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Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer.

Abstract：

OBJECTIVE:To test the anticancer potential activity of the combination of thymoquinone (TQ) and resveratrol (RES) against breast cancer in mice. METHODS:The antiproliferative activity of TQ, RES and their combination was assessed against three breast cancer cell lines and one normal cells using MTT assay. The combination index was calculated using isobolographic method. Balb/C mice were inoculated with EMT6/P cells and in vivo antitumor activity was evaluated. RESULTS:The combination therapy also caused significant decrease in tumor size with a percentage cure of 60%. The combination therapy induced geographic necrosis, enhanced apoptosis, and decreased VEGF expression. Serum levels of IFN-γ were elevated in mice treated with combination therapy with no liver or kidney toxicity. CONCLUSIONS:The combination of TQ and RES against breast cancer in mice can work synergistically. The anticancer effect of this combination is mediated by apoptosis induction, angiogenesis inhibition and immune modulation.

journal_name

Asian Pac J Trop Med

journal_title

Asian Pacific journal of tropical medicine

authors

Alobaedi OH,Talib WH,Basheti IA

doi

10.1016/j.apjtm.2017.03.026

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

400-408

issue

4

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(17)30581-3

journal_volume

10

pub_type

杂志文章

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