Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy.

abstract：:Subcutaneous white adipose tissue (scWAT) is the major fat depot in humans and is a central player in regulating whole body metabolism. Skin exposure to UV wavelengths from sunlight is required for Vitamin D synthesis and pigmentation, although it is plausible that longer visible wavelengths that penetrate the skin ma...

journal_title：Scientific reports

authors： Ondrusova K,Fatehi M,Barr A,Czarnecka Z,Long W,Suzuki K,Campbell S,Philippaert K,Hubert M,Tredget E,Kwan P,Touret N,Wabitsch M,Lee KY,Light PE

更新日期：2017-11-27 00:00:00

abstract：:Halophilic proteins subjected to below about 15% salt in vitro denature through misfolding, aggregation and/or precipitation. Halobacteria, however, have been detected in environments of fluctuating salinity such as coastal salterns and even around fresh water springs in the depths of the Dead Sea. In order to identif...

journal_title：Scientific reports

authors： Vauclare P,Natali F,Kleman JP,Zaccai G,Franzetti B

更新日期：2020-02-24 00:00:00

abstract：:Zika virus (ZIKV) causes significant public health concerns because of its association with congenital malformations, neurological disorders in adults, and, more recently, death. Considering the necessity to mitigate ZIKV-associated diseases, antiviral interventions are an urgent necessity. Sofosbuvir, a drug in clini...

journal_title：Scientific reports

authors： Ferreira AC,Zaverucha-do-Valle C,Reis PA,Barbosa-Lima G,Vieira YR,Mattos M,Silva PP,Sacramento C,de Castro Faria Neto HC,Campanati L,Tanuri A,Brüning K,Bozza FA,Bozza PT,Souza TML

更新日期：2017-08-25 00:00:00

abstract：:Plant microbiota is a key determinant of plant health and productivity. The composition and structure of plant microbiota varies according to plant tissue and compartment, which are specific habitats for microbial colonization. To investigate the structural composition of the microbiome associated with tomato roots un...

journal_title：Scientific reports

authors： Lee SA,Kim Y,Kim JM,Chu B,Joa JH,Sang MK,Song J,Weon HY

更新日期：2019-06-26 00:00:00

abstract：:G-proteins are implicated in plant productivity, but their genome-wide roles in regulating agronomically important traits remain uncharacterized. Transcriptomic analyses of rice G-protein alpha subunit mutant (rga1) revealed 2270 differentially expressed genes (DEGs) including those involved in C/N and lipid metabolis...

journal_title：Scientific reports

authors： Pathak RR,Mandal VK,Jangam AP,Sharma N,Madan B,Jaiswal DK,Raghuram N

更新日期：2021-01-27 00:00:00

abstract：:The development of high energy-density lithium-ion secondary batteries as storage batteries in vehicles is attracting increasing attention. In this study, high-voltage bipolar stacked batteries with a quasi-solid-state electrolyte containing a Li-Glyme complex were prepared, and the performance of the device was evalu...

journal_title：Scientific reports

authors： Gambe Y,Sun Y,Honma I

更新日期：2015-03-09 00:00:00

abstract：:Synthetic biology enables infinite possibilities in biotechnology via employing genetic modules. However, not many researches have explored the potentials of synthetic biology in environmental bioprocesses. In this study, we introduced a genetic module harboring the codon-optimized tetracycline degrading gene, tetX.co...

journal_title：Scientific reports

authors： Xia PF,Li Q,Tan LR,Liu MM,Jin YS,Wang SG

更新日期：2018-02-13 00:00:00

abstract：:The Xanthomonadaceae family consists of species of non-pathogenic and pathogenic γ-proteobacteria that infect different hosts, including humans and plants. In this study, we performed a comparative analysis using 69 fully sequenced genomes belonging to this family, with a focus on identifying proteins enriched in phyt...

journal_title：Scientific reports

authors： Assis RAB,Polloni LC,Patané JSL,Thakur S,Felestrino ÉB,Diaz-Caballero J,Digiampietri LA,Goulart LR,Almeida NF,Nascimento R,Dandekar AM,Zaini PA,Setubal JC,Guttman DS,Moreira LM

更新日期：2017-11-23 00:00:00

abstract：:Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms. To determine its effects on female reproductive physiology and investigate whether changes in the expression levels of genes related...

journal_title：Scientific reports

authors： Santangeli S,Maradonna F,Gioacchini G,Cobellis G,Piccinetti CC,Dalla Valle L,Carnevali O

更新日期：2016-02-25 00:00:00

abstract：:In this study, 111 Cryptosporidium parvum IId isolates from several species of animals in China, Sweden, and Egypt were subtyped by multilocus sequence typing (MLST). One to eleven subtypes were detected at each of the 12 microsatellite, minisatellite, and single nucleotide polymorphism (SNP) loci, forming 25 MLST sub...

