Abstract：
:The goal of this study was to evaluate if isolated sarcomeres and half-sarcomeres produce a long-lasting increase in force after a stretch is imposed during activation. Single and half-sarcomeres were isolated from myofibrils using micro-needles, which were also used for force measurements. After full force development, both preparations were stretched by different magnitudes. The sarcomere length (SL) or half-sarcomere length variations (HSL) were extracted by measuring the initial and final distances from the Z-line to the adjacent Z-line or to a region externally adjacent to the M-line of the sarcomere, respectively. Half-sarcomeres generated approximately the same amount of isometric force (29.0 ± SD 15.5 nN·μm(-2)) as single sarcomeres (32.1 ± SD 15.3 nN·μm(-2)) when activated. In both cases, the steady-state forces after stretch were higher than the forces during isometric contractions at similar conditions. The results suggest that stretch-induced force enhancement is partly caused by proteins within the half-sarcomere.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Minozzo FC,Baroni BM,Correa JA,Vaz MA,Rassier DEdoi
10.1038/srep02320subject
Has Abstractpub_date
2013-01-01 00:00:00pages
2320issn
2045-2322pii
srep02320journal_volume
3pub_type
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