02-10 00:00:00
abstract::Conflicting results of survival outcomes for primary and secondary muscle-invasive bladder cancer (MIBC) have been reported in previous studies. Primary MIBC is defined as presentation of muscle-invasive disease at initial diagnosis while secondary MIBC presumes that non-muscle invasive disease later progressed to MIB...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-26002-6
更新日期:2018-05-15 00:00:00
abstract::We demonstrate a self-cleanable, waterproof, highly transparent, and flexible Ag network covered by a very thin transparent polytetrafluoroethylene (PTFE) layer using typical magnetron sputtering for multi-functional flexible thin film heaters used in smart windows. By passivation of the self-assembled Ag network with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53243-w
更新日期:2019-11-13 00:00:00
abstract::The use of cardiac troponins (cTn) is the gold standard for diagnosing myocardial infarction. Independent of myocardial infarction (MI), however, sex, age and kidney function affect cTn levels. Here we developed a method to adjust cTnI levels for age, sex, and renal function, maintaining a unified cut-off value such a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26120-1
更新日期:2018-05-24 00:00:00
abstract::To examine the influence on postoperative endothelial cell density (ECD) caused by preoperative temperature change from 4 °C to room temperature in donor corneas for Descemet stripping automated endothelial keratoplasty (DSAEK). This retrospective, case-controlled comparison of 100 eyes that underwent DSAEK using impo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57614-6
更新日期:2020-01-20 00:00:00
abstract::While neurofilament light chain (NfL) measurement in serum is a well-established marker of neuroaxonal damage in multiple sclerosis (MS), data on astroglial markers in serum are missing. In our study, glial fibrillary acid protein (GFAP) and NfL were measured in cerebrospinal fluid (CSF) and serum of MS patients and p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33158-8
更新日期:2018-10-04 00:00:00
abstract::Calotropis gigantea (C. gigantea) extract with an ecofriendly nanotechnology approach could provide promising antimicrobial activity against skin pathogens. This study investigates the antimicrobial capability of green synthesized binary ZnO-CuO nanocomposites from C. gigantea against non-MDR (Staphylococcus aureus an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79547-w
更新日期:2021-01-08 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases. Yihuo Huatan Formula (YHF), as a proven Chinese Herbal Medicine (CHM), has been verified to be effective in the treatment of stable COPD through years' of practice. Nevertheless, its working mechanism is still unclear. We soug...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50064-9
更新日期:2019-09-17 00:00:00
abstract::Emerging evidence suggests that the mammalian target of rapamcyin (mTOR) pathway is associated with radio-resistance in cancer treatment. We hypothesised that phosphorylated ribosomal S6 kinase 1 (p-S6K1), a major downstream regulator of the mTOR pathway, may play a role in predicting radio-resistance. Therefore, we e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57496-8
更新日期:2020-01-20 00:00:00
abstract::This paper explores the empirical links between achieving the Sustainable Development Goals (SDGs) and subjective well-being. Globally, we find that in terms of well-being, there are increasing marginal returns to sustainable development. Unpacking the SDGs by looking at how each SDG relates to well-being shows, in mo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71916-9
更新日期:2020-09-15 00:00:00
abstract::Lung adenosquamous cell carcinomas (ASCs) is a rare variant of NSCLC with a poorer prognosis and fewer treatment option than the more common variants. PD-L1 expression is reported to be the predictor of clinical response in trials of NSCLC. In our study, PD-L1 expression was evaluated via immunohistochemistry using a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46209
更新日期:2017-04-07 00:00:00
abstract::For the application of formic acid as a liquid organic hydrogen carrier, development of efficient catalysts for dehydrogenation of formic acid is a challenging topic, and most studies have so far focused on the composition of metals and supports, the size effect of metal nanoparticles, and surface chemistry of support...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33502
更新日期:2016-09-26 00:00:00
abstract::The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce the variance in the Aβ CL unit between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 partici...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70978-z
更新日期:2020-09-11 00:00:00
abstract::Mangrove forests are among the most productive and diverse ecosystems on the planet, despite limited nitrogen (N) availability. Under such conditions, animal-microbe associations (holobionts) are often key to ecosystem functioning. Here, we investigated the role of fiddler crabs and their carapace-associated microbial...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70834-0
