Abstract:
:The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions. However, what regulates R axon lamination and how lamination affects R neuron function remain unknown. We show here that the EB is sequentially innervated by small-field and large-field neurons and that early developing EB neurons play an important regulatory role in EB laminae formation. The transmembrane proteins semaphorin-1a (Sema-1a) and plexin A function together to regulate R axon lamination. R neurons recruit both GABA and GABA-A receptors to their axon terminals in the EB, and optogenetic stimulation coupled with electrophysiological recordings show that Sema-1a-dependent R axon lamination is required for preventing the spread of synaptic inhibition between adjacent EB lamina. These results provide direct evidence that EB lamination is critical for local pre-synaptic inhibitory circuit organization.
journal_name
Elifejournal_title
eLifeauthors
Xie X,Tabuchi M,Brown MP,Mitchell SP,Wu MN,Kolodkin ALdoi
10.7554/eLife.25328subject
Has Abstractpub_date
2017-06-20 00:00:00issn
2050-084Xjournal_volume
6pub_type
杂志文章相关文献
eLife文献大全abstract::Brain connectivity maps display a delicate balance between individual variation and stereotypy, suggesting the existence of dedicated mechanisms that simultaneously permit and limit individual variation. We show that during the development of the Drosophila central nervous system, mutual inhibition among groups of nei...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00337
更新日期:2013-03-05 00:00:00
abstract::Baboons, members of the genus Papio, comprise six closely related species distributed throughout sub-Saharan Africa and southwest Arabia. The species exhibit more ecological flexibility and a wider range of social systems than many other primates. This article summarizes our current knowledge of the natural history of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50989
更新日期:2019-11-12 00:00:00
abstract::The importance of cultural processes to behavioural diversity in our closest living relatives is central to revealing the evolutionary origins of human culture. However, the bonobo is often overlooked as a candidate model. Further, a prominent critique to many examples of proposed animal cultures is premature exclusio...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59191
更新日期:2020-09-01 00:00:00
abstract::Sparse, sequential patterns of neural activity have been observed in numerous brain areas during timekeeping and motor sequence tasks. Inspired by such observations, we construct a model of the striatum, an all-inhibitory circuit where sequential activity patterns are prominent, addressing the following key challenges...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26084
更新日期:2017-05-08 00:00:00
abstract::Plasmodium falciparum causes malaria in humans with over 450,000 deaths annually. The asexual blood stage involves invasion of erythrocytes by merozoites, in which they grow and divide to release daughter merozoites, which in turn invade new erythrocytes perpetuating the cycle responsible for malaria. A key step in me...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21347
更新日期:2017-02-14 00:00:00
abstract::Mitochondrial division, essential for survival in mammals, is enhanced by an inter-organellar process involving ER tubules encircling and constricting mitochondria. The force for constriction is thought to involve actin polymerization by the ER-anchored isoform of the formin protein inverted formin 2 (INF2). Unknown i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08828
更新日期:2015-08-25 00:00:00
abstract::The anterior cingulate cortex (ACC) encodes information supporting mnemonic and cognitive processes. We show here that a rat's position can be decoded with high spatiotemporal resolution from ACC activity. ACC neurons encoded the current state of the animal and task, except for brief excursions that sometimes occurred...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.29793
更新日期:2018-04-17 00:00:00
abstract::Chemosensory neurons extract information about chemical cues from the environment. How is the activity in these sensory neurons transformed into behavior? Using Caenorhabditis elegans, we map a novel sensory neuron circuit motif that encodes odor concentration. Primary neurons, AWC(ON) and AWA, directly detect the foo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10181
更新日期:2015-09-22 00:00:00
abstract::The β-catenin transcriptional coregulator is involved in various biological and pathological processes; however, its requirements in hematopoietic cells remain controversial. We re-targeted the Ctnnb1 gene locus to generate a true β-catenin-null mutant mouse strain. Ablation of β-catenin alone, or in combination with ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55360
更新日期:2020-08-21 00:00:00
abstract::Calcineurin is responsible for mediating a wide variety of cellular processes in response to dynamic calcium (Ca(2+)) signals, yet the precise mechanisms involved in the spatiotemporal control of calcineurin signaling are poorly understood. Here, we use genetically encoded fluorescent biosensors to directly probe the ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03765
更新日期:2014-07-23 00:00:00
abstract::In addition to their role in desensitization and internalization of G protein-coupled receptors (GPCRs), β-arrestins are essential scaffolds linking GPCRs to Erk1/2 signaling. However, their role in GPCR-operated Erk1/2 activation differs between GPCRs and the underlying mechanism remains poorly characterized. Here, w...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23777
更新日期:2017-02-07 00:00:00
abstract::Upon detecting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive cellular changes to reestablish homeostasis. If stress resolution fails, the UPR commits the cell to apoptotic death. Here we show that in hematopoietic cells, including multiple myeloma (MM), lymphoma, and leuk...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47084
更新日期:2019-08-27 00:00:00
abstract::The calcium release-activated calcium channel Orai regulates Ca2+ entry into non-excitable cells and is required for proper immune function. While the channel typically opens following Ca2+ release from the endoplasmic reticulum, certain pathologic mutations render the channel constitutively open. Previously, using on...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62772
