A principle of economy predicts the functional architecture of grid cells.

abstract：:Why does a first pregnancy after age 35 increase the risk of breast cancer, and what can be done to combat this? ...

journal_title：eLife

authors： Chakravarthi BV,Varambally S

更新日期：2013-12-31 00:00:00

abstract：:Many pathogens possess the capacity for sex through outcrossing, despite being able to reproduce also asexually and/or via selfing. Given that sex is assumed to come at a cost, these mixed reproductive strategies typical of pathogens have remained puzzling. While the ecological and evolutionary benefits of outcrossing...

journal_title：eLife

authors： Laine AL,Barrès B,Numminen E,Siren JP

更新日期：2019-06-18 00:00:00

abstract：:Mood and anxiety disorders are the most prevalent psychiatric conditions and are exacerbated by stress. Recent studies have suggested cyclooxygenase-2 (COX-2) inhibition could represent a novel treatment approach or augmentation strategy for affective disorders including anxiety disorders and major depression. We show...

journal_title：eLife

authors： Gamble-George JC,Baldi R,Halladay L,Kocharian A,Hartley N,Silva CG,Roberts H,Haymer A,Marnett LJ,Holmes A,Patel S

更新日期：2016-05-10 00:00:00

abstract：:We recently reported that the C2AB portion of Synaptotagmin 1 (Syt1) could self-assemble into Ca(2+)-sensitive ring-like oligomers on membranes, which could potentially regulate neurotransmitter release. Here we report that analogous ring-like oligomers assemble from the C2AB domains of other Syt isoforms (Syt2, Syt7,...

journal_title：eLife

authors： Zanetti MN,Bello OD,Wang J,Coleman J,Cai Y,Sindelar CV,Rothman JE,Krishnakumar SS

更新日期：2016-07-19 00:00:00

abstract：:Epicardial cells on the heart's surface give rise to coronary artery smooth muscle cells (caSMCs) located deep in the myocardium. However, the differentiation steps between epicardial cells and caSMCs are unknown as are the final maturation signals at coronary arteries. Here, we use clonal analysis and lineage tracing...

journal_title：eLife

authors： Volz KS,Jacobs AH,Chen HI,Poduri A,McKay AS,Riordan DP,Kofler N,Kitajewski J,Weissman I,Red-Horse K

更新日期：2015-10-19 00:00:00

abstract：:RNA molecules cause the proteins involved in the formation of germ granules to coalesce into liquid droplets. ...

journal_title：eLife

authors： Trcek T,Lehmann R

更新日期：2017-01-24 00:00:00

abstract：:The number of ions required to drive substrate transport through a secondary active transporter determines the protein's ability to create a substrate gradient, a feature essential to its physiological function, and places fundamental constraints on the transporter's mechanism. Stoichiometry is known for a wide array ...

journal_title：eLife

authors： Fitzgerald GA,Mulligan C,Mindell JA

更新日期：2017-01-25 00:00:00

abstract：:Psychological theories of suicide suggest that certain traits may reduce aversion to physical threat and increase the probability of transitioning from suicidal ideation to action. Here, we investigated whether blunted sensitivity to bodily signals is associated with suicidal action by comparing individuals with a his...

journal_title：eLife

authors： DeVille DC,Kuplicki R,Stewart JL,Tulsa 1000 Investigators.,Paulus MP,Khalsa SS

更新日期：2020-04-07 00:00:00

abstract：:The brain has an impressive ability to withstand neural damage. Diseases that kill neurons can go unnoticed for years, and incomplete brain lesions or silencing of neurons often fail to produce any behavioral effect. How does the brain compensate for such damage, and what are the limits of this compensation? We propos...

journal_title：eLife

authors： Barrett DG,Denève S,Machens CK

更新日期：2016-12-09 00:00:00

abstract：:Atopic dermatitis can result from loss of structural proteins in the outermost epidermal layers, leading to a defective epidermal barrier. To test whether this influences tumour formation, we chemically induced tumours in EPI-/- mice, which lack three barrier proteins-Envoplakin, Periplakin, and Involucrin. EPI-/- mic...

