Abstract:
:SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of Syngap1 in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walkup et al., 2016). For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young Syngap1+/-mice. Here we show that only females and not males show a highly significant correlation between an increase in TARP and a decrease in synGAP in the PSDs of Syngap1+/-rodents. The data reveal a sex difference in the adaptation of the PSD scaffold to synGAP haploinsufficiency.
journal_name
Elifejournal_title
eLifeauthors
Mastro TL,Preza A,Basu S,Chattarji S,Till SM,Kind PC,Kennedy MBdoi
10.7554/eLife.52656subject
Has Abstractpub_date
2020-01-15 00:00:00issn
2050-084Xpii
52656journal_volume
9pub_type
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