更新日期:2020-11-30 00:00:00
abstract::Cognitive functions such as working memory (WM) are emergent properties of large-scale network interactions. Synchronisation of oscillatory activity might contribute to WM by enabling the coordination of long-range processes. However, causal evidence for the way oscillatory activity shapes network dynamics and behavio...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22001
更新日期:2017-03-14 00:00:00
abstract::Individuals vary in their responses to stroke and trauma, hampering predictions of outcomes. One reason might be that neural circuits contain hidden variability that becomes relevant only when those individuals are challenged by injury. We found that in the mollusc, Tritonia diomedea, subtle differences between animal...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02598
更新日期:2014-06-11 00:00:00
abstract::Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S. kambucha, which mate to form viable hybrid diploids that effici...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02630
更新日期:2014-06-24 00:00:00
abstract::Many primary sensory cilia exhibit unique architectures that are critical for transduction of specific sensory stimuli. Although basic ciliogenic mechanisms are well described, how complex ciliary structures are generated remains unclear. Seminal work performed several decades ago provided an initial but incomplete de...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01948
更新日期:2014-03-25 00:00:00
abstract::We present a reanalysis of the stochastic model of organelle production and show that the equilibrium distributions for the organelle numbers predicted by this model can be readily calculated in three different scenarios. These three distributions can be identified as standard distributions, and the corresponding exac...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10167
更新日期:2015-12-22 00:00:00
abstract::How proteins harness mechanical force to control function is a significant biological question. Here we describe a human cell surface receptor that couples ligand binding and force to trigger a chemical event which controls the adhesive properties of the receptor. Our studies of the secreted platelet oxidoreductase, E...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34843
更新日期:2018-06-22 00:00:00
abstract::Many pathogens possess the capacity for sex through outcrossing, despite being able to reproduce also asexually and/or via selfing. Given that sex is assumed to come at a cost, these mixed reproductive strategies typical of pathogens have remained puzzling. While the ecological and evolutionary benefits of outcrossing...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47091
更新日期:2019-06-18 00:00:00
abstract::Smoothened (Smo) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling. Ptch, a proton driven antiporter, is required for Smo inhibition via an unknown mechanism. Hh ligand binding to Ptch reverses this inhibition and activated Smo initiates the Hh response. To determine whether Ptch inhibits Smo strictly...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17634
更新日期:2016-08-23 00:00:00
abstract::Ribosomes are universally important in biology and their production is dysregulated by developmental disorders, cancer, and virus infection. Although presumed required for protein synthesis, how ribosome biogenesis impacts virus reproduction and cell-intrinsic immune responses remains untested. Surprisingly, we find t...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49551
更新日期:2019-12-16 00:00:00
abstract::Negative regulators of adult neurogenesis are of particular interest as targets to enhance neuronal repair, but few have yet been identified. Planarians can regenerate their entire CNS using pluripotent adult stem cells, and this process is robustly regulated to ensure that new neurons are produced in proper abundance...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47293
更新日期:2020-01-20 00:00:00
abstract::Oomycete pathogens secrete host cell-entering effector proteins to manipulate host immunity during infection. We previously showed that PsAvh52, an early-induced RxLR effector secreted from the soybean root rot pathogen, Phytophthora sojae, could suppress plant immunity. Here, we found that PsAvh52 is required for ful...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40039
更新日期:2018-10-22 00:00:00
abstract::Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the molecular and cellular mechanisms underpinning these ageing processes re...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56221
更新日期:2020-08-25 00:00:00
abstract::As the staff of the MRC Laboratory of Molecular Biology settle into their new building in Cambridge, its director Hugh Pelham explains the challenges of living up to its prestigious past. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00856
更新日期:2013-05-28 00:00:00
abstract::The speed at which a cell fate decision in nematode worms evolves is due to the number of genes that control the decision, rather than to a high mutation rate. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.62689
更新日期:2020-10-14 00:00:00
abstract::The neuronal DNA-/RNA-binding protein Pur-alpha is a transcription regulator and core factor for mRNA localization. Pur-alpha-deficient mice die after birth with pleiotropic neuronal defects. Here, we report the crystal structure of the DNA-/RNA-binding domain of Pur-alpha in complex with ssDNA. It reveals base-specif...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11297
更新日期:2016-01-08 00:00:00
abstract::Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage. Here, we examine the impact of brief periods of sleep deprivation on dendritic structure. In mice, we find that five hours o...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.13424
更新日期:2016-08-23 00:00:00
abstract::With implantation, mouse stromal cells begin to transform into epithelial-like cells surrounding the implantation chamber forming an avascular zone called the primary decidual zone (PDZ). In the mouse, the PDZ forms a transient, size-dependent permeable barrier to protect the embryo from maternal circulating harmful a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.61762
更新日期:2020-09-29 00:00:00