Body ownership promotes visual awareness.

abstract：:Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear. We found that PTBP1 binding in the flanking introns allowed normal U2AF and U1 sn...

journal_title：eLife

authors： Wongpalee SP,Vashisht A,Sharma S,Chui D,Wohlschlegel JA,Black DL

更新日期：2016-11-24 00:00:00

abstract：:Yes. ...

journal_title：eLife

authors： Goldstein RE

更新日期：2018-07-23 00:00:00

abstract：:Axons span extreme distances and are subject to significant stretch deformations during limb movements or sudden head movements, especially during impacts. Yet, axon biomechanics, and its relation to the ultrastructure that allows axons to withstand mechanical stress, is poorly understood. Using a custom developed for...

journal_title：eLife

authors： Dubey S,Bhembre N,Bodas S,Veer S,Ghose A,Callan-Jones A,Pullarkat P

更新日期：2020-04-08 00:00:00

abstract：:Peroxiredoxins are H2O2 scavenging enzymes that also carry out H2O2 signaling and chaperone functions. In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both promoting resistance to H2O2 and extending lifespan upon caloric restriction. We show here that Tsa1 effects both these functions not by scavengi...

journal_title：eLife

authors： Roger F,Picazo C,Reiter W,Libiad M,Asami C,Hanzén S,Gao C,Lagniel G,Welkenhuysen N,Labarre J,Nyström T,Grøtli M,Hartl M,Toledano MB,Molin M

更新日期：2020-07-14 00:00:00

abstract：:Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm. An additional 68 worms were collected from 60 human hosts in Kenyan vil...

journal_title：eLife

authors： Easton A,Gao S,Lawton SP,Bennuru S,Khan A,Dahlstrom E,Oliveira RG,Kepha S,Porcella SF,Webster J,Anderson R,Grigg ME,Davis RE,Wang J,Nutman TB

更新日期：2020-11-06 00:00:00

abstract：:Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological blood pressure and contribute to hypertension in vivo. We generate...

journal_title：eLife

authors： Bulley S,Fernández-Peña C,Hasan R,Leo MD,Muralidharan P,Mackay CE,Evanson KW,Moreira-Junior L,Mata-Daboin A,Burris SK,Wang Q,Kuruvilla KP,Jaggar JH

更新日期：2018-12-04 00:00:00

abstract：: ...

journal_title：eLife

authors： MacKay CE,Leo MD,Fernández-Peña C,Hasan R,Yin W,Mata-Daboin A,Bulley S,Gammons J,Mancarella S,Jaggar JH

更新日期：2020-06-30 00:00:00

abstract：:Microtubule dynamics facilitate neurite growth and establish morphology, but the role of minus-end binding proteins in these processes is largely unexplored. CAMSAP homologs associate with microtubule minus-ends, and are important for the stability of epithelial cell adhesions. In this study, we report morphological d...

journal_title：eLife

authors： Marcette JD,Chen JJ,Nonet ML

更新日期：2014-02-25 00:00:00

abstract：:The emergence of subpopulations that perform distinct metabolic roles has been observed in populations of genetically identical bacteria. ...

journal_title：eLife

authors： Dal Co A,Brannon C,Ackermann M

更新日期：2018-06-29 00:00:00

abstract：:Hox genes are essential regulators of embryonic development. Their step-wise transcriptional activation follows their genomic topology and the various states of activation are subsequently memorized into domains of progressively overlapping gene products. We have analyzed the 3D chromatin organization of Hox clusters ...

journal_title：eLife

authors： Noordermeer D,Leleu M,Schorderet P,Joye E,Chabaud F,Duboule D

更新日期：2014-04-29 00:00:00

abstract：:Systemic oxygen restriction (SOR) is prevalent in numerous clinical conditions, including chronic obstructive pulmonary disease (COPD), and is associated with increased susceptibility to viral infections. However, the influence of SOR on T cell immunity remains uncharacterized. Here we show the detrimental effect of h...

journal_title：eLife

authors： Saragovi A,Abramovich I,Omar I,Arbib E,Toker O,Gottlieb E,Berger M

更新日期：2020-11-23 00:00:00

abstract：:During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about their intracellular mechanisms remains limited. Here we show that Ra...

