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eLife文献大全abstract::Conventional Ly6Chi monocytes have developmental plasticity for a spectrum of differentiated phagocytes. Here we show, using conditional deletion strategies in a mouse model of Toll-like receptor (TLR) 7-induced inflammation, that the spectrum of developmental cell fates of Ly6Chi monocytes, and the resultant inflamma...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57007
更新日期:2020-07-29 00:00:00
abstract::The equilibrium between proliferation and quiescence of myogenic progenitor and stem cells is tightly regulated to ensure appropriate skeletal muscle growth and repair. The non-receptor tyrosine phosphatase Ptpn11 (Shp2) is an important transducer of growth factor and cytokine signals. Here we combined complex genetic...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21552
更新日期:2017-05-02 00:00:00
abstract::A heat exchange mechanism in the head of kissing bugs helps to prevent stress and regulate their temperature while they feed on warm blood. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.33035
更新日期:2017-11-21 00:00:00
abstract::Using knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30373
更新日期:2018-03-07 00:00:00
abstract::Pore-blocking toxins inhibit voltage-dependent K(+) channels (Kv channels) by plugging the ion-conduction pathway. We have solved the crystal structure of paddle chimera, a Kv channel in complex with charybdotoxin (CTX), a pore-blocking toxin. The toxin binds to the extracellular pore entryway without producing discer...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00594
更新日期:2013-05-21 00:00:00
abstract::The Frank-Starling relation is a fundamental auto-regulatory property of the heart that ensures the volume of blood ejected in each heartbeat is matched to the extent of venous filling. At the cellular level, heart muscle cells generate higher force when stretched, but despite intense efforts the underlying molecular ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.24081
更新日期:2017-02-23 00:00:00
abstract::A small transparent crustacean called Parhyale hawaiensis has become a powerful model system for the study of limb and appendage regeneration. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.21583
更新日期:2016-10-25 00:00:00
abstract::Perturbation of neuronal activity is key to understanding the brain's functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in identified target n...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52757
更新日期:2020-02-19 00:00:00
abstract::Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelle...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25014
更新日期:2017-06-30 00:00:00
abstract::Our understanding of the antigen presentation pathway has recently been enhanced with the identification that the tapasin-related protein TAPBPR is a second major histocompatibility complex (MHC) class I-specific chaperone. We sought to determine whether, like tapasin, TAPBPR can also influence MHC class I peptide sel...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09617
更新日期:2015-10-06 00:00:00
abstract::The biology of sponges provides clues about how early animals may have dealt with low levels of oxygen. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.34756
更新日期:2018-02-06 00:00:00
abstract::Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocy...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25903
更新日期:2017-05-16 00:00:00
abstract::The gut microbiota of patients recently diagnosed with rheumatoid arthritis is enriched in microbes belonging to the Prevotella genus. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.01608
更新日期:2013-11-05 00:00:00
abstract::Single-molecule experiments reveal the dynamics of transcription through a nucleosome with single-base-pair accuracy. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.50761
更新日期:2019-09-13 00:00:00
abstract::Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens. RNA viruses typically have high mutation rates, resulting in frequent production of protein variants with compromised biophysical properties. Their evolution i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28652
更新日期:2017-09-26 00:00:00
abstract::The orbitofrontal cortex (OFC) is critical for updating reward-directed behaviours flexibly when outcomes are devalued or when task contingencies are reversed. Failure to update behaviour in outcome devaluation and reversal learning procedures are considered canonical deficits following OFC lesions in non-human primat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37357
更新日期:2018-07-25 00:00:00
abstract::Convenient, efficient and fast whole-brain delivery of transgenes presents a persistent experimental challenge in neuroscience. Recent advances demonstrate whole-brain gene delivery by retro-orbital injection of virus, but slow and sparse expression and the large injection volumes required make this approach cumbersom...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53639
更新日期:2020-05-18 00:00:00