journal_title：Scientific reports

authors： Wang R,Zhang L,Axén C,Bjorkman C,Jian F,Amer S,Liu A,Feng Y,Li G,Lv C,Zhao Z,Qi M,Dong H,Wang H,Sun Y,Ning C,Xiao L

更新日期：2014-02-27 00:00:00

abstract：:Using the universal structure predictor algorithm, we proposed that two-dimensional MnB structures with p4mmm (α-MnB) and pmma (β-MnB) symmetries could be synthesized. This finding was verified by calculating the dynamical stability, molecular dynamics, and mechanical properties. The α-MnB had an in-plane stiffness Y ...

journal_title：Scientific reports

authors： Farooq MU,Hashmi A,Khan I,Hong J

更新日期：2017-12-06 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep46667. ...

journal_title：Scientific reports

authors： Chen TT,Wu SM,Ho SC,Chuang HC,Liu CY,Chan YF,Kuo LW,Feng PH,Liu WT,Chen KY,Hsiao TC,Juang JN,Lee KY

更新日期：2017-12-22 00:00:00

abstract：:The goal of this study was to evaluate if isolated sarcomeres and half-sarcomeres produce a long-lasting increase in force after a stretch is imposed during activation. Single and half-sarcomeres were isolated from myofibrils using micro-needles, which were also used for force measurements. After full force developmen...

journal_title：Scientific reports

authors： Minozzo FC,Baroni BM,Correa JA,Vaz MA,Rassier DE

更新日期：2013-01-01 00:00:00

abstract：:Real-time quantitative polymerase chain reaction (qPCR) data are found to display periodic patterns in the fluorescence intensity as a function of sample number for fixed cycle number. This behavior is seen for technical replicate datasets recorded on several different commercial instruments; it occurs in the baseline...

journal_title：Scientific reports

authors： Spiess AN,Rödiger S,Burdukiewicz M,Volksdorf T,Tellinghuisen J

更新日期：2016-12-13 00:00:00

abstract：:DNA methylation is an essential epigenetic marker associated with the silencing of gene expression. Although various genome-wide studies revealed aberrantly methylated gene targets as molecular biomarkers for early detection, the survival rate of lung cancer patients is still poor. In order to identify methylation-dri...

journal_title：Scientific reports

authors： Lenka G,Tsai MH,Lin HC,Hsiao JH,Lee YC,Lu TP,Lee JM,Hsu CP,Lai LC,Chuang EY

更新日期：2017-02-15 00:00:00

abstract：:Hypertension is the most common and lethal risk factor for cardiovascular disease (CVD). Numerous variants have been associated with hypertension, however, most of which failed to get replication due to ethnic differences. In this study, we analyzed associations of 10 newly reported single nucleotide polymorphisms (SN...

journal_title：Scientific reports

authors： Yu Q,Sun HP,Chen WQ,Chen XQ,Xu Y,He YH,Kong QP

更新日期：2015-10-21 00:00:00

abstract：:Modern microbial mats can provide key insights into early Earth ecosystems, and Shark Bay, Australia, holds one of the best examples of these systems. Identifying the spatial distribution of microorganisms with mat depth facilitates a greater understanding of specific niches and potentially novel microbial interaction...

journal_title：Scientific reports

authors： Wong HL,Smith DL,Visscher PT,Burns BP

更新日期：2015-10-26 00:00:00

abstract：:Hot-iron disbudding, a routine procedure that prevents horn bud growth through cauterization, is painful for calves. The resulting burns remain sensitive to touch for weeks, but it is unknown whether calves experience ongoing, non-evoked pain. We evaluated conditioned place preference for analgesia in 44 calves disbud...

journal_title：Scientific reports

authors： Adcock SJJ,Tucker CB

更新日期：2020-03-02 00:00:00

abstract：:Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5, and Smad9 by creating constitutively active forms (Smad(DVD)). Transcriptional activity of Smad9(DVD) was lower than that of Smad1(DVD) ...

journal_title：Scientific reports

authors： Tsukamoto S,Mizuta T,Fujimoto M,Ohte S,Osawa K,Miyamoto A,Yoneyama K,Murata E,Machiya A,Jimi E,Kokabu S,Katagiri T

更新日期：2014-12-23 00:00:00

abstract：:Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environmental pollutants....

