Abstract:
:Leptin signaling in the hypothalamus plays a crucial role in the regulation of body weight. Leptin resistance, in which leptin signaling is disrupted, is a major obstacle to the improvement of obesity. We herein demonstrated that protein tyrosine phosphatase receptor type J (Ptprj) is expressed in hypothalamic neurons together with leptin receptors, and that PTPRJ negatively regulates leptin signaling by inhibiting the activation of JAK2, the primary tyrosine kinase in leptin signaling, through the dephosphorylation of Y813 and Y868 in JAK2 autophosphorylation sites. Leptin signaling is enhanced in Ptprj-deficient mice, and they exhibit lower weight gain than wild-type mice because of a reduced food intake. Diet-induced obesity and the leptin treatment up-regulated PTPRJ expression in the hypothalamus, while the overexpression of PTPRJ induced leptin resistance. Thus, the induction of PTPRJ is a factor contributing to the development of leptin resistance, and the inhibition of PTPRJ may be a potential strategy for improving obesity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shintani T,Higashi S,Suzuki R,Takeuchi Y,Ikaga R,Yamazaki T,Kobayashi K,Noda Mdoi
10.1038/s41598-017-12070-7subject
Has Abstractpub_date
2017-09-14 00:00:00pages
11627issue
1issn
2045-2322pii
10.1038/s41598-017-12070-7journal_volume
7pub_type
杂志文章abstract::Pancreatic adenocarcinoma upregulated factor (PAUF) is a ligand of toll-like receptors (TLRs) and has been reported to be involved in pancreatic tumor development. However, the significance of PAUF expression in epithelial ovarian cancer remains unclear. We aimed to investigate the possible clinical significance of PA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30582-8
更新日期:2018-08-15 00:00:00
abstract::Molecular characterization of the coral host and the microbial assemblages associated with it (referred to as the coral holobiont) is currently undertaken via marker gene sequencing. This requires bulky instruments and controlled laboratory conditions which are impractical for environmental experiments in remote areas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72589-0
更新日期:2020-09-28 00:00:00
abstract::The effect of intravenous fluids (IVF) has been investigated clinically through the assessment of post-treatment reactions. However, the responses to IVF vary from patient-to-patient. It is important to understand the response of IVF treatment to be able to provide optimal IVF care. Herein, we investigated the impact ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61296-5
更新日期:2020-07-16 00:00:00
abstract::Soil zinc (Zn) plays a crucial role in plant growth, but excessive accumulation in the environment may lead to air, water and soil pollution. It is affected by various chemical, environmental and spatial factors. Therefore, it is important to identify the factors influencing Zn content in the landscape. The main motiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33745-9
更新日期:2018-10-22 00:00:00
abstract::Despite increasing work detailing the presence of foraging specializations across a range of taxa, limited attention so far has been given to the role of spatiotemporal variation in food predictability in shaping individual resource selection. Here, we studied the exploitation of human-provided carrion resources diffe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33564-y
更新日期:2018-10-11 00:00:00
abstract::Although cisplatin plays a central role in cancer chemotherapy, the mechanisms of cell response to this drug have been unexplored. The present study demonstrates the relationships between the intracellular pH (pHi), cell bioenergetics and the response of cervical cancer to cisplatin. pHi was measured using genetically...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09426-4
更新日期:2017-08-21 00:00:00
abstract::We have studied differentially regulated nuclear proteome of the clinical tissue specimens of glioblastoma (GBM, WHO Grade IV) and lower grades of gliomas (Grade II and III) using high resolution mass spectrometry- based quantitative proteomics approach. The results showed altered expression of many regulatory protein...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47360-9
更新日期:2019-07-29 00:00:00
abstract::Receptor tyrosine kinases (RTKs) are key regulators of normal cellular processes and have a critical role in the development and progression of many diseases. RTK ligand-induced stimulation leads to activation of the cytoplasmic kinase domain that controls the intracellular signalling. Although the kinase domain of RT...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62460-7
更新日期:2020-03-25 00:00:00
abstract::Oscillatory media can exhibit the coexistence of synchronized and desynchronized regions, so-called chimera states, for uniform parameters and symmetrical coupling. In a phase-balanced chimera state, where the totals of synchronized and desynchronized regions, respectively, are of the same size, the symmetry of the sy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09883
更新日期:2015-04-30 00:00:00
abstract::Siglec-2 undergoes constitutive endocytosis and is a drug target for autoimmune diseases and B cell-derived malignancies, including hairy cell leukaemia, marginal zone lymphoma, chronic lymphocytic leukaemia and non-Hodgkin's lymphoma (NHL). An alternative to current antibody-based therapies is the use of liposomal na...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36012
更新日期:2016-11-03 00:00:00
abstract::This corrects the article DOI: 10.1038/srep41699. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/srep46942
更新日期:2018-02-12 00:00:00
abstract::Recent advances in microfluidic cell cultures enable the construction of in vitro human skin models that can be used for drug toxicity testing, disease study. However, current in vitro skin model have limitations to emulate real human skin due to the simplicity of model. In this paper, we describe the development of '...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37471
更新日期:2016-11-21 00:00:00
abstract::We propose a scheme of designing polygonal rotator with homogenous materials by using linear coordinate transformation. Our strategy is available for both time-harmonic electromagnetic field case and static field case. In particular, we found that only one anisotropic material is needed in static field case, and the d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51637-4
更新日期:2019-10-22 00:00:00
