Abstract:
:Adult-born neurons are continually produced in the dentate gyrus but it is unclear whether synaptic integration of new neurons affects the pre-existing circuit. Here we investigated how manipulating neurogenesis in adult mice alters excitatory synaptic transmission to mature dentate neurons. Enhancing neurogenesis by conditional deletion of the pro-apoptotic gene Bax in stem cells reduced excitatory postsynaptic currents (EPSCs) and spine density in mature neurons, whereas genetic ablation of neurogenesis increased EPSCs in mature neurons. Unexpectedly, we found that Bax deletion in developing and mature dentate neurons increased EPSCs and prevented neurogenesis-induced synaptic suppression. Together these results show that neurogenesis modifies synaptic transmission to mature neurons in a manner consistent with a redistribution of pre-existing synapses to newly integrating neurons and that a non-apoptotic function of the Bax signaling pathway contributes to ongoing synaptic refinement within the dentate circuit.
journal_name
Elifejournal_title
eLifeauthors
Adlaf EW,Vaden RJ,Niver AJ,Manuel AF,Onyilo VC,Araujo MT,Dieni CV,Vo HT,King GD,Wadiche JI,Overstreet-Wadiche Ldoi
10.7554/eLife.19886subject
Has Abstractpub_date
2017-01-30 00:00:00issn
2050-084Xjournal_volume
6pub_type
杂志文章相关文献
eLife文献大全abstract::The roles of long non-coding RNAs (lncRNAs) in regulating cancer and stem cells are being increasingly appreciated. Its diverse mechanisms provide the regulatory network with a bigger repertoire to increase complexity. Here we report a novel LncRNA, Lnc34a, that is enriched in colon cancer stem cells (CCSCs) and initi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14620
更新日期:2016-04-14 00:00:00
abstract::Animals seek out relevant information by moving through a dynamic world, but sensory systems are usually studied under highly constrained and passive conditions that may not probe important dimensions of the neural code. Here, we explored neural coding in the barrel cortex of head-fixed mice that tracked walls with th...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12559
更新日期:2015-12-23 00:00:00
abstract::Heterogeneity broadly exists in various cell types both during development and at homeostasis. Investigating heterogeneity is crucial for comprehensively understanding the complexity of ontogeny, dynamics, and function of specific cell types. Traditional bulk-labeling techniques are incompetent to dissect heterogeneit...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52024
更新日期:2020-01-06 00:00:00
abstract::Rod and cone photoreceptors are highly similar in many respects but they have important functional and molecular differences. Here, we investigate genome-wide patterns of DNA methylation and chromatin accessibility in mouse rods and cones and correlate differences in these features with gene expression, histone marks,...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11613
更新日期:2016-03-07 00:00:00
abstract::The integrity of the nuclear membranes coupled to the selective barrier of nuclear pore complexes (NPCs) are essential for the segregation of nucleoplasm and cytoplasm. Mechanical membrane disruption or perturbation to NPC assembly triggers an ESCRT-dependent surveillance system that seals nuclear pores: how these por...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45284
更新日期:2019-04-03 00:00:00
abstract::Progression through the mitotic cell cycle requires periodic regulation of gene function at the levels of transcription, translation, protein-protein interactions, post-translational modification and degradation. However, the role of alternative splicing (AS) in the temporal control of cell cycle is not well understoo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10288
更新日期:2016-03-25 00:00:00
abstract::INAD assembles key enzymes of the Drosophila compound eye photo-transduction pathway into a supramolecular complex, supporting efficient and fast light signaling. However, the molecular mechanism that governs the interaction between INAD and NORPA (phospholipase Cβ, PLCβ), a key step for the fast kinetics of the light...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.41848
更新日期:2018-12-10 00:00:00
abstract::Humans employ different strategies when making decisions. Previous research has reported reduced reliance on model-based strategies with aging, but it remains unclear whether this is due to cognitive or motivational factors. Moreover, it is not clear how aging affects the metacontrol of decision making, that is the dy...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49154
更新日期:2019-08-09 00:00:00
abstract::Genome-wide association studies identified the BIN1 locus as a leading modulator of genetic risk in Alzheimer's disease (AD). One limitation in understanding BIN1's contribution to AD is its unknown function in the brain. AD-associated BIN1 variants are generally noncoding and likely change expression. Here, we determ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57354
更新日期:2020-07-13 00:00:00
abstract::Mouse GnT1IP-L, and membrane-bound GnT1IP-S (MGAT4D) expressed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltransferase that initiates the synthesis of hybrid and complex N-glycans. However, it is not known where in the secretory pathway GnT1IP-L inhibits MGAT1, nor whether GnT1IP-L inhibits other N-glycan...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08916
更新日期:2015-09-15 00:00:00
abstract::Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a 'multi-omics' approach to demonstrate that the duration of polymerase pausing generally limits the productive frequency of transcription i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.29736
更新日期:2017-10-10 00:00:00
abstract::In homeostatic scaling at central synapses, the depth and breadth of cellular mechanisms that detect the offset from the set-point, detect the duration of the offset and implement a cellular response are not well understood. To understand the time-dependent scaling dynamics we treated cultured rat hippocampal cells wi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33322
更新日期:2018-02-15 00:00:00
abstract::The design of synthetic optogenetic tools that allow precise spatiotemporal control of biological processes previously inaccessible to optogenetic control has developed rapidly over the last years. Rational design of such tools requires detailed knowledge of allosteric light signaling in natural photoreceptors. To und...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11860