journal_title：eLife

authors： Chen X,Shibata AC,Hendi A,Kurashina M,Fortes E,Weilinger NL,MacVicar BA,Murakoshi H,Mizumoto K

更新日期：2018-07-31 00:00:00

abstract：:Recent work draws attention to community-community encounters ('coalescence') as likely an important factor shaping natural ecosystems. This work builds on MacArthur's classic model of competitive coexistence to investigate such community-level competition in a minimal theoretical setting. It is shown that the ability...

journal_title：eLife

authors： Tikhonov M

更新日期：2016-06-16 00:00:00

abstract：:Oligomeric assemblies of intraflagellar transport (IFT) particles build cilia through sequential recruitment and transport of ciliary cargo proteins within cilia. Here we present the 1.8 Å resolution crystal structure of the Chlamydomonas IFT-B protein IFT80, which reveals the architecture of two N-terminal β-propelle...

journal_title：eLife

authors： Taschner M,Lorentzen A,Mourão A,Collins T,Freke GM,Moulding D,Basquin J,Jenkins D,Lorentzen E

更新日期：2018-04-16 00:00:00

abstract：:Oomycete pathogens secrete host cell-entering effector proteins to manipulate host immunity during infection. We previously showed that PsAvh52, an early-induced RxLR effector secreted from the soybean root rot pathogen, Phytophthora sojae, could suppress plant immunity. Here, we found that PsAvh52 is required for ful...

journal_title：eLife

authors： Li H,Wang H,Jing M,Zhu J,Guo B,Wang Y,Lin Y,Chen H,Kong L,Ma Z,Wang Y,Ye W,Dong S,Tyler B,Wang Y

更新日期：2018-10-22 00:00:00

abstract：:Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant populations of two species of mussels (Mytilus chilensis in South America and M. edulis in Eur...

journal_title：eLife

authors： Yonemitsu MA,Giersch RM,Polo-Prieto M,Hammel M,Simon A,Cremonte F,Avilés FT,Merino-Véliz N,Burioli EA,Muttray AF,Sherry J,Reinisch C,Baldwin SA,Goff SP,Houssin M,Arriagada G,Vázquez N,Bierne N,Metzger MJ

更新日期：2019-11-05 00:00:00

abstract：:SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of Syngap1 in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walku...

journal_title：eLife

authors： Mastro TL,Preza A,Basu S,Chattarji S,Till SM,Kind PC,Kennedy MB

更新日期：2020-01-15 00:00:00

abstract：:Grid cells in the brain respond when an animal occupies a periodic lattice of 'grid fields' during navigation. Grids are organized in modules with different periodicity. We propose that the grid system implements a hierarchical code for space that economizes the number of neurons required to encode location with a giv...

journal_title：eLife

authors： Wei XX,Prentice J,Balasubramanian V

更新日期：2015-09-03 00:00:00

abstract：:Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney. The lack of potent, specific modulators of TRPV5 has limited the ability to probe the contribution of TRPV5 in disease phenotypes such as hypercalcemia a...

journal_title：eLife

authors： Hughes TE,Del Rosario JS,Kapoor A,Yazici AT,Yudin Y,Fluck EC 3rd,Filizola M,Rohacs T,Moiseenkova-Bell VY

更新日期：2019-10-25 00:00:00

abstract：:The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions. However, what regulates R axon lamination and how lamination affects R neuron function re...

journal_title：eLife

authors： Xie X,Tabuchi M,Brown MP,Mitchell SP,Wu MN,Kolodkin AL

更新日期：2017-06-20 00:00:00

abstract：:Down syndrome (DS) results in various degrees of cognitive deficits. In DS mouse models, recovery of behavioral and neurophysiological deficits using GABAAR antagonists led to hypothesize an excessive activity of inhibitory circuits in this condition. Nonetheless, whether over-inhibition is present in DS and whether t...

journal_title：eLife

authors： Zorrilla de San Martin J,Donato C,Peixoto J,Aguirre A,Choudhary V,De Stasi AM,Lourenço J,Potier MC,Bacci A