journal_title：Scientific reports

authors： Sharma M,Zhang X,Zhang S,Niu L,Ho SM,Chen A,Huang S

更新日期：2017-05-18 00:00:00

abstract：:Three dimensional hierarchical nanostructures have attracted great attention for electrochemical energy storage applications. In this work, self-supported TiO2@Ni(OH)2 core-shell nanowire arrays are prepared on carbon fiber paper via the combination of hydrothermal synthesis and chemical bath deposition. In this core-...

journal_title：Scientific reports

authors： Ke Q,Zheng M,Liu H,Guan C,Mao L,Wang J

更新日期：2015-09-10 00:00:00

abstract：:The therapeutic value of FK228 as a cancer treatment option is well known, and various types of cancer have been shown to respond to this drug. However, the complete mechanism of FK228 and the affect it has on histone lysine acetylation and the colon cancer cell proteome are largely unknown. In the present study, we u...

journal_title：Scientific reports

authors： Wang TY,Jia YL,Zhang X,Sun QL,Li YC,Zhang JH,Zhao CP,Wang XY,Wang L

更新日期：2015-12-17 00:00:00

abstract：:Mammalian cytokinetic abscission is mediated by the ESCRT membrane fission machinery. While much has been clarified on the topology and kinetics of abscission through high-resolution microscopy, key questions regarding the mechanism of abscission remain open. Here we apply cryogenic soft-X-ray tomography to elucidate ...

journal_title：Scientific reports

authors： Sherman S,Kirchenbuechler D,Nachmias D,Tamir A,Werner S,Elbaum M,Elia N

更新日期：2016-06-10 00:00:00

abstract：:A coherent anti-Stokes Raman scattering (CARS) rigid endoscope was developed to visualize peripheral nerves without labeling for nerve-sparing endoscopic surgery. The developed CARS endoscope had a problem with low imaging speed, i.e. low imaging rate. In this study, we demonstrate that noise reduction with deep learn...

journal_title：Scientific reports

authors： Yamato N,Niioka H,Miyake J,Hashimoto M

更新日期：2020-09-16 00:00:00

abstract：:CRISPR/Cas9 is a valuable tool for both basic and applied research that has been widely applied to different plant species. Nonetheless, a systematical assessment of the efficiency of this method is not available for the allotetraploid Brassica napus-an important oilseed crop. In this study, we examined the mutation e...

journal_title：Scientific reports

authors： Yang H,Wu JJ,Tang T,Liu KD,Dai C

更新日期：2017-08-08 00:00:00

abstract：:Spermatogenesis in the mouse has been extensively studied for decades. Previous methods, such as histological staining or bulk transcriptome analysis, either lacked resolution at the single-cell level or were focused on a very narrowly defined set of factors. Here, we present the first comprehensive, unbiased single-c...

journal_title：Scientific reports

authors： Lukassen S,Bosch E,Ekici AB,Winterpacht A

更新日期：2018-04-25 00:00:00

abstract：:The estrogen signaling pathway has been reported to modulate prostate cancer (PCa) progression through the activity of estrogen receptors α and β (ERα and ERβ). Given that selective estrogen receptor modulators (SERMs) are used to treat breast cancer, ERs have been proposed as attractive therapeutic targets in PCa. Ho...

journal_title：Scientific reports

authors： Lafront C,Germain L,Weidmann C,Audet-Walsh É

更新日期：2020-03-04 00:00:00

abstract：:For the first time, high-surface-area (approximately 1465 m(2) g(-1)), highly porous and heteroatom-enriched activated carbon (HAC) was prepared from banana stems (Musa paradisiaca, Family: Musaceae) at different carbonization temperatures of 700, 800 and 900 °C (HAC) using a simple and eco-friendly method. The amount...

journal_title：Scientific reports

authors： Madhu R,Veeramani V,Chen SM

更新日期：2014-04-23 00:00:00

abstract：:Different anti-PD-1 and anti-PD-L1 antibodies bind different epitopes. However, whether the results from the SP142 and 22C3 immunochemistry (IHC) assays can be interchanged to determine patient eligibility for immunotherapy remains largely unknown. Histologic sections from 135 tumor samples were probed with both 22C3 ...

journal_title：Scientific reports

authors： Xu H,Lin G,Huang C,Zhu W,Miao Q,Fan X,Wu B,Zheng X,Lin X,Jiang K,Hu D,Li C

更新日期：2017-12-05 00:00:00

abstract：:Conventional disease animal models have limitations on the conformity to the actual clinical situation. Disease-syndrome combination (DS) modeling may provide a more efficient strategy for biomedicine research. Disease model and DS model of renal fibrosis in chronic kidney disease were established by ligating the left...

journal_title：Scientific reports

authors： Li S,Xu P,Han L,Mao W,Wang Y,Luo G,Yang N

更新日期：2017-08-18 00:00:00