更新日期:2020-08-18 00:00:00
abstract::Prasinophytes are a paraphyletic group of nine lineages of green microalgae that are currently classified either at the class or order level or as clades without formal taxonomic description. Prasinophyte clade VII comprises picoplanktonic algae that are important components of marine phytoplankton communities, partic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12412-5
更新日期:2017-10-25 00:00:00
abstract::Defense mechanisms of plant genomes can epigenetically inactivate repetitive sequences and exogenous transgenes. Loss of mutant phenotypes in intronic T-DNA insertion lines by interaction with another T-DNA locus, termed T-DNA suppression, has been observed in Arabidopsis thaliana, although the molecular basis of esta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45166
更新日期:2017-03-24 00:00:00
abstract::Protein phosphorylation is one of the most prevalent and well-understood protein modifications. Oxidation of protein-bound methionine, which has been traditionally perceived as an inevitable damage derived from oxidative stress, is now emerging as another modification capable of regulating protein activity during stre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40403
更新日期:2017-01-12 00:00:00
abstract::Clostridium difficile is a gastrointestinal pathogen but how the bacterium colonises this niche is still little understood. Sortase enzymes covalently attach specific bacterial proteins to the peptidoglycan cell wall and are often involved in colonisation by pathogens. Here we show C. difficile proteins CD2537 and CD3...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08322-1
更新日期:2017-08-23 00:00:00
abstract::The Killari Earthquake (Moment magnitude 6.1) of September 30, 1993, occurred in the state of Maharashtra, India, has an epicenter (18°03' N, 76°33' E) located at ~ 40 km SSW of Killari Town. The ~ 125 km long basin of Tirna River, close to the Killari Town, currently occupies the area that has witnessed episodic intr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77542-9
更新日期:2020-11-25 00:00:00
abstract::Although thimerosal, an ethylmercury-based preservative, has been removed from most pediatric vaccines in the United States, some multidose vaccines, such as influenza vaccines, still contain thimerosal. Considering that a growing number of studies indicate involvement of the gut microbiome in infant immune developmen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34019-0
更新日期:2018-10-26 00:00:00
abstract::The molecular mechanisms underlying viral pathogenesis are yet poorly understood owed to the large number of factors involved and the complexity of their interactions. Could we identify a minimal set of host transcription factors (TF) whose misregulation would result in the transcriptional profile characteristic of in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01006
更新日期:2012-01-01 00:00:00
abstract::Channelopathy mutations prove informative on disease causing mechanisms and channel gating dynamics. We have identified a novel heterozygous mutation in the KCNA1 gene of a young proband displaying typical signs and symptoms of Episodic Ataxia type 1 (EA1). This mutation is in the S4 helix of the voltage-sensing domai...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03041-z
更新日期:2017-07-04 00:00:00
abstract::Phlebotomine sand flies are remarkable vectors of several etiologic agents (virus, bacterial, trypanosomatid Leishmania), posing a heavy health burden for human populations mainly located at developing countries. Their intestinal microbiota is involved in a wide range of biological and physiological processes, and cou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53769-z
更新日期:2019-11-28 00:00:00
abstract::Nettles are commonly consumed in South Africa, Europe and Asia and are used in traditional medicine to treat a variety of ailments. In this study, the nutritional value of the leaves of nettles (Laportea alatipes and Obetia tenax) was evaluated and compared, when cooked and uncooked. The results showed a decrease in t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67055-w
更新日期:2020-06-17 00:00:00
abstract::Antimonite [Sb(III)]-oxidizing bacteria can transform the toxic Sb(III) into the less toxic antimonate [Sb(V)]. Recently, the cytoplasmic Sb(III)-oxidase AnoA and the periplasmic arsenite [As(III)] oxidase AioAB were shown to responsible for bacterial Sb(III) oxidation, however, disruption of each gene only partially ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43225
更新日期:2017-03-02 00:00:00
abstract::CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) plays an important role in tumor progression and a number of studies have suggested that it is an indicator of tumor prognosis. This current meta-analysis systematically reevaluated the predictive potential of CD147/EMMPRIN in various cancers. We searched ...
journal_title:Scientific reports
pub_type: 杂志文章,评审
doi:10.1038/srep32804
更新日期:2016-09-09 00:00:00