abstract::Bone destruction relies on interactions between bone and immune cells. Bone-resorbing osteoclasts (OCLs) were recently identified as innate immune cells activating T cells toward tolerance or inflammation. Thus, pathological bone destruction not only relies on increased osteoclast differentiation, but also on the pres...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54493
更新日期:2020-05-13 00:00:00
abstract::Rats exhibit 'empathy' making them a model to understand the neural underpinnings of such behavior. We show data consistent with these findings, but also that behavior and dopamine (DA) release reflects subjective rather than objective evaluation of appetitive and aversive events that occur to another. We recorded DA ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.38090
更新日期:2018-11-28 00:00:00
abstract::Seasonal influenza virus A/H3N2 is a major cause of death globally. Vaccination remains the most effective preventative. Rapid mutation of hemagglutinin allows viruses to escape adaptive immunity. This antigenic drift necessitates regular vaccine updates. Effective vaccine strains need to represent H3N2 populations ci...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60067
更新日期:2020-09-02 00:00:00
abstract::Drosophila larvae and adults possess a potent innate immune response, but the response of Drosophila eggs is poor. In contrast to Drosophila, eggs of the beetle Tribolium are protected by a serosa, an extraembryonic epithelium that is present in all insects except higher flies. In this study, we test a possible immune...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04111
更新日期:2014-12-09 00:00:00
abstract::Toothed whales use sonar to detect, locate, and track prey. They adjust emitted sound intensity, auditory sensitivity and click rate to target range, and terminate prey pursuits with high-repetition-rate, low-intensity buzzes. However, their narrow acoustic field of view (FOV) is considered stable throughout target ap...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.05651
更新日期:2015-03-20 00:00:00
abstract::The genome-scale transcriptional programs that specify the mammalian trachea and esophagus are unknown. Though NKX2-1 and SOX2 are hypothesized to be co-repressive master regulators of tracheoesophageal fates, this is untested at a whole transcriptomic scale and their downstream networks remain unidentified. By combin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55526
更新日期:2020-06-09 00:00:00
abstract::Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological blood pressure and contribute to hypertension in vivo. We generate...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.42628
更新日期:2018-12-04 00:00:00
abstract::Many pathogens possess the capacity for sex through outcrossing, despite being able to reproduce also asexually and/or via selfing. Given that sex is assumed to come at a cost, these mixed reproductive strategies typical of pathogens have remained puzzling. While the ecological and evolutionary benefits of outcrossing...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47091
更新日期:2019-06-18 00:00:00
abstract::We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcriptional activity, prostate cancer (PCa) cell growth, and androgen sensitivity. We have now uncovered that the AR directly interacts with CHK2 and ionizing radiation (IR) increases this int...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51378
更新日期:2020-06-24 00:00:00
abstract::The factors that govern assembly of the gut microbiota are insufficiently understood. Here, we test the hypothesis that inter-individual microbiota variation can arise solely from differences in the order and timing by which the gut is colonized early in life. Experiments in which mice were inoculated in sequence eith...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36521
更新日期:2018-09-18 00:00:00
abstract::Termination of messenger RNA translation in Bacteria and Archaea is initiated by release factors (RFs) 1 or 2 recognizing a stop codon in the ribosomal A site and releasing the peptide from the P-site transfer RNA. After release, RF-dissociation is facilitated by the G-protein RF3. Structures of ribosomal complexes wi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00411
更新日期:2013-06-04 00:00:00
abstract::Dietary restriction increases the longevity of many organisms, but the cell signaling and organellar mechanisms underlying this capability are unclear. We demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells activate lipid-droplet (LD) consumption through micro-lipophagy (...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21690
更新日期:2017-04-10 00:00:00
abstract::In endoplasmic reticulum-associated protein degradation (ERAD), membrane proteins are ubiquitinated, extracted from the membrane, and degraded by the proteasome. The cytosolic ATPase Cdc48 drives extraction by pulling on polyubiquitinated substrates. How hydrophobic transmembrane (TM) segments are moved from the phosp...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56945
更新日期:2020-06-26 00:00:00