更新日期：2020-08-12 00:00:00

abstract：:MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that regulate transcription in response to a wide range of chemical signals. Although specific features of MarR family function have been described, the role of atomic motions in MarRs remains unexplored thus limiting insights int...

journal_title：eLife

authors： Capdevila DA,Huerta F,Edmonds KA,Le MT,Wu H,Giedroc DP

更新日期：2018-10-17 00:00:00

abstract：:Understanding how the brain captures transient experience and converts it into long lasting changes in neural circuits requires the identification and investigation of the specific ensembles of neurons that are responsible for the encoding of each experience. We have developed a Robust Activity Marking (RAM) system th...

journal_title：eLife

authors： Sørensen AT,Cooper YA,Baratta MV,Weng FJ,Zhang Y,Ramamoorthi K,Fropf R,LaVerriere E,Xue J,Young A,Schneider C,Gøtzsche CR,Hemberg M,Yin JC,Maier SF,Lin Y

更新日期：2016-09-23 00:00:00

abstract：:Nervous systems distinguish between self- and other-generated movements by monitoring discrepancies between planned and performed actions. To do so, corollary discharges are conveyed to sensory areas and gate expected reafference. Such gating is observed in neonatal rats during wake-related movements. In contrast, twi...

journal_title：eLife

authors： Tiriac A,Blumberg MS

更新日期：2016-08-03 00:00:00

abstract：:Cohesin tethers together regions of DNA, thereby mediating higher order chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regulation. Cohesin contains a heterodimeric ATP-binding Cassette (ABC) ATPase comprised of Smc1 and Smc3 ATPase active sites. These ATPases are ...

journal_title：eLife

authors： Çamdere G,Guacci V,Stricklin J,Koshland D

更新日期：2015-11-19 00:00:00

abstract：:Metabolism of host-targeted drugs by the microbiome can substantially impact host treatment success. However, since many host-targeted drugs inadvertently hamper microbiome growth, repeated drug administration can lead to microbiome evolutionary adaptation. We tested if evolved bacterial resistance against host-target...

journal_title：eLife

authors： Rosener B,Sayin S,Oluoch PO,García González AP,Mori H,Walhout AJ,Mitchell A

更新日期：2020-11-30 00:00:00

abstract：:The roles of long non-coding RNAs (lncRNAs) in regulating cancer and stem cells are being increasingly appreciated. Its diverse mechanisms provide the regulatory network with a bigger repertoire to increase complexity. Here we report a novel LncRNA, Lnc34a, that is enriched in colon cancer stem cells (CCSCs) and initi...

journal_title：eLife

authors： Wang L,Bu P,Ai Y,Srinivasan T,Chen HJ,Xiang K,Lipkin SM,Shen X

更新日期：2016-04-14 00:00:00

abstract：:C-type inactivation of potassium channels fine-tunes the electrical signaling in excitable cells through an internal timing mechanism that is mediated by a hydrogen bond network in the channels' selectively filter. Previously, we used nonsense suppression to highlight the role of the conserved Trp434-Asp447 indole hyd...

journal_title：eLife

authors： Lueck JD,Mackey AL,Infield DT,Galpin JD,Li J,Roux B,Ahern CA

更新日期：2016-10-06 00:00:00

abstract：: ...

journal_title：eLife

authors： Hayasaka N,Hirano A,Miyoshi Y,Tokuda IT,Yoshitane H,Matsuda J,Fukada Y

更新日期：2021-01-25 00:00:00

abstract：:Genome-wide association studies identified the BIN1 locus as a leading modulator of genetic risk in Alzheimer's disease (AD). One limitation in understanding BIN1's contribution to AD is its unknown function in the brain. AD-associated BIN1 variants are generally noncoding and likely change expression. Here, we determ...

journal_title：eLife

authors： Voskobiynyk Y,Roth JR,Cochran JN,Rush T,Carullo NV,Mesina JS,Waqas M,Vollmer RM,Day JJ,McMahon LL,Roberson ED

更新日期：2020-07-13 00:00:00