journal_title：eLife

authors： Cipolat S,Hoste E,Natsuga K,Quist SR,Watt FM

更新日期：2014-05-05 00:00:00

abstract：:Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers. Technical advances in cryo-electron microscopy brought a slew of full-length structu...

journal_title：eLife

authors： Baranovic J,Plested AJ

更新日期：2018-12-06 00:00:00

abstract：:Sex-specific synaptic connectivity is beginning to emerge as a remarkable, but little explored feature of animal brains. We describe here a novel mechanism that promotes sexually dimorphic neuronal function and synaptic connectivity in the nervous system of the nematode Caenorhabditis elegans. We demonstrate that a ph...

journal_title：eLife

authors： Bayer EA,Stecky RC,Neal L,Katsamba PS,Ahlsen G,Balaji V,Hoppe T,Shapiro L,Oren-Suissa M,Hobert O

更新日期：2020-10-06 00:00:00

abstract：:The voltage-gated K+ channel Kv2.1 serves a major structural role in the soma and proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to endoplasmic reticulum (ER). Although Kv2.1 clustering at neuronal ER-PM junctions (EPJs) is tightly regulated and highly conserved, its function remains...

journal_title：eLife

authors： Vierra NC,Kirmiz M,van der List D,Santana LF,Trimmer JS

更新日期：2019-10-30 00:00:00

abstract：:Human-based modelling and simulations are becoming ubiquitous in biomedical science due to their ability to augment experimental and clinical investigations. Cardiac electrophysiology is one of the most advanced areas, with cardiac modelling and simulation being considered for virtual testing of pharmacological therap...

journal_title：eLife

authors： Tomek J,Bueno-Orovio A,Passini E,Zhou X,Minchole A,Britton O,Bartolucci C,Severi S,Shrier A,Virag L,Varro A,Rodriguez B

更新日期：2019-12-24 00:00:00

abstract：:Seed dormancy is a complex life history trait that determines the timing of germination and is crucial for local adaptation. Genetic studies of dormancy are challenging, because the trait is highly plastic and strongly influenced by the maternal environment. Using a combination of statistical and experimental approach...

journal_title：eLife

authors： Kerdaffrec E,Filiault DL,Korte A,Sasaki E,Nizhynska V,Seren Ü,Nordborg M

更新日期：2016-12-14 00:00:00

abstract：:Adult-born neurons are continually produced in the dentate gyrus but it is unclear whether synaptic integration of new neurons affects the pre-existing circuit. Here we investigated how manipulating neurogenesis in adult mice alters excitatory synaptic transmission to mature dentate neurons. Enhancing neurogenesis by ...

journal_title：eLife

authors： Adlaf EW,Vaden RJ,Niver AJ,Manuel AF,Onyilo VC,Araujo MT,Dieni CV,Vo HT,King GD,Wadiche JI,Overstreet-Wadiche L

更新日期：2017-01-30 00:00:00

abstract：:Claims that magnetic fields can be used to manipulate biological systems contradict some basic laws of physics. ...

journal_title：eLife

authors： Anikeeva P,Jasanoff A

更新日期：2016-09-08 00:00:00

abstract：:Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune system. Here we report ...

journal_title：eLife

authors： Bazzi W,Cattenoz PB,Delaporte C,Dasari V,Sakr R,Yuasa Y,Giangrande A

更新日期：2018-07-11 00:00:00

abstract：:Optical imaging has become a powerful tool for studying brains in vivo. The opacity of adult brains makes microendoscopy, with an optical probe such as a gradient index (GRIN) lens embedded into brain tissue to provide optical relay, the method of choice for imaging neurons and neural activity in deeply buried brain s...

journal_title：eLife

authors： Meng G,Liang Y,Sarsfield S,Jiang WC,Lu R,Dudman JT,Aponte Y,Ji N

更新日期：2019-01-04 00:00:00

abstract：:The vascular pathogen Verticillium dahliae infects the roots of plants to cause Verticillium wilt. The molecular mechanisms underlying V. dahliae virulence and host resistance remain elusive. Here, we demonstrate that a secretory protein, VdSCP41, functions as an intracellular effector that promotes V. dahliae virulen...