更新日期:2016-01-12 00:00:00
abstract::The genome-scale transcriptional programs that specify the mammalian trachea and esophagus are unknown. Though NKX2-1 and SOX2 are hypothesized to be co-repressive master regulators of tracheoesophageal fates, this is untested at a whole transcriptomic scale and their downstream networks remain unidentified. By combin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55526
更新日期:2020-06-09 00:00:00
abstract::We analyzed 2898 scientific papers published between 1995 and 2017 in which two or more authors shared the first author position. For papers in which the first and second authors made equal contributions, mixed-gender combinations were most frequent, followed by male-male and then female-female author combinations. Fo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36399
更新日期:2019-01-29 00:00:00
abstract::White adipose tissue (WAT) inflammation contributes to the development of insulin resistance in obesity. While the role of adipose tissue macrophage (ATM) pro-inflammatory signalling in the development of insulin resistance has been established, it is less clear how WAT inflammation is initiated. Here, we show that AT...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47990
更新日期:2019-08-16 00:00:00
abstract::Hawaiian isolates of the nematode species Caenorhabditis elegans have long been known to harbor genetic diversity greater than the rest of the worldwide population, but this observation was supported by only a small number of wild strains. To better characterize the niche and genetic diversity of Hawaiian C. elegans a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50465
更新日期:2019-12-03 00:00:00
abstract::Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption and recycling respectively. Recently, we demonstrated that ferroportin is also found in cardiomyocytes, and that its cardiac-spe...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.19804
更新日期:2016-11-29 00:00:00
abstract::The link between the combined action of neuromodulators in the brain and global brain states remains a mystery. In this study, using biophysically realistic models of the thalamocortical network, we identified the critical intrinsic and synaptic mechanisms, associated with the putative action of acetylcholine (ACh), G...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18607
更新日期:2016-11-16 00:00:00
abstract::Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm. An additional 68 worms were collected from 60 human hosts in Kenyan vil...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.61562
更新日期:2020-11-06 00:00:00
abstract::Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed mas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.63430
更新日期:2020-12-17 00:00:00
abstract::Deinococcus radiodurans (DR) survives in the presence of hundreds of double-stranded DNA (dsDNA) breaks by efficiently repairing such breaks. RecO, a protein that is essential for the extreme radioresistance of DR, is one of the major recombination mediator proteins in the RecA-loading process in the RecFOR pathway. H...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50945
更新日期:2020-04-16 00:00:00
abstract::Correct neuronal development requires tailored neurite outgrowth. Neurite outgrowth is driven in part by microtubule-sliding - the transport of microtubules along each other. We have recently demonstrated that a 'mitotic' kinesin-6 (Pavarotti in Drosophila) effectively inhibits microtubule-sliding and neurite outgrowt...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52009
更新日期:2020-02-05 00:00:00
abstract::Visual perception and behavior are mediated by cortical areas that have been distinguished using architectonic and retinotopic criteria. We employed fluorescence imaging and GCaMP6 reporter mice to generate retinotopic maps, revealing additional regions of retinotopic organization that extend into barrel and retrosple...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18372
更新日期:2017-01-06 00:00:00
abstract::Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. Here, we demonstrate that chromatin-associated RNA contributes to the stable association of SUV39H...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25299
更新日期:2017-08-01 00:00:00
abstract::Visual perception and imagery rely on similar representations in the visual cortex. During perception, visual activity is characterized by distinct processing stages, but the temporal dynamics underlying imagery remain unclear. Here, we investigated the dynamics of visual imagery in human participants using magnetoenc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33904
更新日期:2018-05-29 00:00:00
abstract::Our understanding of nonlinear stimulus transformations by neural circuits is hindered by the lack of comprehensive yet interpretable computational modeling frameworks. Here, we propose a data-driven approach based on deep neural networks to directly model arbitrarily nonlinear stimulus-response mappings. Reformulatin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53445
更新日期:2020-06-26 00:00:00
abstract::Regulation of food intake is fundamental to energy homeostasis in animals. The contribution of non-nutritive and metabolic signals in regulating feeding is unclear. Here we show that enteric neurons play a major role in regulating feeding through specialized mechanosensory ion channels in Drosophila. Modulating activi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04402
更新日期:2014-10-06 00:00:00
abstract::Optical imaging has become a powerful tool for studying brains in vivo. The opacity of adult brains makes microendoscopy, with an optical probe such as a gradient index (GRIN) lens embedded into brain tissue to provide optical relay, the method of choice for imaging neurons and neural activity in deeply buried brain s...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40805
更新日期:2019-01-04 00:00:00
abstract::Drosophila larvae and adults possess a potent innate immune response, but the response of Drosophila eggs is poor. In contrast to Drosophila, eggs of the beetle Tribolium are protected by a serosa, an extraembryonic epithelium that is present in all insects except higher flies. In this study, we test a possible immune...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04111
更新日期:2014-12-09 00:00:00