Loss of Ptpn11 (Shp2) drives satellite cells into quiescence.


:The equilibrium between proliferation and quiescence of myogenic progenitor and stem cells is tightly regulated to ensure appropriate skeletal muscle growth and repair. The non-receptor tyrosine phosphatase Ptpn11 (Shp2) is an important transducer of growth factor and cytokine signals. Here we combined complex genetic analyses, biochemical studies and pharmacological interference to demonstrate a central role of Ptpn11 in postnatal myogenesis of mice. Loss of Ptpn11 drove muscle stem cells out of the proliferative and into a resting state during muscle growth. This Ptpn11 function was observed in postnatal but not fetal myogenic stem cells. Furthermore, muscle repair was severely perturbed when Ptpn11 was ablated in stem cells due to a deficit in stem cell proliferation and survival. Our data demonstrate a molecular difference in the control of cell cycle withdrawal in fetal and postnatal myogenic stem cells, and assign to Ptpn11 signaling a key function in satellite cell activity.






Griger J,Schneider R,Lahmann I,Schöwel V,Keller C,Spuler S,Nazare M,Birchmeier C




Has Abstract


2017-05-02 00:00:00










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    abstract::The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear. Using electron microscopy, we have determined the structure of the CMG in the presence of ATPγS and a DNA duplex bearing a 3' single-stranded tail. The struc...


    pub_type: 杂志文章


    authors: Costa A,Renault L,Swuec P,Petojevic T,Pesavento JJ,Ilves I,MacLellan-Gibson K,Fleck RA,Botchan MR,Berger JM

    更新日期:2014-08-12 00:00:00

  • Evidence for transmission of COVID-19 prior to symptom onset.

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    authors: Tindale LC,Stockdale JE,Coombe M,Garlock ES,Lau WYV,Saraswat M,Zhang L,Chen D,Wallinga J,Colijn C

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    authors: Sadanandappa MK

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    pub_type: 杂志文章


    authors: Agmon H,Burak Y

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    pub_type: 评论,杂志文章


    authors: Kim I,Koh GY

    更新日期:2017-01-31 00:00:00

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    更新日期:2018-03-23 00:00:00

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  • Building for the future.

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    authors: Pelham H

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    authors: Andersen JP,Nielsen MW,Simone NL,Lewiss RE,Jagsi R

    更新日期:2020-06-15 00:00:00

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    authors: Maruno T,Fukuda A,Goto N,Tsuda M,Ikuta K,Hiramatsu Y,Ogawa S,Nakanishi Y,Yamaga Y,Yoshioka T,Takaori K,Uemoto S,Saur D,Chiba T,Seno H

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    authors: Preston-Ferrer P,Coletta S,Frey M,Burgalossi A

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    pub_type: 杂志文章


    authors: Wales P,Schuberth CE,Aufschnaiter R,Fels J,García-Aguilar I,Janning A,Dlugos CP,Schäfer-Herte M,Klingner C,Wälte M,Kuhlmann J,Menis E,Hockaday Kang L,Maier KC,Hou W,Russo A,Higgs HN,Pavenstädt H,Vogl T,Roth J,Qual

    更新日期:2016-12-06 00:00:00

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    pub_type: 评论,杂志文章


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    pub_type: 杂志文章


    authors: Baldi S,Bolognesi A,Meinema AC,Barral Y

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Tomek J,Bueno-Orovio A,Passini E,Zhou X,Minchole A,Britton O,Bartolucci C,Severi S,Shrier A,Virag L,Varro A,Rodriguez B

    更新日期:2019-12-24 00:00:00

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    pub_type: 杂志文章


    authors: Murase S,Lantz CL,Quinlan EM

    更新日期:2017-09-06 00:00:00

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    pub_type: 杂志文章


    authors: Madhwal S,Shin M,Kapoor A,Goyal M,Joshi MK,Ur Rehman PM,Gor K,Shim J,Mukherjee T

    更新日期:2020-12-29 00:00:00

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    更新日期:2017-07-31 00:00:00

  • Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma.

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    pub_type: 杂志文章


    authors: Tenente IM,Hayes MN,Ignatius MS,McCarthy K,Yohe M,Sindiri S,Gryder B,Oliveira ML,Ramakrishnan A,Tang Q,Chen EY,Petur Nielsen G,Khan J,Langenau DM

    更新日期:2017-01-12 00:00:00