journal_title：eLife

authors： Qin J,Wang K,Sun L,Xing H,Wang S,Li L,Chen S,Guo HS,Zhang J

更新日期：2018-05-14 00:00:00

abstract：:Phenazines are natural bacterial antibiotics that can protect crops from disease. However, for most crops it is unknown which producers and specific phenazines are ecologically relevant, and whether phenazine biodegradation can counter their effects. To better understand their ecology, we developed and environmentally...

journal_title：eLife

authors： Dar D,Thomashow LS,Weller DM,Newman DK

更新日期：2020-09-15 00:00:00

abstract：:As the staff of the MRC Laboratory of Molecular Biology settle into their new building in Cambridge, its director Hugh Pelham explains the challenges of living up to its prestigious past. ...

journal_title：eLife

authors： Pelham H

更新日期：2013-05-28 00:00:00

abstract：:Direct activation of the human phospholipase C-γ isozymes (PLC-γ1, -γ2) by tyrosine phosphorylation is fundamental to the control of diverse biological processes, including chemotaxis, platelet aggregation, and adaptive immunity. In turn, aberrant activation of PLC-γ1 and PLC-γ2 is implicated in inflammation, autoimmu...

journal_title：eLife

authors： Hajicek N,Keith NC,Siraliev-Perez E,Temple BR,Huang W,Zhang Q,Harden TK,Sondek J

更新日期：2019-12-31 00:00:00

abstract：:Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular sources of neuroinflammation during malignancy are unknown. In a mouse model of pancreatic ductal adenocarcinoma (PDAC), we observed ea...

journal_title：eLife

authors： Burfeind KG,Zhu X,Norgard MA,Levasseur PR,Huisman C,Buenafe AC,Olson B,Michaelis KA,Torres ER,Jeng S,McWeeney S,Raber J,Marks DL

更新日期：2020-05-11 00:00:00

abstract：:Toxoplasma gondii contains a limited subset of actin binding proteins. Here we show that the putative actin regulator cyclase-associated protein (CAP) is present in two different isoforms and its deletion leads to significant defects in some but not all actin dependent processes. We observe defects in cell-cell commun...

journal_title：eLife

authors： Hunt A,Russell MRG,Wagener J,Kent R,Carmeille R,Peddie CJ,Collinson L,Heaslip A,Ward GE,Treeck M

更新日期：2019-10-02 00:00:00

abstract：:Being exposed to cannabinoids in the womb has different consequences for male and female rats. ...

journal_title：eLife

authors： Musardo S,Bellone C

更新日期：2018-09-28 00:00:00

abstract：:The orbitofrontal cortex (OFC) is critical for updating reward-directed behaviours flexibly when outcomes are devalued or when task contingencies are reversed. Failure to update behaviour in outcome devaluation and reversal learning procedures are considered canonical deficits following OFC lesions in non-human primat...

journal_title：eLife

authors： Panayi MC,Killcross S

更新日期：2018-07-25 00:00:00

abstract：:Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-ra...

journal_title：eLife

authors： Fernandez LM,Vantomme G,Osorio-Forero A,Cardis R,Béard E,Lüthi A

更新日期：2018-12-25 00:00:00

abstract：:We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcriptional activity, prostate cancer (PCa) cell growth, and androgen sensitivity. We have now uncovered that the AR directly interacts with CHK2 and ionizing radiation (IR) increases this int...

journal_title：eLife

authors： Ta HQ,Dworak N,Ivey ML,Roller DG,Gioeli D

更新日期：2020-06-24 00:00:00

abstract：:Complexin regulates spontaneous and activates Ca(2+)-triggered neurotransmitter release, yet the molecular mechanisms are still unclear. Here we performed single molecule fluorescence resonance energy transfer experiments and uncovered two conformations of complexin-1 bound to the ternary SNARE complex. In the cis con...

journal_title：eLife

authors： Choi UB,Zhao M,Zhang Y,Lai Y,Brunger AT

更新日期：2016-06-02 00:00:00