abstract::Sideroflexin4 (SFXN4) is a member of a family of nuclear-encoded mitochondrial proteins. Rare germline mutations in SFXN4 lead to phenotypic characteristics of mitochondrial disease including impaired mitochondrial respiration and hematopoetic abnormalities. We sought to explore the function of this protein. We show t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55907-z
更新日期:2019-12-23 00:00:00
abstract::Invasive motor Cortex Stimulation (iMCS) was introduced in the 1990's for the treatment of chronic neuropathic orofacial pain (CNOP), although its effectiveness remains doubtful. However, CNOP is known to be a heterogeneous group of orofacial pain disorders, which can lead to different responses to iMCS. Therefore, th...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-020-64177-z
更新日期:2020-04-28 00:00:00
abstract::Dissolved organic carbon (DOC) concentrations and water colour are increasing in many inland waters across northern Europe and northeastern North America. This inland-water "browning" has profound physical, chemical and biological repercussions for aquatic ecosystems affecting water quality, biological community struc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52912-0
更新日期:2019-11-13 00:00:00
abstract::Surface defect of nanomaterials is an important physical parameter which significantly influences their physical and chemical performances. In this work, high concentration of surface oxygen vancancies (SOVs) are successfully introduced on {001} facets exposed BiOBr nanosheets via a simple surface modification using p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24918
更新日期:2016-04-26 00:00:00
abstract::The interaction between two different materials can present novel phenomena that are quite different from the physical properties observed when each material stands alone. Strong electronic correlations, such as magnetism and superconductivity, can be produced as the result of enhanced Coulomb interactions between ele...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21460
更新日期:2016-02-18 00:00:00
abstract::Fibrous scaffolds are used for bone tissue engineering purposes with great success across a variety of polymers with different physical and chemical properties. It is now evident that the correct degree of curvature promotes increased cytoskeletal tension on osteoprogenitors leading to osteogenic differentiation. Howe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37554-y
更新日期:2019-01-30 00:00:00
abstract::Human lactoferrin (hLF) is a valuable protein for pharmaceutical products and functional foods, and worldwide demand for this protein has steadily increased. However, large-scale recombinant human lactoferrin (rhLF) production using current animal bioreactor techniques is limited by the low expression of foreign prote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11462-z
更新日期:2017-09-06 00:00:00
abstract::Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to searc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04768
更新日期:2014-04-24 00:00:00
abstract::Frequency domain measures of heart rate variability (HRV) are associated with adverse events after a myocardial infarction. However, patterns in the traditional frequency domain (measured in Hz, or cycles per second) may capture different cardiac phenomena at different heart rates. An alternative is to consider freque...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34540
更新日期:2016-10-06 00:00:00
abstract::Proteus mirabilis forms extensive crystalline biofilms on indwelling urethral catheters that block urine flow and lead to serious clinical complications. The Bcr/CflA efflux system has previously been identified as important for development of P. mirabilis crystalline biofilms, highlighting the potential for efflux pu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12445-w
更新日期:2017-09-22 00:00:00
abstract::Inflammatory reactions activated by pattern recognition receptors (PRRs) on the membrane of innate immune cells play an important role in atherosclerosis. Whether the PRRs of the C-type lectin receptor (CLR) family including Dectin-2 may be involved in the pathogenesis of atherosclerosis remains largely unknown. Recen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40663-x
更新日期:2019-03-13 00:00:00
abstract::A highly effective method for the research and development of a novel macroscopic hydrogel sensor and bilayer hydrogel is reported. Based on Rhodamine 6G, an Hg2+ sensitive fluorescent functional monomer was synthesized, then the monomer was utilized to synthesize hydrogel sensors and bilayer hydrogels. Hydrogel senso...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64549-5
更新日期:2020-05-07 00:00:00
abstract::The investigation of chemical and structural dynamics in battery materials is essential to elucidation of structure-property relationships for rational design of advanced battery materials. Spatially resolved techniques, such as scanning/transmission electron microscopy (S/TEM), are widely applied to address this chal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05694
更新日期:2014-07-16 00:00:00
abstract::The reduced micromorphic model (RMM) is used to study the effect of the applied force on a hemisphere made of phononic crystals that belongs to the metamaterials group. The strain tensor, the micro-strain tensor and the coupling between them are the kinematic relations used to measure the deformation and micro-deforma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59696-8
更新日期:2020-02-18 00:00:00
abstract::We report on a novel electrically tunable hybrid graphene-gold Fano resonator. The proposed metamaterial consists of a square graphene patch and a square gold frame. The destructive interference between the narrow- and broadband dipolar surface plasmons, which are induced respectively on the surfaces of the graphene p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02105
更新日期:2013-01-01 00:00:00
abstract::Some insect galls are formed on sumac plants by certain aphid species and have been used for medicinal and chemical purposes as they are rich in tannins. The most prominent species among gall aphids in China is Schlechtendalia chinensis, which formed horn-shaped galls on the winged rachis of Rhus chinensis. S. chinens...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06806-8
更新日期:2017-07-25 00:00:00
abstract::The core of the Vibrio Harveyi clade contains V. harveyi, V. campbellii, V. owensii, V. jasicida, and V. rotiferianus. They are well recognized aquatic animal pathogens, but misclassification has been common due to similarities in their rDNA sequences and phenotypes. To better understand their evolutionary relationshi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41394
更新日期:2017-02-01 00:00:00